Teresa P. DiLorenzo

On defining the rules for interactions between the T cell receptor and its ligand: A critical role for a specific amino acid residue of the T cell receptor β chain

Wang, Fuming, Ono, Toshiro, Kalergis, Alexis M., Zhang, Weijia, DiLorenzo, Teresa P., Lim, Kap, ...

The specificity of T cell-mediated immune responses is primarily determined by the interaction between the T cell receptor (TCR) and the antigenic peptide presented by the major histocompatibility...

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

DiLorenzo, Teresa P., Graser, Robert T., Ono, Toshiro, Christianson, Gregory J., Chapman, Harold D., Roopenian, Derry C., ...

Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major histocompatibility complex...

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

Lieberman, Scott M., Evans, Anne M., Han, Bingye, Takaki, Toshiyuki, Vinnitskaya, Yuliya, Caldwell, Jennifer A., ...

Type 1 diabetes is an autoimmune disease in which autoreactive T cells attack and destroy the insulin-producing pancreatic β cells. CD8+ T cells are essential for this β cell destruction, yet their...

Developmental control of CD8+ T cell–avidity maturation in autoimmune diabetes

Han, Bingye, Serra, Pau, Yamanouchi, Jun, Amrani, Abdelaziz, Elliott, John F., Dickie, Peter, ...

The progression of immune responses is generally associated with an increase in the overall avidity of antigen-specific T cell populations for peptide-MHC. This is thought to result from preferential...

On defining the rules for interactions between the T cell receptor and its ligand: A critical role for a specific amino acid residue of the T cell receptor β chain

Wang, Fuming, Ono, Toshiro, Kalergis, Alexis M., Zhang, Weijia, DiLorenzo, Teresa P., Lim, Kap, ...

The specificity of T cell-mediated immune responses is primarily determined by the interaction between the T cell receptor (TCR) and the antigenic peptide presented by the major histocompatibility...

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

DiLorenzo, Teresa P., Graser, Robert T., Ono, Toshiro, Christianson, Gregory J., Chapman, Harold D., Roopenian, Derry C., ...

Nonobese diabetic (NOD) mice develop insulin-dependent diabetes mellitus due to autoimmune T lymphocyte-mediated destruction of pancreatic β cells. Although both major histocompatibility complex...

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

Lieberman, Scott M., Evans, Anne M., Han, Bingye, Takaki, Toshiyuki, Vinnitskaya, Yuliya, Caldwell, Jennifer A., ...

Type 1 diabetes is an autoimmune disease in which autoreactive T cells attack and destroy the insulin-producing pancreatic β cells. CD8+ T cells are essential for this β cell destruction, yet their...

Developmental control of CD8+ T cell–avidity maturation in autoimmune diabetes

Han, Bingye, Serra, Pau, Yamanouchi, Jun, Amrani, Abdelaziz, Elliott, John F., Dickie, Peter, ...

The progression of immune responses is generally associated with an increase in the overall avidity of antigen-specific T cell populations for peptide-MHC. This is thought to result from preferential...

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function

Chattopadhyay, Kausik, Ramagopal, Udupi A., Mukhopadhaya, Arunika, Malashkevich, Vladimir N., DiLorenzo, Teresa P., Brenowitz, Michael, ...

Glucocorticoid-induced TNF receptor ligand (GITRL), a recently identified member of the TNF family, binds to its receptor GITR on both effector and regulatory T cells and generates positive...

Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

Mukhopadhaya, Arunika, Hanafusa, Tadashi, Jarchum, Irene, Chen, Yi-Guang, Iwai, Yoshiko, Serreze, David V., ...

Type 1 diabetes (T1D) is an autoimmune disease resulting from defects in central and peripheral tolerance and characterized by T cell-mediated destruction of islet β cells. Cytotoxic CD8+ T cells,...