Toyama, Tatsuya, Yamashita, Hiroko, Sugiura, Hiroshi, Kondo, Naoto, Iwase, Hirotaka, Fujii, Yoshitaka
Objective The CYP2D6 enzyme plays a major role in converting tamoxifen to its active metabolites. We investigated whether there is an association between the CYP2D6*10 allele and clinical outcome in...
Toyama, Tatsuya, Yamashita, Hiroko, Kondo, Naoto, Okuda, Katsuhiro, Takahashi, Satoru, Sasaki, Hidefumi, ...
Abstract Background Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these...
Identification of biomarkers in ductal carcinoma in situof the breast with microinvasion (2008)
Okumura, Yasuhiro, Yamamoto, Yutaka, Zhang, Zhenhuan, Toyama, Tatsuya, Kawasoe, Teru, Ibusuki, Mutsuko, ...
Abstract Background Widespread use of mammography in breast cancer screening has led to the identification of increasing numbers of patients with ductal carcinoma in situ (DCIS). DCIS of the breast...
Hamaguchi, Maho, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Kondo, Naoto, Fujii, Yoshitaka, ...
Objective Genetic polymorphisms associated with breast cancer risk are likely to differ among ethnic and molecular subtypes. The ability to identify genetic polymorphisms affecting the risk of...
Mita, Keiko, Zhang, Zhenhuan, Ando, Yoshiaki, Toyama, Tatsuya, Hamaguchi, Maho, Kobayashi, Shunzo, ...
Background Expression of estrogen-regulated genes has been considered as potential predictive markers for endocrine therapy. We focused on two insulin-like growth factor binding proteins (IGFBPs):...
Toyama, Tatsuya, Zhang, Zhenhuan, Nishio, Mariko, Hamaguchi, Maho, Kondo, Naoto, Iwase, Hirotaka, ...
Abstract Introduction Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 (also known as p53 ) gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been...
Sugiura, Hiroshi, Toyama, Tatsuya, Hara, Yasuo, Zhang, Zhenhuan, Kobayashi, Shunzo, Fujii, Yoshitaka, ...
Background The clinical value of estrogen receptor (ER) β and its variants has been investigated. However, reported results have frequently been discordant. Methods We investigated mRNA and protein...
Yamashita, Hiroko, Toyama, Tatsuya, Nishio, Mariko, Ando, Yoshiaki, Hamaguchi, Maho, Zhang, Zhenhuan, ...
Abstract Introduction Endocrine therapy is the most important treatment option for women with hormone receptor-positive breast cancer. The potential mechanisms for endocrine resistance involve...
Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...
Background: While Snail is a zinc-finger transcription factor that triggers the epithelial-mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...
Toyama, Tatsuya, Zhang, Zhenhuan, Iwase, Hirotaka, Yamashita, Hiroko, Ando, Yoshiaki, Hamaguchi, Maho, ...
Background: While Snail is a zinc-finger transcription factor that triggers the epithelial- mesenchymal transition, it has also been reported to be indirectly regulated by estrogen receptor α (ERα)...
Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, ...
Abstract Introduction Many laboratories are currently evaluating the usefulness of determination of HER2, p53, and Ki67 proliferation indices using immunohistochemical techniques in cancer. Although...
Zhang, Zhenhuan, Yamashita, Hiroko, Toyama, Tatsuya, Omoto, Yoko, Sugiura, Hiroshi, Hara, Yasuo, ...
Abstract Background Estrogen is a mitogenic factor that is implicated in the genesis and progression of breast cancer via its binding to estrogen receptor (ER)-α. Synthesis of estrogen in situ is...
Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer (2002)
Shibata, Yasuyuki, Haruki, Nobuhiro, Kuwabara, Yoshiyuki, Ishiguro, Hideyuki, Shinoda, Noriyuki, Sato, Atsushi, ...
Cell cycle progression is monitored by checkpoint mechanisms to ensure the integrity of the genome and the fidelity of sister chromatid separation. Failure of such checkpoint functions results in...
Expression of PTTG (Pituitary Tumor Transforming Gene) in Esophageal Cancer (2002)
Shibata, Yasuyuki, Haruki, Nobuhiro, Kuwabara, Yoshiyuki, Nishiwaki, Tadashi, Kato, Joji, Shinoda, Noriyuki, ...
Background: Recently, a vertebrate securin [pituitary tumor transforming gene (PTTG) in humans] has been identified that inhibits sister chromatid separation and is involved in malignant...
Zhang, Zhenhuan, Yamashita, Hiroko, Toyama, Tatsuya, Omoto, Yoko, Sugiura, Hiroshi, Hara, Yasuo, ...
Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, ...
Zhang, Zhenhuan, Yamashita, Hiroko, Toyama, Tatsuya, Omoto, Yoko, Sugiura, Hiroshi, Hara, Yasuo, ...
Yamashita, Hiroko, Nishio, Mariko, Toyama, Tatsuya, Sugiura, Hiroshi, Zhang, Zhenhuan, Kobayashi, Shunzo, ...
Yamashita, Hiroko, Toyama, Tatsuya, Nishio, Mariko, Ando, Yoshiaki, Hamaguchi, Maho, Zhang, Zhenhuan, ...
Toyama, Tatsuya, Zhang, Zhenhuan, Nishio, Mariko, Hamaguchi, Maho, Kondo, Naoto, Iwase, Hirotaka, ...