Tanaka, Michiko, Sata, Tetsutaro, Kawaguchi, Yasushi
Abstract The herpes simplex virus 1 (HSV-1) UL7 gene is highly conserved among herpesviridae . Since the construction of recombinant HSV-1 with a mutation in the UL7 gene has not been reported, the...
All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition (2007)
Kinomoto, Masanobu, Kanno, Takayuki, Shimura, Mari, Ishizaka, Yukihito, Kojima, Asato, Kurata, Takeshi, ...
Approximately 17% of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, L1) non-LTR retrotransposons. L1 retrotransposition is known to be the cause of several genetic...
Integration of HIV-1 Caused STAT3-Associated B Cell Lymphoma in an AIDS Patient (2005)
Katano, Harutaka, Sato, Yuko, Hoshino, Satomi, Mori, Shigeo, Sata, Tetsutaro, Weiden, Micheal D, ...
No abstract available.
Kino, Nao, Sata, Tetsutaro, Sato, Yuko, Sugase, Motoyasu, Matsukura, Toshihiko
The genome of a novel human papillomavirus (HPV-82) was cloned from a vaginal intraepithelial neoplasia grade I. In our series of 291 biopsy specimens, HPV-82 was identified in one case each of...
Katano, Harutaka, Iwasaki, Takuya, Baba, Nobuyoshi, Terai, Masanori, Mori, Shigeo, Iwamoto, Aikichi, ...
To establish a sensitive and specific antibody assay, potent antigenic proteins encoded by human herpesvirus 8 (HHV8) were studied. Fifteen recombinant HHV8-encoded proteins were produced as...
Isolation of Borna Disease Virus from Human Brain Tissue
Nakamura, Yurie, Takahashi, Hirokazu, Shoya, Yuko, Nakaya, Takaaki, Watanabe, Makiko, Tomonaga, Keizo, ...
Serological and molecular epidemiological studies indicate that Borna disease virus (BDV) can infect humans and is possibly associated with certain neuropsychiatric disorders. We examined brain...
Sakurada, Shinsaku, Katano, Harutaka, Sata, Tetsutaro, Ohkuni, Hisashi, Watanabe, Toshiki, Mori, Shigeo
Cell-free transmission of human herpesvirus 8 (HHV-8) to human cells in vitro has been reported to be difficult, if not impossible. The present experiments were conducted with the idea that cell-cell...
Tanaka, Michiko, Kagawa, Hiroyuki, Yamanashi, Yuji, Sata, Tetsutaro, Kawaguchi, Yasushi
In recent years, several laboratories have reported on the cloning of herpes simplex virus type 1 (HSV-1) genomes as bacterial artificial chromosomes (BACs) in Escherichia coli and on procedures to...
Sugimoto, Chie, Tadakuma, Kei, Otani, Isao, Moritoyo, Takashi, Akari, Hirofumi, Ono, Fumiko, ...
The pathogenesis of AIDS virus infection in a nonhuman primate AIDS model was studied by comparing plasma viral loads, CD4+ T-cell subpopulations in peripheral blood mononuclear cells, and simian...
Dewan, M. Zahidunnabi, Terashima, Kazuo, Taruishi, Midori, Hasegawa, Hideki, Ito, Mamoru, Tanaka, Yuetsu, ...
We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/γcnull (NOG) mice. This model is very useful for investigating the mechanism of...
Shoya, Yuko, Tokunaga, Kenzo, Sawa, Hirofumi, Maeda, Masae, Ueno, Tomonori, Yoshikawa, Tomoki, ...
Although HIV type 1 (HIV-1) cannot efficiently replicate in simian cells, the mechanism(s) involved in the restriction of virus tropism remain unclear. To investigate this, we have focused on the...
Izumi, Yasuyuki, Ami, Yasushi, Matsuo, Kazuhiro, Someya, Kenji, Sata, Tetsutaro, Yamamoto, Naoki, ...
To be effective, a vaccine against human immunodeficiency virus type 1 (HIV-1) must induce virus-specific T-cell responses and it must be safe for use in humans. To address these issues, we developed...
Huy, Tran Thien-Tuan, Ushijima, Hiroshi, Maung Win, Khin, Luengrojanakul, Pairoj, Krishna Shrestha, Pradeep, Zhong, Zhao-Hua, ...
It has been reported that hepatitis B virus (HBV) mutants carrying mutations in the pre-S region can be found in infected patients. In this study, we investigated the prevalence of the HBV variant...
Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication
Zheng, Yong-Hui, Irwin, Dan, Kurosu, Takeshi, Tokunaga, Kenzo, Sata, Tetsutaro, Peterlin, B. Matija
Recently, APOBEC3G has been identified as a host factor that blocks retroviral replication. It introduces G to A hypermutations in newly synthesized minus strand viral cDNA at the step of reverse...
Ichinohe, Takeshi, Watanabe, Izumi, Ito, Satoshi, Fujii, Hideki, Moriyama, Masami, Tamura, Shin-ichi, ...
The mucosal adjuvant effect of synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid [poly(I:C)] against influenza virus was examined under intranasal coadministration with...
Izumi, Yasuyuki, Ami, Yasushi, Matsuo, Kazuhiro, Someya, Kenji, Sata, Tetsutaro, Yamamoto, Naoki, ...
The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus
Ida-Hosonuma, Miki, Iwasaki, Takuya, Yoshikawa, Tomoki, Nagata, Noriyo, Sato, Yuko, Sata, Tetsutaro, ...
Poliovirus selectively replicates in neurons in the spinal cord and brainstem, although poliovirus receptor (PVR) expression is observed in both the target and nontarget tissues in humans and...
Kinomoto, Masanobu, Yokoyama, Masaru, Sato, Hironori, Kojima, Asato, Kurata, Takeshi, Ikuta, Kazuyoshi, ...
We have previously described a human immunodeficiency virus type 1 (HIV-1) proviral clone, pL2, derived from defective viral particles with higher fusogenicity than the prototypic NL4-3 virus. In...
Morikawa, Shigeru, Sakiyama, Tokuki, Hasegawa, Hideki, Saijo, Masayuki, Maeda, Akihiko, Kurane, Ichiro, ...
The potential threat of smallpox bioterrorism has made urgent the development of lower-virulence vaccinia virus vaccines. An attenuated LC16m8 (m8) vaccine was developed in 1975 from the Lister...
Kato, Akihisa, Yamamoto, Mayuko, Ohno, Takashi, Tanaka, Michiko, Sata, Tetsutaro, Nishiyama, Yukihiro, ...
UL13 and Us3 are protein kinases encoded by herpes simplex virus 1. We report here that Us3 is a physiological substrate for UL13 in infected cells, based on the following observations. (i) The...
Saijo, Masayuki, Ami, Yasushi, Suzaki, Yuriko, Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, ...
The potential threat of smallpox as a bioweapon has led to the production and stockpiling of smallpox vaccine in some countries. Human monkeypox, a rare but important viral zoonosis endemic to...
Kino, Nao, Sata, Tetsutaro, Sato, Yuko, Sugase, Motoyasu, Matsukura, Toshihiko
The genome of a novel human papillomavirus (HPV-82) was cloned from a vaginal intraepithelial neoplasia grade I. In our series of 291 biopsy specimens, HPV-82 was identified in one case each of...
Katano, Harutaka, Iwasaki, Takuya, Baba, Nobuyoshi, Terai, Masanori, Mori, Shigeo, Iwamoto, Aikichi, ...
To establish a sensitive and specific antibody assay, potent antigenic proteins encoded by human herpesvirus 8 (HHV8) were studied. Fifteen recombinant HHV8-encoded proteins were produced as...
Isolation of Borna Disease Virus from Human Brain Tissue
Nakamura, Yurie, Takahashi, Hirokazu, Shoya, Yuko, Nakaya, Takaaki, Watanabe, Makiko, Tomonaga, Keizo, ...
Serological and molecular epidemiological studies indicate that Borna disease virus (BDV) can infect humans and is possibly associated with certain neuropsychiatric disorders. We examined brain...
Sakurada, Shinsaku, Katano, Harutaka, Sata, Tetsutaro, Ohkuni, Hisashi, Watanabe, Toshiki, Mori, Shigeo
Cell-free transmission of human herpesvirus 8 (HHV-8) to human cells in vitro has been reported to be difficult, if not impossible. The present experiments were conducted with the idea that cell-cell...
Tanaka, Michiko, Kagawa, Hiroyuki, Yamanashi, Yuji, Sata, Tetsutaro, Kawaguchi, Yasushi
In recent years, several laboratories have reported on the cloning of herpes simplex virus type 1 (HSV-1) genomes as bacterial artificial chromosomes (BACs) in Escherichia coli and on procedures to...
Sugimoto, Chie, Tadakuma, Kei, Otani, Isao, Moritoyo, Takashi, Akari, Hirofumi, Ono, Fumiko, ...
The pathogenesis of AIDS virus infection in a nonhuman primate AIDS model was studied by comparing plasma viral loads, CD4+ T-cell subpopulations in peripheral blood mononuclear cells, and simian...
