Takeshi Nagasaka

Analysis of Fecal DNA Methylation to Detect Gastrointestinal Neoplasia (2009)

Nagasaka, Takeshi, Tanaka, Noriaki, Cullings, Harry M., Sun, Dong-Sheng, Sasamoto, Hiromi, Uchida, Takuyuki, ...

BackgroundThe development of noninvasive screening tests is important to reduce mortality from gastrointestinal neoplasia. We sought to develop such a test by analysis of DNA methylation from...

Detection of Fecal DNA Methylation for Colorectal Neoplasia : Does It Lead to an Optimal Screening Test? (2006)

Nagasaka, Takeshi, Goel, Ajay, Matsubara, Nagahide, Tanaka, Noriaki

Aberrant promoter methylation, an 'epigenetic' form of genomic instability that leads to transcriptional silencing of tumor suppressor genes, is increasingly being recognized as a crucial component...

Methylation profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients (2005)

Kimura, Naoki, Nagasaka, Takeshi, Murakami, Jun, Sasamoto, Hiromi, Murakami, Masahiro, Tanaka, Noriaki, ...

Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes can be a molecular...

Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome

Nagasaka, Takeshi, Nishifuji, Koji, Ota, Takayuki, Whittock, Neil V., Amagai, Masayuki

Desmogleins (Dsgs), cadherin-type cell adhesion molecules, are targeted in skin-blistering diseases such as pemphigus and staphylococcal scalded skin syndrome (SSSS). The role of Dsg4, a new isoform,...

Methylation profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients

Kimura, Naoki, Nagasaka, Takeshi, Murakami, Jun, Sasamoto, Hiromi, Murakami, Masahiro, Tanaka, Noriaki, ...

Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes can be a molecular...

Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome

Nagasaka, Takeshi, Nishifuji, Koji, Ota, Takayuki, Whittock, Neil V., Amagai, Masayuki

Desmogleins (Dsgs), cadherin-type cell adhesion molecules, are targeted in skin-blistering diseases such as pemphigus and staphylococcal scalded skin syndrome (SSSS). The role of Dsg4, a new isoform,...

Methylation profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients

Kimura, Naoki, Nagasaka, Takeshi, Murakami, Jun, Sasamoto, Hiromi, Murakami, Masahiro, Tanaka, Noriaki, ...

Aberrant methylation of DNA has been shown to play an important role in a variety of human cancers, developmental disorders and aging. Hence, aberrant methylation patterns in genes can be a molecular...