Thermal-noise-limited underground interferometer CLIO (2009)
Agatsuma, Kazuhiro, Arai, Koji, Fujimoto, Masa-Katsu, Kawamura, Seiji, Kuroda, Kazuaki, Miyakawa, Osamu, ...
We report on the current status of CLIO (Cryogenic Laser Interferometer Observatory), which is a prototype interferometer for LCGT (Large scale Cryogenic Gravitational-wave Telescope). LCGT is a...
Direct Measurement of Thermal Fluctuation of High-Q Pendulum (2009)
Agatsuma, Kazuhiro, Uchiyama, Takashi, Yamamoto, Kazuhiro, Ohashi, Masatake, Kawamura, Seiji, Miyoki, Shinji, ...
We achieved for the first time a direct measurement of the thermal fluctuation of a pendulum in an off-resonant region using a laser interferometric gravitational wave detector. These measurements...
Hashimoto-Okada, Mutsumi, Kitawaki, Toshio, Kadowaki, Norimitsu, Iwata, Satoshi, Morimoto, Chikao, Hori, Toshiyuki, ...
CD70 expressed on dendritic cells (DCs) has been shown to play a critical role in inducing effective CD8+ T cell responses and a Th1 response in mice. However, it has not been extensively examined...
Kanda, Junya, Mizumoto, Chisaki, Kawabata, Hiroshi, Ichinohe, Tatsuo, Tsuchida, Hideyuki, Tomosugi, Naohisa, ...
The association of iron overload with complications of allogeneic hematopoietic stem cell transplantation (HSCT) has been suggested in previous studies. Because hepcidin plays a central role in the...
Kirikoshi, Hiroyuki, Saito, Satoru, Yoneda, Masato, Fujita, Koji, Mawatari, Hironori, Uchiyama, Takashi, ...
Abstract Background Spontaneous rupture is rare complication of hepatocellular carcinoma (HCC) with high mortality rate in cirrhotic cases. The aim of this study was to determine the factors...
MDM2 is a novel E3 ligase for HIV-1 Vif (2009)
Izumi, Taisuke, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Higashitsuji, Hiroaki, Itoh, Katsuhiko, Io, Katsuhiro, ...
Abstract The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G). Vif interacts with A3G and induces...
Hashimoto-Okada, Mutsumi, Kitawaki, Toshio, Kadowaki, Norimitsu, Iwata, Satoshi, Morimoto, Chikao, Hori, Toshiyuki, ...
CD70 expressed on dendritic cells (DCs) has been shown to play a critical role in inducing effective CD8+ T cell responses and a Th1 response in mice. However, it has not been extensively examined...
Rimpei Morita, Takashi Uchiyama, Toshiyuki Hori
NO, a free radical gas, is known to be critically involved not only in vascular relaxation but also in host defense. Besides direct bactericidal effects, NO has been shown to inhibit Th1 responses...
Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH) (2008)
Yoneda, Masato, Uchiyama, Takashi, Kato, Shingo, Endo, Hiroki, Fujita, Koji, Yoneda, Kyoko, ...
Abstract Background The changes in the liver in nonalcoholic fatty liver disease (NAFLD) range over a wide spectrum, extending from steatosis to steatohepatitis (NASH). However it has remained...
Yoneda, Masato, Hotta, Kikuko, Nozaki, Yuichi, Endo, Hiroki, Uchiyama, Takashi, Mawatari, Hironori, ...
Abstract Background Genetic factors as well as environmental factors are important in the development of NAFLD and in this study we investigated associations between polymorphisms of peroxisome...
Yamamoto, Kazuhiro, Hayakawa, Hideaki, Okada, Atsushi, Uchiyama, Takashi, Miyoki, Shinji, Ohashi, Masatake, ...
We investigated the noise of interferometric gravitational wave detectors due to heat energy deposited by cosmic-ray particles. We derived a general formula that describes the response of a mirror...
Search for continuous gravitational waves from PSR J0835-4510 using CLIO data (2008)
Akutsu, Tomomi, Ando, Masaki, Haruyama, Tomiyoshi, Kanda, Nobuyuki, Kuroda, Kazuaki, Miyoki, Shinji, ...
We search for continuous gravitational waves from PSR J0835-4510 at twice its rotational frequency using CLIO (Cryogenic Laser Interferometric Observatory) in the Kamioka mine. In this search, we use...
