Takashi Shimada

Swimming in Granular Media (2009)

Shimada, Takashi, Kadau, Dirk, Shinbrot, Troy, Herrmann, Hans J.

We study a simple model of periodic contraction and extension of large intruders in a granular bed to understand the mechanism for swimming in an otherwise solid media. Using an event-driven...

Bulk ACCVD Generation of SWNTs with Narrow Chirality Distribution (2009)

Shigeo Maruyama, Yuhei Miyauchi, Takashi Shimada, Yoichi Murakami, Kenichi Sato, Yuji Ozeki, ...

By scaling up the alcohol CCVD (ACCVD) generation technique [1,2] of single-walled carbon nanotubes (SWNTs), bulk amount of sample is being prepared. By dissolving zeolite used as catalysts support,...

Selective Optical Property Modification of Double Walled Carbon Nanotubes by (2009)

Takuya Hayashi, Daisuke Shimamoto, Yoong Ahm Kim, Hiroyuki Muramatsu, Fujio Okinor, Hidekazu Touhara, ...

We found that by fluorination of double walled carbon nanotubes (DWNTs), it is possible to suppress only the Raman radial breathing mode and absorption peaks from the outer (large diameter) tubes of...

Nonequilibrium Microscopic Distribution of Thermal Current in Particle Systems (2009)

Yukawa, Satoshi, Shimada, Takashi, Ogushi, Fumiko, Ito, Nobuyasu

A nonequilibrium distribution function of microscopic thermal current is studied by a direct numerical simulation in a thermal conducting steady state of particle systems. Two characteristic...

Effects of stochastic population fluctuations in two models of biological macroevolution (2008)

Murase, Yohsuke, Shimada, Takashi, Ito, Nobuyasu, Rikvold, Per Arne

Two mathematical models of macroevolution are studied. These models have population dynamics at the species level, and mutations and extinction of species are also included. The population dynamics...

Selective optical property modification of double-walled carbon nanotubes by fluorination (2008)

Hayashi, Takuya, Shimamoto, Daisuke, Kim, Yoong Ahm, Muramatsu, Hiroyuki, Okino, Fujio, Touhara, Hidekazu, ...

We found that by fluorination of double-walled carbon nanotubes (DWNTs), it is possible to suppress only the Raman radial breathing mode and absorption peaks from the outer (large diameter) tubes of...

Effects of Neutral Salts and Alcohols on the Activity of Streptomyces caespitosus Neutral Protease (2007)

Inouye, Kuniyo, Shimada, Takashi, Yasukawa, Kiyoshi

Streptomyces caespitosus neutral protease (ScNP) is one of the smallest metalloproteinase with a molecular mass of 14 kDa. Effects of solvent composition on ScNP activity were examined using a...

Distribution of Microscopic Energy Flux in Equilibrium State (2007)

Shimada, Takashi, Ogushi, Fumiko, Ito, Nobuyasu

The distribution function P(j) of the microscopic energy flux, j, in equilibrium state is studied. It is observed that P(j) has a broad peak in small j regime and a stretched-exponential decay for...

Characterization of Cyanobacteriochrome TePixJ from a Thermophilic Cyanobacterium Thermosynechococcus elongatus Strain BP-1 (2006)

Ishizuka, Takami, Shimada, Takashi, Okajima, Koji, Yoshihara, Shizue, Ochiai, Yuriko, Katayama, Mitsunori, ...

A putative photoreceptor gene, TepixJ, of a thermophilic cyanobacterium is homologous to SypixJ1 that mediates positive phototaxis in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803....

Characterization of cyanobacteriochrome TePixJ from a thermophilic cyanobacterium Thermosynechococcus elongatus strain BP-1 (2006)

Ishizuka, Takami, Shimada, Takashi, Okajima, Koji, Yoshihara, Shizue, Ochiai, Yuriko, Katayama, Mitsunori, ...

A putative photoreceptor gene, TepixJ, of a thermophilic cyanobacterium is homologous to SypixJ1 that mediates positive phototaxis in the unicellular motile cyanobacterium Synechocystis sp. PCC 6803....

