Moriyama, Shunsuke, Ogihara, Jun, Kato, Jun, Hori, Tetsuya, Mizuno, Shigeki
The two chicken genes, PKCI-W on the W chromosome and PKCI-Z on the Z chromosome, belong to the gene family encoding the Hint (histidine triad nucleotide–binding protein)-branch proteins in the...
Hori, Tetsuya, Ishijima, Jun, Yokomizo, Takehiko, Ago, Hideo, Shimizu, Takao, Miyano, Masashi
The crystal structure of the ternary complex of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin (15-oxo-PG) 13-reductase (LTB4 12HD/PGR), an essential enzyme for eicosanoid inactivation...
Hori, Tetsuya, Ishijima, Jun, Yokomizo, Takehiko, Ago, Hideo, Shimizu, Takao, Miyano, Masashi
The crystal structure of the ternary complex of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin (15-oxo-PG) 13-reductase (LTB4 12HD/PGR), an essential enzyme for eicosanoid inactivation...
Yokomine, Takaaki, Shirohzu, Hisao, Purbowasito, Wahyu, Toyoda, Atsushi, Iwama, Hisakazu, Ikeo, Kazuho, ...
Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its...
Yokomine, Takaaki, Shirohzu, Hisao, Purbowasito, Wahyu, Toyoda, Atsushi, Iwama, Hisakazu, Ikeo, Kazuho, ...
Previous studies revealed that Igf2 and Mpr/Igf2r are imprinted in eutherian mammals and marsupials but not in monotremes or birds. Igf2 lies in a large imprinted cluster in eutherians, and its...
Hori, Tetsuya, Moriyama, Hideaki, Kawaguchi, Jitsutaro, Hayashi-Iwasaki, Yoko, Oshima, Tairo, Tanaka, Nobuo
A temperature-jump (T-jump) time-resolved X-ray crystallographic technique using the Laue method was developed to detect small, localized structural changes of proteins in crystals exposed to a...
宮原, 道明, 讃井, 浩喜, 保利, 哲也, Miyahara, Michiaki, Sanui, Hiroki, Hori, Tetsuya, ...
九州大学医療技術短期大学部
CENP-C Is Involved in Chromosome Segregation, Mitotic Checkpoint Function, and Kinetochore Assembly
Kwon, Mi-Sun, Hori, Tetsuya, Okada, Masahiro, Fukagawa, Tatsuo
CENP-C is a conserved inner kinetochore component. To understand the precise roles of CENP-C in the kinetochore, we created a cell line with a conditional knockout of CENP-C with the...
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation
Kline, Susan L., Cheeseman, Iain M., Hori, Tetsuya, Fukagawa, Tatsuo, Desai, Arshad
During cell division, kinetochores form the primary chromosomal attachment sites for spindle microtubules. We previously identified a network of 10 interacting kinetochore proteins conserved between...
Kimura, Hiroshi, Takizawa, Nanako, Allemand, Eric, Hori, Tetsuya, Iborra, Francisco J., Nozaki, Naohito, ...
In eukaryotic nuclei, DNA is wrapped around a protein octamer composed of the core histones H2A, H2B, H3, and H4, forming nucleosomes as the fundamental units of chromatin. The modification and...
KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates
Cheeseman, Iain M., Hori, Tetsuya, Fukagawa, Tatsuo, Desai, Arshad
Chromosome segregation during mitosis requires the assembly of a large proteinaceous structure termed the kinetochore. In Caenorhabditis elegans, KNL-1 is required to target multiple outer...
CENP-O Class Proteins Form a Stable Complex and Are Required for Proper Kinetochore Function
Hori, Tetsuya, Okada, Masahiro, Maenaka, Katsumi, Fukagawa, Tatsuo
We previously identified a multisubunit complex (CENP-H/I complex) in kinetochores from human and chicken cells. We showed that the CENP-H/I complex is divided into three functional classes. In the...
Crystal Structure of Squid Rhodopsin with Intracellularly Extended Cytoplasmic Region*S⃞
Shimamura, Tatsuro, Hiraki, Kenji, Takahashi, Naoko, Hori, Tetsuya, Ago, Hideo, Masuda, Katsuyoshi, ...
G-protein-coupled receptors play a key step in cellular signal transduction cascades by transducing various extracellular signals via G-proteins. Rhodopsin is a prototypical G-protein-coupled...
Kawashima, Toshiyuki, Bao, Ying Chun, Minoshima, Yukinori, Nomura, Yasushi, Hatori, Tomonori, Hori, Tetsuya, ...
In addition to their pleiotropic functions under physiological conditions, transcription factors STAT3 and STAT5 also have oncogenic activities, but how activated STATs are transported to the nucleus...