Tao Xu

Analysis, simulation and design of nonlinear RF circuits (2009)

Xu, Tao

The PhD project consists of two parts. The first part concerns the development of Computer Aided Design (CAD) algorithms for high-frequency circuits. Novel Padébased algorithms for numerical...

Analysis, simulation and design of nonlinear RF circuits (2009)

Xu, Tao

The PhD project consists of two parts. The first part concerns the development of Computer Aided Design (CAD) algorithms for high-frequency circuits. Novel Padébased algorithms for numerical...

Structure-based substrate screening for an enzyme (2009)

Xu, Tao, Zhang, Lujia, Wang, Xuedong, Wei, Dongzhi, Li, Tianbi

Abstract Background Nowadays, more and more novel enzymes can be easily found in the whole enzyme pool with the rapid development of genetic operation. However, experimental work for substrate...

Improving detection of differentially expressed gene sets by applying cluster enrichment analysis to Gene Ontology (2009)

Xu, Tao, Gu, JianLei, Zhou, Yan, Du, LinFang

Abstract Background Gene set analysis based on Gene Ontology (GO) can be a promising method for the analysis of differential expression patterns. However, current studies that focus on individual GO...

De-noising and Recovering Images (2009)

Pengcheng Xi, Tao Xu

Principal Component Analysis (PCA) is a basis transformation to diagonalize an estimate of the covariance matrix of input data and, the new coordinates in the Eigenvector basis are called principal...

Design methodology for a maximum sequence length MASH digital delta-sigma modulator (2009)

Xu, Tao, Condon, Marissa

The paper proposes a novel structure for a MASH digital delta-sigma modulator (DDSM) in order to achieve a long sequence length. The expression for the sequence length is derived. The condition to...

Design methodology for a maximum sequence length MASH digital delta-sigma modulator (2009)

Xu, Tao, Condon, Marissa

The paper proposes a novel structure for a MASH digital delta-sigma modulator (DDSM) in order to achieve a long sequence length. The expression for the sequence length is derived. The condition to...

A clinical evaluation of amlexanox oral adhesive pellicles in the treatment of recurrent aphthous stomatitis and comparison with amlexanox oral tablets: a randomized, placebo controlled, blinded, multicenter clinical trial (2009)

Meng, Wenxia, Dong, Yi, Liu, Jie, Wang, Zhi, Zhong, Xiaobo, Chen, Ruiyang, ...

Abstract Background Amlexanox has been developed as a 5 percent topical oral paste for the treatment of patients with recurrent aphthous stomatitis (RAS) in most European countries. However, it is...

Ultrasonic synthesis of the microporous metal–organic framework Cu3(BTC)2 at ambient temperature and pressure: An efficient and environmentally friendly method (2009)

Li, Zong-Qun, Qiu, Ling-Guang, Xu, Tao, Wu, Yun, Wang, Wei, Wu, Zhen-Yu, ...

A three-dimensional (3-D) metal–organic framework (MOF) with 3-D channels, i.e. Cu3(BTC)2 (HKUST-1, BTC = benzene-1,3,5-tricarboxylate), was synthesized by using ultrasonic method for the first...

Symbolic-computation study of integrable properties for the (2 + 1)-dimensional Gardner equation with the two-singular manifold method (2009)

Zhang, Hai-Qiang, Tian, Bo, Li, Juan, Xu, Tao, Zhang, Ya-Xing

The singular manifold method from the Painlevé analysis can be used to investigate many important integrable properties for the non-linear partial differential equations. In this paper, the...

Bis[1-(2-naphthyliminomethyl)-2-naphtholato-κ2N,O]copper(II) (2009)

Zhenghua Guo, Lianzhi Li, Chengyuan Wang, Jinghong Li, Tao Xu

In the title complex, [Cu(C21H14NO)2], the CuII atom, lying on an inversion center, is coordinated by two bidentate 1-(2-naphthyliminomethyl)-2-naphtholate ligands in a trans arrangement, forming a...

