Akasaka-Manya, Keiko, Manya, Hiroshi, Sakurai, Yoko, Wojczyk, Boguslaw S, Kozutsumi, Yasunori, Saito, Yuko, ...
Alteration of glycoprotein glycans often changes various properties of the target glycoprotein and contributes to a wide variety of diseases. Here, we focused on the N-glycans of amyloid precursor...
Kanagawa, Motoi, Nishimoto, Akemi, Chiyonobu, Tomohiro, Takeda, Satoshi, Miyagoe-Suzuki, Yuko, Wang, Fan, ...
Hypoglycosylation and reduced laminin-binding activity of α-dystroglycan are common characteristics of dystroglycanopathy, which is a group of congenital and limb-girdle muscular dystrophies....
Miura, Yuri, Kano, Mayumi, Yamada, Masaki, Nishine, Tsutomu, Urano, Shiro, Suzuki, Shozo, ...
We investigated high- or low-dose irradiation-responsive proteins using proteomics on two-dimensional (2D) PAGE, and the effects of ageing on cell responses to radiation in variously aged rat...
Molecular cloning and characterization of rat Pomt1 and Pomt2 (2006)
Manya, Hiroshi, Chiba, Atsuro, Margolis, Richard U., Endo, Tamao
Mammalian O-mannosylation, although an uncommon type of protein modification, is essential for normal brain and muscle development. Defective O-mannosylation causes congenital muscular dystrophy with...
Molecular cloning and characterization of rat Pomt1 and Pomt2 (2006)
Manya, Hiroshi, Chiba, Atsuro, Margolis, Richard U., Endo, Tamao
Mammalian O-mannosylation, although an uncommon type of protein modification, is essential for normal brain and muscle development. Defective O-mannosylation causes congenital muscular dystrophy with...
Molecular cloning and characterization of rat Pomt1 and Pomt2 (2006)
Manya, Hiroshi, Chiba, Atsuro, Margolis, Richard U., Endo, Tamao
Mammalian O-mannosylation, although an uncommon type of protein modification, is essential for normal brain and muscle development. Defective O-mannosylation causes congenital muscular dystrophy with...
Sasaki, Tasuku, Hirabayashi, Jun, Manya, Hiroshi, Kasai, Ken-ichi, Endo, Tamao
Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation, and survival. An agent that enhances production...
Worldwide distribution and broader clinical spectrum of muscle-eye-brain disease (2003)
Taniguchi, Kiyomi, Kobayashi, Kazuhiro, Saito, Kayoko, Yamanouchi, Hideo, Ohnuma, Akira, Hayashi, Yukiko K., ...
Muscle–eye–brain disease (MEB), an autosomal recessive disorder prevalent in Finland, is characterized by congenital muscular dystrophy, brain malformation and ocular abnormalities. Since the MEB...
Sasaki, Tasuku, Hirabayashi, Jun, Manya, Hiroshi, Kasai, Ken-ichi, Endo, Tamao
Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation and survival. An agent that enhances production...
Sasaki, Tasuku, Hirabayashi, Jun, Manya, Hiroshi, Kasai, Ken-ichi, Endo, Tamao
Brain-derived neurotrophic factor (BDNF) is a neuroprotective polypeptide that is thought to be responsible for neuron proliferation, differentiation and survival. An agent that enhances production...
Takahashi, Seiichiro, Sasaki, Tasuku, Manya, Hiroshi, Chiba, Yasunori, Yoshida, Aruto, Mizuno, Mamoru, ...
Recent studies have shown that O-mannosyl glycans are present in several mammalian glycoproteins. Although knowledge on the functional roles of these glycans is accumulating, their biosynthetic...
Manya, Hiroshi, Sato, Yuji, Eguchi, Naomi, Seiki, Kousuke, Oda, Hiroshi, Nakajima, Hiroshi, ...
Lipocalin-type prostaglandin D synthase (L-PGDS) is a highly glycosylated member of the lipocalin gene family and is secreted into various human body fluids. We comparatively analyzed the structures...
Wright, Ann, Sato, Yuji, Okada, Toyohiro, Chang, Kern Hee, Endo, Tamao, Morrison, Sherie L.
We have now produced mouse–human chimeric IgG1 in wild-type Chinese hamster ovary (CHO) cell lines Pro-5 as well as in the glycosylation mutants Lec 2, Lec 8, and Lec 1. Analysis of the attached...
Structural studies of the N-linked sugar chains of human rhodopsin (1994)
Fujita, Shigeharu, Endo, Tamao, Ju, Jermin, Kobata, Akira, Kean, Edward L., Kobata, Akira
Human rhodopsin is a glycoprotein containing two N-linked sugar chains. After the isolation and purification of rhodop-sins from human retinas, structural studies of their N-linked sugar chains were...
