Unexpected role of STAT1 serine727 for NK cell function (2009)
Putz, Eva M, Zebedin, Eva, Csiszar, Agnes, Prchal, Michaela, Berger, Angelika, Decker, Thomas, ...
No abstract available.
Quantum Algorithm for Identifying Hidden Polynomial Function Graphs (2008)
Thomas Decker, Jan Draisma, Pawel Wocjan
We introduce the Hidden Polynomial Function Graph Problem as a natural generalization of an abelian Hidden Subgroup Problem (HSP) where the subgroups and their cosets correspond to graphs of linear...
STAT1 Ser727 – key regulator for NK cell-mediated cytotoxicity and tumor surveillance (2008)
Putz, Eva M, Zebedin-Brandl, Eva, Prchal, Michaela, Decker, Thomas, Kovarik, Pavel, Sexl, Veronika
No abstract available.
IL-27 inhibits the development of regulatory T cells via STAT3 (2008)
Huber, Magdalena, Steinwald, Vera, Guralnik, Anna, Brüstle, Anne, Kleemann, Peter, Rosenplänter, Christine, ...
Regulatory CD4+ T cells are important for the homeostasis of the immune system and their absence correlates with autoimmune disorders. Here, we investigate the capacity of IL-27, a cytokine with pro-...
Introduction A major research area in the University of Paderborn is Parallel Computing. Next to computer scientists, also researchers in mathematics, electrical and machine engineering, and...
Towards a Scalable Parallel Algorithm for Polynomial Real Root Isolation Extended Abstract (2007)
roots. If the degree of the polynomials is 2, 3, or 4, one can use formulae for the roots; if the degree is higher, search methods must be used. Numerical search methods are fast, but, in
Phase-by-Phase Schedules for identical Malleable Tasks (2007)
Scheduling is one of the most important problem in parallel processing. It corresponds to determine at what time and on which processor the tasks of a parallel program will be executed. In general,...
How much is a quantum controller controlled by the controlled system? (2007)
Janzing, Dominik, Decker, Thomas
We consider unitary transformations on a bipartite system A x B. To what extent entails the ability to transmit information from A to B the ability to transfer information in the converse direction?...
The Optimal Single Copy Measurement for the Hidden Subgroup Problem (2007)
The optimization of measurements for the state distinction problem has recently been applied to the theory of quantum algorithms with considerable successes, including efficient new quantum...
Kluttig, Alexander, Trocchi, Pietro, Heinig, Anke, Holzhausen, Hans-Juergen, Taege, Christiane, Hauptmann, Steffen, ...
Abstract Background The planned nationwide implementation of mammography screening 2007 in Germany will increase the occurrence of mammographically detected breast abnormalities. These abnormalities...
Efficient Quantum Algorithm for Identifying Hidden Polynomials (2007)
Decker, Thomas, Draisma, Jan, Wocjan, Pawel
We consider a natural generalization of an abelian Hidden Subgroup Problem where the subgroups and their cosets correspond to graphs of linear functions over a finite field F with d elements. The...
Efficient Quantum Algorithm for Hidden Quadratic and Cubic Polynomial Function Graphs (2007)
We introduce the Hidden Polynomial Function Graph Problem as a natural generalization of an abelian Hidden Subgroup Problem (HSP) where the subgroups and their cosets correspond to graphs of linear...
Symmetric measurements attaining the accessible information (2005)
A theorem of Davies states that for symmetric quantum states there exists a symmetric POVM maximizing the mutual information. To apply this theorem the representation of the symmetry group has to be...
Janzing, Dominik, Decker, Thomas
In a previous paper we have presented a general scheme for the implementation of symmetric generalized measurements (POVMs) on a quantum computer. This scheme is based on representation theory of...
Implementation of group-covariant POVMs by orthogonal measurements (2004)
Decker, Thomas, Janzing, Dominik, Roetteler, Martin
We consider group-covariant positive operator valued measures (POVMs) on a finite dimensional quantum system. Following Neumark's theorem a POVM can be implemented by an orthogonal measurement on a...
