Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice (2009)
Jiang, Fang, Yoshida, Taku, Nakaki, Fumio, Terawaki, Seigo, Chikuma, Shunsuke, Kato, Yu, ...
The non-obese diabetic (NOD) mouse strain is prone to developing various autoimmune syndromes including type I diabetes mellitus (T1DM), sialadenitis, thyroiditis and pancreatitis. Although the...
PD-1 and PD-1 ligands: from discovery to clinical application (2007)
Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon...
Terawaki, Seigo, Tanaka, Yoshimasa, Nagakura, Tomokazu, Hayashi, Tamon, Shibayama, Shiro, Muroi, Kaori, ...
The negative co-stimulatory receptor, programmed cell death 1 (PD-1), is induced on activated T cells and delivers inhibitory signals upon engagement with its ligands PD-L1 and PD-L2, which are...
Mandelboim, Ofer, Kent, Sally, Davis, Daniel M., Wilson, S. Brian, Okazaki, Taku, Jackson, Richard, ...
Proliferation of human CD4+ αβ T cells expressing a natural killer cell activating receptor (NKAR) has been shown to be enhanced, particularly in response to low doses of antigen, if the target...
Okazaki, Taku, Maeda, Akito, Nishimura, Hiroyuki, Kurosaki, Tomohiro, Honjo, Tasuku
PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region. Studies on PD-1-deficient mice have shown that PD-1 plays...
Iwai, Yoshiko, Ishida, Masayoshi, Tanaka, Yoshimasa, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro
PD-1 is a receptor of the Ig superfamily that negatively regulates T cell antigen receptor signaling by interacting with the specific ligands (PD-L) and is suggested to play a role in the maintenance...
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
Wang, Jian, Yoshida, Taku, Nakaki, Fumio, Hiai, Hiroshi, Okazaki, Taku, Honjo, Tasuku
Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family, spontaneously develop lupus-like...
Mandelboim, Ofer, Kent, Sally, Davis, Daniel M., Wilson, S. Brian, Okazaki, Taku, Jackson, Richard, ...
Proliferation of human CD4+ αβ T cells expressing a natural killer cell activating receptor (NKAR) has been shown to be enhanced, particularly in response to low doses of antigen, if the target...
Okazaki, Taku, Maeda, Akito, Nishimura, Hiroyuki, Kurosaki, Tomohiro, Honjo, Tasuku
PD-1 is an immunoreceptor that belongs to the immunoglobulin (Ig) superfamily and contains two tyrosine residues in the cytoplasmic region. Studies on PD-1-deficient mice have shown that PD-1 plays...
Iwai, Yoshiko, Ishida, Masayoshi, Tanaka, Yoshimasa, Okazaki, Taku, Honjo, Tasuku, Minato, Nagahiro
PD-1 is a receptor of the Ig superfamily that negatively regulates T cell antigen receptor signaling by interacting with the specific ligands (PD-L) and is suggested to play a role in the maintenance...
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
Wang, Jian, Yoshida, Taku, Nakaki, Fumio, Hiai, Hiroshi, Okazaki, Taku, Honjo, Tasuku
Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging to the CD28/cytotoxic T lymphocyte-associated antigen-4 family, spontaneously develop lupus-like...
Hamanishi, Junzo, Mandai, Masaki, Iwasaki, Masashi, Okazaki, Taku, Tanaka, Yoshimasa, Yamaguchi, Ken, ...
The ligands for programmed cell death 1 (PD-1), an immunoinhibitory receptor belonging to CD28/cytotoxic T lymphocyte antigen 4 family, are PD-1 ligand 1 and 2 (PD-Ls). Recent reports suggest that...
Okazaki, Taku, Otaka, Yumi, Wang, Jian, Hiai, Hiroshi, Takai, Toshiyuki, Ravetch, Jeffrey V., ...
Because most autoimmune diseases are polygenic, analysis of the synergistic involvement of various immune regulators is essential for a complete understanding of the molecular pathology of these...
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver
Iwai, Yoshiko, Terawaki, Seigo, Ikegawa, Masaya, Okazaki, Taku, Honjo, Tasuku
Unlike naive T cells, effector T cells can be activated by either T cell receptor signal or costimulatory signal alone and therefore the absence of costimulatory molecules on tissue cells cannot...
Freeman, Gordon J., Long, Andrew J., Iwai, Yoshiko, Bourque, Karen, Chernova, Tatyana, Nishimura, Hiroyuki, ...
PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune...
Green, Kathy A., Okazaki, Taku, Honjo, Tasuku, Cook, W. James, Green, William R.
Pathology due to the immune system's response to viral infections often represents a delicate balance between inhibition of viral pathogenesis and regulation of protective immunity. In susceptible...
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
Lin, David Yin-wei, Tanaka, Yoshimasa, Iwasaki, Masashi, Gittis, Apostolos G., Su, Hua-Poo, Mikami, Bunzo, ...
Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays an important role in the...
Yoshida, Taku, Jiang, Fang, Honjo, Tasuku, Okazaki, Taku
Although many autoimmune diseases are associated with particular HLA/H-2 haplotypes, the mechanisms through which specific HLA/H-2 haplotypes afford autoimmune susceptibility remain enigmatic. Here,...