Double-wall carbon nanotube field-effect transistors: Ambipolar transport characteristics (2004)

Shimada, Takashi, Sugai, Toshiki, Ohno, Yutaka, Kishimoto, Shigeru, Mizutani, Takashi, Yoshida, Hiromichi, ...

Double-wall carbon nanotubes (DWNTs) have been used as channels of field-effect transistors (FETs) to obtain information on their transport characteristics. DWNTs-FETs show metallic or semiconducting...

Universal Fluorescent Labeling (UFL) Method for Automated Microsatellite Analysis (2002)

Shimizu, Masashi, Kosaka, Natsuki, Shimada, Takashi, Nagahata, Takemitsu, Iwasaki, Hironori, Nagai, Hisaki, ...

We have devised a novel method for automated microsatellite analysis using “universal” fluorescent labeling. This system is based on polymerase chain reactions driven by sequence-specific primers...

Simulational Study on Dimensionality-Dependence of Heat Conduction (2000)

Shimada, Takashi, Murakami, Teruyoshi, Yukawa, Satoshi, Saito, Keiji, Ito, Nobuyasu

Heat conduction phenomena are studied theoretically using computer simulation. The systems are crystal with nonlinear interaction, and fluid of hard-core particles. Quasi-one-dimensional system of...

Binding Proteins to Phytochrome A in Etiolated Pea Seedlings (1999)

Shimada, Takashi, Miyao-Tokutomi, Mitsue, Tokutomi, Satoru

In order to detect and characterize a putative receptor(s) for a signal from PhyA, proteins that bind to purified pea PhyA were searched for in the crude extract of etiolated pea seedlings with...

Identification of two initiator elements in the bidirectional promoter of the human dihydrofolate reductase and mismatch repair protein 1 genes (1994)

Shinya, Eiji, Shimada, Takashi

The human dihydrofolate reductase (DHFR) gene and mismatch repair protein 1 (MRP1) genes are organized in a head-to-head configuration separated by an 90 base pair sequence. We have previously shown...

Cloning of the Mitochondrial Genome of Rana catesbeiana and the Nucleotide Sequences of the ND2 and Five tRNA Genes (1988)

Fujii, Hiroyuki, Shimada, Takashi, Goto, Yoshitaka, Okazaki, Taro

The entire mitochondrial genome of Rana catesbeiana was cloned into a plasmid vector pBR322 at the unique BamHI site and the nucleotide sequences of the ND2 gene and of its flanking genes were...

Differential susceptibilities of DNA polymerases-{alpha}and -{beta}to polyanions (1978)

Shimada, Takashi, Yamada, Michiyuki, Miwa, Masanao, Nagano, Hiroshi, Mano, Yoshitake

The effects of various polyanions including synthetic polynucleotides on DNA polymerasesand-α and -β from blastulae of the sea urchin Hemicentrotus pulcherrimus and HeLa cells were studied. Only...

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Shimada, Takashi, Mizutani, Satoru, Muto, Takanori, Yoneya, Takashi, Hino, Rieko, Takeda, Shu, ...

Tumor-induced osteomalacia (TIO) is one of the paraneoplastic diseases characterized by hypophosphatemia caused by renal phosphate wasting. Because removal of responsible tumors normalizes phosphate...

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

Mochizuki, Hideki, Hayakawa, Hideki, Migita, Makoto, Shibata, Mamoru, Tanaka, Ryota, Suzuki, Asuka, ...

Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a...

Factors Governing the Activity In Vivo of Ribozymes Transcribed by RNA Polymerase III

Koseki, Shiori, Tanabe, Tsuyoshi, Tani, Kenzaburo, Asano, Shigetaka, Shioda, Tatsuo, Nagai, Yoshiyuki, ...

In order to determine the parameters that govern the activity of a ribozyme in vivo, we made a systematic analysis of chimeric tRNAVal ribozymes by measuring their cleavage activities in vitro as...

Site-Specific Integration of an Adeno-Associated Virus Vector Plasmid Mediated by Regulated Expression of Rep Based on Cre-loxP Recombination

Satoh, Wataru, Hirai, Yukihiko, Tamayose, Kenji, Shimada, Takashi

Recombinant adeno-associated virus (AAV) type 2 has attracted attention because it appears to have the potential to serve as a vector for human gene therapy. An interesting feature of wild-type AAV...

Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer

Takahashi, Hiroshi, Hirai, Yukihiko, Migita, Makoto, Seino, Yoshihiko, Fukuda, Yuh, Sakuraba, Hitoshi, ...

Fabry disease is a systemic disease caused by genetic deficiency of a lysosomal enzyme, α-galactosidase A (α-gal A), and is thought to be an important target for enzyme replacement therapy. We...

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, Takashi, Kakitani, Makoto, Yamazaki, Yuji, Hasegawa, Hisashi, Takeuchi, Yasuhiro, Fujita, Toshiro, ...

Inorganic phosphate is essential for ECM mineralization and also as a constituent of important molecules in cellular metabolism. Investigations of several hypophosphatemic diseases indicated that a...

Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection

Kashiwakura, Yuji, Tamayose, Kenji, Iwabuchi, Kazuhisa, Hirai, Yukihiko, Shimada, Takashi, Matsumoto, Kunio, ...

After the first attachment of virus to the cell surface through a primary receptor, efficient entry of virus requires the presence of a coreceptor. For adeno-associated virus type 2 (AAV2) infection,...

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

Shimada, Takashi, Mizutani, Satoru, Muto, Takanori, Yoneya, Takashi, Hino, Rieko, Takeda, Shu, ...

Tumor-induced osteomalacia (TIO) is one of the paraneoplastic diseases characterized by hypophosphatemia caused by renal phosphate wasting. Because removal of responsible tumors normalizes phosphate...

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

Mochizuki, Hideki, Hayakawa, Hideki, Migita, Makoto, Shibata, Mamoru, Tanaka, Ryota, Suzuki, Asuka, ...

Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a...

Factors Governing the Activity In Vivo of Ribozymes Transcribed by RNA Polymerase III

Koseki, Shiori, Tanabe, Tsuyoshi, Tani, Kenzaburo, Asano, Shigetaka, Shioda, Tatsuo, Nagai, Yoshiyuki, ...

In order to determine the parameters that govern the activity of a ribozyme in vivo, we made a systematic analysis of chimeric tRNAVal ribozymes by measuring their cleavage activities in vitro as...

Site-Specific Integration of an Adeno-Associated Virus Vector Plasmid Mediated by Regulated Expression of Rep Based on Cre-loxP Recombination

Satoh, Wataru, Hirai, Yukihiko, Tamayose, Kenji, Shimada, Takashi

Recombinant adeno-associated virus (AAV) type 2 has attracted attention because it appears to have the potential to serve as a vector for human gene therapy. An interesting feature of wild-type AAV...

Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer

Takahashi, Hiroshi, Hirai, Yukihiko, Migita, Makoto, Seino, Yoshihiko, Fukuda, Yuh, Sakuraba, Hitoshi, ...

Fabry disease is a systemic disease caused by genetic deficiency of a lysosomal enzyme, α-galactosidase A (α-gal A), and is thought to be an important target for enzyme replacement therapy. We...

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Shimada, Takashi, Kakitani, Makoto, Yamazaki, Yuji, Hasegawa, Hisashi, Takeuchi, Yasuhiro, Fujita, Toshiro, ...

Inorganic phosphate is essential for ECM mineralization and also as a constituent of important molecules in cellular metabolism. Investigations of several hypophosphatemic diseases indicated that a...

Hepatocyte Growth Factor Receptor Is a Coreceptor for Adeno-Associated Virus Type 2 Infection

Kashiwakura, Yuji, Tamayose, Kenji, Iwabuchi, Kazuhisa, Hirai, Yukihiko, Shimada, Takashi, Matsumoto, Kunio, ...

After the first attachment of virus to the cell surface through a primary receptor, efficient entry of virus requires the presence of a coreceptor. For adeno-associated virus type 2 (AAV2) infection,...

Cyanobacteriochrome CcaS is the green light receptor that induces the expression of phycobilisome linker protein

Hirose, Yuu, Shimada, Takashi, Narikawa, Rei, Katayama, Mitsunori, Ikeuchi, Masahiko

Cyanobacteriochromes are a newly recognized group of photoreceptors that are distinct relatives of phytochromes but are found only in cyanobacteria. A putative cyanobacteriochrome, CcaS, is known to...