Enth. ausserdem 8 Sonderabdr. aus verschiedenen Zeitschr. - Beitr. teilw. dt., teilw. engl.
Osnabrück, Universiẗat, Diss., 2004 (Nicht für den Austausch).
Quantum circuits for single-qubit measurements corresponding to platonic solids (2003)
Decker, Thomas, Janzing, Dominik, Beth, Thomas
Each platonic solid defines a single-qubit positive operator valued measure (POVM) by interpreting its vertices as points on the Bloch sphere. We construct simple circuits for implementing this kind...
Measuring 4-local n-qubit observables could probabilistically solve PSPACE (2003)
Wocjan, Pawel, Janzing, Dominik, Decker, Thomas, Beth, Thomas
We consider a hypothetical apparatus that implements measurements for arbitrary 4-local quantum observables A on n qubits. The apparatus implements the ``measurement algorithm'' after receiving a...
Janzing, Dominik, Decker, Thomas, Beth, Thomas
An n-qubit quantum register can in principle be completely controlled by operating on a single qubit that interacts with the register via an appropriate fixed interaction. We consider a hypothetical...
polymake: an approach to modular software design in computational geometry, in (2001)
The efficiency of a parallel algorithm with input x on P 1 processors is defined as
Virtual Data Space -- Load balancing for irregular applications (2000)
Load balancing is a key issue in the development of parallel algorithms with irregular structures. Existing load balancing systems each support only one specic programming paradigm and thus are of...
Towards optimal load balancing topologies (2000)
Thomas Decker, Burkhard Monien, Robert Preis
Abstract. Many load balancing algorithms balance the load according to a topology. Its choice can significantly influence the performance of the algorithm. We consider the two phase balancing model....
Klaus Brockmann, Thomas Decker
In this paper, the problem of short-term production planning in flexible flow lines is considered. A MIP model formulation of the proportional lot sizing problem for multilevel production processes...
Paderborn, Univ., Diss., 2000.
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation (2000)
Kieslinger, Matthias, Woldman, Irina, Moriggl, Richard, Hofmann, Johannes, Marine, Jean-Christophe, Ihle, James N., ...
Parallel real root isolation using the Descartes method (1999)
Many sequential methods for polynomial real root isolation proceed by interval bisection. The associated binary search trees tend to be narrow and hence do not offer much parallelism. For this...
Parallel Real Root Isolation using the Descartes Method (1999)
Thomas Decker, Werner Krandick
. Two new scheduling algorithms are presented. They are used to isolate polynomial real roots on massively parallel systems. One algorithm schedules computations modeled by a pyramid DAG. This is a...
Halle, Univ., Diss., 1998.
Mapping of Coarse-Grained Applications onto Workstation-Clusters (1997)
. We present an environment for configuring and co-ordinating coarse grained parallel applications on workstation clusters. The environment named CoPA is based on PVM and allows an automatic...
An Open, Distributed CAE Environment (1997)
Thomas Decker, Ralf Diekmann, Peter Klingebiel, Jürgen Seuss
CAMeL is an environment for the simulation of mechatronical devices developed at the Mechatronic Laboratory Paderborn. In this paper we present a parallelization of this toolset using a general...
Mapping of Coarse-Grained Applications onto Workstation-Clusters (1997)
We present an environment for configuring and coordinating coarse grained parallel applications on workstation clusters. The environment named CoPA is based on PVM and allows an automatic...
Virtual Data Space - A Universal Load Balancing Scheme (1997)
The Virtual Data Space is a standard C-library which automatically distributes the work-packets generated by parallel applications across the processing nodes. VDS is a universal system offering...
Virtual Data Space - A Universal Load Balancing Scheme (1997)
The Virtual Data Space is a standard C-library which automatically distributes the work-packets generated by parallel applications across the processing nodes. VDS is a universal system offering...
Mikrofiche-Ausg.: 2 Mikrofiches : 24x.
