Scientific Commons: Thomas Erwin Haselhorst

We report an easy and direct application of 'Saturation Transfer Double Difference' (STDD) NMR spectroscopy to identify ligands that bind to a Sepharose-immobilised target protein. The model protein,...

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

Yes

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

Yes

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Yes

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

Yes

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

Yes

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

Yes

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Yes

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Molecular Cloning of the Leishmania major UDP-glucose Pyrophosphorylase, Functional Characterization, and Ligand Binding Analyses Using NMR Spectroscopy (2006)

Lamerz, Anne-Christin, Haselhorst, Thomas Erwin, Bergfeld, Ann, Von Itzstein, Mark, Gerardy-Schahn, Rita

The dense glycocalyx surrounding the protozoan parasite Leishmania is an essential virulence factor. It protects the parasite from hostile environments in the sandfly vector and mammalian host and...

A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase (2006)

Haselhorst, Thomas Erwin, Oschlies, Melanie, Abu-Izneid, Tareq, Kiefel, Milton, Tiralongo, Giuseppe, Münster-Kühnel, Anja K., ...

CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and CTP to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP i . Saturation Transfer Difference (STD) NMR...

STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core (2006)

Haselhorst, Thomas Erwin, Blanchard, Helen, Frank, Martin, Kraschnefski, Mark, Kiefel, Milton, Szyczew, Alexander Jeffery, ...

The VP8* subunit of rotavirus spike protein VP4 contains a sialic acid (Sia)-binding domain important for host cell attachment and infection. In this study, the binding epitope of the...

Endosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation (2006)

Haselhorst, Thomas Erwin, Stummeyer, Katharina, Mühlenhoff, Martina, Schaper, Wiebke, Gerardy-Schahn, Rita, Von Itzstein, Mark

Phages infecting the polySia-encapsulated human pathogen E. coli K1 are equipped with capsule-degrading tail spikes known as endosialidases, which are the only identified enzymes that specifically...

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

Yes

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

Yes

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy. (2005)

Haselhorst, Thomas Erwin, Muenster-Kuehnel, Anja K., Stolz, Anita, Oschiles, Melanie, Tiralongo, Giuseppe, Kitajima, Ken, ...

CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and cytidine-5′-triphosphate (CTP) to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PPi. STD NMR experiments...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark, ...

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Yes

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Yes

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Liakatos, Angela, Kiefel, Milton, Dyason, Jeffrey Clifford, Von Itzstein, Mark

Nuclear magnetic resonance (NMR) spectroscopy was used to investigate the transfer of sialic acid from a range of sialic acid donor compounds to acceptor molecules, catalyzed by Trypanosoma cruzi...

Saturation transfer difference (STD) 1H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. (2004)

Haselhorst, Thomas Erwin, Wilson, Jenny, Thomson, Robin Joy, McAtamney, Sarah, Menting, John G., Coppel, Ross L., ...

Saturation transfer difference (STD) 1H NMR experiments were used to probe the epitope binding characteristics of the sialidase [EC 3.2.1.18] from the bacterium Vibrio cholerae, the causative agent...

Molecular recognition of sialyl Lewis(x) and related saccharides by two lectins (2001)

Haselhorst, Thomas Erwin, Weimar, Thomas, Peters, Thomas

The interaction of sialyl Lewis(x), Lewis(x), and α-L-Fuc-(1→3)-β-D-GlcNAc with isolectin A from Lotus tetragonolobus (LTL-A), and with Aleuria aurantia agglutinin (AAA) was studied using NMR...

Molecular recognition of sialyl Lewis(x) and related saccharides by two lectins (2001)

Haselhorst, Thomas Erwin, Weimar, Thomas, Peters, Thomas

The interaction of sialyl Lewis(x), Lewis(x), and α-L-Fuc-(1→3)-β-D-GlcNAc with isolectin A from Lotus tetragonolobus (LTL-A), and with Aleuria aurantia agglutinin (AAA) was studied using NMR...

Molecular recognition of sialyl Lewis(x) and related saccharides by two lectins (2001)

Haselhorst, Thomas Erwin, Weimar, Thomas, Peters, Thomas

The interaction of sialyl Lewis(x), Lewis(x), and α-L-Fuc-(1→3)-β-D-GlcNAc with isolectin A from Lotus tetragonolobus (LTL-A), and with Aleuria aurantia agglutinin (AAA) was studied using NMR...

Molecular recognition of sialyl Lewis(x) and related saccharides by two lectins (2001)

Haselhorst, Thomas Erwin, Weimar, Thomas, Peters, Thomas

The interaction of sialyl Lewis(x), Lewis(x), and α-L-Fuc-(1→3)-β-D-GlcNAc with isolectin A from Lotus tetragonolobus (LTL-A), and with Aleuria aurantia agglutinin (AAA) was studied using NMR...

Conformational analysis of a Chlamydia-specific disaccharide α-Kdo-(2→8)-α-Kdo-(2→0)-allyl in aqueous solution and bound to a monoclonal antibody - observation of intermolecular transfer NOEs. (1998)

Sololowski, Tobias, Haselhorst, Thomas Erwin, Scheffler, Karoline, Weisemann, Rudiger, Kosma, Paul, Brade, Helmut, ...

Yes

Conformational analysis of a Chlamydia-specific disaccharide α-Kdo-(2→8)-α-Kdo-(2→0)-allyl in aqueous solution and bound to a monoclonal antibody - observation of intermolecular transfer NOEs. (1998)

Sololowski, Tobias, Haselhorst, Thomas Erwin, Scheffler, Karoline, Weisemann, Rudiger, Kosma, Paul, Brade, Helmut, ...

Conformational analysis of a Chlamydia-specific disaccharide α-Kdo-(2→8)-α-Kdo-(2→0)-allyl in aqueous solution and bound to a monoclonal antibody - observation of intermolecular transfer NOEs. (1998)

Sololowski, Tobias, Haselhorst, Thomas Erwin, Scheffler, Karoline, Weisemann, Rudiger, Kosma, Paul, Brade, Helmut, ...

Thomas Erwin Haselhorst

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