Walduck, Anna K, Weber, Matthias, Wunder, Christian, Juettner, Stefan, Stolte, Manfred, Vieth, Michael, ...
Abstract Background Helicobacter pylori is a crucial determining factor in the pathogenesis of benign and neoplastic gastric diseases. Cyclooxygenase-2 (Cox-2) is the inducible key enzyme of...
Bramsen, Jesper B., Laursen, Maria B., Nielsen, Anne F., Hansen, Thomas B., Bus, Claus, Langkjær, Niels, ...
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is...
Bramsen, Jesper B., Laursen, Maria B., Nielsen, Anne F., Hansen, Thomas B., Bus, Claus, Langkjaer, Niels, ...
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is...
Complex kinase requirements for Chlamydia trachomatis Tarp phosphorylation (2008)
Mehlitz, Adrian, Banhart, Sebastian, Hess, Simone, Selbach, Matthias, Meyer, Thomas F.
Aebischer, Toni, Bumann, Dirk, Epple, H. J., Metzger, Wolfram G., Schneider, T., Cherepnev, Georgy, ...
Braun, Peter R., Al-Younes, Hesham M., Gussmann, Joscha, Klein, Jeannette, Schneider, Erwin, Meyer, Thomas F.
Pathogenomics: An updated European Research Agenda (2008)
Demuth, Andreas, Aharonowitz, Yair, Bachmann, Till T., Blum-Oehler, Gabriele, Buchrieser, Carmen, Covacci, Antonello, ...
A vaccine against Helicobacter pylori: Towards understanding the mechanism of protection (2008)
Aebischer, Toni, WaIduck, Anna, Schroeder, Juliane, Wehrens, Andrea, Chijioke, Obinna, Schreiber, Soeren, ...
Long-term effects of natural amino acids on infection with Chlamydia trachomatis (2008)
Gussmann, Joscha, Al-Younes, Hesham M., Braun, Peter R., Brinkmann, Volker, Meyer, Thomas F.
André P. Mäurer, Adrian Mehlitz, Hans J. Mollenkopf, Thomas F. Meyer
The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic...
Mäurer, André P., Mehlitz, Adrian, Mollenkopf, Hans J., Meyer, Thomas F.
The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic...
Moese, Stefan, Selbach, Matthias, Brinkmann, Volker, Karlas, Alexander, Haimovich, Beatrice, Backert, Steffen, ...
Pflock, Michael, Bathon, Melanie, Schär, Jennifer, Müller, Stefanie, Mollenkopf, Hans J., Meyer, Thomas F., ...
Striptease on glass: Validation of an improved stripping procedure for in situ microarrays (2007)
Hahnke, Karin, Jacobsen, Marc, Gruetzkau, Andreas, Gruen, Joachim R., Koch, Markus, Emoto, Masashi, ...
Tackling the intractable – approaching the genetics of Chlamydiales (2007)
Heuer, Dagmar, Kneip, Christoph, Mäurer, André P., Meyer, Thomas F.
Pathogenomics of helicobacter. (2007)
Josenhans, Christine, Beier, Dagmar, Linz, Bodo, Meyer, Thomas F.
Cloning of a cholesterol-alpha-glucosyltransferase from Helicobacter pylori (2006)
Lebrun, Anne-Helene, Wunder, Christian, Hildebrand, Janosch, Churin, Yuri, Zahringer, Ulrich, Lindner, Buko, ...
Cholesterol glucosylation promotes immune evasion by Helicobacter pylori (2006)
Wunder, Christian, Churin, Yuri, Winau, Florian, Warnecke, Dirk, Vieth, Michael, Lindner, Buko, ...
Characterization of the ArsRS regulon of Helicobacter pylori, involved in acid adaptation (2006)
Pflock, Michael, Finsterer, Nadja, Joseph, Biju, Mollenkopf, Hans J., Meyer, Thomas F., Beier, Dagmar
Robust Salmonella metabolism limits possibilities for new antimicrobials (2006)
Becker, Daniel, Selbach, Matthias, Rollenhagen, Claudia, Ballmaier, Matthias, Meyer, Thomas F., Mann, Matthias, ...