(Methoxo-κO)oxidobis(quinolin-8-olato-κ2N,O)vanadium(V) (2009)

Zhenghua Guo, Lianzhi Li, Chengyuan Wang, Tao Xu, Jinghong Li

In the title complex, [V(C9H6NO)2(CH3O)O], the central VV atom is coordinated by the O atoms from the oxido and methoxo ligands and the N and O atoms of two bis-chelating quinolin-8-olate ligands,...

Di-μ-oxido-bis[(4-formyl-2-methoxyphenolato-κO1)oxido(1,10-phenanthroline-κ2N,N′)vanadium(V)] (2009)

Zhenghua Guo, Lianzhi Li, Tao Xu, Jinghong Li

The title complex, [V2(C8H7O3)2O4(C12H8N2)2], is a centrosymmetric dimer formed by two VV complex units bridged by two μ2-oxido groups. The VV atom is six-coordinated by three oxide O atoms, one...

Aqua{6,6′-dimethoxy-2,2′-[ethane-1,2-diylbis(nitrilomethylidyne)]diphenolato}nickel(II) (2009)

Zhenghua Guo, Lianzhi Li, Tao Xu, Jinghong Li, Daqi Wang

The title complex, [Ni(C18H18N2O4)(H2O)], lies on a mirror plane with the NiII ion coordinated by two N and two O atoms of a tetradentate Schiff base ligand and one water O atom in a distorted...

Evaluation of GO-based functional similarity measures using S. cerevisiaeprotein interaction and expression profile data (2008)

Xu, Tao, Du, LinFang, Zhou, Yan

Abstract Background Researchers interested in analysing the expression patterns of functionally related genes usually hope to improve the accuracy of their results beyond the boundaries of currently...

An effective method for the determination of the locking range of an injection-locked frequency divider (2008)

Xu, Tao, Condon, Marissa

The paper proposes a methodology for the determination of the locking range of an Injection-Locked Frequency Divider. The technique involves the use of the Warped Multi-time scale model and is...

An effective method for the determination of the locking range of an injection-locked frequency divider (2008)

Xu, Tao, Condon, Marissa

The paper proposes a methodology for the determination of the locking range of an Injection-Locked Frequency Divider. The technique involves the use of the Warped Multi-time scale model and is...

Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol (2008)

Pan, Zhiqiang, Agarwal, Ameeta K, Xu, Tao, Feng, Qin, Baerson, Scott R, Duke, Stephen O, ...

Abstract Background Pterostilbene, a naturally occurring phenolic compound produced by agronomically important plant genera such as Vitis and Vacciunium , is a phytoalexin exhibiting potent...

Defect-Aware Synthesis of Droplet-Based Microfluidic Biochips* (2008)

Tao Xu, Krishnendu Chakrabarty, Fei Su

Recent advances in microfluidics technology have led to the emergence of miniaturized biochip devices for biochemical analysis. A promising category of microfluidic biochips relies on the principle...

Parallel Scan-Like Test and Multiple-Defect Diagnosis for Digital Microfluidic Biochips (2008)

Tao Xu, Student Member, Krishnendu Chakrabarty

Abstract—Dependability is an important attribute for microfluidic biochips that are used for safety-critical applications such as point-of-care health assessment, air-quality monitoring, and...

(2,2′-Bipyridine-κ2N,N′)[N-(2-oxido-1-naphthylidene)threoninato-κ3O1,N,O2]copper(II) (2008)

Zhanglei Qiu, Lianzhi Li, Yan Liu, Tao Xu, Daqi Wang

In the title complex, [Cu(C15H13NO4)(C10H8N2)], the Schiff base ligand is derived from the condensation of 2-hydroxy-1-naphthaldehyde and l-threonine. The CuII atom is five-coordinated by one N atom...

Global Analysis of Posttranslational Protein Arginylation (2007)

Tao Xu, Reena Rai, Aaron O. Bailey, Yuri I. Wolf, ...

Posttranslational arginylation is critical for embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are largely...

Symbolic-computation study of integrable properties for the (2+1)-dimensional Gardner equation with the two-singular-manifold method (2007)

Zhang, Hai-Qiang, Li, Juan, Xu, Tao, Zhang, Ya-Xing, Tian, Bo

The singular manifold method from the Painleve analysis can be used to investigate many important integrable properties for the nonlinear partial differential equations.In this paper, the...

