Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...
Abstract Background Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To...
Sensing of intermediates in V(D)J recombination by ATM (2002)
Perkins, Eric J., Nair, Ayyappan, Cowley, Dale O., Van Dyke, Terry, Chang, Yung, Ramsden, Dale A.
Lübbert, Hermann, Hoffman, Beth J., Snutch, Terry P., Van Dyke, Terry, Levine, Arnold J., Hartig, Paul R., ...
We describe a strategy for the cloning of neurotransmitter-receptor and ion-channel cDNAs that is based on electrophysiological assays of mRNA-injected Xenopus oocytes. This procedure circumvents the...
Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction
Liao, Mai-Jing, Yin, Chaoying, Barlow, Carrolee, Wynshaw-Boris, Anthony, Van Dyke, Terry
Both p53 and ATM are checkpoint regulators with roles in genetic stabilization and cancer susceptibility. ATM appears to function in the same DNA damage checkpoint pathway as p53. However, ATM’s...
Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb...
No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma
Liao, Mai-Jing, Zhang, Xiao-Xiang, Hill, Rosina, Gao, Jingjin, Qumsiyeh, Mazin B., Nichols, Warren, ...
The p53 tumor suppressor is activated in response to a variety of cellular stress signals, although specific in vivo signals that trigger tumor suppression are unknown. In mouse thymocytes, where p53...
Tolbert, Dawn, Lu, Xiangdong, Yin, Chaoying, Tantama, Mathew, Van Dyke, Terry
Recent studies have shown the p19ARF tumor suppressor to be involved in the response to oncogenic stress by regulating the activity of p53. This response is mediated by antagonizing the function of...
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
Liao, Mai-Jing, Van Dyke, Terry
Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and in mouse Atm−/− thymoma, suggesting the involvement of V(D)J...
Cowley, Dale O., Muse, Ginger W., Van Dyke, Terry
Aneuploidy is a common feature of human tumors, often correlating with poor prognosis. The mitotic spindle checkpoint is thought to play a major role in aneuploidy suppression. To investigate the...
Adeno-associated virus vectors: potential applications for cancer gene therapy
Li, Chengwen, Bowles, Dawn E, Van Dyke, Terry, Samulski, Richard Jude
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success in animal models. The primary hurdle of fully exploiting the arsenal of molecular targets and...
Sensing of intermediates in V(D)J recombination by ATM
Perkins, Eric J., Nair, Ayyappan, Cowley, Dale O., Van Dyke, Terry, Chang, Yung, Ramsden, Dale A.
Ataxia-telangiectasia mutated (ATM) is required for resistance to radiation-induced DNA breaks. Here we use chromatin immunoprecipitation to show that ATM also localizes to breaks associated with...
Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction
Liao, Mai-Jing, Yin, Chaoying, Barlow, Carrolee, Wynshaw-Boris, Anthony, Van Dyke, Terry
Both p53 and ATM are checkpoint regulators with roles in genetic stabilization and cancer susceptibility. ATM appears to function in the same DNA damage checkpoint pathway as p53. However, ATM’s...
Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb...
No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma
Liao, Mai-Jing, Zhang, Xiao-Xiang, Hill, Rosina, Gao, Jingjin, Qumsiyeh, Mazin B., Nichols, Warren, ...
The p53 tumor suppressor is activated in response to a variety of cellular stress signals, although specific in vivo signals that trigger tumor suppression are unknown. In mouse thymocytes, where p53...
Tolbert, Dawn, Lu, Xiangdong, Yin, Chaoying, Tantama, Mathew, Van Dyke, Terry
Recent studies have shown the p19ARF tumor suppressor to be involved in the response to oncogenic stress by regulating the activity of p53. This response is mediated by antagonizing the function of...
Sensing of intermediates in V(D)J recombination by ATM
Perkins, Eric J., Nair, Ayyappan, Cowley, Dale O., Van Dyke, Terry, Chang, Yung, Ramsden, Dale A.
Ataxia-telangiectasia mutated (ATM) is required for resistance to radiation-induced DNA breaks. Here we use chromatin immunoprecipitation to show that ATM also localizes to breaks associated with...
Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma
Liao, Mai-Jing, Van Dyke, Terry
Chromosome translocations involving T cell receptor (TCR) loci have been found in tumors from Ataxia telangiectasia (AT) patients and in mouse Atm−/− thymoma, suggesting the involvement of V(D)J...
Cowley, Dale O., Muse, Ginger W., Van Dyke, Terry
Aneuploidy is a common feature of human tumors, often correlating with poor prognosis. The mitotic spindle checkpoint is thought to play a major role in aneuploidy suppression. To investigate the...
Herschkowitz, Jason I, Simin, Karl, Weigman, Victor J, Mikaelian, Igor, Usary, Jerry, Hu, Zhiyuan, ...
Comparison of mammary tumor gene-expression profiles from thirteen murine models using microarrays and with that of human breast tumors showed that many of the defining characteristics of human...
Johnson, Carrie E., Huang, Yolanda Y., Parrish, Amanda B., Smith, Michelle I., Vaughn, Allyson E., Zhang, Qian, ...
Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly...
Aurora-A Kinase Is Essential for Bipolar Spindle Formation and Early Development▿ †
Cowley, Dale O., Rivera-Pérez, Jaime A., Schliekelman, Mark, He, Yizhou Joseph, Oliver, Trudy G., Lu, Lucy, ...
Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was previously implicated in mitotic entry and spindle assembly, although contradictory results prevented...