Vaccination prevents Helicobacter pylori-induced alterations of the gastric flora in mice (2006)
Aebischer, Toni, Fischer, Andre, Walduck, Anna, Schlötelburg, Cord, Lindig, Mirko, Schreiber, Sören, ...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori (2005)
Helga Gressmann, Bodo Linz, Rohit Ghai, Klaus-Peter Pleissner, Ralph Schlapbach, Yoshio Yamaoka, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Nebe,C. Thomas, Rother,Marion, Brechtel,Ingrid, Costina,Victor, Neumaier,Michael, Zentgraf,Hanswalter, ...
Nebe, C. Thomas, Rother, Marion, Brechtel, Ingrid, Costina, Victor, Neumaier, Michael, Zentgraf, Hanswalter, ...
Machuy, Nikolaus, Thiede, Bernd, Rajalingam, Krishnaraj, Dimmler, Christiane, Thieck, Oliver, Meyer, Thomas F., ...
Development of a vaccine against Helicobacter pylori (2005)
Aebischer, Toni, Bumann, Dirk, Epple, H. J., Graham, David Y., Metzger, Wolfram G., Schneider, T., ...
Gain and loss of multiple genes during the evolution of Helicobacter pylori (2005)
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Backert, Steffen, Gressmann, Helga, Kwok, Terry, Zimny-Arndt, Ursula, Konig, Wolfgang, Jungblut, Peter R., ...
Brief report: Helicobacter pylori infection in anterior uveitis (2005)
Otasevic, L., Walduck, Anna, Meyer, Thomas F., Aebischer, Toni, Hartmann, C, Orlic, N., ...
Helicobacter pylori vaccine development: Facing the challenge (2005)
Aebischer, Toni, Schmitt, Andrea, Walduck, Anna, Meyer, Thomas F.
Sabarth, Nicolas, Hurvitz, Robert, Schmidt, Monika, Zimny-Arndt, Ursula, Jungblut, Peter R., Meyer, Thomas F., ...
Inhibition of Marburg virus protein expression and viral release by RNA interference (2005)
Fowler, Trent, Bamberg, Sandra, Moller, Peggy, Klenk, Hans-Dieter, Meyer, Thomas F., Becker, Stephan, ...
Backert, Steffen, Kwok, Terry, Schmid, Monika, Selbach, Matthias, Moese, Stefan, Peek, Richard M., ...
Sugar turns benefit of cholesterol into immune evasion in microbial infection (2005)
Wunder, Christian, Churin, Yuri, Winau, Florian, Meyer, Thomas F.
RNA interference and infectious agents. (2005)
Meyer, Thomas F., Fowler, Trent, Rejman Lipinski, Anette, Heuer, Dagmar, Müller, Elke, Rudel, Thomas, ...
Lack of stage-specific proteins in coccoid Helicobacter pylori cells (2004)
Bumann,Dirk, Habibi,Hajar, Kan,Biao, Schmid,Monika, Goosmann,Christian, Brinkmann,Volker, ...
Helicobacter pylori exists in two distinct forms, rod shaped or coccoid, in stomachs of infected patients. Based on in vitro proteome comparisons, there are no detectable coccoid-specific proteins,...
Wehrl,Wolfgang, Meyer,Thomas F., Jungblut,Peter R., Muller,Eva-Christina, Szczepek,Agnes J.
Chlamydophila pneumoniae is an obligate intracellular pathogen implicated in a variety of acute and chronic diseases. Long-term infections are associated with a persistent life stage, in which...
Helicobacter pylori vaccine development based on combined subproteome analysis (2004)
Bumann,Dirk, Jungblut,Peter R., Meyer,Thomas F.
Effective vaccines could provide long-term solutions to many important infectious diseases, however, vaccine development has been hampered by the slow identification of protective antigens....
The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin (2004)
Selbach,Matthias, Moese,Stefan, Backert,Steffen, Jungblut,Peter R., Meyer,Thomas F.
Helicobacter pylori is one of the most wide-spread bacterial pathogens and infects the human stomach to cause diseases, such as gastritis, gastric ulceration, and gastric cancer. A major virulence...
Walduck,Anna, Schmitt,Andrea, Lucas,Bernadette, Aebischer,Toni, Meyer,Thomas F.
Development of a vaccine against H. pylori is regarded as desirable alternative to the current antibiotic therapy regimens. Mice immunized with an attenuated recombinant Salmonella typhimurium...
Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway (2004)
Al-Younes,Hesham M., Brinkmann,Volker, Meyer,Thomas F.
