Reddy, Pradeep, Adhikari, Deepak, Zheng, Wenjing, Liang, Shawn, Hämäläinen, Tuula, Tohonen, Virpi, ...
The molecular mechanisms that control reproductive aging and menopausal age in females are poorly understood. Here, we provide genetic evidence that 3-phosphoinositide-dependent protein kinase-1...
Ito, Chizuru, Akutsu, Hidenori, Yao, Ryoji, Kyono, Koichi, Suzuki-Toyota, Fumie, Toyama, Yoshiro, ...
BACKGROUNDRecent studies indicate that round-headed sperm cannot activate oocytes and lack the postacrosomal sheath (PAS) or perinuclear theca (PT), although normal flat-headed sperm can activate...
Pancreatic β Cell Mass Preserved in Heterozygous PDK1 Knockout Mice (2008)
Takeda, Akihiko, Kido, Yoshiaki, Hashimoto, Naoko, Noda, Tetsuo, Kasuga, Masato
We have demonstrated that 3-phosphoinositide-dependent protein kinase 1 (PDK1)contributes to signaling by insulin or insulin-like growth fctor-1 (IGF-1) that isresponsible for the regulation of both...
Masuya, Hiroshi, Nishida, Keiichiro, Furuichi, Tatsuya, Toki, Hideaki, Nishimura, Gen, Kawabata, Hidehiko, ...
Growth and differentiation factor 5 (GDF5) has been implicated in chondrogenesis and joint formation, and an association of GDF5 and osteoarthritis (OA) has been reported recently. However, the in...
Masaru Ushijima, Satoshi Miyata, Shinto Eguchi, Masanori Kawakita, Masataka Yoshimoto, Takuji Iwase, ...
We propose a method for biomarker discovery from mass spectrometry data, improving the common peak approach developed by Fushiki et al. (BMC Bioinformatics, 7:358, 2006). The common peak method is a...
Ma, Li, Teruya-Feldstein, Julie, Behrendt, Nille, Chen, Zhenbang, Noda, Tetsuo, Hino, Okio, ...
The role of tumor suppressor haploinsufficiency in oncogenesis is still poorly understood. The PTEN and TSC2 tumor suppressors function to antagonize mTOR (mammalian target of rapamycin) activation...
Ma, Li, Teruya-Feldstein, Julie, Behrendt, Nille, Chen, Zhenbang, Noda, Tetsuo, Hino, Okio, ...
The role of tumor suppressor haploinsufficiency in oncogenesis is still poorly understood. The PTEN and TSC2 tumor suppressors function to antagonize mTOR (mammalian target of rapamycin) activation...
Masuya, Hiroshi, Shimizu, Kunihiko, Sezutsu, Hideki, Sakuraba, Yoshiyuki, Nagano, Junko, Shimizu, Aya, ...
Amelogenesis imperfecta (AI) is a group of commonly inherited defects of dental enamel formation, which exhibits marked genetic and clinical heterogeneity. The genetic basis of this heterogeneity is...
Masuya, Hiroshi, Shimizu, Kunihiko, Sezutsu, Hideki, Sakuraba, Yoshiyuki, Nagano, Junko, Shimizu, Aya, ...
Amelogenesis imperfecta (AI) is a group of commonly inherited defects of dental enamel formation, which exhibit marked genetic and clinical heterogeneity. The genetic basis of this heterogeneity is...
Ma, Li, Teruya-Feldstein, Julie, Behrendt, Nille, Chen, Zhenbang, Noda, Tetsuo, Hino, Okio, ...
The role of tumor suppressor haploinsufficiency in oncogenesis is still poorly understood. The PTEN and TSC2 tumor suppressors function to antagonize mTOR (mammalian target of rapamycin) activation...
Inoue, Maki, Sakuraba, Yoshiyuki, Motegi, Hiromi, Kubota, Naoto, Toki, Hideaki, Matsui, Junko, ...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale...
Inoue, Maki, Sakuraba, Yoshiyuki, Motegi, Hiromi, Kubota, Naoto, Toki, Hideaki, Matsui, Junko, ...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale...
Inoue, Maki, Sakuraba, Yoshiyuki, Motegi, Hiromi, Kubota, Naoto, Toki, Hideaki, Matsui, Junko, ...
Mutant mouse models are indispensable tools for clarifying the functions of genes and for elucidating the underlying pathogenic mechanisms of human diseases. Currently, several large-scale...
Mice lacking a transcriptional corepressor Tob are predisposed to cancer (2003)
Yoshida, Yutaka, Nakamura, Takahisa, Komoda, Masato, Satoh, Hitoshi, Suzuki, Toru, Tsuzuku, Junko K., ...
Kashiwagi, Kenji, Shiba, Kiyotaka, Fukami-Kobayashi, Kaoru, Noda, Tetsuo, Nishikawa, Ken, Noguchi, Hiroshi
The family of periplasmic binding proteins (PBPs) is believed to have arisen from a common ancestor and to have differentiated into two types. At first approximation, both types of PBPs have the same...
Shiba, Kiyotaka, Shirai, Tsuyoshi, Honma, Takako, Noda, Tetsuo
Repetitiousness is often observed in the primary and tertiary structures of proteins. We are intrigued by the potential role played by periodicity in the evolution of proteins and have created...
Kitamura, Tomohiro, Kawamori, Toshihiko, Uchiya, Naoaki, Itoh, Masaki, Noda, Tetsuo, Matsuura, Mamoru, ...
Cyclooxygenase (COX)-2, one enzyme isoform responsible for producing prostanoids from arachidonic acid, contributes to colon carcinogenesis. Recently, genetic disruption of COX-1, the other isoform,...