Two types of generalized integrable decompositions and new solitary-wave solutions for the modified Kadomtsev-Petviashvili equation with symbolic computation (2007)

Xu, Tao, Zhang, Hai-Qiang, Zhang, Ya-Xing, Li, Juan, Tian, Bo

The modified Kadomtsev-Petviashvili (mKP) equation is shown in this paper to be decomposable into the first two soliton equations of the 2N-coupled Chen-Lee-Liu and Kaup-Newell hierarchies by...

Automated Design of Pin-Constrained Digital Microfluidic Biochips • 14:23 (2007)

Tao Xu, William L. Hwang, Fei Su

Microfluidics-based biochips, also referred to as lab-on-a-chip, are devices that integrate fluidhandling functions such as sample preparation, analysis, separation, and detection. This emerging...

Scalable direction representation for image compression with direction-adaptive discrete wavelet transform,” presented at (2007)

Tao Xu, Chuo-ling Chang, Bernd Girod

The direction-adaptive discrete wavelet transform (DA-DWT) locally adapts the filtering direction to the geometric flow in the image. DA-DWT image coders have been shown to achieve a rate-distortion...

A new method for the determination of the locking range of oscillators (2007)

Christoffersen, Carlos E., Condon, Marissa, Xu, Tao

A time-domain method for the determination of the injection-locking range of oscillators is presented. The method involves three time dimensions: the first and the second are warped time scales used...

A new method for the determination of the locking range of oscillators (2007)

Christoffersen, Carlos E., Condon, Marissa, Xu, Tao

A time-domain method for the determination of the injection-locking range of oscillators is presented. The method involves three time dimensions: the first and the second are warped time scales used...

Characterization of (Nd,Y)-TZP ceramics prepared by a colloidal suspension coating technique (2007)

Xu, Tao, Kan, Yanmei, Wang, Peiling, Li, Lin, ...

A stabiliser coating technique was applied to prepare mixed Nd2O3 + Y2O3 coated ZrO2 nanopowder from an alcohol/water based suspension of neodymium nitrate, yttrium nitrate and monoclinic zirconia...

Munc13-1 is required for the sustained release of insulin from pancreatic β cells (2006)

Kang, Lijun J., He, Zixuan, Xu, Pingyong, Fan, Junmei, Betz, Andrea, Brose, Nils, ...

Munc13-1 is a presynaptic protein that is essential for synaptic vesicle priming. Deletion of Munc13-1/unc13 causes total arrest of synaptic transmission due to a complete loss of fusion-competent...

Ulysses - an application for the projection of molecular interactions across species (2005)

Kemmer, Danielle, Huang, Yong, Shah, Sohrab P, Lim, Jonathan, Brumm, Jochen, Yuen, Macaire MS, ...

Abstract We developed Ulysses as a user-oriented system that uses a process called Interolog Analysis for the parallel analysis and display of protein interactions detected in various species....

Evaluation of the HMA pavement structure on a cement concrete bridge deck using a compound beam (2005)

Gao, Ying, Huang, Xiaoming, Xu, Tao

This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document...

Evaluation of the HMA pavement structure on a cement concrete bridge deck using a compound beam (2005)

Gao, Ying, Huang, Xiaoming, Xu, Tao

This paper was transferred from the original CD ROM created for this conference. The material on the CD ROM was published using Adobe Acrobat technology. The original CD ROM was produced by Document...

Atlas – a data warehouse for integrative bioinformatics (2005)

Shah, Sohrab P, Huang, Yong, Xu, Tao, Yuen, Macaire MS, Ling, John, Ouellette, BF Francis

Abstract Background We present a biological data warehouse called Atlas that locally stores and integrates biological sequences, molecular interactions, homology information, functional annotations...

Fabricating Neural and Cardiomyogenic Stem Cell Structures by a Novel Rapid Prototyping--the Inkjet Printing Method (2005)

Xu, Tao, Gregory, Cassie, Molnar, Peter, Boland, Thomas

Direct printing of living cardiomyogenic stem cells and embryonic cortical neurons to generate complex cellular patterns and structures of such cells was demonstrated in the study. Furthermore, the...