Chlamydiae are obligate intracellular pathogens that replicate within a membrane-bound compartment (the inclusion) and are associated with important human diseases, such as trachoma, pneumonia, and...
Metzger,Wolfram G., Mansouri,E., Kronawitter,M, Diescher,Susanne, Soerensen,Meike, Hurwitz,Robert, ...
Orally administered recombinant Salmonella vaccines represent an attractive option for mass vaccination programmes against various infectious diseases. Therefore, it is crucial to gather knowledge...
Moese,Stefan, Selbach,Matthias, Kwok,Terry, Brinkmann,Volker, Konig,Wolfgang, Meyer,Thomas F., ...
Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in...
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins (2004)
Morand,Philippe C., Bille,Emmanuelle, Morelle,Sandrine, Eugene,Emmanuel, Beretti,Jean-Luc, Wolfgang,Matthew, ...
Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a...
Berger,Cedric N., Billker,Oliver, Meyer,Thomas F., Servin,Alain L., Kansau,Imad
Little is known about the molecular bases underlying the virulence of diffusely adhering Escherichia coli (DAEC) harbouring the Afa/Dr family of adhesins. These adhesins recognize as receptors the...
Niehus,Eike, Gressmann,Helga, Ye,Fang, Schlapbach,Ralph, Dehio,Michaela, Dehio,Christoph, ...
The flagellar system of Helicobacter pylori, which comprises more than 40 mostly unclustered genes, is essential for colonization of the human stomach mucosa. In order to elucidate the complex...
Web-accessible proteome databases for microbial research (2004)
Pleissner,Klaus-Peter, Eifert,Till, Buettner,Sven, Schmidt,Frank, Boehme,Martina, Meyer,Thomas F., ...
The analysis of proteomes of biological organisms represents a major challenge of the post-genome era. Classical proteomics combines two-dimensional electrophoresis (2-DE) and mass spectrometry (MS)...
Backert,Steffen, Schwarz,Tobias, Miehlke,Stephan, Kirsch,Christian, Sommer,Christian, Kwok,Terry, ...
Helicobacter pylori is the causative agent of a variety of gastric diseases, but the clinical relevance of bacterial virulence factors is still controversial. Virulent strains carrying the cag...
Proteomic and gene profiling approaches to study host responses to bacterial infection (2004)
Walduck,Anna, Rudel,Thomas, Meyer,Thomas F.
Infectious disease is the result of an intimate relationship between the pathogen and host, which involves cross-talk. After an initial flood of mainly descriptive reports on the influence of acute...
Krah,Alexander, Miehlke,Stephan, Pleissner,Klaus-Peter, Zimny-Arndt,Ursula, Kirsch,Christian, Lehn,Norbert, ...
Helicobacter pylori colonizes the stomach of almost half the world population and is a causative agent of gastric carcinomas and duodenal ulcers. Only a small fraction of infected people will develop...
Wehrl,Wolfgang, Brinkmann,Volker, Jungblut,Peter R., Meyer,Thomas F., Szczepek,Agnes J.
Summary Polymorphic membrane protein (Pmp)21 otherwise known as PmpD is the longest of 21 Pmps expressed by Chlamydophila pneumoniae. Recent bioinformatical analyses annotated PmpD as belonging to a...
Strowski,Mathias Z., Cramer,Thorsten, Schafer,Georgia, Juttner,Stefan, Walduck,Anna, Schipani,Ernestina, ...
SPECIFIC AIMS Vascular endothelial growth factor-A (VEGF-A) is a key regulator of inflammatory and tumor-associated angiogenesis. Helicobacter pylori (H. pylori) plays a critical role in the...
The immunoproteome of Helicobacter pylori. (2004)
Aebischer,Toni, Bumann,Dirk, Jungblut,Peter R., Meyer,Thomas F.
Backert, Steffen, Schwarz, Tobias, Miehlke, Stephan, Kirsch, Christian, Sommer, Christian, Kwok, Terry, ...
Strowski, Mathias Z., Cramer, Thorsten, Schafer, Georgia, Juttner, Stefan, Walduck, Anna, Schipani, Ernestina, ...
Moese, Stefan, Selbach, Matthias, Kwok, Terry, Brinkmann, Volker, Konig, Wolfgang, Meyer, Thomas F., ...