Characterization of recombinant murine interleukin 5 expressed in Chinese hamster ovary cells (1992)
Kodama, Shiho, Endo, Tamao, Tsujimoto, Masafumi, Kobata, Akira
We have purified recombinant murine mterleukin 5 (rmIL-5) from the supernatant of Chinese hamster ovary cells. Each peptide fragment of the purified rmIL-5 generated by Achromobacter protease I...
Carbohydrate Structures of Human Interleukin 5 Expressed in Chinese Hamster Ovary Cells (1991)
Kodama, Shiho, Endo, Tamao, Tsuruoka, Nobuo, Tsujimoto, Masafumi, Kobata, Akira
The asparagine-linked sugar chains of recombinant human interleukin 5 produced by Chinese hamster ovary cells were released quantitatively as oligosaccharides by hydra-zinolysis. After N-acetylation...
Primary Structure of a Fucose-Specific Lectin Obtained from a Mushroom, Aleuria aurantia (1990)
Fukumori, Fumiyasu, Takeuchi, Naomi, Hagiwara, Toshihiko, Ohbayashi, Hirokazu, Endo, Tamao, Kochibe, Naohisa, ...
Aleuria aurantia lectin (AAL) is a protein composed of two identical subunits having no carbohydrate chain and shows sugar-binding specificity for L-fucose. Full-length cDNA encoding for the lectin...
Structures of Asparagine-Linked Oligosaccharides of Human Placental Fibronectin (1989)
Takamoto, Masaya, Endo, Tamao, Isemura, Mamoru, Koehibe, Naohisa, Kobata, Akira
The asparagine-linked sugar chains of fibronectin purified from human placenta were quantitatively released as oligosaccharides by hydrazinolysis. After N-acetylation, they were converted to...
Takamoto, Masaya, Endo, Tamao, Isemura, Mamoru, Yamaguchi, Yu, Okamura, Kunihiro, Kochibe, Naohisa, ...
Fibronectin purified from human term amniotie fluid contains 10 asparagine-linked sugar chains in one molecule. The sugar chains were quantitatively liberated as radioactive oligosaccharides from the...
Hara, Takahiko, Endo, Tamao, Furukawa, Kiyoshi, Kawakita, Masao, Kobata, Akira
Had-1, which was isolated from mouse FM3A carcinoma cells, was a non-permissive mutant cell line to Newcastle disease virus infection. Comparative study of the asparagine-linked sugar chains of the...
Structural Study on the Carbohydrate Moiety of Human Placental Alkaline Phosphatase (1988)
Endo, Tamao, Ohbayashi, Hirokazu, Hayashi, Yukari, Ikehara, Yukio, Kochibe, Naohisa, Kobata, Akira
Alkaline phosphatase purified from human placenta contains a single asparagine-linked sugar chain in one molecule. The sugar chain was quantitatively liberated as radioactive oligosaccharides from...
ENDO, Tamao, INOUE, Keizo, NOJIMA, Shoshichi, SEKIYA, Takashi, OHKI, Kazuo, NOZAWA, Yoshinori
Structures of aqueous dispersions prepared from monoglycosyldiglycerides and from mixtures of monoglycosyldiglyceride and phosphatidylcholine were studied by freeze-fracture electron microscopy....
Physical Properties and Barrier Functions of Synthetic Glyceroglycolipids (1982)
ENDO, Tamao, INOUE, Keizo, NOJIMA, Shoshichi
Four glyceroglycolipids containing dipalmitylglycerol were synthesized. The thermotropic behavior and barrier function of aqueous suspensions of these glyceroglycolipids were studied. The gel to...
Intermolecular Interaction between Glycolipids and Glycophorin on Liposomal Membranes (1982)
ENDO, Tamao, NOJIMA, Shoshichi, INOUE, Keizo
The haptenic activity of Forssman glycolipid was affected by glycophorin, and the interaction of glycophorin with lectins was also affected by the glycolipids, when both glycophorin and Forssman...
Manya, Hiroshi, Chiba, Atsuro, Yoshida, Aruto, Wang, Xiaohui, Chiba, Yasunori, Jigami, Yoshifumi, ...
Defects in O-mannosylation of α-dystroglycan are thought to cause certain types of congenital muscular dystrophies with neuronal migration disorders. Among these muscular dystrophies,...
Manya, Hiroshi, Chiba, Atsuro, Yoshida, Aruto, Wang, Xiaohui, Chiba, Yasunori, Jigami, Yoshifumi, ...
Defects in O-mannosylation of α-dystroglycan are thought to cause certain types of congenital muscular dystrophies with neuronal migration disorders. Among these muscular dystrophies,...
Kanagawa, Motoi, Nishimoto, Akemi, Chiyonobu, Tomohiro, Takeda, Satoshi, Miyagoe-Suzuki, Yuko, Wang, Fan, ...
Hypoglycosylation and reduced laminin-binding activity of α-dystroglycan are common characteristics of dystroglycanopathy, which is a group of congenital and limb-girdle muscular dystrophies....