Terry D. Connell

Phase variation of gonococcal protein II: Regulation of gene expression by slipped-strand mispairing of a repetitive DNA sequence (1989)

Murphy, George L., Connell, Terry D., Barritt, Diana S., Koomey, Michael, Cannon, Janne G.

Expression of outer membrane protein II (P.II) of Neisseria gonorrhoeae is subject to reversible phase variation at a rate of 10-3-10-4/cell/generation. The signal peptide coding regions of P.II...

The structure and genetic regulation of PII genes in Neisseria gonorrhoeae--[microform] /--by Terry D. Connell. (1989)

Connell, Terry D.

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 1989.

Feeding ecology and demography of the shore fly S̲c̲a̲t̲e̲l̲l̲a̲ p̲i̲c̲e̲a̲ (Walker) (Diptera: Ephydridae) /--by Terry D. Connell. (1981)

Connell, Terry D.

Typescript.

Genetic Characterization of Wild-Type and Mutant fur Genes of Bordetella avium

Murphy, Erin R., Dickenson, Amy, Militello, Kevin T., Connell, Terry D.

For most, if not all, organisms, iron (Fe) is an essential element. In response to the nutritional requirement for Fe, bacteria evolved complex systems to acquire the element from the environment....

Comparative Analysis of the Mucosal Adjuvanticity of the Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb

Martin, Michael, Metzger, Daniel J., Michalek, Suzanne M., Connell, Terry D., Russell, Michael W.

Cholera toxin (CT) and the heat-labile enterotoxin of Escherichia coli (LT-I) are members of the serogroup I heat-labile enterotoxins (HLT) and can serve as systemic and mucosal adjuvants. However,...

Mutations in the Extracellular Protein Secretion Pathway Genes (eps) Interfere with Rugose Polysaccharide Production in and Motility of Vibrio cholerae

Ali, Afsar, Johnson, Judith A., Franco, Augusto A., Metzger, Daniel J., Connell, Terry D., Morris, J. Glenn, ...

Vibrio cholerae is the causal organism of the diarrheal disease cholera. The rugose variant of V. cholerae is associated with the secretion of an exopolysaccharide. The rugose polysaccharide has been...

Mutations in the Extracellular Protein Secretion Pathway Genes (eps) Interfere with Rugose Polysaccharide Production in and Motility of Vibrio cholerae

Ali, Afsar, Johnson, Judith A., Franco, Augusto A., Metzger, Daniel J., Connell, Terry D., Morris, J. Glenn, ...

Recombinant Antigen-Enterotoxin A2/B Chimeric Mucosal Immunogens Differentially Enhance Antibody Responses and B7-Dependent Costimulation of CD4+ T Cells

Martin, Michael, Hajishengallis, George, Metzger, Daniel J., Michalek, Suzanne M., Connell, Terry D., Russell, Michael W.

The ADP-ribosylating enterotoxins, cholera toxin (CT) and the Escherichia coli heat-labile toxin (LT-IIa), have been shown to enhance mucosal and systemic antibody (Ab) responses to coadministered...

Distinct Cytokine Regulation by Cholera Toxin and Type II Heat-Labile Toxins Involves Differential Regulation of CD40 Ligand on CD4+ T Cells

Martin, Michael, Metzger, Daniel J., Michalek, Suzanne M., Connell, Terry D., Russell, Michael W.

Cholera toxin (CT) and the type II heat-labile enterotoxins (HLT) LT-IIa and LT-IIb act as potent systemic and mucosal adjuvants and induce distinct T-helper (Th)-cell cytokine profiles. In the...

Heme Utilization in Bordetella avium Is Regulated by RhuI, a Heme-Responsive Extracytoplasmic Function Sigma Factor

Kirby, Amy E., Metzger, Daniel J., Murphy, Erin R., Connell, Terry D.

Efficient utilization of heme as an iron (Fe) source by Bordetella avium requires bhuR, an Fe-regulated gene which encodes an outer membrane heme receptor. Upstream of bhuR is a 507-bp open reading...