Krah, Alexander, Miehlke, Stephan, Pleissner, Klaus-Peter, Zimny-Arndt, Ursula, Kirsch, Christian, Lehn, Norbert, ...
Metzger, Wolfram G., Mansouri, E., Kronawitter, M, Diescher, Susanne, Soerensen, Meike, Hurwitz, Robert, ...
Lack of stage-specific proteins in coccoid Helicobacter pylori cells (2004)
Bumann, Dirk, Habibi, Hajar, Kan, Biao, Schmid, Monika, Goosmann, Christian, Brinkmann, Volker, ...
The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin (2004)
Selbach, Matthias, Moese, Stefan, Backert, Steffen, Jungblut, Peter R., Meyer, Thomas F.
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins (2004)
Morand, Philippe C., Bille, Emmanuelle, Morelle, Sandrine, Eugene, Emmanuel, Beretti, Jean-Luc, Wolfgang, Matthew, ...
Web-accessible proteome databases for microbial research (2004)
Pleissner, Klaus-Peter, Eifert, Till, Buettner, Sven, Schmidt, Frank, Boehme, Martina, Meyer, Thomas F., ...
The immunoproteome of Helicobacter pylori. (2004)
Aebischer, Toni, Bumann, Dirk, Jungblut, Peter R., Meyer, Thomas F.
Rizos,Konstantin, Lattemann,Claus T., Bumann,Dirk, Meyer,Thomas F., Aebischer,Toni
Live attenuated Salmonella strains expressing antigens of pathogens are promising oral vaccine candidates. There is growing evidence that the topology of expression of the foreign antigens can have a...
Juttner,Stefan, Cramer,Thorsten, Wessler,Silja, Walduck,Anna, Gao,Feng, Schmitz,Frank, ...
Cyclooxygenase-2 (COX-2) represents the inducible key enzyme of arachidonic acid metabolism and contributes to the pathogenesis of gastroduodenal ulcers and gastric cancer. Helicobacter pylori...
Heuer,Dagmar, Brinkmann,Volker, Meyer,Thomas F., Szczepek,Agnes J.
Summary Chlamydial protease-like activity factor (CPAF) is secreted to the cytoplasm of the infected cells where it proteolytically cleaves eukaryotic transcription factor RFX5. Here, we determined...
The integration site of the iga gene in commensal Neisseria sp. (2003)
Jose,J., Otto,G. W., Meyer,Thomas F.
An IgA1 protease is produced by the human pathogens Neisseria gonorrhoeae and N. meningitidis but not by related non-pathogenic, commensal, Neisseria species. In this study, the chromosomal iga locus...
Churin,Yuri, Al-Ghoul,Laila, Kepp,Oliver, Meyer,Thomas F., Birchmeier,Walter, Naumann,Michael
Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptor...
High throughput RNA interference for gene function analysis in mammalian cells (2003)
Rudel,Thomas, Machuy,Nikolaus, Meyer,Thomas F.
The release of the complete human genome sequence in 2001 marked an important point on the way to the ultimate goal to unravel the function of every protein. The prime technology for investigating...
Selbach,Matthias, Moese,Stefan, Hurwitz,Robert, Hauck,Christof R., Meyer,Thomas F., Backert,Steffen
The gastric pathogen Helicobacter pylori translocates the CagA protein into epithelial cells by a type IV secretion process. Translocated CagA is tyrosine phosphorylated (CagA(P-Tyr)) on specific...
'Small' talk: Opa proteins as mediators of Neisseria-host-cell communication (2003)
Hauck,Christof R., Meyer,Thomas F.
Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells. They have emerged as a...
Integrated, automated system for efficient gene silencing (2003)
Machuy,Nikolaus, Dimmler,Chris, Rudel,Thomas, Meyer,Thomas F., Dennig,Jorg, Ferfers,Claudia, ...
Automated procedures for RNA interference (RNAi) would be valuable tools for high-throughput gene silencing experiments, allowing efficient screening for proteins of interest. We used a range of...
Selbach, Matthias, Moese, Stefan, Hurwitz, Robert, Hauck, Christof R., Meyer, Thomas F., Backert, Steffen
Integrated, automated system for efficient gene silencing (2003)
Machuy, Nikolaus, Dimmler, Chris, Rudel, Thomas, Meyer, Thomas F., Dennig, Jorg, Ferfers, Claudia, ...
