Takeshi Takahashi

Galois points for a normal hypersurface (2009)

Fukasawa, Satoru, Takahashi, Takeshi

We study Galois points for a hypersurface $X$ with $\dim {\rm Sing}(X) \le \dim X-2$. The purpose of this article is to determine the set $\Delta(X)$ of Galois points in characteristic zero: Indeed,...

Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells (2009)

Nakayama, Satoshi, Torikoshi, Yasuhiro, Takahashi, Takeshi, Yoshida, Tomokazu, Sudo, Tamotsu, Matsushima, Tomoko, ...

Abstract Introduction Paclitaxel is used widely in the treatment of breast cancer. Not all tumors respond to this drug, however, and the characteristics that distinguish resistant tumors from...

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/{gamma}cnull (NOG) mice (hu-HSC NOG mice) (2009)

Watanabe, Yohei, Takahashi, Takeshi, Okajima, Akira, Shiokawa, Miho, Ishii, Naoto, Katano, Ikumi, ...

‘Humanized mice’ are anticipated to be a valuable tool for studying the human immune system, but the reconstituted human immune cells have not yet been well characterized. Here, we extensively...

Article URL (2008)

Yasuhiro Torikoshi, Takeshi Takahashi, Tomokazu Yoshida, Tamotsu Sudo, Tomoko Matsushima, Yuko Kawasaki, ...

PDF corresponds to the article as it appeared upon acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon. Prediction of paclitaxel sensitivity by...

Mapping of the Genome Sequence Using Two-stage Self Organizing Maps (2007)

Dozono, Hiroshi, Takahashi, Takeshi

In this paper, we introduce an algorithm of Self-Organizing Maps(SOM) which can map the genome sequence continuously on the map. The DNA sequences are considered to have the special features...

using 3D (2007)

Takeshi Takahashi, Adviser Sanjiv Singh

2D localization of outdoor mobile robots

Biweekly Paclitaxel and Gemcitabine for Patients with Advanced Urothelial Cancer Ineligible for Cisplatin-Based Regimen (2006)

Takahashi, Takeshi, Higashi, Shin, Nishiyama, Hiroyuki, Segawa, Takeshiko, Nakamura, Eijiro, Kinoshita, Hidefumi, ...

Background: To avoid cisplatin-related gastrointestinal, renal and other toxicity while maintaining efficacy in the palliative setting or second line chemotherapeutic regimen for cisplatin-resistant...

Association of the PIG3 Promoter Polymorphism with Invasive Bladder Cancer in a Japanese Population (2006)

Ito, Masaaki, Nishiyama, Hiroyuki, Watanabe, Jun, Kawanishi, Hiroaki, Takahashi, Takeshi, Kamoto, Toshiyuki, ...

PIG3 (p53-induced gene 3) is one of the targets of TP53 and is involved in apoptosis. The promoter of PIG3 contains a variable number of tandem repeats (VNTRs) of pentanucleotides (TGYCC)n (Y...

Biweekly Paclitaxel and Gemcitabine for Patients with Advanced Urothelial Cancer Ineligible forCisplatin-Based Regimen (2006)

Takahashi, Takeshi, Higashi, Shin, Nishiyama, Hiroyuki, Segawa, Takeshiko, Nakamura, Eijiro, Kinoshita, Hidefumi, ...

Background: To avoid cisplatin-related gastrointestinal, renal and other toxicity while maintaining efficacy in the palliative setting or second line chemotherapeutic regimen for cisplatin-resistant...

Association of the PIG3 Promoter Polymorphism with Invasive Bladder Cancer in a Japanese Population (2006)

Ito, Masaaki, Nishiyama, Hiroyuki, Watanabe, Jun, Kawanishi, Hiroaki, Takahashi, Takeshi, Kamoto, Toshiyuki, ...

PIG3 (p53-induced gene 3) is one of the targets of TP53 and is involved in apoptosis. The promoter of PIG3 contains a variable number of tandem repeats (VNTRs) of pentanucleotides (TGYCC)n (Y = C...

A New Detection Approach for the Fingerprint Core Location Using Extended Relation Graph (2005)

OHTSUKA, Tomohiko, TAKAHASHI, Takeshi

This paper describes a new approach to detect a fingerprint core location using the extended relational graph, which is generated by the segmentation of the ridge directional image. The extended...