Towards Developing Universal Dynamic Mapping Algorithms (1995)
Thomas Decker, Ralf Diekmann, Reinhard Lüling, Burkhard Monien
We investigate the problem of mapping dynamically generated tasks onto the processors of an MIMD-system. Our main concern is to construct an algorithm which can be integrated in distributed runtime...
Towards Developing Universal Dynamic Mapping Algorithms (Extended Abstract) (1995)
Thomas Decker, Ralf Diekmann, Reinhard Lüling, Burkhard Monien
Abstract We investigate the problem of mapping dynamically generated tasks onto the processors of an MIMD-system. Our main concern is to construct an algorithm which can be integrated in distributed...
Thesis (doctoral)--Johannes Gutenberg-Universität Mainz, 1995.
Molekulare Mechanismen der Geninduktion durch Interferone. (1992)
Mikroreprod. eines Ms. 68 Bl. : Ill., graph. Darst.
Strehlow, Inga, Decker, Thomas
The 9/27 and GBP mRNAs are both inducible by Interferon-7 (IFN-7). The promoters of both genes contain an Interferon Stimulation Response Element (ISRE), but while the GBP gene is strongly induced...
Immunologische Funktionen von Zellen des mononukleären Phagocytensystems in der Leber. (1986)
Freiburg (Breisgau), Univ., Diss., 1986 (Nicht f.d. Austausch).
Dresden, Med. Akad., Diss. A, 1979 (Nicht f.d. Austausch).
Vita.
Kovarik, Pavel, Stoiber, Dagmar, Eyers, Patrick A., Menghini, Rossella, Neininger, Armin, Gaestel, Matthias, ...
STAT1 is an essential transcription factor for macrophage activation by IFN-γ and requires phosphorylation of the C-terminal Ser727 for transcriptional activity. In macrophages, Ser727...
Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, ...
Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice...
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation
Ramsauer, Katrin, Sadzak, Iwona, Porras, Almudena, Pilz, Andreas, Nebreda, Angel R., Decker, Thomas, ...
The transcription factor signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Tyr-701 and Ser-727 for full activation. IFN-γ induces phosphorylation of both...
Kovarik, Pavel, Mangold, Monika, Ramsauer, Katrin, Heidari, Hamid, Steinborn, Ralf, Zotter, Angelika, ...
Complete activation of signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Y701 and a conserved PMS727P sequence. S727 phosphorylation of STAT1 in...
IFNs and STATs in innate immunity to microorganisms
Decker, Thomas, Stockinger, Silvia, Karaghiosoff, Marina, Müller, Mathias, Kovarik, Pavel
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
Kieslinger, Matthias, Woldman, Irina, Moriggl, Richard, Hofmann, Johannes, Marine, Jean-Christophe, Ihle, James N., ...
Stat5 is activated by multiple receptors of hematopoietic cytokines. To study its role during hematopoiesis, we have generated primary chicken myeloblasts expressing different dominant-negative (dn)...
Sepsis: avoiding its deadly toll
Systemic bacterial infection may culminate in a frequently fatal septic shock syndrome. The underlying pathology is the result of an uncontrolled inflammatory response, stimulated by the pathogen and...
Pilz, Andreas, Ramsauer, Katrin, Heidari, Hamid, Leitges, Michael, Kovarik, Pavel, Decker, Thomas
Stat1 (signal transducer and activator of transcription 1) regulates transcription in response to the type I interferons IFN-α and IFN-β, either in its dimerized form or as a subunit of the...
Kovarik, Pavel, Stoiber, Dagmar, Eyers, Patrick A., Menghini, Rossella, Neininger, Armin, Gaestel, Matthias, ...
STAT1 is an essential transcription factor for macrophage activation by IFN-γ and requires phosphorylation of the C-terminal Ser727 for transcriptional activity. In macrophages, Ser727...
Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, ...
Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice...
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation
Ramsauer, Katrin, Sadzak, Iwona, Porras, Almudena, Pilz, Andreas, Nebreda, Angel R., Decker, Thomas, ...
The transcription factor signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Tyr-701 and Ser-727 for full activation. IFN-γ induces phosphorylation of both...
Kovarik, Pavel, Mangold, Monika, Ramsauer, Katrin, Heidari, Hamid, Steinborn, Ralf, Zotter, Angelika, ...
Complete activation of signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Y701 and a conserved PMS727P sequence. S727 phosphorylation of STAT1 in...
IFNs and STATs in innate immunity to microorganisms
Decker, Thomas, Stockinger, Silvia, Karaghiosoff, Marina, Müller, Mathias, Kovarik, Pavel
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation
Kieslinger, Matthias, Woldman, Irina, Moriggl, Richard, Hofmann, Johannes, Marine, Jean-Christophe, Ihle, James N., ...
Stat5 is activated by multiple receptors of hematopoietic cytokines. To study its role during hematopoiesis, we have generated primary chicken myeloblasts expressing different dominant-negative (dn)...
Sepsis: avoiding its deadly toll
Systemic bacterial infection may culminate in a frequently fatal septic shock syndrome. The underlying pathology is the result of an uncontrolled inflammatory response, stimulated by the pathogen and...
Pilz, Andreas, Ramsauer, Katrin, Heidari, Hamid, Leitges, Michael, Kovarik, Pavel, Decker, Thomas
Stat1 (signal transducer and activator of transcription 1) regulates transcription in response to the type I interferons IFN-α and IFN-β, either in its dimerized form or as a subunit of the...
Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1▿
Zupkovitz, Gordin, Tischler, Julia, Posch, Markus, Sadzak, Iwona, Ramsauer, Katrin, Egger, Gerda, ...
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from core histones. Because of their capacity to induce local condensation of chromatin, HDACs are generally considered repressors...
Kluttig, Alexander, Trocchi, Pietro, Heinig, Anke, Holzhausen, Hans-Juergen, Taege, Christiane, Hauptmann, Steffen, ...
Ramsauer, Katrin, Farlik, Matthias, Zupkovitz, Gordin, Seiser, Christian, Kröger, Andrea, Hauser, Hansjörg, ...
A subgroup of genes induced by IFN-γ requires both STAT1 and IRF1 for transcriptional activation. Using WT, stat1−/−, or irf1−/− cells, we analyzed the changes induced by IFN-γ in gbp2...
Regulation and innovation in biogas technology in selected European countries
Thomas Decker, Klaus Menrad, Stefan Berenz, Robert Wagner
The development of biogas plants shows differing structures and levels in Denmark, Austria and Germany. Every country had made specific efforts to promote biogas plants which differ in the political...
Zwaferink, Heather, Stockinger, Silvia, Reipert, Siegfried, Decker, Thomas
Murine macrophage death upon infection with Listeria monocytogenes was previously shown to be increased by beta interferon, produced by the infected cells. We saw that interferon-upregulated caspase...
Characterization of the Interferon-Producing Cell in Mice Infected with Listeria monocytogenes
Stockinger, Silvia, Kastner, Renate, Kernbauer, Elisabeth, Pilz, Andreas, Westermayer, Sandra, Reutterer, Benjamin, ...
Production of type I interferons (IFN-I, mainly IFNα and IFNβ) is a hallmark of innate immune responses to all classes of pathogens. When viral infection spreads to lymphoid organs, the majority of...
Soulat, Didier, Bürckstümmer, Tilmann, Westermayer, Sandra, Goncalves, Adriana, Bauch, Angela, Stefanovic, Adrijana, ...
TANK-binding kinase 1 (TBK1) is of central importance for the induction of type-I interferon (IFN) in response to pathogens. We identified the DEAD-box helicase DDX3X as an interaction partner of...
Maldonado, Roberto A., Soriano, Michelle A., Perdomo, L. Carolina, Sigrist, Kirsten, Irvine, Darrell J., Decker, Thomas, ...
The antigen recognition interface formed by T helper precursors (Thps) and antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signaling molecules necessary...