Takashi Saku

Establishment and characterization of pleomorphic adenoma cell systems: an in-vitro demonstration of carcinomas arising secondarily from adenomas in the salivary gland (2009)

Maruyama, Satoshi, Cheng, Jun, Shingaki, Susumu, Tamura, Takashi, Asakawa, Shuichi, Minoshima, Shinsei, ...

Abstract Background Among the salivary gland carcinomas, carcinoma in pleomorphic adenoma has been regarded as a representative carcinoma type which arises secondarily in the background of a...

Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products (2002)

Fushinobu, Shinya, Saku, Takashi, Hidaka, Masafumi, Jun, So-Young, Nojiri, Hideaki, Yamane, Hisakazu, ...

2-Hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase (CumD) from Pseudomonas fluorescens IP01 hydrolyzes a meta-cleavage product generated in the cumene (isopropylbenzene) degradation pathway. The...

Basement Membrane Heparan Sulfate Proteoglycan (Perlecan) Synthesized by ACC3, Adenoid Cystic Carcinoma Cells of Human Salivary Gland Origin (1999)

Kimura, Shinn, Cheng, Jun, Toyoshima, Koh-éi, Oda, Kimimitsu, Saku, Takashi

The biosynthesis of basement membrane heparan sulfate proteoglycan (HSPG), known as perlecan, in ACC3 cells established from a adenoid cystic carcinoma of the human salivary gland was studied using...

An Immunocytochemical Study on Distinct Intracellular Localization of Cathepsin E and Cathepsin D in Human Gastric Cells and Various Rat Cells (1991)

Saku, Takashi, Sakai, Hideaki, Shibata, Yasuaki, Kato, Yuzo, Yamamoto, Kenji

Immunocytochemical localization of two distinct intracellular aspartic proteinases, cathepsins E and D, in human gastric mucosal cells and various rat cells was investigated by immunogold technique...

Characterization of Hemoglobin-Hydrolyzing Acidic Proteinases in Human and Rat Neutrophils (1990)

Ichimaru, Eiji, Sakai, Hideaki, Saku, Takashi, Kunimatsu, Kazushi, Kato, Yuzo, Kato, Ihachi, ...

The nature and levels of hemoglobin (Hb)-hydrolyzing acidic proteinases including cathepsin D and cathepsin E, which were most active at pH 3.5–4.0, were enzymatically and immunochemically compared...

The Localization of Human Keratin Proteins at Cytological and Histological Levels in Carcinomatous and Sarcomatous Lesions (1986)

YAGI, YUKIO, IMAMURA, YASUSHI, SAKU, TAKASHI, SHIMOTSU, TAKASHI, HATAE, MASANORI, YAGI, SHUNICHI

Immunoperoxidase staining for human keratin proteins was performed cytologically on samples from 90 patients with malignant tumors, and histologically on samples from 164 patients with malignant...

Antibody against 25,000 Dalton Tryptic Fragment of Subfragment-1 from Chicken Skeletal Muscle Myosin: Functional Implication of the 25,000 Fragment Region in Subfragment-1 (1984)

MIYANISHI, Takayuki, SAKU, Takashi, MATSUDA, Genji

Antibody was prepared against the 25,000-dalton tryptic fragment of subfragment-1 from skeletal muscle myosin. The antibody was found to inhibit the Mg2+-ATPase activity and the initial P1-burst...

Large Scale Molecular Analysis Identifies Genes with Altered Expression in Salivary Adenoid Cystic Carcinoma

Frierson, Henry F., El-Naggar, Adel K., Welsh, John B., Sapinoso, Lisa M., Su, Andrew I., Cheng, Jun, ...

Salivary gland cancers comprise a heterogeneous group of neoplasms whose biological and clinical characteristics differ considerably from those of mucosal squamous cell carcinomas of the head and...

Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products

Fushinobu, Shinya, Saku, Takashi, Hidaka, Masafumi, Jun, So-Young, Nojiri, Hideaki, Yamane, Hisakazu, ...

2-Hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase (CumD) from Pseudomonas fluorescens IP01 hydrolyzes a meta-cleavage product generated in the cumene (isopropylbenzene) degradation pathway. The...