'Small' talk : Opa proteins as mediators of Neisseria-host-cell communication (2003)
Hauck, Christof R., Meyer, Thomas F.
Opa proteins are variable outer membrane proteins of Neisseria gonorrhoeae and Neisseria meningitidis that mediate tight interaction of these pathogens with human cells. They have emerged as a...
Helicobacter pylori type IV secretion, host cell signalling and vaccine development. (2002)
Backert,Steffen, Churin,Yuri, Meyer,Thomas F.
Helicobacter pylori is a bacterial pathogen specialised to colonise and persist the gastric mucosa and to cause severe gastroduodenal disease. A major disease-associated bacterial component is a type...
Bumann,Dirk, Holland,Petra, Siejak,Frank, Koesling,Jan, Sabarth,Nicolas, Lamer,Stefanie, ...
Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter...
Sabarth,Nicolas, Hurwitz,Robert, Meyer,Thomas F., Bumann,Dirk
A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other...
Sabarth,Nicolas, Lamer,Stefanie, Zimny-Arndt,Ursula, Jungblut,Peter R., Meyer,Thomas F., Bumann,Dirk
Helicobacter pylori is a widespread human pathogen that can cause gastric ulcers and cancer. To identify surface proteins that may play a role in pathogen-host interactions and represent potential...
Moese,Stefan, Selbach,Matthias, Meyer,Thomas F., Backert,Steffen
Infection with cag(+) but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule I is up- regulated and...
Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pylori (2002)
Bumann,Dirk, Aksu,Sevil, Wendland,Meike, Janek,Katharina, Zimny-Arndt,Ursula, Sabarth,Nicolas, ...
Secreted proteins (the secretome) of the human pathogen Helicobacter pylori may mediate important pathogen-host interactions, but such proteins are technically difficult to analyze. Here, we report...
Muller,Anne, Rassow,Joachim, Grimm,Jan, Machuy,Nikolaus, Meyer,Thomas F., Rudel,Thomas
The human pathogen Neisseria gonorrhoeae induces host cell apoptosis during infection by delivering the outer membrane protein PorB to the host cell's mitochondria. PorB is a pore- forming...
Kwok,Terry, Backert,Steffen, Schwarz,Heinz, Berger,Jurgen, Meyer,Thomas F.
Although Helicobacter pylori has generally been considered an extracellular pathogen, a number of in vitro infection experiments and biopsy examinations have shown that it is capable of occasionally...
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo (2002)
Selbach,Matthias, Moese,Stefan, Hauck,Christof R., Meyer,Thomas F., Backert,Steffen
The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes phosphorylated on...
Muenzner,Petra, Billker,Oliver, Meyer,Thomas F., Naumann,Michael
The human-specific pathogen Neisseria gonorrhoeae expresses opacity-associated (Opa) protein adhesins that bind to various members of the carcinoembryonic antigen-related cellular adhesion molecule...
Wessler,Silja, Rapp,Ulf R., Wiedenmann,Bertram, Meyer,Thomas F., Schoneberg,Torsten, Hocker,Michael, ...
Histidine decarboxylase (HDC) is the key enzyme for gastric histamine synthesis, and enhanced HDC expression is critically involved in the pathogenesis of gastric disorders, including gastroduodenal...
Immunoproteomics of Helicobacter pylori infection and relation to gastric disease (2002)
Haas,Gaby, Karaali,Galip, Ebermayer,Karl, Metzger,Wolfram G., Lamer,Stefanie, Zimny-Arndt,Ursula, ...
The Gram negative bacterium Helicobacter pylori is a human pathogen which infects the gastric mucosa and causes an inflammatory process leading to gastritis, ulceration and cancer. A systematic,...
Billker,Oliver, Popp,Andreas, Brinkmann,Volker, Wenig,Gerald, Schneider,Jutta, Caron,Emmanuelle, ...
Opa adhesins of pathogenic Neisseria species target four members of the human carcinoembryonic anti. gen-related cellular adhesion molecule (CEACAM) family. CEACAM receptors mediate...
Selbach,Matthias, Moese,Stefan, Meyer,Thomas F., Backert,Steffen
The type IV secretion machinery encoded by the cag pathogenicity island (PAI) of Helicobacter pylori has been implicated in a series of host responses during infection. Here, we analyzed the function...
Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans (2002)
Tsirpouchtsidis,Anastasios, Hurwitz,Robert, Brinkmann,Volker, Meyer,Thomas F., Haas,Gaby
We have previously shown that immunoglobulin A1 (IgA1) protease, an exoenzyme of pathogenic neisseriae, can trigger the release of proinflammatory cytokines from human monocytic subpopulations. Here,...
Neisserial immunoglobulin A1 protease induces specific T-cell responses in humans (2002)
Tsirpouchtsidis, Anastasios, Hurwitz, Robert, Brinkmann, Volker, Meyer, Thomas F., Haas, Gaby
Wessler, Silja, Rapp, Ulf R., Wiedenmann, Bertram, Meyer, Thomas F., Schoneberg, Torsten, Hocker, Michael, ...
Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo (2002)
Selbach, Matthias, Moese, Stefan, Hauck, Christof R., Meyer, Thomas F., Backert, Steffen
Billker, Oliver, Popp, Andreas, Brinkmann, Volker, Wenig, Gerald, Schneider, Jutta, Caron, Emmanuelle, ...
Immunoproteomics of Helicobacter pylori infection and relation to gastric disease (2002)
Haas, Gaby, Karaali, Galip, Ebermayer, Karl, Metzger, Wolfram G., Lamer, Stefanie, Zimny-Arndt, Ursula, ...
Proteome analysis of secreted proteins of the gastric pathogen Helicobacter pylori (2002)
Bumann, Dirk, Aksu, Sevil, Wendland, Meike, Janek, Katharina, Zimny-Arndt, Ursula, Sabarth, Nicolas, ...
Sabarth, Nicolas, Lamer, Stefanie, Zimny-Arndt, Ursula, Jungblut, Peter R., Meyer, Thomas F., Bumann, Dirk
Helicobacter pylori type IV secretion, host cell signalling and vaccine development. (2002)
Backert, Steffen, Churin, Yuri, Meyer, Thomas F.
Helicobacter pylori is a bacterial pathogen specialised to colonise and persist the gastric mucosa and to cause severe gastroduodenal disease. A major disease-associated bacterial component is a type...
Selbach, Matthias, Moese, Stefan, Hurwitz, Robert, Hauck, Christof R., Meyer, Thomas F., Backert, Steffen
The gastric pathogen Helicobacter pylori translocates the CagA protein into epithelial cells by a type IV secretion process. Translocated CagA is tyrosine phosphorylated (CagAP-Tyr) on specific EPIYA...
Src Is the Kinase of the Helicobacter pylori CagA Protein in Vitro and in Vivo (2002)
Selbach, Matthias, Moese, Stefan, Hauck, Christof R., Meyer, Thomas F., Backert, Steffen
The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes phosphorylated on...
Bumann,Dirk, Metzger,Wolfram G., Mansouri,E., Palme,O., Wendland,M., Hurwitz,Robert, ...
Helicobacter pylori urease was expressed in the common Eve typhoid vaccine Ty21 a yielding Ty21a(pDB1). Nine volunteers received Ty21a(pDB1) and three control volunteers received Ty21 a. No serious...
PrimeArray: genome-scale primer design for DNA-microarray construction (2001)
Raddatz, Günter, Dehio, Michaela, Meyer, Thomas F., Dehio, Christoph
Summary: PrimeArray is a Windows program that computes oligonuceotide primer pairs for genome-scale gene amplification by the Polymerase Chain Reaction (PCR). The program supports the automated...
Hauck, Christof R., Grassmé, Heike, Bock, J., Jendrossek, Verena, Ferlinz, Klaus, Meyer, Thomas F., ...
The interaction with human phagocytes is a hallmark of symptomatic Neisseria gonorrhoeae infections. Gonococcal outer membrane proteins of the Opa family induce the opsoninindependent uptake of the...
Hauck, Christof R., Gulbins, Erich, Lang, Florian, Meyer, Thomas F.
Opa proteins of Neisseria gonorrhoeae bind to CD66 receptors on human phagocytes, thereby inducing efficient uptake of the bacteria in the absence of opsonins. The interaction of Opa proteins and...
Hauck, Christof R., Meyer, Thomas F., Lang, Florian, Gulbins, Erich
The interaction of Neisseria gonorrhoeae with human phagocytes is a hallmark of gonococcal infections. Recently, CD66 molecules have been characterized as receptors for Opa52-expressing gonococci on...