Endochitinase Is Transported to the Extracellular Milieu by the eps-Encoded General Secretory Pathway of Vibrio cholerae

Connell, Terry D., Metzger, Daniel J., Lynch, Jennifer, Folster, Jason P.

The chiA gene of Vibrio cholerae encodes a polypeptide which degrades chitin, a homopolymer of N-acetylglucosamine (GlcNAc) found in cell walls of fungi and in the integuments of insects and...

Iron Starvation of Bordetella avium Stimulates Expression of Five Outer Membrane Proteins and Regulates a Gene Involved in Acquiring Iron from Serum

Connell, Terry D., Dickenson, Amy, Martone, Andrew J., Militello, Kevin T., Filiatraut, Melanie J., Hayman, Mark L., ...

Iron starvation of Bordetella avium induced expression of five outer membrane proteins with apparent molecular masses of 95, 92, 91.5, 84, and 51 kDa. Iron-responsive outer membrane proteins (FeRPs)...

BhuR, a Virulence-Associated Outer Membrane Protein of Bordetella avium, Is Required for the Acquisition of Iron from Heme and Hemoproteins

Murphy, Erin R., Sacco, Randy E., Dickenson, Amy, Metzger, Daniel J., Hu, Yan, Orndorff, Paul E., ...

Iron (Fe) is an essential element for most organisms which must be obtained from the local environment. In the case of pathogenic bacteria, this fundamental element must be acquired from the fluids...

The Extracellular Transport Signal of the Vibrio cholerae Endochitinase (ChiA) Is a Structural Motif Located between Amino Acids 75 and 555

Folster, Jason P., Connell, Terry D.

ChiA, an 88-kDa endochitinase encoded by the chiA gene of the gram-negative enteropathogen Vibrio cholerae, is secreted via the eps-encoded main terminal branch of the general secretory pathway...

RhuR, an Extracytoplasmic Function Sigma Factor Activator, Is Essential for Heme-Dependent Expression of the Outer Membrane Heme and Hemoprotein Receptor of Bordetella avium

Kirby, Amy E., King, Natalie D., Connell, Terry D.

Genes involved in iron (Fe) acquisition often are regulated in response to the local availability of Fe. In many bacteria, Fe-dependent responsiveness is mediated by Fur, a global Fe-dependent...

The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells

Hajishengallis, George, Nawar, Hesham, Tapping, Richard I., Russell, Michael W., Connell, Terry D.

The type II heat-labile enterotoxins, LT-IIa and LT-IIb, exhibit potent adjuvant properties. However, little is known about their immunomodulatory activities upon interaction with innate immune...

Mucosal Adjuvant Properties of Mutant LT-IIa and LT-IIb Enterotoxins That Exhibit Altered Ganglioside-Binding Activities

Nawar, Hesham F., Arce, Sergio, Russell, Michael W., Connell, Terry D.

LT-IIa and LT-IIb, the type II heat-labile enterotoxins of Escherichia coli, are closely related in structure and function to cholera toxin and LT-I, the type I heat-labile enterotoxins of Vibrio...

Transcriptional Control of the rhuIR-bhuRSTUV Heme Acquisition Locus in Bordetella avium

King, Natalie D., Kirby, Amy E., Connell, Terry D.

Iron (Fe) is an essential nutrient for most bacterial pathogens. In these organisms, a variety of regulatory systems that respond to specific Fe complexes found within their vertebrate hosts have...

Toll-Like Receptor 2 Mediates Cellular Activation by the B Subunits of Type II Heat-Labile Enterotoxins

Hajishengallis, George, Tapping, Richard I., Martin, Michael H., Nawar, Hesham, Lyle, Elizabeth A., Russell, Michael W., ...

The type II heat-labile enterotoxins (LT-IIa and LT-IIb) of Escherichia coli have an AB5 subunit structure similar to that of cholera toxin (CT) and other type I enterotoxins, despite significant...

Differential Binding of Escherichia coli Enterotoxins LT-IIa and LT-IIb and of Cholera Toxin Elicits Differences in Apoptosis, Proliferation, and Activation of Lymphoid Cells

Arce, Sergio, Nawar, Hesham F., Russell, Michael W., Connell, Terry D.

Cholera toxin (CT), LT-IIa, and LT-IIb are potent adjuvants which induce distinct T-helper (Th)-cell cytokine profiles and immunoglobulin G (IgG) subclass and IgA antibody responses. To determine if...

Enterotoxin-Based Mucosal Adjuvants Alter Antigen Trafficking and Induce Inflammatory Responses in the Nasal Tract

Van Ginkel, Frederik W., Jackson, Raymond J., Yoshino, Naoto, Hagiwara, Yukari, Metzger, Daniel J., Connell, Terry D., ...

The safety of nasal vaccines containing enterotoxin-based mucosal adjuvants has not been studied in detail. Previous studies have indicated that native cholera toxin (nCT) can alter antigen...

Comparison of the Genome Sequence of the Poultry Pathogen Bordetella avium with Those of B. bronchiseptica, B. pertussis, and B. parapertussis Reveals Extensive Diversity in Surface Structures Associated with Host Interaction

Sebaihia, Mohammed, Preston, Andrew, Maskell, Duncan J., Kuzmiak, Holly, Connell, Terry D., King, Natalie D., ...

Bordetella avium is a pathogen of poultry and is phylogenetically distinct from Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis, which are other species in the...

Genetic Characterization of Wild-Type and Mutant fur Genes of Bordetella avium

Murphy, Erin R., Dickenson, Amy, Militello, Kevin T., Connell, Terry D.

For most, if not all, organisms, iron (Fe) is an essential element. In response to the nutritional requirement for Fe, bacteria evolved complex systems to acquire the element from the environment....

Comparative Analysis of the Mucosal Adjuvanticity of the Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb

Martin, Michael, Metzger, Daniel J., Michalek, Suzanne M., Connell, Terry D., Russell, Michael W.

Cholera toxin (CT) and the heat-labile enterotoxin of Escherichia coli (LT-I) are members of the serogroup I heat-labile enterotoxins (HLT) and can serve as systemic and mucosal adjuvants. However,...

Mutations in the Extracellular Protein Secretion Pathway Genes (eps) Interfere with Rugose Polysaccharide Production in and Motility of Vibrio cholerae

Ali, Afsar, Johnson, Judith A., Franco, Augusto A., Metzger, Daniel J., Connell, Terry D., Morris, J. Glenn, ...

Vibrio cholerae is the causal organism of the diarrheal disease cholera. The rugose variant of V. cholerae is associated with the secretion of an exopolysaccharide. The rugose polysaccharide has been...

Mutations in the Extracellular Protein Secretion Pathway Genes (eps) Interfere with Rugose Polysaccharide Production in and Motility of Vibrio cholerae

Ali, Afsar, Johnson, Judith A., Franco, Augusto A., Metzger, Daniel J., Connell, Terry D., Morris, J. Glenn, ...

Recombinant Antigen-Enterotoxin A2/B Chimeric Mucosal Immunogens Differentially Enhance Antibody Responses and B7-Dependent Costimulation of CD4+ T Cells

Martin, Michael, Hajishengallis, George, Metzger, Daniel J., Michalek, Suzanne M., Connell, Terry D., Russell, Michael W.

The ADP-ribosylating enterotoxins, cholera toxin (CT) and the Escherichia coli heat-labile toxin (LT-IIa), have been shown to enhance mucosal and systemic antibody (Ab) responses to coadministered...

Distinct Cytokine Regulation by Cholera Toxin and Type II Heat-Labile Toxins Involves Differential Regulation of CD40 Ligand on CD4+ T Cells

Martin, Michael, Metzger, Daniel J., Michalek, Suzanne M., Connell, Terry D., Russell, Michael W.