Layer-By-Layer Printing of Cells and its Application to Tissue Engineering (2005)

Kesari, Priya, Xu, Tao, Boland, Thomas

Tissues and organs exhibit distinct shapes and functions nurtured by vascular connectivity. In order to mimic and examine these intricate structure-function relationships, it is necessary to develop...

BMC Bioinformatics Database Atlas – a data warehouse for integrative bioinformatics (2005)

Sohrab P Shah, Yong Huang, Tao Xu, Macaire Ms Yuen, John Ling, Francis Ouellette, ...

This is an Open Access article distributed under the terms of the Creative Commons Attribution License

2005 Kemmer et Volume al. 6, Issue 12, Article R106 Open Access (2005)

Danielle Kemmer, Yong Huang, Sohrab P Shah, Jonathan Lim, Jochen Brumm, Macaire Ms Yuen, ...

Software Ulysses- an application for the projection of molecular interactions across species

Pegasys: software for executing and integrating analyses of biological sequences (2004)

Shah, Sohrab P, He, David YM, Sawkins, Jessica N, Druce, Jeffrey C, Quon, Gerald, Lett, Drew, ...

Abstract Background We present Pegasys – a flexible, modular and customizable software system that facilitates the execution and data integration from heterogeneous biological sequence analysis...

Matrix free fiber reinforced polymeric composites via high-temperature high-pressure sintering (2004)

Xu, Tao

A novel manufacturing process called high-temperature high-pressure sintering was studied and explored. Solid fiber reinforced composites are produced by consolidating and compacting layers of...

Matrix free fiber reinforced polymeric composites via high-temperature high-pressure sintering (2004)

Xu, Tao

A novel manufacturing process called high-temperature high-pressure sintering was studied and explored. Solid fiber reinforced composites are produced by consolidating and compacting layers of...

Molecular rectification and related nanostructures / (2003)

Xu, Tao.

Thesis (Ph. D.)--University of Alabama, 2003.

A constant extension ensembles model of double-stranded chain molecules (2002)

Liu, Fei, Dai, Luru, Xu, Tao, Ou-Yang, Zhong-can

Because the constant extension ensemble of single chain molecule is not always equivalent with constant force ensemble, a model of double-stranded conformations, as in RNA molecules and...

Shear-induced phase behavior of SBR/PBD blends / (2001)

Xu, Tao.

Thesis (M.S.)--University of Connecticut, 2001.

The topological structure of the vortices in the O(n) symmetric TDGL model (1998)

Duan, Yishi, Jiang, Ying, Xu, Tao

In the light of $\phi $--mapping method and topological current theory, the topological structure of the vortex state in TDGL model and the topological quantization of the vortex topological charges...

Ship Maintenance Project: Phases II and III. Volume 2 - Study of Fatigue of Proposed Critical Structural Details in Double Hull Tankers. (1997)

Bea, Robert G., Xu, Tao

This report presents the results of the second and third phases of the subject project of which phase one was first presented in our four volume set - SSC-386. These studies investigated the...

Ship Maintenance Project: Phases II and III. Volume 5. Fitness for Purpose Evaluation of Critical Structural Details in Tankers. (1997)

Bea, Robert G., Xu, Tao

This report presents the results of the second and third phases of the subject project of which phase one was first presented in our four volume set - SSC-386. These studies investigated the...

Contributions to the theory of machine dynamics /--by Tao Xu. (1993)

Xu, Tao.

Thesis (Ph. D.)--City University of New York, 1993. [Graduate Faculty in Engineering]

The antifungal activities of human salivary histatins on candida albicans /--Tao Xu. (1988)

Xu, Tao.

Thesis (D. Sc.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1988 (Oral Biology).

Subpopulations of chloroplast ribosomes change during photoregulated development of Zea mays leaves: Ribosomal proteins L2, L21, and L29

Zhao, You-Yang, Xu, Tao, Zucchi, Paola, Bogorad, Lawrence

Seedlings grown in darkness, i.e., etiolated seedlings, lack chlorophyll and most other components of the photosynthetic apparatus. On illumination, the plastids become photosynthetically competent...

TRM1, a YY1-like suppressor of rbcS-m3 expression in maize mesophyll cells

Xu, Tao, Purcell, Marc, Zucchi, Paola, Helentjaris, Tim, Bogorad, Lawrence

The genes rbcS and rbcL encode, respectively, the small and large subunits of the photosynthetic carbon dioxide fixation enzyme ribulose bisphosphate carboxylase/oxygenase. There is a single rbcL...

Anticandida Activity Is Retained in P-113, a 12-Amino-Acid Fragment of Histatin 5

Rothstein, David M., Spacciapoli, Peter, Tran, Linh T., Xu, Tao, Roberts, F. Donald, Dalla Serra, Mauro, ...

Through the analysis of a series of 25 peptides composed of various portions of the histatin 5 sequence, we have identified P-113, a 12-amino-acid fragment of histatin 5, as the smallest fragment...

Sensitization of regulated exocytosis by protein kinase C

Zhu, Hongliang, Hille, Bertil, Xu, Tao

Activation of protein kinase C (PKC) increases vesicular secretion in many cell types. We determined the calcium dependence of secretion and the size of the readily releasable pool of secretory...

Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25

Wei, Shunhui, Xu, Tao, Ashery, Uri, Kollewe, Astrid, Matti, Ulf, Antonin, Wolfram, ...

The highly conserved SNARE proteins, SNAP-25, syntaxin and synaptobrevin, form a tight ternary complex, which is essential for exocytosis. Crystallization of this complex revealed a four-helix bundle...

Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: Constitutive and ligand-induced internalization

Xia, Sheng, Kjær, Svend, Zheng, Kang, Hu, Ping-Sheng, Bai, Li, Jia, Jun-Yong, ...

Trafficking of the galanin R2 receptor (GALR2) fused with enhanced GFP (EGFP) was studied by using confocal fluorescence microscopy. The fusion protein was predominantly localized on the plasma...

Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition

Liu, Dongfang, Xu, Liang, Yang, Fan, Li, Dongdong, Gong, Feili, Xu, Tao

Natural killer (NK) cells play important roles in defense against tumor, viral infection, and cell-mediated xenograft rejection through secretion of secretory lysosomes. In this study, we used high...

Three-Dimensional Tracking of Single Secretory Granules in Live PC12 Cells

Li, Dongdong, Xiong, Jun, Qu, Anlian, Xu, Tao

Deconvolution wide-field fluorescence microscopy and single-particle tracking were used to study the three-dimensional mobility of single secretory granules in live PC12 cells. Acridine...

Ulysses - an application for the projection of molecular interactions across species

Kemmer, Danielle, Huang, Yong, Shah, Sohrab P, Lim, Jonathan, Brumm, Jochen, Yuen, Macaire MS, ...

Ulysses, a new software for the parallel analysis and display of protein interactions detected in various species, is described.

Subpopulations of chloroplast ribosomes change during photoregulated development of Zea mays leaves: Ribosomal proteins L2, L21, and L29

Zhao, You-Yang, Xu, Tao, Zucchi, Paola, Bogorad, Lawrence

Seedlings grown in darkness, i.e., etiolated seedlings, lack chlorophyll and most other components of the photosynthetic apparatus. On illumination, the plastids become photosynthetically competent...

TRM1, a YY1-like suppressor of rbcS-m3 expression in maize mesophyll cells

Xu, Tao, Purcell, Marc, Zucchi, Paola, Helentjaris, Tim, Bogorad, Lawrence

The genes rbcS and rbcL encode, respectively, the small and large subunits of the photosynthetic carbon dioxide fixation enzyme ribulose bisphosphate carboxylase/oxygenase. There is a single rbcL...

Anticandida Activity Is Retained in P-113, a 12-Amino-Acid Fragment of Histatin 5

Rothstein, David M., Spacciapoli, Peter, Tran, Linh T., Xu, Tao, Roberts, F. Donald, Dalla Serra, Mauro, ...

Through the analysis of a series of 25 peptides composed of various portions of the histatin 5 sequence, we have identified P-113, a 12-amino-acid fragment of histatin 5, as the smallest fragment...

