Poster Submission Title: Preservation of bistability in the reduction of an apoptosis model (2008)
Steffen Waldherr, Thomas Eissing, Madalena Chaves, S. Waldherr, T. Eissing, M. Chaves, ...
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Bistability preserving model reduction in apoptosis (2007)
Waldherr, Steffen, Eissing, Thomas, Chaves, Madalena, Allgower, Frank
Biological systems are typically very complex and need to be reduced before they are amenable to a thorough analysis. Also, they often possess functionally important dynamic features like...
Eissing, Thomas, Waldherr, Steffen, Allgöwer, Frank, Scheurich, Peter, Bullinger, Eric
Recently, a mathematical model of the mitochondrial apoptotic pathway was proposed. In that study, the robustness of different simplified signaling models with respect to parameter changes was also...
Steady state and (bi-) stability evaluation of simple protease signalling networks (2007)
Eissing, Thomas, Waldherr, Steffen, Allgöwer, Frank, Scheurich, Peter, Bullinger, Eric
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper understanding requires a system analysis. Important aspects are the number, location and stability of...
Eissing, Thomas, Waldherr, Steffen, Gondro, Cedric, Bullinger, Eric, Sawodny, Oliver, Allgöwer, Frank, ...
Proc. of the IEEE Conference on Control Applications
Bistability analyses of a caspase activation model for receptor-induced apoptosis (2004)
Eissing, Thomas, Conzelmann, Holger, Gilles, Ernst Dieter, Allgöwer, Frank, Bullinger, Eric, Scheurich, Peter
Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed...