The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation (2009)
Claudio, Estefania, Sonder, Soren Ulrik, Saret, Sun, Carvalho, Gabrielle, Ramalingam, Thirumalai R., Wynn, Thomas A., ...
IL-17 is the signature cytokine of recently discovered Th type 17 (Th17) cells, which are prominent in defense against extracellular bacteria and fungi as well as in autoimmune diseases, such as...
Allen W Cheever, Dragana Jankovic, George S Yap, Marika C Kullberg, Alan Sher, Thomas A Wynn
Schistosoma mansoni infections are associated with a strong Th2 cytokine response. Treatment of mice with IL-12 or anti-IL-2 or anti-IL-4 before i.v. injection of eggs increased IFNγ production and...
Silvia ML Montenegro, Paulo Miranda, Frederico GC Abath, Kirte M Teixeira, Eridan M Coutinho, Ana LC Domingues, ...
Studies about in vivo IL-10 immunoregulation demonstrated that CD4+ cells from Schistosoma mansoni infected mice produced large amounts of IL-10 and that this response was temporally and...
The production of Th1-type cytokines is associated with strong cell-mediated immunity while Th2-type cytokines are typically involved in the generation of humoral immune responses. In mice vaccinated...
Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity
Thompson, Robert W., Pesce, John T., Ramalingam, Thirumalai, Wilson, Mark S., White, Sandy, Cheever, Allen W., ...
Cationic amino acid transporters (CAT) are important regulators of NOS2 and ARG1 activity because they regulate L-arginine availability. However, their role in the development of Th1/Th2 effector...
Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice
Lumsden, Joanne M., McCarty, Thomas, Petiniot, Lisa K., Shen, Rhuna, Barlow, Carrolee, Wynn, Thomas A., ...
Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein...
Chiaramonte, Monica G., Mentink-Kane, Margaret, Jacobson, Bruce A., Cheever, Allen W., Whitters, Matthew J., Goad, Mary E.P., ...
Highly polarized type 2 cytokine responses can be harmful and even lethal to the host if they are too vigorous or persist too long. Therefore, it is important to elucidate the mechanisms that...
Gao, Ji-Liang, Wynn, Thomas A., Chang, Yun, Lee, Eric J., Broxmeyer, Hal E., Cooper, Scott, ...
CC chemokine receptor 1 (CCR1) is expressed in neutrophils, monocytes, lymphocytes, and eosinophils, and binds the leukocyte chemoattractant and hematopoiesis regulator macrophage inflammatory...
Jankovic, Dragana, Cheever, Allen W., Kullberg, Marika C., Wynn, Thomas A., Yap, George, Caspar, Patricia, ...
The effector functions of CD4+ T lymphocytes are generally thought to be controlled by distinct populations of regulatory T cells and their soluble products. The role of B cells in the regulation of...
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
Pesce, John T., Ramalingam, Thirumalai R., Mentink-Kane, Margaret M., Wilson, Mark S., El Kasmi, Karim C., Smith, Amber M., ...
Macrophage-specific expression of Arginase-1 is commonly believed to promote inflammation, fibrosis, and wound healing by enhancing L-proline, polyamine, and Th2 cytokine production. Here, however,...
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
Pesce, John T., Ramalingam, Thirumalai R., Wilson, Mark S., Mentink-Kane, Margaret M., Thompson, Robert W., Cheever, Allen W., ...
Retnla (Resistin-like molecule alpha/FIZZ1) is induced during Th2 cytokine immune responses. However, the role of Retnla in Th2-type immunity is unknown. Here, using Retnla−/− mice and three...