Yamamoto, Kazuhiro, Hayakawa, Hideaki, Okada, Atsushi, Uchiyama, Takashi, Miyoki, Shinji, Ohashi, Masatake, ...
We investigated the noise of interferometric gravitational wave detectors due to heat energy deposited by cosmic-ray particles. We derived a general formula that describes the response of a mirror...
Yamamoto, Kazuhiro, Hayakawa, Hideaki, Okada, Atsushi, Uchiyama, Takashi, Miyoki, Shinji, Ohashi, Masatake, ...
Yoshiki
Tomaru, Takayuki, Tokunari, Masao, Kuroda, Kazuaki, Uchiyama, Takashi, Okutomi, Akira, Ohashi, Masatake, ...
A large heat load caused by thermal radiation through a metal shield pipe was observed in a cooling test of a cryostat for a prototype of a cryogenic interferometric gravitational wave detector. The...
Current status of Japanese detectors (2007)
Tatsumi, Daisuke, Takahashi, Ryutaro, Arai, Koji, Nakagawa, Noriyasu, Agatsuma, Kazuhiro, Yamazaki, Toshitaka, ...
Current status of TAMA and CLIO detectors in Japan is reported in this article. These two interferometric gravitational-wave detectors are being developed for the large cryogenic gravitational wave...
Yamamoto, Kazuhiro, Miyoki, Shinji, Uchiyama, Takashi, Ishitsuka, Hideki, Ohashi, Masatake, Kuroda, Kazuaki, ...
We have measured the mechanical loss of a dielectric multilayer reflective coating (ion-beam sputtered SiO$_2$ and Ta$_2$O$_5$) in cooled mirrors. The loss was nearly independent of the temperature...
Sugimoto, Naoshi, Oida, Takatoku, Hirota, Keiji, Nakamura, Kyoko, Nomura, Takashi, Uchiyama, Takashi, ...
Naturally occurring CD25+CD4+ regulatory T cells (Tregs) actively engage in the maintenance of immunologic self-tolerance and immunoregulation. They specifically express the transcription factor...
Kitawaki, Toshio, Kadowaki, Norimitsu, Sugimoto, Naoshi, Kambe, Naotomo, Hori, Toshiyuki, Miyachi, Yoshiki, ...
Dendritic cells (DCs) and mast cells (MCs) co-localize in peripheral tissues of antigen entry, i.e. skin and mucosa. Due to the proximity of these two cell types, activation of MCs may affect DC...
Sugimoto, Naoshi, Oida, Takatoku, Hirota, Keiji, Nakamura, Kyoko, Nomura, Takashi, Uchiyama, Takashi, ...
Naturally occurring CD25+CD4+ regulatory T cells (Tregs) actively engage in the maintenance of immunologic self-tolerance and immunoregulation. They specifically express the transcription factor...
Kitawaki, Toshio, Kadowaki, Norimitsu, Sugimoto, Naoshi, Kambe, Naotomo, Hori, Toshiyuki, Miyachi, Yoshiki, ...
Dendritic cells (DCs) and mast cells (MCs) co-localize in peripheral tissues of antigen entry, i.e. skin and mucosa. Due to the proximity of these two cell types, activation of MCs may affect DC...
APOBEC3G targets human T-cell leukemia virus type 1 (2005)
Sasada, Amane, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Kobayashi, Masayuki, Abudu, Aierkin, Hishizawa, Masakatsu, ...
Abstract Background Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cellular protein with a broad antiviral activity. It inhibits infectivitiy of a wide...
YOSHIZAWA, Kazuya, KOSHIMIZU, Satoshi, UCHIYAMA, Takashi
Environmental history in Lake Yamanaka was investigated based on diatom assemblages obtained from the 17.5m length borehole core in the lake center. Lake Yamanaka (surface area 6.89km²; maximun...
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells (2004)
Yagi, Haruhiko, Nomura, Takashi, Nakamura, Kyoko, Yamazaki, Sayuri, Kitawaki, Toshio, Hori, Shohei, ...
Naturally occurring CD25+CD4+ regulatory T cells are engaged in the maintenance of immunological self-tolerance and down-regulation of various immune responses. Recent studies with mice...
Tomaru, Takayuki, Miyoki, Shinji, Ohashi, Masatake, Kuroda, Kazuaki, Uchiyama, Takashi, Suzuki, Toshikazu, ...
We evaluated the performance of polished mirror surfaces for the TAMA interferometric gravitational wave detector by comparing the experimental results with a wave-front tracing simulation. The TAMA...