Hauck, Christof R., Meyer, Thomas F.
Lysosomal/phagosomal membranes of mammalian cells are coated by highly conserved glycoproteins (lamps) that are thought to protect the membranes from degradation. Interestingly, we identified an...
Hauck, Christof R., Lorenzen, Dirk, Saas, Joachim, Meyer, Thomas F.
The extreme host specificity of pathogenic neisseriae limits investigations aimed at the analysis of bacterialhost interactions almost completely to the use of in vitro models. Although permanent...
The pastor in ministry with the principal and teachers of a Lutheran elementary school / (1972)
Thesis (B.D.)--Concordia Theological Seminary, Springfield, Ill., 1972.
Maurer, Jochen, Jose, Joachim, Meyer, Thomas F.
The current model for autodisplay suggests a mechanism that allows a passenger protein to be translocated across the outer membrane by coordinate action of a C-terminal β-barrel and its preceding...
Lattemann, Claus T., Maurer, Jochen, Gerland, Elke, Meyer, Thomas F.
Members of the protein family of immunoglobulin A1 protease-like autotransporters comprise multidomain precursors consisting of a C-terminal autotransporter domain that promotes the translocation of...
Scheuerpflug, Ina, Rudel, Thomas, Ryll, Roland, Pandit, Jasmine, Meyer, Thomas F.
Unlike other type 4 pili, the neisserial pili consist of at least two distinct proteins, the highly variable major subunit PilE forming the pilus fiber and the tip-associated adhesin PilC. PilC...
Hauck, Christof R., Gulbins, Erich, Lang, Florian, Meyer, Thomas F.
Opa proteins of Neisseria gonorrhoeae bind to CD66 receptors on human phagocytes, thereby inducing efficient uptake of the bacteria in the absence of opsonins. The interaction of Opa proteins and...
Muenzner, Petra, Dehio, Christoph, Fujiwara, Taku, Achtman, Mark, Meyer, Thomas F., Gray-Owen, Scott D.
The carcinoembryonic antigen (CEA) family member CEACAM1 (previously called biliary glycoprotein or CD66a) was previously shown to function as a receptor that can mediate the binding of Opa...
Neisseria gonorrhoeae Porin Modifies the Oxidative Burst of Human Professional Phagocytes
Lorenzen, Dirk R., Günther, Dirk, Pandit, Jasmine, Rudel, Thomas, Brandt, Ernst, Meyer, Thomas F.
A hallmark of infection with the gram-negative bacterium Neisseria gonorrhoeae is the local infiltration and subsequent activation of polymorphonuclear neutrophils. Several gonococcal outer membrane...
Aebischer, Toni, Laforsch, Stephanie, Hurwitz, Robert, Brombacher, Frank, Meyer, Thomas F.
Vaccination of interleukin-4 (IL-4) receptor α (IL-4Rα) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica...
Lucas, Bernadette, Bumann, Dirk, Walduck, Anna, Koesling, Jan, Develioglu, Leyla, Meyer, Thomas F., ...
Protection in the murine model of Helicobacter pylori infection may be mediated by CD4+ T cells, but the mechanism remains unclear. To better understand how protection occurs in this model, we...
Ramarao, Nalini, Meyer, Thomas F.
Helicobacter pylori infection of the stomach epithelium is characterized by an infiltration of polymorphonuclear and mononuclear cells. These immune cells contribute to mucosal damage which may...
Rajalingam, Krishnaraj, Al-Younes, Hesham, Müller, Anne, Meyer, Thomas F., Szczepek, Agnes J., Rudel, Thomas
The obligate intracellular pathogen Chlamydophila pneumoniae (Chlamydia pneumoniae) initiates infections in humans via the mucosal epithelia of the respiratory tract. Here, we report that epithelial...
Billker, Oliver, Popp, Andreas, Brinkmann, Volker, Wenig, Gerald, Schneider, Jutta, Caron, Emmanuelle, ...
Opa adhesins of pathogenic Neisseria species target four members of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family. CEACAM receptors mediate...
VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways
Müller, Anne, Rassow, Joachim, Grimm, Jan, Machuy, Nikolaus, Meyer, Thomas F., Rudel, Thomas
The human pathogen Neisseria gonorrhoeae induces host cell apoptosis during infection by delivering the outer membrane protein PorB to the host cell’s mitochondria. PorB is a pore-forming β-barrel...
