Review TRENDS in Neurosciences Vol.26 No.9 September 2003 507 Parsing reward (2008)
Kent C. Berridge, Terry E. Robinson
Advances in neurobiology permit neuroscientists to manipulate specific brain molecules, neurons and systems. This has lead to major advances in the neuroscience of reward. Here, it is argued that...
Venton, Barbara J., Robinson, Terry E., Kennedy, Robert T., Maren, Stephen
Glutamate and gamma-aminobutyric acid (GABA) release in the amygdala are thought to be crucial for the acquisition and expression of fear memories, but the time course of amino acid changes during...
Briand, Lisa A., Robinson, Terry E., Maren, Stephen
Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages...
Crombag, Hans S., Gorny, Grazyna, Li, Yilin, Kolb, Bryan, Robinson, Terry E.
We studied the long-term effects of amphetamine self-administration experience (or sucrose reward training) on dendritic morphology (spine density) in nucleus accumbens (Nacc), medial (MPC) and...
Briand, Lisa A., Robinson, Terry E., Maren, Stephen
Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages...
Briand, Lisa A., Robinson, Terry E., Maren, Stephen
Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages...
Incentive-sensitization and drug ‘wanting’ (2004)
Berridge, Kent C., Robinson, Terry E.
Peer Reviewed
Crombag, Hans S., Gorny, Grazyna, Li, Yilin, Kolb, Bryan, Robinson, Terry E.
We studied the long-term effects of amphetamine self-administration experience (or sucrose reward training) on dendritic morphology (spine density) in nucleus accumbens (Nacc), medial (MPC) and...
Crombag, Hans S., Gorny, Grazyna, Li, Yilin, Kolb, Bryan, Robinson, Terry E.
We studied the long-term effects of amphetamine self-administration experience (or sucrose reward training) on dendritic morphology (spine density) in nucleus accumbens (Nacc), medial (MPC) and...
Robinson, Terry E., Gorny, Grazyna, Savage, Virginia R., Kolb, Bryan
We studied the effects of self-administered (SA) vs. experimenter-administered (EA) morphine on dendritic spines in the hippocampal formation (CA1 and dentate), nucleus accumbens shell (NAcc-s),...
Kabbaj, M., Robinson, Terry E., Kollack-Walker, Sara, Akil, Huda, Norton, Camille S., Watson, S.
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across...
Robinson, Terry E., Gorny, Grazyna, Mitton, Elizabeth, Kolb, Bryan
We studied the influence of cocaine use on the structure of neurons in brain regions that contribute to its rewarding effects by allowing rats to self-administer cocaine (0.33 mg/infusion) for 1 h a...
Crombag, Hans S., Badiani, Aldo, Maren, Stephen, Robinson, Terry E.
The environmental context in which psychostimulant drugs are administered can have a large effect on both their acute psychomotor activating effects and their ability to induce the psychomotor...
Badiani, Aldo, Oates, M. M., Browman, Kaitlin E., Wolf, M. E., Ostrander, M. M., ...
Rationale: We have previously shown that environmental novelty enhances the behavioral activating effects of amphetamine and amphetamine-induced expression of the immediate early gene c- fos in the...
Modulation of morphine sensitization in the rat by contextual stimuli (2000)
Robinson, Terry E., Oates, M. M., Badiani, Aldo
Rationale: The repeated administration of addictive drugs, such as amphetamine, cocaine, and morphine, produces a progressive enhancement (sensitization) of their psychomotor activating effects. We...
Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats (1999)
Robinson, Terry E., Kolb, Bryan
Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed for 24–25 days before their brains were processed for Golgi-Cox staining. Prior exposure to morphine...
Robinson, Terry E., Badiani, Aldo, Browman, Kaitlin E.
The acute psychomotor response and development of sensitization to amphetamine is attenuated if IP injections are given in the cage where a rat lives relative to when injections are given in a...
