Tetsuya Nosaka

Novel internal promoterminusb;enhancer of HTLV-I for Tax expression (1993)

Nosaka, Tetsuya, Ariumi, Yasuo, Sakurai, Mamoru, Takeuchi, Ryo, Hatanaka, Masakazu

The transcription initiation signals in retroviruses lie within the long terminal repeat (LTR) sequences. We have found a new transcriptional promoter in a central portion of the genome of human...

A method to identify cDNAs based on localization of green fluorescent protein fusion products

Misawa, Kazuhide, Nosaka, Tetsuya, Morita, Sumiyo, Kaneko, Azusa, Nakahata, Tatsutoshi, Asano, Shigetaka, ...

We previously established a high-efficiency, retrovirus-mediated expression cloning method. Using this system, we now have developed an expression cloning method (FL-REX; fluorescence...

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

Onishi, Mayumi, Nosaka, Tetsuya, Misawa, Kazuhide, Mui, Alice L.-F., Gorman, Daniel, McMahon, Martin, ...

STAT (signal transducers and activators of transcription) proteins are transcription factors which are activated by phosphorylation on tyrosine residues upon stimulation by cytokines. Seven members...

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...

Vasorin, a transforming growth factor β-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo

Ikeda, Yuichi, Imai, Yasushi, Kumagai, Hidetoshi, Nosaka, Tetsuya, Morikawa, Yoshihiro, Hisaoka, Tomoko, ...

Growth factors, cell-surface receptors, adhesion molecules, and extracellular matrix proteins play critical roles in vascular pathophysiology by affecting growth, migration, differentiation, and...

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...

Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia

Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...

AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....

Disruption of Sept6, a Fusion Partner Gene of MLL, Does Not Affect Ontogeny, Leukemogenesis Induced by MLL-SEPT6, or Phenotype Induced by the Loss of Sept4

Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...

Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...

A method to identify cDNAs based on localization of green fluorescent protein fusion products

Misawa, Kazuhide, Nosaka, Tetsuya, Morita, Sumiyo, Kaneko, Azusa, Nakahata, Tatsutoshi, Asano, Shigetaka, ...

We previously established a high-efficiency, retrovirus-mediated expression cloning method. Using this system, we now have developed an expression cloning method (FL-REX; fluorescence...

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

Onishi, Mayumi, Nosaka, Tetsuya, Misawa, Kazuhide, Mui, Alice L.-F., Gorman, Daniel, McMahon, Martin, ...

STAT (signal transducers and activators of transcription) proteins are transcription factors which are activated by phosphorylation on tyrosine residues upon stimulation by cytokines. Seven members...

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

Nosaka, Tetsuya, Morita, Sumiyo, Kitamura, Hidetomo, Nakajima, Hideaki, Shibata, Fumi, Morikawa, Yoshihiro, ...

Dorsoventral patterning depends on the local concentrations of the morphogens. Twisted gastrulation (TSG) regulates the extracellular availability of a mesoderm inducer, bone morphogenetic protein 4...

Vasorin, a transforming growth factor β-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo

Ikeda, Yuichi, Imai, Yasushi, Kumagai, Hidetoshi, Nosaka, Tetsuya, Morikawa, Yoshihiro, Hisaoka, Tomoko, ...

Growth factors, cell-surface receptors, adhesion molecules, and extracellular matrix proteins play critical roles in vascular pathophysiology by affecting growth, migration, differentiation, and...

Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis

Ono, Ryoichi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kumagai, Hidetoshi, Kawashima, Toshiyuki, Taki, Tomohiko, ...

The mechanisms by which mixed-lineage leukemia (MLL) fusion products resulting from in utero translocations in 11q23 contribute to leukemogenesis and infant acute leukemia remain elusive. It is still...

Infertility with Defective Spermiogenesis in Mice Lacking AF5q31, the Target of Chromosomal Translocation in Human Infant Leukemia

Urano, Atsushi, Endoh, Masaki, Wada, Tadashi, Morikawa, Yoshihiro, Itoh, Miyuki, Kataoka, Yuki, ...

AF5q31 (also called MCEF) was identified by its involvement in chromosomal translocation with the gene MLL (mixed lineage leukemia), which is associated with infant acute lymphoblastic leukemia....

Disruption of Sept6, a Fusion Partner Gene of MLL, Does Not Affect Ontogeny, Leukemogenesis Induced by MLL-SEPT6, or Phenotype Induced by the Loss of Sept4

Ono, Ryoichi, Ihara, Masafumi, Nakajima, Hideaki, Ozaki, Katsutoshi, Kataoka-Fujiwara, Yuki, Taki, Tomohiko, ...

Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into filaments. Recent studies have revealed that septins are involved in not only diverse normal cellular...

Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

Kawashima, Toshiyuki, Bao, Ying Chun, Nomura, Yasushi, Moon, Yuseok, Tonozuka, Yukio, Minoshima, Yukinori, ...

STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind...

Human Parainfluenza Virus Type 2 V Protein Inhibits Genome Replication by Binding to the L Protein: Possible Role in Promoting Viral Fitness ▿

Nishio, Machiko, Ohtsuka, Junpei, Tsurudome, Masato, Nosaka, Tetsuya, Kolakofsky, Daniel

The human parainfluenza virus type 2 (hPIV2) V protein plays important roles in inhibiting the host interferon response and promoting virus growth, but its role in hPIV2 replication and transcription...

A Rac GTPase-Activating Protein, MgcRacGAP, Is a Nuclear Localizing Signal-Containing Nuclear Chaperone in the Activation of STAT Transcription Factors▿ †

Kawashima, Toshiyuki, Bao, Ying Chun, Minoshima, Yukinori, Nomura, Yasushi, Hatori, Tomonori, Hori, Tetsuya, ...

In addition to their pleiotropic functions under physiological conditions, transcription factors STAT3 and STAT5 also have oncogenic activities, but how activated STATs are transported to the nucleus...