Molecular Determinant of Regioselective Hydroxylation of Docetaxel by CYP3A4 (2009)
Bernard Monsarrat, Odile Thoison, Joelle Dubois, Thierry Cresteil
The metabolism of taxanes by human liver microsomes is regioselective: the major metabolite of paclitaxel formed by CYP2C8 results from the hydroxylation on the taxane ring at C-6. Hydroxylations on...
Marie, Sandrine, Anderson, Alan, Cresteil, Thierry
Induction of cytochromes P-450c and P-450d have been compared in fetal and adult rat liver. A single dose of 3-methylcholanthrene (MC) 16 h before death, resulted in a pronounced accumulation of both...