Cholera toxin (CT) and the type II heat-labile enterotoxins (HLT) LT-IIa and LT-IIb act as potent systemic and mucosal adjuvants and induce distinct T-helper (Th)-cell cytokine profiles. In the...

Heme Utilization in Bordetella avium Is Regulated by RhuI, a Heme-Responsive Extracytoplasmic Function Sigma Factor

Kirby, Amy E., Metzger, Daniel J., Murphy, Erin R., Connell, Terry D.

Efficient utilization of heme as an iron (Fe) source by Bordetella avium requires bhuR, an Fe-regulated gene which encodes an outer membrane heme receptor. Upstream of bhuR is a 507-bp open reading...

Endochitinase Is Transported to the Extracellular Milieu by the eps-Encoded General Secretory Pathway of Vibrio cholerae

Connell, Terry D., Metzger, Daniel J., Lynch, Jennifer, Folster, Jason P.

The chiA gene of Vibrio cholerae encodes a polypeptide which degrades chitin, a homopolymer of N-acetylglucosamine (GlcNAc) found in cell walls of fungi and in the integuments of insects and...

Iron Starvation of Bordetella avium Stimulates Expression of Five Outer Membrane Proteins and Regulates a Gene Involved in Acquiring Iron from Serum

Connell, Terry D., Dickenson, Amy, Martone, Andrew J., Militello, Kevin T., Filiatraut, Melanie J., Hayman, Mark L., ...

Iron starvation of Bordetella avium induced expression of five outer membrane proteins with apparent molecular masses of 95, 92, 91.5, 84, and 51 kDa. Iron-responsive outer membrane proteins (FeRPs)...

BhuR, a Virulence-Associated Outer Membrane Protein of Bordetella avium, Is Required for the Acquisition of Iron from Heme and Hemoproteins

Murphy, Erin R., Sacco, Randy E., Dickenson, Amy, Metzger, Daniel J., Hu, Yan, Orndorff, Paul E., ...

Iron (Fe) is an essential element for most organisms which must be obtained from the local environment. In the case of pathogenic bacteria, this fundamental element must be acquired from the fluids...

The Extracellular Transport Signal of the Vibrio cholerae Endochitinase (ChiA) Is a Structural Motif Located between Amino Acids 75 and 555

Folster, Jason P., Connell, Terry D.

ChiA, an 88-kDa endochitinase encoded by the chiA gene of the gram-negative enteropathogen Vibrio cholerae, is secreted via the eps-encoded main terminal branch of the general secretory pathway...

RhuR, an Extracytoplasmic Function Sigma Factor Activator, Is Essential for Heme-Dependent Expression of the Outer Membrane Heme and Hemoprotein Receptor of Bordetella avium

Kirby, Amy E., King, Natalie D., Connell, Terry D.

Genes involved in iron (Fe) acquisition often are regulated in response to the local availability of Fe. In many bacteria, Fe-dependent responsiveness is mediated by Fur, a global Fe-dependent...

The Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb and Their Respective B Pentamers Differentially Induce and Regulate Cytokine Production in Human Monocytic Cells

Hajishengallis, George, Nawar, Hesham, Tapping, Richard I., Russell, Michael W., Connell, Terry D.

The type II heat-labile enterotoxins, LT-IIa and LT-IIb, exhibit potent adjuvant properties. However, little is known about their immunomodulatory activities upon interaction with innate immune...

Mucosal Adjuvant Properties of Mutant LT-IIa and LT-IIb Enterotoxins That Exhibit Altered Ganglioside-Binding Activities

Nawar, Hesham F., Arce, Sergio, Russell, Michael W., Connell, Terry D.

LT-IIa and LT-IIb, the type II heat-labile enterotoxins of Escherichia coli, are closely related in structure and function to cholera toxin and LT-I, the type I heat-labile enterotoxins of Vibrio...

Transcriptional Control of the rhuIR-bhuRSTUV Heme Acquisition Locus in Bordetella avium

King, Natalie D., Kirby, Amy E., Connell, Terry D.