Badiani, Aldo, Anagnostaras, S. G., Robinson, Terry E.
Two experiments were designed to assess the effect of a “novel” environment on the development of sensitization to the psychomotor activating effects of d -amphetamine. In the first experiment,...
Paulson, Pamela E., Robinson, Terry E.
The purpose of this study was to compare the effects of amphetamine exposure on subsequent amphetamine-induced changes in behavior and dopamine (DA) release in the dorsal and ventral striatum, as a...
Camp, Dianne M., Browman, Kaitlin E., Robinson, Terry E.
The effects of an acute systemic injection of methamphetamine (mAMP) or cocaine (COC) on motor behavior (stereotypy, locomotor activity, and rearing) and extracellular dopamine (DA) in the ventral...
Crippens, Donita, Robinson, Terry E.
The effect of withdrawal from chronic morphine or amphetamine treatment on dopamine (DA) neurotransmission in the ventral-medial striatum was studied by use of in vivo microdialysis. There was no...
Robinson, Terry E., Noordhoorn, Maura, Chan, Emily M., Mocsary, Zoltan, Camp, Dianne M., Whishaw, Ian Q.
In animals with a large unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) system the traditional “rotational behavior model” states that amphetamine will induce...
Crippens, Donita, Camp, Dianne M., Robinson, Terry E.
The basal extracellular concentration of dopamine in the nucleus accumbens was quantified using the `no net flux' microdialysis method, in rats undergoing withdrawal from -amphetamine. Rats were...
Meisel, Robert L., Camp, Dianne M., Robinson, Terry E.
Microdialysis was used to study the effects of exposure to a male hamster on extracellular concentrations of dopamine, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindole...
The neural basis of drug craving: An incentive-sensitization theory of addiction (1993)
Robinson, Terry E., Berridge, Kent C.
This paper presents a biopsychological theory of drug addiction, the `Incentive-Sensitization Theory'. The theory addresses three fundamental questions. The first is: why do addicts crave drugs? That...
an incentive-sensitization theory of addiction (1993)
Terry E. Robinson, Kent C. Berridge
The neural basis of drug craving:
Castaneda, Edward, Whishaw, Ian Q., Robinson, Terry E.
It has been hypothesized that neocortical damage is accompanied by secondary changes in other brain areas (the shock or diaschisis of von Monakow), which contributes to initial non-specific...
Robinson, Terry E., Camp, Dianne M.
The effects of 4 days of continuous microdialysis with a small-diameter concentric-style probe on indices of striatal dopamine (DA) and serotonin neurotransmission were assessed. It was found that...
Robinson, Terry E., Paulson, Pamela E.
Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however,...
Paulson, Pamela E., Camp, Dianne M., Robinson, Terry E.
This experiment was designed to characterize the withdrawal syndrome produced by discontinuation of treatment with escalating, non-neurotoxic doses of d -amphetamine (AMPH). AMPH withdrawal was...
Robinson, Terry E., Yew, Jay, Paulson, Pamela E., Camp, Dianne M.
The extracellular concentrations of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum were measured by in vivo...
Castaneda, Edward, Whishaw, Ian Q., Lermer, Leonard, Robinson, Terry E.
Rats depleted of dopamine (DA) by intraventricular 6-hydroxydopamine (6-OHDA) in infancy show behavioral impairments as adults, but their basic sensory-motor functions and feeding abilities are...
Becker, Jill B., Robinson, Terry E., Barton, Peter, Sintov, Amnon, Siden, Rivka, Levy, Robert J.
This study was conducted to determine if the behavioral asymmetry associated with unilateral nigrostriatal dopamine (DA) depletion could be alleviated by placing a small DA-releasing silicone polymer...
Robinson, Terry E., Jurson, Phillip A., Bennett, Julie A., Bentgen, Kris M.
In humans the repeated use of amphetamine (AMPH) produces a hypersensitivity to the psychotogenic effects of AMPH that persists for months to years after the cessation of drug use. To explore the...
Camp, Dianne M., Robinson, Terry E.
There are sex differences in a number of behaviors elicited by amphetamine (AMPH). The purpose of the present experiment was to determine if there are also sex differences in the sensitization of the...
Camp, Dianne M., Robinson, Terry E.
Repeated amphetamine use produces an enduring sensitization of brain dopamine (DA) systems and behavior. Repeated exposure to stress can also produce sensitization, and amphetamine and stress may be...
Becker, Jill B., Adams, Frank, Robinson, Terry E.
A new method is described to estimate the cerebrospinal fluid (CSF) concentrations of monoamine metabolites (dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid...
Robinson, Terry E., Whishaw, Ian Q.
It has been hypothesized that striatal dopamine (DA) terminals undergo compensatory changes in response to partial damage of the mesostriatal DA system, which results in higher concentrations of DA...
Castaneda, Edward, Becker, Jill B., Robinson, Terry E.
Exposure to amphetamine (AMPH) in vivo produces an enduring enhancement (`sensitization') in AMPH-stimulated striatal DA release in vitro. Experiments were conducted to determine whether striatal DA...
Robinson, Terry E., Becker, Jill B., Young, Elizabeth A., Akil, Huda, Castaneda, Edward
The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine....
Robinson, Terry E., Camp, Dianne M.
The repeated intermittent administration of relatively low doses of amphetamine (AMPH) produces an enduring hypersensitivity to the motor stimulant effects of AMPH (behavioral sensitization), and...
Camp, Dianne M., Becker, Jill B., Robinson, Terry E.
The effects of gonadectomy on amphetamine-induced rotational behavior were studied in male and female rats. Different systemic doses were used to produce equivalent brain concentrations of the drug...
Robinson, Terry E., Becker, Jill B.
Some people who repeatedly use stimulant drugs, such as amphetamine (AMPH), develop an AMPH-induced psychosis that is similar to paranoid schizophrenia. There has been, therefore, considerable...
Robinson, Terry E., Becker, Jill B.
8. SummarySome people who repeatedly use stimulant drugs, such as amphetamine (AMPH), develop an AMPH-induced psychosis that is similar to paranoid schizophrenia. There has been, therefore,...
Wilcox, Richard A., Robinson, Terry E., Becker, Jill B.
Peer Reviewed
Robinson, Terry E., Becker, Jill B., Moore, C. J., Castaneda, Edward, Mittleman, Guy
It is reported that in rats the repeated intermittent administration of amphetamine produces a long-lasting enhancement in medial frontal cortex dopamine utilization. This change in mesocortical...
Robinson, Terry E., Angus, Amy L., Becker, Jill B.
In rats with a unilateral 6-OHDA lesion of the substantia nigra exposure to footshock or immobilization stress produced a long-lasting enhancement in the rotational behavior evoked by a subsequent...
Sensitization of rotational behavior produced by a single exposure to cocaine (1985)
Lin-Chu, Guan, Robinson, Terry E., Becker, Jill B.
In rats with a unilateral 6-OHDA lesion of the substantia nigra a single exposure to cocaine significantly enhanced the ipsiversive rotational behavior produced by a second injection given one week...
Castaneda, Edward, Robinson, Terry E., Becker, Jill B.
This experiment was conducted to determine if nigrostriatal dopamine (DA) neurons are necessary for the contraversive rotational behavior evoked by electrical stimulation in the lateral hypothalamus....
Factors influencing the behavioral sensitization (“reverse tolerance”) produced by intermittent amphetamine (AMPH) injections were studied by quantifying rotational behavior in rats that had a...
Becker, Jill B., Beer, Mary E., Robinson, Terry E.
The release of endogenous dopamine (DA) from rat striatal tissue was studied in an in vitro superfusion system following hormonal manipulations in vivo. Progesterone treatment in estrogen-primed...
Camp, Dianne M., Robinson, Terry E., Becker, Jill B.