Thermal lensing in cryogenic sapphire substrates (2002)
Tomaru, Takayuki, Suzuki, Toshikazu, Miyoki, Shinji, Uchiyama, Takashi, Taylor, C. T., Yamamoto, Akira, ...
We report the reduction of the thermal lensing in cryogenic sapphire mirrors, which is planed to be used in the Large scale Cryogenic Gravitational wave Telescope (LCGT) project. We measured three...
Tomaru, Takayuki, Uchiyama, Takashi, Tatsumi, Daisuke, Miyoki, Shinji, Ohashi, Masatake, Kuroda, Kazuaki, ...
We have applied laser calorimetry to the measurement of optical absorption in mono-crystalline sapphire at cryogenic temperatures. Sapphire is a promising candidate for the mirror substrates of the...
IL-4 down-regulates IL-2 receptor p75 by accelerating its endocytosis (1991)
Ishikawa, Takayuki, Uchiyama, Takashi, Kamio, Masanori, Onishi, Rie, Kodaka, Tai-ichl, Okuma, Minoru, ...
We examined the effects of interleukin 4 (IL-4) on the expression of IL-2 receptor p75 (IL-2R p75) or β chain on various human T cells. IL-4 promptly down-regulated surface IL-2 receptor (IL-2R) p75...
Kamio, Masanori, Uchiyama, Takashi, Arima, Nobuyoshi, Itoh, Katsuhlko, Ishikawa, Takayuki, Horl, Toshiyuki, ...
Using anti-Tac (antl-α chain) and 2R-B (anti-β chain) antibodies, we studied the roles of IL-2 receptor subunits (α and β chains) in the formation of IL-2 and high-affinity IL-2 receptor complex,...
Stepwise formation of the high-affinity complex of the interleukin 2 receptor (1990)
Saito, Yuji, Ogura, Toshihiko, Kamio, Masanori, Sabe, Hisataka, Uchiyama, Takashi, Honjo, Tasuku, ...
The interleukin 2 receptor (IL-2R) is composed of at least two polypeptides—a 55 kd protein (the L chain, p55, or α chain) and a 75 kd protein (the H chain, p75 or β chain). The high-affinity...
Yamaguchi, Akira, Ide, Takashi, Hatakeyama, Masanori, Doi, Takeshi, Kono, Takeshi, Uchiyama, Takashi, ...
The structural basis of the high affinity interleukin-2 receptor which was previously reconstituted in a cultured murine T cell line, EL4 by expressing either wild-type Tac antigen complementary DNA...
The Validity of the Long-run Heckscher-Ohlin Theorem in the Ricardian System
Applying Burgstaller's Ricardian two-sector growth model to the two-country open economy, this paper shows that the long-run Heckscher-Ohlin theorem holds also in a Ricardian world. In addition it is...
Sakaida, Hitoshi, Hori, Toshiyuki, Yonezawa, Akihito, Sato, Akihiko, Isaka, Yoshitaka, Yoshie, Osamu, ...
Certain types of chemokine receptors have been identified as coreceptors for HIV-1 infection. The process of viral entry is initiated by the interaction between an envelope protein gp120 of HIV-1,...
Yonezawa, Akihito, Hori, Toshiyuki, Takaori-Kondo, Akifumi, Morita, Rinpei, Uchiyama, Takashi
Interaction between the human immunodeficiency virus type 1 (HIV-1) envelope and the relevant chemokine receptors is crucial for subsequent membrane fusion and viral entry. Although the V3 region of...
Yonezawa, Akihito, Morita, Rimpei, Takaori-Kondo, Akifumi, Kadowaki, Norimitsu, Kitawaki, Toshio, Hori, Toshiyuki, ...
Natural alpha interferon (IFN-α)-producing cells (IPCs) are now recognized as identical to plasmacytoid dendritic cell (DC) precursors in human blood and are thought to play an important role in...
APOBEC3G Targets Specific Virus Species
Kobayashi, Masayuki, Takaori-Kondo, Akifumi, Shindo, Keisuke, Abudu, Aierken, Fukunaga, Keiko, Uchiyama, Takashi
Human APOBEC3G (huAPOBEC3G), also known as CEM15, is a broad antiretroviral host factor that deaminates dC to dU in the minus strand DNA of human immunodeficiency virus type 1 (HIV-1), other...
APOBEC3G targets human T-cell leukemia virus type 1
Sasada, Amane, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Kobayashi, Masayuki, Abudu, Aierkin, Hishizawa, Masakatsu, ...
Unno, Naoki, Nakamura, Toshio, Mitsuoka, Hiroshi, Uchiyama, Takashi, Yamamoto, Naoto, Saito, Takaaki, ...
Sakaida, Hitoshi, Hori, Toshiyuki, Yonezawa, Akihito, Sato, Akihiko, Isaka, Yoshitaka, Yoshie, Osamu, ...
Certain types of chemokine receptors have been identified as coreceptors for HIV-1 infection. The process of viral entry is initiated by the interaction between an envelope protein gp120 of HIV-1,...
Yonezawa, Akihito, Hori, Toshiyuki, Takaori-Kondo, Akifumi, Morita, Rinpei, Uchiyama, Takashi
Interaction between the human immunodeficiency virus type 1 (HIV-1) envelope and the relevant chemokine receptors is crucial for subsequent membrane fusion and viral entry. Although the V3 region of...
Yonezawa, Akihito, Morita, Rimpei, Takaori-Kondo, Akifumi, Kadowaki, Norimitsu, Kitawaki, Toshio, Hori, Toshiyuki, ...
Natural alpha interferon (IFN-α)-producing cells (IPCs) are now recognized as identical to plasmacytoid dendritic cell (DC) precursors in human blood and are thought to play an important role in...
APOBEC3G Targets Specific Virus Species
Kobayashi, Masayuki, Takaori-Kondo, Akifumi, Shindo, Keisuke, Abudu, Aierken, Fukunaga, Keiko, Uchiyama, Takashi
Human APOBEC3G (huAPOBEC3G), also known as CEM15, is a broad antiretroviral host factor that deaminates dC to dU in the minus strand DNA of human immunodeficiency virus type 1 (HIV-1), other...
APOBEC3G targets human T-cell leukemia virus type 1
Sasada, Amane, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Kobayashi, Masayuki, Abudu, Aierkin, Hishizawa, Masakatsu, ...
Unno, Naoki, Nakamura, Toshio, Mitsuoka, Hiroshi, Uchiyama, Takashi, Yamamoto, Naoto, Saito, Takaaki, ...
Costimulation through OX40 is crucial for induction of an alloreactive human T-cell response
Ukyo, Naoya, Hori, Toshiyuki, Yanagita, Soshi, Ishikawa, Takayuki, Uchiyama, Takashi
The alloreactive immune response is a series of events initiated by the interaction of T cells with allogeneic dendritic cells (DCs), involving alloantigen recognition and costimulatory signals. In...
Carbon Monoxide Inhalation Protects Rat Intestinal Grafts from Ischemia/Reperfusion Injury
Nakao, Atsunori, Kimizuka, Kei, Stolz, Donna B., Neto, Joao Seda, Kaizu, Takashi, Choi, Augustine M. K., ...
Carbon monoxide (CO), a byproduct of heme catalysis by heme oxygenases, has been shown to exert anti-inflammatory effects. This study examines the cytoprotective efficacy of inhaled CO during...
Yano, Hiroki, Ishida, Takashi, Imada, Kazunori, Sakai, Tomomi, Ishii, Toshihiko, Inagaki, Atsushi, ...
Ricardo on machinery: a dynamic analysis
I construct a dynamic two-sector model which formalizes Ricardos argument on the effects of the introduction of machinery. My model does not require the inappropriate assumptions common to other...
Yoneda, Masato, Hotta, Kikuko, Nozaki, Yuichi, Endo, Hiroki, Uchiyama, Takashi, Mawatari, Hironori, ...
Plasma Pentraxin3 is a Novel Marker for Nonalcoholic Steatohepatitis (NASH)
Yoneda, Masato, Uchiyama, Takashi, Kato, Shingo, Endo, Hiroki, Fujita, Koji, Yoneda, Kyoko, ...
MDM2 is a novel E3 ligase for HIV-1 Vif
Izumi, Taisuke, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Higashitsuji, Hiroaki, Itoh, Katsuhiko, Io, Katsuhiro, ...
The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G). Vif interacts with A3G and induces its...
Ozone production by amino acids contributes to killing of bacteria
Yamashita, Kouhei, Miyoshi, Takashi, Arai, Toshiyuki, Endo, Nobuyuki, Itoh, Hiroshi, Makino, Keisuke, ...
Reactive oxygen species produced by phagocytosing neutrophils are essential for innate host defense against invading microbes. Previous observations revealed that antibody-catalyzed ozone formation...