Burnett, James C., Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G., Ruthel, Gordon, Hermone, Ann R., ...
We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including...
Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., ...
Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include...
Novel Small Molecule Inhibitors of Botulinum Neurotoxin a Metalloprotease Activity (2003)
Burnett, James C., Schmidt, James J., Stafford, Robert G., Panchal, Rekha G., Nguyen, Tam L., Hermone, Ann R., ...
Botulinum neurotoxins (BoNTs) are among the most lethal biological substances to have been weaponized and are listed as biodefense category A agents. Currently, no small molecule (non-peptidic)...
Wu, Chia Kuei, Hu, Bing, Rose, John P., Liu, Zhi-Jie, Nguyen, Tam L., Zheng, Changsheng, ...
The structures of des 1–6 bovine neurophysin-II in the unliganded state and as its complex with lysine vasopressin were determined crystallographically at resolutions of 2.4 Å and 2.3...
Association of Ebola Virus Matrix Protein VP40 with Microtubules (1998)
Ruthel, Gordon, Demmin, Gretchen L., Kallstrom, George, Javid, Melodi P., Badie, Shirin S., Will, Amy B., ...
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for...
Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., ...
Botulinum neurotoxins (BoNTs) are the most potent of the known biological toxins, and consequently are listed as category A biowarfare agents. Currently, the only treatments against BoNTs include...
Nguyen, Tam L., Schoehn, Guy, Weissenhorn, Winfried, Hermone, Ann R., Burnett, James C., Panchal, Rekha G., ...
The matrix protein VP40 is an indispensable component of viral assembly and budding by the Ebola virus. VP40 is a monomer in solution, but can fold into hexameric and octameric states, two oligomeric...
Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade (1998)
Halverson, Kelly M., Panchal, Rekha G., Nguyen, Tam L., Gussio, Rick, Little, Stephen F., Misakian, Martin, ...
Bacillus anthracis secretes three proteins (protective antigen, PA; lethal factor, LF; and edema factor, EF) that are the basis for anthrax infection. We present electrophysiological measurements...
Association of Ebola Virus Matrix Protein VP40 with Microtubules
Ruthel, Gordon, Demmin, Gretchen L., Kallstrom, George, Javid, Melodi P., Badie, Shirin S., Will, Amy B., ...
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for...
Association of Ebola Virus Matrix Protein VP40 with Microtubules
Ruthel, Gordon, Demmin, Gretchen L., Kallstrom, George, Javid, Melodi P., Badie, Shirin S., Will, Amy B., ...
Viruses exploit a variety of cellular components to complete their life cycles, and it has become increasingly clear that use of host cell microtubules is a vital part of the infection process for...
Wu, Chia Kuei, Hu, Bing, Rose, John P., Liu, Zhi-Jie, Nguyen, Tam L., Zheng, Changsheng, ...
The structures of des 1–6 bovine neurophysin-II in the unliganded state and as its complex with lysine vasopressin were determined crystallographically at resolutions of 2.4 Å and 2.3 Å,...
Sizing the Bacillus anthracis PA63 Channel with Nonelectrolyte Poly(Ethylene Glycols)
Nablo, Brian J., Halverson, Kelly M., Robertson, Joseph W. F., Nguyen, Tam L., Panchal, Rekha G., Gussio, Rick, ...
Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA63). Based on the ability of...