The influence of early experience (preweaning handling) on the development of several postural/motor asymmetries (side bias in an open field, turn preference in a T-maze, amphetamine-induced...
Becker, Jill B., Castaneda, Edward, Robinson, Terry E., Beer, Mary E.
An easily constructed, inexpensive and simple system is described for the superfusion of neural tissue. To characterize the system, the dynamics of endogenous dopamine and dihydroxyphenylacetic acid...
Robinson, Terry E., Becker, Jill B.
A basic assumption of the `rotational behavior model' is that amphetamine (AMPH) produces ipsiversive rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal...
Robinson, Terry E., Becker, Jill B., Presty, Sharon K.
Amphetamine (AMPH)-induced rotational behavior in non-lesioned rats and AMPH-stimulated dopamine (DA) release from striatal tissue fragments in vitro were used to study the long-term effects of a...
Robinson, Terry E., Becker, Jill B.
Peer Reviewed
Robinson, Terry E., Camp, Dianne M., Jacknow, Dale S., Becker, Jill B.
In this study electrical stimulation-induced rotational behavior was used as a behavioral index of mesostriatal dopamine (DA) activity to investigate gender and hormonal influences on the DA system....
Sex difference and estrous cycle variations in amphetamine-elicited rotational behavior (1982)
Becker, Jill B., Robinson, Terry E., Lorenz, Kimberly A.
The experiments reported here were designed to determine if there are sex- and/or estrous cycle-dependent differences in amphetamine (AMPH)-elicited rotational behavior in unlesioned rats. Whole...
Robinson, Terry E., Camp, Dianne M., Becker, Jill B.
Rotational behavior induced by electrical stimulation of ascending dopamine neurons is used as a behavioral model to investigate gender and hormonal influences on extra-hypothalamic dopamine systems....
Vanderwolf, C. H., Robinson, Terry E., Pappas, B. A.
A large dose of reserpine abolishes an atropine-resistant form of neocortical low voltage fast activity (LVFA) which normally accompanies certain patterns of motor activity in rats. An attempt was...
Robinson, Terry E., Becker, Jill B., Ramirez, V. D.
Sex differences are described in both a lateralized behavior (amphetamine-elicited rotation) and in the lateralization of striatal dopamine (DA) content. Amphetamine (AMPH) elicited significantly...
The literature concerning the correlates of hippocampal RSA (theta) has seen a wealth of hypotheses generated from seemingly contradictory data. Two possible reasons for this are examined here. (1)...
Kolb, Bryan, Gorny, Grazyna, Li, Yilin, Samaha, Anne-Noël, Robinson, Terry E.
Drugs of abuse and many other kinds of experiences share the ability to alter the morphology of neuronal dendrites and spines, the primary site of excitatory synapses in the brain. We hypothesized,...
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
Wei, Qiang, Lu, Xin-Yun, Liu, Li, Schafer, Gwen, Shieh, Kun-Ruey, Burke, Sharon, ...
The molecular mechanisms that control the range and stability of emotions are unknown, yet this knowledge is critical for understanding mood disorders, especially bipolar illness. Here, we show that...
Kolb, Bryan, Gorny, Grazyna, Li, Yilin, Samaha, Anne-Noël, Robinson, Terry E.
Drugs of abuse and many other kinds of experiences share the ability to alter the morphology of neuronal dendrites and spines, the primary site of excitatory synapses in the brain. We hypothesized,...
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
Wei, Qiang, Lu, Xin-Yun, Liu, Li, Schafer, Gwen, Shieh, Kun-Ruey, Burke, Sharon, ...
The molecular mechanisms that control the range and stability of emotions are unknown, yet this knowledge is critical for understanding mood disorders, especially bipolar illness. Here, we show that...
The incentive sensitization theory of addiction: some current issues
Robinson, Terry E, Berridge, Kent C
We present a brief overview of the incentive sensitization theory of addiction. This posits that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems...