Sabatti, Chiara, Service, Susan K., Hartikainen, Anna-Liisa, Pouta, Anneli, Ripatti, Samuli, Brodsky, Jae, ...
Genome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation of environmental and genetic influences on complex traits. We report GWAS results for nine quantitative...
Linkage and linkage disequilibrium scan for autism loci in an extended pedigree from Finland (2009)
Kilpinen, Helena, Ylisaukko-oja, Tero, Rehnström, Karola, Gaál, Emilia, Turunen, Joni A., Kempas, Elli, ...
Population isolates, such as Finland, have proved beneficial in mapping rare causative genetic variants due to a limited number of founders resulting in reduced genetic heterogeneity and extensive...
Service, Susan, DeYoung, Joseph, Karayiorgou, Maria, Roos, J. Louw, Pretorious, Herman, Bedoya, Gabriel, ...
The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples...
Service, Susan, DeYoung, Joseph, Karayiorgou, Maria, Roos, J. Louw, Pretorious, Herman, Bedoya, Gabriel, ...
The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples...
Paunio, Tiina, Tuulio-Henriksson, Annamari, Hiekkalinna, Tero, Perola, Markus, Varilo, Teppo, Partonen, Timo, ...
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analysed genomewide data for 168 schizophrenia families using...
Paunio, Tiina, Tuulio-Henriksson, Annamari, Hiekkalinna, Tero, Perola, Markus, Varilo, Teppo, Partonen, Timo, ...
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analyzed genome-wide data for 168 schizophrenia families using...
Paunio, Tiina, Tuulio-Henriksson, Annamari, Hiekkalinna, Tero, Perola, Markus, Varilo, Teppo, Partonen, Timo, ...
Research to identify predisposing genes for complex diseases relying solely on clinical diagnosis is probably not ideal. Here, we analysed genomewide data for 168 schizophrenia families using...
Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...
Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...
Hennah, William, Varilo, Teppo, Kestilä, Marjo, Paunio, Tiina, Arajärvi, Ritva, Haukka, Jari, ...
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes...
Chromosome 1 loci in Finnish schizophrenia families (2001)
Ekelund, Jesper, Hovatta, Iiris, Parker, Alex, Paunio, Tiina, Varilo, Teppo, Martin, Rory, ...
We have earlier reported evidence for linkage to two regions on chromosome 1q32–q42 in schizophrenia families collected for two separate studies in Finland. Here we report the results of a fine...
Ekelund, Jesper, Lichtermann, Dirk, Hovatta, Iiris, Ellonen, Pekka, Suvisaari, Jaana, Terwilliger, Joseph D., ...
We report the results of a four-stage genome-wide scan in a schizophrenia study sample consisting of 134 affected sib-pairs collected in Finland. In stage I we genotyped 370 markers from the Weber 6...
Diss. -- Helsingin yliopisto.
Molecular genetics of the Finnishdisease heritage (1999)
Peltonen, Leena, Jalanko, Anu, Varilo, Teppo
Finland, located at the edge of the inhabitable world,is one of the best-studied genetic isolates. The characteristicfeatures of population isolatesfounder effect, geneticdrift and isolationhave,...
Assignment of the Locus for Hydrolethalus Syndrome to a Highly Restricted Region on 11q23-25
Visapää, Ilona, Salonen, Riitta, Varilo, Teppo, Paavola, Paulina, Peltonen, Leena
Hydrolethalus syndrome is a recessively inherited lethal malformation syndrome characterized by hydrocephaly with absent midline structures of the brain, micrognathia, polydactyly, and several other...
Hovatta, Iiris, Varilo, Teppo, Suvisaari, Jaana, Terwilliger, Joseph D., Ollikainen, Vesa, Arajärvi, Ritva, ...
Schizophrenia is a severe mental disorder affecting ∼1% of the world's population. Here, we report the results from a three-stage genomewide screen performed in a study sample from an internal...
Mutations in the Translated Region of the Lactase Gene (LCT) Underlie Congenital Lactase Deficiency
Kuokkanen, Mikko, Kokkonen, Jorma, Enattah, Nabil Sabri, Ylisaukko-oja, Tero, Komu, Hanna, Varilo, Teppo, ...
Congenital lactase deficiency (CLD) is a severe gastrointestinal disorder characterized by watery diarrhea in infants fed with breast milk or other lactose-containing formulas. We initially assigned...
Auranen, Mari, Vanhala, Raija, Varilo, Teppo, Ayers, Kristin, Kempas, Elli, Ylisaukko-oja, Tero, ...
To identify genetic loci for autism-spectrum disorders, we have performed a two-stage genomewide scan in 38 Finnish families. The detailed clinical examination of all family members revealed...
Hakonen, Anna H., Heiskanen, Silja, Juvonen, Vesa, Lappalainen, Ilse, Luoma, Petri T., Rantamäki, Maria, ...
Mutations in the catalytic subunit of the mitochondrial DNA polymerase γ (POLG) have been found to be an important cause of neurological disease. Recently, we and collaborators reported a new...
Assignment of the Locus for Hydrolethalus Syndrome to a Highly Restricted Region on 11q23-25
Visapää, Ilona, Salonen, Riitta, Varilo, Teppo, Paavola, Paulina, Peltonen, Leena
Hydrolethalus syndrome is a recessively inherited lethal malformation syndrome characterized by hydrocephaly with absent midline structures of the brain, micrognathia, polydactyly, and several other...
Hovatta, Iiris, Varilo, Teppo, Suvisaari, Jaana, Terwilliger, Joseph D., Ollikainen, Vesa, Arajärvi, Ritva, ...
Schizophrenia is a severe mental disorder affecting ∼1% of the world's population. Here, we report the results from a three-stage genomewide screen performed in a study sample from an internal...
Mutations in the Translated Region of the Lactase Gene (LCT) Underlie Congenital Lactase Deficiency
Kuokkanen, Mikko, Kokkonen, Jorma, Enattah, Nabil Sabri, Ylisaukko-oja, Tero, Komu, Hanna, Varilo, Teppo, ...
Congenital lactase deficiency (CLD) is a severe gastrointestinal disorder characterized by watery diarrhea in infants fed with breast milk or other lactose-containing formulas. We initially assigned...
The Genome-wide Patterns of Variation Expose Significant Substructure in a Founder Population
Jakkula, Eveliina, Rehnström, Karola, Varilo, Teppo, Pietiläinen, Olli P.H., Paunio, Tiina, Pedersen, Nancy L., ...
Although high-density SNP genotyping platforms generate a momentum for detailed genome-wide association (GWA) studies, an offshoot is a new insight into population genetics. Here, we present an...