Thoas Fioretos

The DNA methylome of pediatric acute lymphoblastic leukemia (2009)

Davidsson, Josef, Lilljebjörn, Henrik, Andersson, Anna, Veerla, Srinivas, Heldrup, Jesper, Behrendtz, Mikael, ...

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with high hyperdiploidy [51–67 chromosomes] and the t(12;21)(p13;q22) [ETV6/RUNX1 fusion] representing the most frequent...

Recurrent and multiple bladder tumors show conserved expression profiles (2008)

Lindgren, David, Gudjonsson, Sigurdur, Jee, Kowan, Liedberg, Fredrik, Aits, Sonja, Andersson, Anna, ...

Abstract Background Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial...

An improved method for detecting and delineating genomic regions with altered gene expression in cancer (2008)

Nilsson, Björn, Johansson, Mikael, Heyden, Anders, Nelander, Sven, Fioretos, Thoas

Abstract Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is...

An improved method for detecting and delineating genomic regions with altered gene expression in cancer (2008)

Nilsson, Björn, Johansson, M, Heyden, Anders, Melander, S, Fioretos, Thoas

Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on...

Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3 (2007)

Davidsson, Josef, Andersson, Anna, Paulsson, Kajsa, Heidenblad, Markus, Isaksson, Margareth, Borg, Åke, ...

Although gain of 1q occurs in 25% of Burkitt lymphomas (BLs) and 10% of pediatric high hyperdiploid acute lymphoblastic leukemias (ALLs), little is known about the origin, molecular genetic...

Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies (2007)

Nilsson, Björn, Håkansson, Petra, Johansson, Mikael, Nelander, Sven, Fioretos, Thoas

Abstract Ontological analysis facilitates the interpretation of microarray data. Here we describe new ontological analysis methods which, unlike existing approaches, are threshold-free and...

Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome. (2007)

Agerstam, Helena, Lilljebjorn, Henrik, Lassen, Carin, Swedin, Agneta, Richter, Johan, Vandenberghe, Peter, ...

Abstract is not available

Tiling resolution array CGH, expression, and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3. (2007)

Davidsson, Josef, Andersson, Anna, Paulsson, Kajsa, Heidenblad, Markus, Isaksson, Margareth, Borg, Ake, ...

Abstract is not available

FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns. (2007)

Andersson, Anna, Paulsson, Kajsa, Lilljebjorn, Henrik, Lassen, Carin, Strombeck, Bodil, Heldrup, Jesper, ...

Abstract is not available

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (2007)

Paulsson, Kajsa, Horvat, Andrea, Strombeck, Bodil, Nilsson, Fredrik, Heldrup, Jesper, Behrendtz, Mikael, ...

Abstract is not available

2007 Nilsson et Volume al. 8, Issue 5, Article R74 Open Access Method (2007)

Björn Nilsson, Petra Håkansson, Mikael Johansson, Sven Nel, Thoas Fioretos

Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies

Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia. (2006)

Karrman, Kristina, Andersson, Anna, Bjorgvinsdóttir, Helga, Strombeck, Bodil, Lassen, Carin, Olofsson, Tor, ...

Abstract is not available

Cross-platform classification in microarray-based leukemia diagnostics. (2006)

Nilsson, Bjorn, Andersson, Anna, Johansson, Mikael, Fioretos, Thoas

Abstract is not available

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene (2006)

Storlazzi, Clelia Tiziana, Fioretos, Thoas, Surace, Cecilia, Lonoce, Angelo, Mastrorilli, Angela, Strömbeck, Bodil, ...

Double minutes (dmin)—circular, extra-chromosomal amplifications of specific acentric DNA fragments—are relatively frequent in malignant disorders, particularly in solid tumors. In acute myeloid...

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene (2006)

Storlazzi, Clelia Tiziana, Fioretos, Thoas, Surace, Cecilia, Lonoce, Angelo, Mastrorilli, Angela, Strömbeck, Bodil, ...

Double minutes (dmin) - circular, extrachromosomal amplifications of specific acentric DNA fragments - are relatively frequent in malignant disorders, particularly in solid tumors. In acute myeloid...

Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia. (2005)

Paulsson, Kajsa, Mörse, Helena, Fioretos, Thoas, Behrendtz, Mikael, Strömbeck, Bodil, Johansson, Bertil

Abstract is not available

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. (2005)

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Bjorn, Ritz, Cecilia, Edén, Patrik, ...

Abstract is not available

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats. (2004)

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Abstract is not available

Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients. (2004)

Andersson, Anna, Johansson, Bertil, Lassen, Carin, Mitelman, Felix, Billström, Rolf, Fioretos, Thoas

Abstract is not available

Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies. (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Abstract is not available

Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays. (2004)

Håkansson, Petra, Segal, David, Lassen, Carin, Gullberg, Urban, Morse, Herbert C, Fioretos, Thoas, ...

Abstract is not available

Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia. (2004)

Paulsson, Kajsa, Horvat, Andrea, Fioretos, Thoas, Mitelman, Felix, Johansson, Bertil

Abstract is not available

Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays (2004)

Hĺkansson, Petra, Segal, David, Lassen, Carin, Gullberg, Urban, Morse III, Herbert, Fioretos, Thoas, ...

ObjectiveThe t(9;22) translocation is associated with more than 95% of cases of chronic myeloid leukemia. The resulting fusion of the BCR and ABL1 loci produces the constitutively active BCR/ABL1...

Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in approximately 1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS)....

Approximate geodesic distances reveal biologically relevant structures in microarray data (2004)

Nilsson, Jens, Fioretos, Thoas, Höglund, Mattias, Fontes, Magnus

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be mathematically represented as points in a high-dimensional gene expression space....

Approximate geodesic distances reveal biologically relevant structures in microarray data (2004)

Nilsson, Jens, Fioretos, Thoas, Höglund, Mattias, Fontes, Magnus

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be represented mathematically as points in a high-dimensional gene expression space....

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in ∼1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS). The...

Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays (2004)

Hĺkansson, Petra, Segal, David, Lassen, Carin, Gullberg, Urban, Morse III, Herbert, Fioretos, Thoas, ...

Objective: The t(9;22) translocation is associated with more than 95% of cases of chronic myeloid leukemia. The resulting fusion of the BCR and ABL1 loci produces the constitutively active BCR/ABL1...

Identification of a commonly amplified 4.3 Mb region with overexpression of the C8FW gene, encoding a phosphoprotein regulated by mitogenic pathways, but not of the MYC gene in MYC-containing double minutes in myeloid malignancies (2004)

Storlazzi, Clelia T., Fioretos, Thoas, Paulsson, Kajsa, Strömbeck, Bodil, Lassen, Carin, Ahlgren, Tomas, ...

Double minutes (dmin), the cytogenetic hallmark of genomic amplification, are found in approximately 1% of karyotypically abnormal acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS)....

Approximate geodesic distances reveal biologically relevant structures in microarray data (2004)

Nilsson, Jens, Fioretos, Thoas, Höglund, Mattias, Fontes, Magnus

Motivation: Genome-wide gene expression measurements, as currently determined by the microarray technology, can be mathematically represented as points in a high-dimensional gene expression space....

Trisomy 8 as the sole chromosomal aberration in myelocytic malignancies. a multicolor and locus-specific fluorescence in situ hybridization study. (2003)

Paulsson, Kajsa, Fioretos, Thoas, Strömbeck, Bodil, Mauritzson, Nils, Tanke, Hans J, Johansson, Bertil

Abstract is not available

A Novel Gene, MSI2, Encoding a Putative RNA-binding Protein Is Recurrently Rearranged at Disease Progression of Chronic Myeloid Leukemia and Forms a Fusion Gene with HOXA9 as a Result of the Cryptic t(7;17)(p15;q23). (2003)

Barmpouti, Aikaterini, Höglund, Mattias, Johansson, Bertil, Lassen, Carin, Nilsson, Per-Gunnar, Hagemeijer, Anne, ...

Abstract is not available

Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1. (2003)

Jonson, Tord, Heidenblad, Markus, Håkansson, Petra, Gorunova, Ludmila, Johansson, Bertil, Fioretos, Thoas, ...