Dewan, M. Zahidunnabi, Terashima, Kazuo, Taruishi, Midori, Hasegawa, Hideki, Ito, Mamoru, Tanaka, Yuetsu, ...
We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/γcnull (NOG) mice. This model is very useful for investigating the mechanism of...
Shoya, Yuko, Tokunaga, Kenzo, Sawa, Hirofumi, Maeda, Masae, Ueno, Tomonori, Yoshikawa, Tomoki, ...
Although HIV type 1 (HIV-1) cannot efficiently replicate in simian cells, the mechanism(s) involved in the restriction of virus tropism remain unclear. To investigate this, we have focused on the...
Izumi, Yasuyuki, Ami, Yasushi, Matsuo, Kazuhiro, Someya, Kenji, Sata, Tetsutaro, Yamamoto, Naoki, ...
To be effective, a vaccine against human immunodeficiency virus type 1 (HIV-1) must induce virus-specific T-cell responses and it must be safe for use in humans. To address these issues, we developed...
Huy, Tran Thien-Tuan, Ushijima, Hiroshi, Maung Win, Khin, Luengrojanakul, Pairoj, Krishna Shrestha, Pradeep, Zhong, Zhao-Hua, ...
It has been reported that hepatitis B virus (HBV) mutants carrying mutations in the pre-S region can be found in infected patients. In this study, we investigated the prevalence of the HBV variant...
Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication
Zheng, Yong-Hui, Irwin, Dan, Kurosu, Takeshi, Tokunaga, Kenzo, Sata, Tetsutaro, Peterlin, B. Matija
Recently, APOBEC3G has been identified as a host factor that blocks retroviral replication. It introduces G to A hypermutations in newly synthesized minus strand viral cDNA at the step of reverse...
Ichinohe, Takeshi, Watanabe, Izumi, Ito, Satoshi, Fujii, Hideki, Moriyama, Masami, Tamura, Shin-ichi, ...
The mucosal adjuvant effect of synthetic double-stranded RNA polyriboinosinic polyribocytidylic acid [poly(I:C)] against influenza virus was examined under intranasal coadministration with...
Izumi, Yasuyuki, Ami, Yasushi, Matsuo, Kazuhiro, Someya, Kenji, Sata, Tetsutaro, Yamamoto, Naoki, ...
The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus
Ida-Hosonuma, Miki, Iwasaki, Takuya, Yoshikawa, Tomoki, Nagata, Noriyo, Sato, Yuko, Sata, Tetsutaro, ...
Poliovirus selectively replicates in neurons in the spinal cord and brainstem, although poliovirus receptor (PVR) expression is observed in both the target and nontarget tissues in humans and...
Kinomoto, Masanobu, Yokoyama, Masaru, Sato, Hironori, Kojima, Asato, Kurata, Takeshi, Ikuta, Kazuyoshi, ...
We have previously described a human immunodeficiency virus type 1 (HIV-1) proviral clone, pL2, derived from defective viral particles with higher fusogenicity than the prototypic NL4-3 virus. In...
Morikawa, Shigeru, Sakiyama, Tokuki, Hasegawa, Hideki, Saijo, Masayuki, Maeda, Akihiko, Kurane, Ichiro, ...
The potential threat of smallpox bioterrorism has made urgent the development of lower-virulence vaccinia virus vaccines. An attenuated LC16m8 (m8) vaccine was developed in 1975 from the Lister...
Kato, Akihisa, Yamamoto, Mayuko, Ohno, Takashi, Tanaka, Michiko, Sata, Tetsutaro, Nishiyama, Yukihiro, ...
UL13 and Us3 are protein kinases encoded by herpes simplex virus 1. We report here that Us3 is a physiological substrate for UL13 in infected cells, based on the following observations. (i) The...
Saijo, Masayuki, Ami, Yasushi, Suzaki, Yuriko, Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, ...
The potential threat of smallpox as a bioweapon has led to the production and stockpiling of smallpox vaccine in some countries. Human monkeypox, a rare but important viral zoonosis endemic to...
Senpuku, Hidenobu, Asano, Toshihiko, Matin, Khairul, Salam, M Abdus, Tsuha, Yuzo, Horibata, Shigeo, ...
NOD/LtSz-prkdcscid/prkdcscid (non-obese diabetic-severe combine immunodeficiency; NOD-scid) mice grafted with human peripheral blood lymphoid cells have been used as an in vivo humanized mouse model...
