Mapping the Genetic Architecture of Gene Expression in Human Liver (2008)
Eric E. Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y. Lum, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...
Cardiovascular Diseases, Thomas A. Drake, Peipei Ping
Abstract Proteins play a central role in a systems view of biologic processes. This review provides an overview of proteomics from a systems perspective. We survey the key tools and methodologies...
Anatole Ghazalpour, Sudheer Doss, Xia Yang, Jason Aten, Edward M. Toomey, Atila Van Nas, ...
thematic review
Supplemental Material can be found at: (2008)
Anatole Ghazalpour, Sudheer Doss, Xia Yang, Jason Aten, Edward M. Toomey, Atila Van, ...
Key words: systems biology; transgenic mice; quantitative trait locus mapping; principal components; Bayesian networks; correlation coefficients; genetics; genomics; proteomics Correspondence:
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight (2006)
Anatole Ghazalpour, Sudheer Doss, Bin Zhang, Susanna Wang, Christopher Plaisier, Ruth Castellanos, ...
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight (2006)
Anatole Ghazalpour, Sudheer Doss, Bin Zhang, Susanna Wang, Christopher Plaisier, Ruth Castellanos, ...
Gene mapping approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. Recently, several groups have proposed...
Susanna Wang, Nadir Yehya, Eric E. Schadt, Hui Wang, Thomas A. Drake, Aldons J. Lusis
The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...
POLYGENETIC DETERMINANTS OF CRANIOFACIAL ABNORMALITIES (2006)
Thomas A. Drake, Eric Schadt, Kambiz Hannani, J. Michael, Kelly Krass, Veronica Colinayo, ...
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Tissue-specific expression and regulation of sexually dimorphic genes in mice (2006)
Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....
Tissue-specific expression and regulation of sexually dimorphic genes in mice (2006)
Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....
Genomic analysis of metabolic pathway gene expression in mice (2005)
Ghazalpour, Anatole, Doss, Sudheer, Sheth, Sonal S, Ingram-Drake, Leslie A, Schadt, Eric E, Lusis, Aldons J, ...
Abstract Background A segregating population of (C57BL/6J × DBA/2J)F2 intercross mice was studied for obesity-related traits and for global gene expression in liver. Quantitative trait locus...
Cis-acting expression quantitative trait loci in mice (2005)
Doss, Sudheer, Schadt, Eric E., Drake, Thomas A., Lusis, Aldons J.
We previously reported the analysis of genome-wide expression profiles and various diabetes-related traits in a segregating cross between inbred mouse strains C57BL/6J (B6) and DBA/2J (DBA). By...
Cis-acting expression quantitative trait loci in mice (2005)
Doss, Sudheer, Schadt, Eric E., Drake, Thomas A., Lusis, Aldons J.
We previously reported the analysis of genome-wide expression profiles and various diabetes-related traits in a segregating cross between inbred mouse strains C57BL/6J (B6) and DBA/2J (DBA). By...
Cover title: Planned unit developments: issues and opportunities.
Drake, Thomas A., Scheld, W. Micheal, Sande, Merle A.
Subinhibitory and sub-bactericidal concentrations of antibiotics significantly influence host-bacterial interactions. This paper reviews the pathogenesis of endocarditis and examines how...
Cis-acting expression quantitative trait loci in mice
Doss, Sudheer, Schadt, Eric E., Drake, Thomas A., Lusis, Aldons J.
We previously reported the analysis of genome-wide expression profiles and various diabetes-related traits in a segregating cross between inbred mouse strains C57BL/6J (B6) and DBA/2J (DBA). By...
Genomic analysis of metabolic pathway gene expression in mice
Ghazalpour, Anatole, Doss, Sudheer, Sheth, Sonal S, Ingram-Drake, Leslie A, Schadt, Eric E, Lusis, Aldons J, ...
In order to evaluate metabolic pathways associated with obesity, global gene-expression data were integrated with phenotypic and genetic segregation analyses, identifying 13 metabolic pathways the...
Wang, Susanna, Yehya, Nadir, Schadt, Eric E, Wang, Hui, Drake, Thomas A, Lusis, Aldons J
The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight
Ghazalpour, Anatole, Doss, Sudheer, Zhang, Bin, Wang, Susanna, Plaisier, Christopher, Castellanos, Ruth, ...
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker...
Cis-acting expression quantitative trait loci in mice
Doss, Sudheer, Schadt, Eric E., Drake, Thomas A., Lusis, Aldons J.
We previously reported the analysis of genome-wide expression profiles and various diabetes-related traits in a segregating cross between inbred mouse strains C57BL/6J (B6) and DBA/2J (DBA). By...
Genomic analysis of metabolic pathway gene expression in mice
Ghazalpour, Anatole, Doss, Sudheer, Sheth, Sonal S, Ingram-Drake, Leslie A, Schadt, Eric E, Lusis, Aldons J, ...
In order to evaluate metabolic pathways associated with obesity, global gene-expression data were integrated with phenotypic and genetic segregation analyses, identifying 13 metabolic pathways the...
Wang, Susanna, Yehya, Nadir, Schadt, Eric E, Wang, Hui, Drake, Thomas A, Lusis, Aldons J
The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight
Ghazalpour, Anatole, Doss, Sudheer, Zhang, Bin, Wang, Susanna, Plaisier, Christopher, Castellanos, Ruth, ...
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker...
Tissue-specific expression and regulation of sexually dimorphic genes in mice
Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....
Meng, Haijin, Vera, Iset, Che, Nam, Wang, Xuping, Wang, Susanna S., Ingram-Drake, Leslie, ...
The genetic factors contributing to the complex disorder of myocardial calcification are largely unknown. Using a mouse model, we fine-mapped the major locus (Dyscalc1) contributing to the dystrophic...
Weighted gene coexpression network analysis strategies applied to mouse weight
Fuller, Tova F., Ghazalpour, Anatole, Aten, Jason E., Drake, Thomas A., Lusis, Aldons J., Horvath, Steve
Systems-oriented genetic approaches that incorporate gene expression and genotype data are valuable in the quest for genetic regulatory loci underlying complex traits. Gene coexpression network...
Mapping the Genetic Architecture of Gene Expression in Human Liver
Schadt, Eric E, Molony, Cliona, Chudin, Eugene, Hao, Ke, Yang, Xia, Lum, Pek Y, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...
High-Resolution Mapping of Gene Expression Using Association in an Outbred Mouse Stock
Ghazalpour, Anatole, Doss, Sudheer, Kang, Hyun, Farber, Charles, Wen, Ping-Zi, Brozell, Alec, ...
Quantitative trait locus (QTL) analysis is a powerful tool for mapping genes for complex traits in mice, but its utility is limited by poor resolution. A promising mapping approach is association...
Drake, Thomas A., Schadt, Eric E., Lusis, Aldons J.
The millions of common DNA variations that occur in the human population, or among inbred strains of mice and rats, perturb the expression (transcript levels) of a large fraction of the genes...