Tatsuro Koike

Microglial Response Factor (MRF)-1: Constitutive Expression in Ramified Microglia and Upregulation upon Neuronal Death Induced by Ischemia or Glutamate Exposure (2000)

Shuuitsu Tanaka, Hiroyuki Kato, Tatsuro Koike

We have isolated a new microglial gene, mrf-1, which is upregulated on microglia in response to apoptosis of granule neurons in cerebellar cell cultures. We examined whether or not upregulation of...

Induction of Bip mRNA upon Programmed Cell Death of Differentiated PC12 Cells as Well as Rat Sympathetic Neurons (1997)

Aoki, Tomokazu, Koike, Tatsuro, Nakano, Toru, Shibahara, Keiichi, Kondo, Shigeru, Kikuchi, Haruhiko, ...

We have found that expression of the Bip (immunoglobulin heavy chain binding protein)/ GRP78 (glucose regulated protein 78) gene is markedly enhanced specifically among the heat shock protein (HSP)...

Synthesis of Oligo-ApGp and Other Oligonucleotides by Ribonuclease N1 (1971)

KOIKE, Tatsuro, UCHIDA, Tsuneko, EGAMI, Fujio

1. The synthesis of IpN, ApGpU, IpApApC and oligo-ApGp by ribonuclease N1 [ribonucleate guaninenucleotido-2′-transferase (cyclizing), Neurospora crassa, EC 2. 7. 7. 26] was studied. 2. The yield of...

Synthesis of Adenylyl-(3', 5')-Nucleosides, Adenylyl-(3', 5')-Guanosine 2',3'-Cyclic Phosphate, and Oligoadenylic Acids by Ribonuclease U2 (1971)

KOIKE, Tatsuro, UCHIDA, Tsuneko, EGAMI, Fujio

1. The synthetic reactions by a novel ribonuclease, RNase U2 [ribonucleate purine-nucleotido-2′-transferase (cyclizing)] were studied. The yield of adenylyl-(3′, 5′)-uridine amounted to 37...

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

Kammoun, Hélène L., Chabanon, Hervé, Hainault, Isabelle, Luquet, Serge, Magnan, Christophe, Koike, Tatsuro, ...

Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the transcription factor...