Abe, Kenji, Kiuchi, Tetsuya, Tanaka, Koichi, Edamoto, Yoshihiro, Aiba, Naoto, Sata, Tetsutaro
Background: Fulminant hepatitis and biliary atresia are serious problems and their causes have not been explained well. We investigated whether or not erythrovirus B19 is a candidate etiologic agent...
Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, Fukushi, Shuetsu, Yokoyama, Masaru, Harashima, Ayako, ...
To understand the pathogenesis and develop an animal model of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV), the Frankfurt 1 SARS-CoV isolate was passaged serially in...
High Expression of HHV-8-Encoded ORF73 Protein in Spindle-Shaped Cells of Kaposi’s Sarcoma
Katano, Harutaka, Sato, Yuko, Kurata, Takeshi, Mori, Shigeo, Sata, Tetsutaro
Human herpesvirus 8 (HHV-8) has been demonstrated previously in Kaposi’s sarcoma (KS) tissues by immunohistochemistry, in situ polymerase chain reaction, and in situ hybridization. The...
Nakajima, Noriko, Ionescu, Petronela, Sato, Yuko, Hashimoto, Michie, Kuroita, Toshihiro, Takahashi, Hidehiro, ...
In situ hybridization is one of the most important techniques to visualize gene expression at the cellular level in various tissues. The in situ hybridization-AT tailing (ISH-AT) method uses a...
All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition
Kinomoto, Masanobu, Kanno, Takayuki, Shimura, Mari, Ishizaka, Yukihito, Kojima, Asato, Kurata, Takeshi, ...
Approximately 17% of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, L1) non-LTR retrotransposons. L1 retrotransposition is known to be the cause of several genetic...
Ogawa-Goto, Kiyoko, Tanaka, Keiko, Ueno, Tomonori, Tanaka, Keisuke, Kurata, Takeshi, Sata, Tetsutaro, ...
p180 was originally reported as a ribosome-binding protein on the rough endoplasmic reticulum membrane, although its precise role in animal cells has not yet been elucidated. Here, we characterized a...
Arita, Minetaro, Nagata, Noriyo, Iwata, Naoko, Ami, Yasushi, Suzaki, Yuriko, Mizuta, Katsumi, ...
Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also sometimes associated with serious neurological disorders. In this study, we characterized the antigenicity and...
Seki, Sayuri, Kawada, Miki, Takeda, Akiko, Igarashi, Hiroko, Sata, Tetsutaro, Matano, Tetsuro
Cytotoxic T-lymphocyte (CTL) responses frequently select for immunodeficiency virus mutations that result in escape from CTL recognition with viral fitness costs. The replication in vivo of such...
Sugimoto, Ken, Uema, Masashi, Sagara, Hiroshi, Tanaka, Michiko, Sata, Tetsutaro, Hashimoto, Yasuhiro, ...
We report here the construction of a triply fluorescent-tagged herpes simplex virus 1 (HSV-1) expressing capsid protein VP26, tegument protein VP22, and envelope protein gB as fusion proteins with...
Kato, Akihisa, Tanaka, Michiko, Yamamoto, Mayuko, Asai, Risa, Sata, Tetsutaro, Nishiyama, Yukihiro, ...
Us3 is a serine/threonine protein kinase encoded by herpes simplex virus 1 (HSV-1). Here, we report the identification of a physiological Us3 phosphorylation site on serine at position 147 (Ser-147)...
Tanaka, Michiko, Sata, Tetsutaro, Kawaguchi, Yasushi
The herpes simplex virus 1 (HSV-1) UL7 gene is highly conserved among herpesviridae. Since the construction of recombinant HSV-1 with a mutation in the UL7 gene has not been reported, the involvement...
Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, Fukushi, Shuetsu, Harashima, Ayako, Sato, Yuko, ...
Advanced age is a risk factor of severe acute respiratory syndrome (SARS) in humans. To understand its pathogenesis, we developed an animal model using BALB/c mice and the mouse-passaged Frankfurt 1...
Haga, Shiori, Yamamoto, Norio, Nakai-Murakami, Chikako, Osawa, Yoshiaki, Tokunaga, Kenzo, Sata, Tetsutaro, ...
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a high-risk infectious pathogen. In the proposed model of respiratory failure, SARS-CoV down-regulates its receptor, angiotensin-converting...
Masujin, Kentaro, Shu, Yujing, Yamakawa, Yoshio, Hagiwara, Ken'ichi, Sata, Tetsutaro, Matsuura, Yuichi, ...
A case of L-type-like atypical bovine spongiform encephalopathy was detected in 14-year-old Japanese black beef cattle (BSE/JP24). To clarify the biological and biochemical properties of the prion in...