Iron (Fe) is an essential nutrient for most bacterial pathogens. In these organisms, a variety of regulatory systems that respond to specific Fe complexes found within their vertebrate hosts have...

Toll-Like Receptor 2 Mediates Cellular Activation by the B Subunits of Type II Heat-Labile Enterotoxins

Hajishengallis, George, Tapping, Richard I., Martin, Michael H., Nawar, Hesham, Lyle, Elizabeth A., Russell, Michael W., ...

The type II heat-labile enterotoxins (LT-IIa and LT-IIb) of Escherichia coli have an AB5 subunit structure similar to that of cholera toxin (CT) and other type I enterotoxins, despite significant...

Differential Binding of Escherichia coli Enterotoxins LT-IIa and LT-IIb and of Cholera Toxin Elicits Differences in Apoptosis, Proliferation, and Activation of Lymphoid Cells

Arce, Sergio, Nawar, Hesham F., Russell, Michael W., Connell, Terry D.

Cholera toxin (CT), LT-IIa, and LT-IIb are potent adjuvants which induce distinct T-helper (Th)-cell cytokine profiles and immunoglobulin G (IgG) subclass and IgA antibody responses. To determine if...

Enterotoxin-Based Mucosal Adjuvants Alter Antigen Trafficking and Induce Inflammatory Responses in the Nasal Tract

Van Ginkel, Frederik W., Jackson, Raymond J., Yoshino, Naoto, Hagiwara, Yukari, Metzger, Daniel J., Connell, Terry D., ...

The safety of nasal vaccines containing enterotoxin-based mucosal adjuvants has not been studied in detail. Previous studies have indicated that native cholera toxin (nCT) can alter antigen...

Comparison of the Genome Sequence of the Poultry Pathogen Bordetella avium with Those of B. bronchiseptica, B. pertussis, and B. parapertussis Reveals Extensive Diversity in Surface Structures Associated with Host Interaction

Sebaihia, Mohammed, Preston, Andrew, Maskell, Duncan J., Kuzmiak, Holly, Connell, Terry D., King, Natalie D., ...

Bordetella avium is a pathogen of poultry and is phylogenetically distinct from Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis, which are other species in the...

Mutants of Type II Heat-Labile Enterotoxin LT-IIa with Altered Ganglioside-Binding Activities and Diminished Toxicity Are Potent Mucosal Adjuvants▿

Nawar, Hesham F., Arce, Sergio, Russell, Michael W., Connell, Terry D.

The structure and function LT-IIa, a type II heat-labile enterotoxin of Escherichia coli, are closely related to the structures and functions of cholera toxin and LT-I, the type I heat-labile...

In Vitro Induction of Immunoglobulin A (IgA)- and IgM-Secreting Plasma Blasts by Cholera Toxin Depends on T-Cell Help and Is Mediated by CD154 Up-Regulation and Inhibition of Gamma Interferon Synthesis▿

Arce, Sergio, Nawar, Hesham F., Muehlinghaus, Gwendolin, Russell, Michael W., Connell, Terry D.

Cholera toxin (CT) and the type II heat-labile enterotoxins (LT-IIa and LT-IIb) are potent immunological adjuvants which are hypothesized to enhance the production of antibody (Ab)-secreting cells,...

Expression of hurP, a Gene Encoding a Prospective Site 2 Protease, Is Essential for Heme-Dependent Induction of bhuR in Bordetella bronchiseptica▿

King-Lyons, Natalie D., Smith, Kelsy F., Connell, Terry D.

Expression of the hurIR bhuRSTUV heme utilization locus in Bordetella bronchiseptica is coordinately controlled by the global iron-dependent regulator Fur and the extracytoplasmic function sigma...

Passively Released Heme from Hemoglobin and Myoglobin Is a Potential Source of Nutrient Iron for Bordetella bronchiseptica▿

Mocny, Jeffrey C., Olson, John S., Connell, Terry D.

Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in...