Abstract is not available

The formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. (2003)

Paulsson, Kajsa, Panagopoulos, Ioannis, Knuutila, Sakari, Jee, Kowan J, Garwicz, Stanislaw, Fioretos, Thoas, ...

Abstract is not available

Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate. (2003)

Barbouti, Aikaterini, Ahlgren, Tomas, Johansson, Bertil, Höglund, Mattias, Lassen, Carin, Turesson, Ingemar, ...

Most chronic myeloid leukaemia (CML) patients are genetically characterized by the t(9;22)(q34;q11), generating the BCR/ABL1 fusion gene. However, a few CML patients with rearrangements of 9q34 and...

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia. (2003)

Paulsson, Kajsa, Panagopoulos, Ioannis, Knuutila, Sakari, Jee, Kowan Ja, Garwicz, Stanislaw, Fioretos, Thoas, ...

Abstract is not available

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. (2002)

Johansson, Bertil, Fioretos, Thoas, Mitelman, Felix

Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called...

Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15). (2002)

Panagopoulos, Ioannis, Fioretos, Thoas, Isaksson, Margareth, Larsson, Gun, Billström, Rolf, Mitelman, Felix, ...

The t(11;20)(p15;q11) is a rare but recurrent translocation that so far has been described in only four acute myeloid leukemias (AMLs), two treatment-related myelodysplastic syndromes (t-MDSs), and...

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. (2002)

Barbouti, Aikaterini, Johansson, Bertil, Höglund, Mattias, Mauritzson, Nils, Strömbeck, Bodil, Nilsson, Per-Gunnar, ...

During the initial indolent chronic phase of chronic myeloid leukemia (CML), the t(9;22)(q34;q11), resulting in the Philadelphia chromosome (Ph), is usually the sole cytogenetic anomaly, but as the...

RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): Identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression. (2002)

Panagopoulos, Ioannis, Fioretos, Thoas, Isaksson, Margareth, Mitelman, Felix, Johansson, Bertil, Theorin, Niklas, ...

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13) (2001)

Panagopoulos, Ioannis, Fioretos, Thoas, Isaksson, Margareth, Samuelsson, Ulf, Billström, Rolf, Strömbeck, Bodil, ...

The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively. We...

Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes (1996)

Fioretos, Thoas

In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the...

Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes (1996)

Fioretos, Thoas

In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the...

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Björn, Ritz, Cecilia, Edén, Patrik, ...

Global expression profiles of a consecutive series of 121 childhood acute leukemias (87 B lineage acute lymphoblastic leukemias, 11 T cell acute lymphoblastic leukemias, and 23 acute myeloid...

The Breakpoint Region of the Most Common Isochromosome, i(17q), in Human Neoplasia Is Characterized by a Complex Genomic Architecture with Large, Palindromic, Low-Copy Repeats

Barbouti, Aikaterini, Stankiewicz, Pawel, Nusbaum, Chad, Cuomo, Christina, Cook, April, Höglund, Mattias, ...

Although a great deal of information has accumulated regarding the mechanisms underlying constitutional DNA rearrangements associated with inherited disorders, virtually nothing is known about the...

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations

Andersson, Anna, Olofsson, Tor, Lindgren, David, Nilsson, Björn, Ritz, Cecilia, Edén, Patrik, ...

Global expression profiles of a consecutive series of 121 childhood acute leukemias (87 B lineage acute lymphoblastic leukemias, 11 T cell acute lymphoblastic leukemias, and 23 acute myeloid...

Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies

Nilsson, Björn, Håkansson, Petra, Johansson, Mikael, Nelander, Sven, Fioretos, Thoas

New ontological analysis methods are described for microarray data interpretation that, unlike existing approaches, are threshold-free and statistically powerful.

An improved method for detecting and delineating genomic regions with altered gene expression in cancer

Nilsson, Björn, Johansson, Mikael, Heyden, Anders, Nelander, Sven, Fioretos, Thoas

A method is presented for identifying genomic regions with altered gene expression in gene expression maps.

Recurrent and multiple bladder tumors show conserved expression profiles

Lindgren, David, Gudjonsson, Sigurdur, Jee, Kowan Ja, Liedberg, Fredrik, Aits, Sonja, Andersson, Anna, ...