Sensitization of regulated exocytosis by protein kinase C

Zhu, Hongliang, Hille, Bertil, Xu, Tao

Activation of protein kinase C (PKC) increases vesicular secretion in many cell types. We determined the calcium dependence of secretion and the size of the readily releasable pool of secretory...

Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25

Wei, Shunhui, Xu, Tao, Ashery, Uri, Kollewe, Astrid, Matti, Ulf, Antonin, Wolfram, ...

The highly conserved SNARE proteins, SNAP-25, syntaxin and synaptobrevin, form a tight ternary complex, which is essential for exocytosis. Crystallization of this complex revealed a four-helix bundle...

Visualization of a functionally enhanced GFP-tagged galanin R2 receptor in PC12 cells: Constitutive and ligand-induced internalization

Xia, Sheng, Kjær, Svend, Zheng, Kang, Hu, Ping-Sheng, Bai, Li, Jia, Jun-Yong, ...

Trafficking of the galanin R2 receptor (GALR2) fused with enhanced GFP (EGFP) was studied by using confocal fluorescence microscopy. The fusion protein was predominantly localized on the plasma...

Rapid biogenesis and sensitization of secretory lysosomes in NK cells mediated by target-cell recognition

Liu, Dongfang, Xu, Liang, Yang, Fan, Li, Dongdong, Gong, Feili, Xu, Tao

Natural killer (NK) cells play important roles in defense against tumor, viral infection, and cell-mediated xenograft rejection through secretion of secretory lysosomes. In this study, we used high...

Three-Dimensional Tracking of Single Secretory Granules in Live PC12 Cells

Li, Dongdong, Xiong, Jun, Qu, Anlian, Xu, Tao

Deconvolution wide-field fluorescence microscopy and single-particle tracking were used to study the three-dimensional mobility of single secretory granules in live PC12 cells. Acridine...

Ulysses - an application for the projection of molecular interactions across species

Kemmer, Danielle, Huang, Yong, Shah, Sohrab P, Lim, Jonathan, Brumm, Jochen, Yuen, Macaire MS, ...

Ulysses, a new software for the parallel analysis and display of protein interactions detected in various species, is described.

Global Analysis of Posttranslational Protein Arginylation

Wong, Catherine C. L, Xu, Tao, Rai, Reena, Bailey, Aaron O, Yates, John R, Wolf, Yuri I, ...

Posttranslational arginylation is critical for embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are largely...

Genome Biology of Actinobacillus pleuropneumoniae JL03, an Isolate of Serotype 3 Prevalent in China

Xu, Zhuofei, Zhou, Yan, Li, Liangjun, Zhou, Rui, Xiao, Shaobo, Wan, Yun, ...

Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumonia, a cause of considerable world wide economic losses in the swine industry. We sequenced the complete...

PKC-induced Sensitization of Ca2+-dependent Exocytosis Is Mediated by Reducing the Ca2+ Cooperativity in Pituitary Gonadotropes

Yang, Hua, Liu, Huisheng, Hu, Zhitao, Zhu, Hongliang, Xu, Tao

The highly cooperative nature of Ca2+-dependent exocytosis is very important for the precise regulation of transmitter release. It is not known whether the number of binding sites on the Ca2+ sensor...

Protein Kinase Activation Increases Insulin Secretion by Sensitizing the Secretory Machinery to Ca2+

Wan, Qun-Fang, Dong, Yongming, Yang, Hua, Lou, Xuelin, Ding, Jiuping, Xu, Tao

Glucose and other secretagogues are thought to activate a variety of protein kinases. This study was designed to unravel the sites of action of protein kinase A (PKA) and protein kinase C (PKC) in...

Na+ channel inactivation: a comparative study between pancreatic islet β-cells and adrenal chromaffin cells in rat

Lou, Xue-Lin, Yu, Xiao, Chen, Xiao-Ke, Duan, Kai-Lai, He, Li-Ming, Qu, An-Lian, ...

A comparative study was carried out on the inactivation of Na+ channels in two types of endocrine cells in rats, β-cells and adrenal chromaffin cells (ACCs), using patch-clamp techniques. The...