Proactive Handover Scheme Based on Forwarding Router Discovery for Mobile IP Networks (2005)

TAKAHASHI, Takeshi, ASATANI, Koichi, HARJU, Jarmo, TOMINAGA, Hideyoshi

One of the main issues of Mobile IPv6 is handover latency that causes service disruption time. Although plenty of proposals significantly reduce the service disruption time, they suffer from...

Realization of Attenuation Poles, Spurious Resonance Suppression and Size Reduction by Microstrip SIR Loaded with Dielectric Rods (2005)

POKHAREL, Ramesh K., WADA, Kouji, HASHIMOTO, Osamu, TAKAHASHI, Takeshi

Characteristics of a class of stepped-impedance resonators (SIRs) which is loaded with two dielectric rods, are investigated by a Finite-Difference Time-Domain (FDTD) method. Dielectric rods to be...

Cyclin D1 gene polymorphism is associated with an increased risk of urinary bladder cancer (2002)

Wang, Lizhong, Habuchi, Tomonori, Takahashi, Takeshi, Mitsumori, Kenji, Kamoto, Toshiyuki, Kakehi, Yoshiyuki, ...

Cyclin D1 is believed to play an important role in the genesis and/or progression of transitional cell cancer (TCC) of the urinary bladder. Cyclin D1 gene (CCND1) mRNA is alternatively spliced to...

A New Approach to Built-In Self-Testable Datapath Synthesis Based on ILP (2000)

Han Bin Kim, Dong Sam Ha, Senior Member, Takeshi Takahashi, Takahiro J. Yamaguchi

Abstract—The focus of high-level built-in self-test (BIST) synthesis is register assignment, which involves system register assignment, BIST register assignment, and interconnection assignment. To...

Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation (2000)

Kuniyasu, Yuhshi, Takahashi, Takeshi, Itoh, Misako, Shimizu, Jun, Toda, Gotaroh, Sakaguchi, Shimon

A CD4+ T cell subpopulation defined by the expression levels of a particular cell surface molecule (e.g. CD5, CD45RB, CD25, CD62L or CD38) bears an autoimmune-preventive activity in various...

Effect of Ethylene on the Increase in Catalase Activity through Microbody Development in Wounded Sweet Potato Root Tissue (1983)

Esaka, Muneharu, Takahashi, Takeshi, Asahi, Tadashi

Catalase activity increases when slices of sweet potato root tissue are incubated in air. The increase is due to de novo synthesis of the enzyme protein and probably also to activation of a precursor...

Studies on Microbody Development in Wounded Sweet Potato Root Tissue: Proposal for the Post-Translational Transport of Catalase into Preexisting Microbodies (1982)

Esaka, Muneharu, Takahashi, Takeshi, Asahi, Tadashi

Pure microbody fractions could be prepared in considerable yields from sweet potato root tissue slices incubated for 16 hr and 3 days. The ratio of catalase activity to phospholipid content in the...

Transport of Nicotinamide Adenine Dinucleotide in an unc Mutant of Escherichia coli (1978)

MURAKAWA, Shigeo, TAKAHASHI, Takeshi

The presence and some properties of an NAD+ transport system were examined in PA5, a Mg, Ca-ATPase [EC 3.6.1.3]-defective mutant strain of Escherichia coli W2252. NAD+ uptake was stimulated by...

Substrate specificity of an α-amino acid ester hydrolase produced by Acetobacter turbidans A.T.C.C. 9325

Takahashi, Takeshi, Yamazaki, Yoshio, Kato, Koichi

A partially purified preparation of an α-amino acid ester hydrolase was obtained from Acetobacter turbidans A.T.C.C. 9325, which catalyses synthesis of...

Substrate specificity of an α-amino acid ester hydrolase produced by Acetobacter turbidans A.T.C.C. 9325

Takahashi, Takeshi, Yamazaki, Yoshio, Kato, Koichi

A partially purified preparation of an α-amino acid ester hydrolase was obtained from Acetobacter turbidans A.T.C.C. 9325, which catalyses synthesis of...

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Setoguchi, Ruka, Hori, Shohei, Takahashi, Takeshi, Sakaguchi, Shimon

Interleukin (IL)-2 plays a crucial role in the maintenance of natural immunologic self-tolerance. Neutralization of circulating IL-2 by anti–IL-2 monoclonal antibody for a limited period elicits...

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Takahashi, Takeshi, Tagami, Tomoyuki, Yamazaki, Sayuri, Uede, Toshimitsu, Shimizu, Jun, Sakaguchi, Noriko, ...

This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for a limited...