Sugitani, Yoshinobu, Nakai, Shigeyasu, Minowa, Osamu, Nishi, Miyuki, Jishage, Kou-ichi, Kawano, Hitoshi, ...
Kawate, Hisaya, Itoh, Riyoko, Sakumi, Kunihiko, Nakabeppu, Yusaku, Tsuzuki, Teruhisa, Ide, Fumio, ...
Mice with mutations in both alleles of the Mgmt and the Mlh1 gene, the former encoding a DNA repair methyltransferase and the latter a protein functioning at an early step of mismatch repair, are as...
Kumada, Kazuki, Yao, Ryoji, Kawaguchi, Tokuichi, Karasawa, Mika, Hoshikawa, Yutaka, Ichikawa, Koji, ...
Separase is an evolutionarily conserved protease that is essential for chromosome segregation and cleaves cohesin Scc1/Rad21, which joins the sister chromatids together. Although mammalian separase...
Tamura, Atsushi, Kikuchi, Shojiro, Hata, Masaki, Katsuno, Tatsuya, Matsui, Takeshi, Hayashi, Hisayoshi, ...
Loss of gastric acid secretion is pathologically known as achlorhydria. Acid-secreting parietal cells are characterized by abundant expression of ezrin (Vil2), one of ezrin/radixin/moesin proteins,...
Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand
Murata, Kazuko, Ishii, Naoto, Takano, Hiroshi, Miura, Shigeto, Ndhlovu, Lishomwa C., Nose, Masato, ...
OX40 expressed on activated T cells is known to be an important costimulatory molecule on T cell activation in vitro. However, the in vivo functional significance of the interaction between OX40 and...
Takei, Yosuke, Kondo, Satoru, Harada, Akihiro, Inomata, Satomi, Noda, Tetsuo, Hirokawa, Nobutaka
Microtubule-associated protein 1B (MAP1B), one of the microtubule-associated proteins (MAPs), is a major component of the neuronal cytoskeleton. It is expressed at high levels in immature neurons...
Yonekawa, Yoshiaki, Harada, Akihiro, Okada, Yasushi, Funakoshi, Takeshi, Kanai, Yoshimitsu, Takei, Yosuke, ...
The nerve axon is a good model system for studying the molecular mechanism of organelle transport in cells. Recently, the new kinesin superfamily proteins (KIFs) have been identified as candidate...
Saitou, Mitinori, Fujimoto, Kazushi, Doi, Yoshinori, Itoh, Masahiko, Fujimoto, Toyoshi, Furuse, Mikio, ...
Occludin is the only known integral membrane protein of tight junctions (TJs), and is now believed to be directly involved in the barrier and fence functions of TJs. Occludin-deficient embryonic stem...
Furuse, Mikio, Hata, Masaki, Furuse, Kyoko, Yoshida, Yoko, Haratake, Akinori, Sugitani, Yoshinobu, ...
The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier function of simple epithelia, but TJs have not been thought to play an important role in the barrier...
Abnormal Features in Skeletal Muscle from Mice Lacking Mitsugumin29
Nishi, Miyuki, Komazaki, Shinji, Kurebayashi, Nagomi, Ogawa, Yasuo, Noda, Tetsuo, Iino, Masamitsu, ...
Physiological roles of the members of the synaptophysin family, carrying four transmembrane segments and being basically distributed on intracellular membranes including synaptic vesicles, have not...
α-Catenin is essential in intestinal adenoma formation
Shibata, Hiroyuki, Takano, Hiroshi, Ito, Masaki, Shioya, Hisashi, Hirota, Morihisa, Matsumoto, Hiroshi, ...
A loss-of-function mutation in the APC gene initiates colorectal carcinogenesis. Although the molecular mechanism of tumor initiation is complex, several modifier genes have been identified using...
Katsuno, Tatsuya, Umeda, Kazuaki, Matsui, Takeshi, Hata, Masaki, Tamura, Atsushi, Itoh, Masahiko, ...
Zonula occludens (ZO)-1/2/3 are the members of the TJ-MAGUK family of membrane-associated guanylate kinases associated with tight junctions. To investigate the role of ZO-1 (encoded by Tjp1) in vivo,...
Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice▿
Shigeyama, Yutaka, Kobayashi, Toshiyuki, Kido, Yoshiaki, Hashimoto, Naoko, Asahara, Shun-ichiro, Matsuda, Tomokazu, ...
Recent studies have demonstrated the importance of insulin or insulin-like growth factor 1 (IGF-1) for regulation of pancreatic β-cell mass. Given the role of tuberous sclerosis complex 2 (TSC2) as...
Hirose, Tomonori, Satoh, Daisuke, Kurihara, Hidetake, Kusaka, Chiho, Hirose, Hiroko, Akimoto, Kazunori, ...
Glomerular visceral epithelial cells (podocytes) contain interdigitated processes that form specialized intercellular junctions, termed slit diaphragms, which provide a selective filtration barrier...
Ushijima, Masaru, Miyata, Satoshi, Eguchi, Shinto, Kawakita, Masanori, Yoshimoto, Masataka, Iwase, Takuji, ...
We propose a method for biomarker discovery from mass spectrometry data, improving the common peak approach developed by Fushiki et al. (BMC Bioinformatics, 7:358, 2006). The common peak method is a...
Kinetochore stretching inactivates the spindle assembly checkpoint
Uchida, Kazuhiko S.K., Takagaki, Kentaro, Kumada, Kazuki, Hirayama, Youko, Noda, Tetsuo, Hirota, Toru
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension;...