Role of Heme in the Antifungal Activity of the Azaoxoaporphine Alkaloid Sampangine▿ †

Agarwal, Ameeta K., Xu, Tao, Jacob, Melissa R., Feng, Qin, Lorenz, Michael C., Walker, Larry A., ...

Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans, and...

Neuropathological quantification of dtg APP/PS1: neuroimaging, stereology, and biochemistry

Manaye, Kebreten F., Wang, Paul C., O’Neil, Jahn N., Huang, Sophia Y., Xu, Tao, Lei, De-Liang, ...

Murine models that mimic the neuropathology of Alzheimer’s disease (AD) have the potential to provide insight into the pathogenesis of the disease and lead to new strategies for the therapeutic...

Postendocytotic traffic of the galanin R1 receptor: A lysosomal signal motif on the cytoplasmic terminus

Xia, Sheng, Dun, Xing-Peng, Hu, Ping-Sheng, Kjaer, Svend, Zheng, Kang, Qian, Yu, ...

The neuropeptide galanin R1 receptor (GalR1) was tagged at its C terminus with EGFP (GalR1–EGFP) to study receptor localization and trafficking. In PC12 and HEK293 cells, functional GalR1–EGFP...

Functional stoichiometry of the unitary calcium-release-activated calcium channel

Ji, Wei, Xu, Pingyong, Li, Zhengzheng, Lu, Jingze, Liu, Lin, Zhan, Yi, ...

Two proteins, STIM1 in the endoplasmic reticulum and Orai1 in the plasma membrane, are required for the activation of Ca2+ release-activated Ca2+ (CRAC) channels at the cell surface. How these...

Crystal structure of the β-finger domain of Prp8 reveals analogy to ribosomal proteins

Yang, Kui, Zhang, Lingdi, Xu, Tao, Heroux, Annie, Zhao, Rui

Prp8 stands out among hundreds of splicing factors as a key regulator of spliceosome activation and a potential cofactor of the splicing reaction. We present here the crystal structure of a...

Direct Quantification of Fusion Rate Reveals a Distal Role for AS160 in Insulin-stimulated Fusion of GLUT4 Storage Vesicles*S⃞

Jiang, Li, Fan, Junmei, Bai, Li, Wang, Yan, Chen, Yu, Yang, Lu, ...

Insulin-stimulated GLUT4 translocation to the plasma membrane constitutes a key process for blood glucose control. However, convenient and robust assays to monitor this dynamic process in real time...

Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice

Liao, Lujian, Park, Sung Kyu, Xu, Tao, Vanderklish, Peter, Yates, John R.

Fragile X syndrome (FXS) is a common inherited form of mental retardation that is caused, in the vast majority of cases, by the transcriptional silencing of a single gene, fmr1. The encoded protein,...

A Residue at the Cytoplasmic Entrance of BK-Type Channels Regulating Single-Channel Opening by Its Hydrophobicity

Guo, Zhaohua, Lv, Caixia, Yi, Hong, Xiong, Yu, Wu, Yingliang, Li, Wenxin, ...

Single large-conductance calcium-activated K+ (BK) channels encoded by the mSlo gene usually have synchronous gating, but a Drosophila dSlo (A2/C2/E2/G5/10) splice variant (dSlo1A) exhibits very...

P-Selectin Cross-Links PSGL-1 and Enhances Neutrophil Adhesion to Fibrinogen and ICAM-1 in a Src Kinase-Dependent, but GPCR-Independent Mechanism

Xu, Tao, Zhang, Lei, Geng, Zhen H, Wang, Hai-Bo, Wang, Jin-Tao, Chen, Ming, ...

Endothelial and platelet P-selectin (CD62P) and leukocyte integrin αMβ2 (CD11bCD18, Mac-1) are cell adhesion molecules essential for host defense and innate immunity. Upon inflammatory challenges,...

GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation

Chen, Yu, Deng, Yongqiang, Zhang, Jinzhong, Yang, Lu, Xie, Xiangyang, Xu, Tao

Insulin stimulates GLUT4 (glucose transporter 4) translocation in adipocytes and muscles. An emerging picture is that Rab10 could bridge the gap between the insulin signalling cascade and GLUT4...