Neisserial Immunoglobulin A1 Protease Induces Specific T-Cell Responses in Humans
Tsirpouchtsidis, Anastasios, Hurwitz, Robert, Brinkmann, Volker, Meyer, Thomas F., Haas, Gaby
We have previously shown that immunoglobulin A1 (IgA1) protease, an exoenzyme of pathogenic neisseriae, can trigger the release of proinflammatory cytokines from human monocytic subpopulations. Here,...
Selbach, Matthias, Moese, Stefan, Meyer, Thomas F., Backert, Steffen
The type IV secretion machinery encoded by the cag pathogenicity island (PAI) of Helicobacter pylori has been implicated in a series of host responses during infection. Here, we analyzed the function...
Kwok, Terry, Backert, Steffen, Schwarz, Heinz, Berger, Jürgen, Meyer, Thomas F.
Although Helicobacter pylori has generally been considered an extracellular pathogen, a number of in vitro infection experiments and biopsy examinations have shown that it is capable of occasionally...
Proteome Analysis of Secreted Proteins of the Gastric Pathogen Helicobacter pylori
Bumann, Dirk, Aksu, Sevil, Wendland, Meike, Janek, Katharina, Zimny-Arndt, Uschi, Sabarth, Nicolas, ...
Secreted proteins (the secretome) of the human pathogen Helicobacter pylori may mediate important pathogen-host interactions, but such proteins are technically difficult to analyze. Here, we report...
Moese, Stefan, Selbach, Matthias, Meyer, Thomas F., Backert, Steffen
Infection with cag+ but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule 1 is up-regulated and...
Bumann, Dirk, Holland, Petra, Siejak, Frank, Koesling, Jan, Sabarth, Nicolas, Lamer, Stefanie, ...
Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter...
Selbach, Matthias, Moese, Stefan, Hurwitz, Robert, Hauck, Christof R., Meyer, Thomas F., Backert, Steffen
The gastric pathogen Helicobacter pylori translocates the CagA protein into epithelial cells by a type IV secretion process. Translocated CagA is tyrosine phosphorylated (CagAP-Tyr) on specific...
Rizos, Konstantin, Lattemann, Claus T., Bumann, Dirk, Meyer, Thomas F., Aebischer, Toni
Live attenuated Salmonella strains expressing antigens of pathogens are promising oral vaccine candidates. There is growing evidence that the topology of expression of the foreign antigens can have a...
Müller, Anne, Günther, Dirk, Brinkmann, Volker, Hurwitz, Robert, Meyer, Thomas F., Rudel, Thomas
Infection of cell cultures with Neisseria gonorrhoeae results in apoptosis that is mediated by the PorB porin. During the infection process porin translocates from the outer bacterial membrane into...
Backert, Steffen, Schwarz, Tobias, Miehlke, Stephan, Kirsch, Christian, Sommer, Christian, Kwok, Terry, ...
Helicobacter pylori is the causative agent of a variety of gastric diseases, but the clinical relevance of bacterial virulence factors is still controversial. Virulent strains carrying the cag...
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins
Morand, Philippe C, Bille, Emmanuelle, Morelle, Sandrine, Eugène, Emmanuel, Beretti, Jean-Luc, Wolfgang, Matthew, ...
Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a...
Helicobacter pylori Induces AGS Cell Motility and Elongation via Independent Signaling Pathways
Moese, Stefan, Selbach, Matthias, Kwok, Terry, Brinkmann, Volker, König, Wolfgang, Meyer, Thomas F., ...
Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in...
Interaction of Chlamydia trachomatis Serovar L2 with the Host Autophagic Pathway
Al-Younes, Hesham M., Brinkmann, Volker, Meyer, Thomas F.
Chlamydiae are obligate intracellular pathogens that replicate within a membrane-bound compartment (the inclusion) and are associated with important human diseases, such as trachoma, pneumonia, and...
Lack of Stage-Specific Proteins in Coccoid Helicobacter pylori Cells
Bumann, Dirk, Habibi, Hajar, Kan, Biao, Schmid, Monika, Goosmann, Christian, Brinkmann, Volker, ...
Helicobacter pylori exists in two distinct forms, rod shaped or coccoid, in stomachs of infected patients. Based on in vitro proteome comparisons, there are no detectable coccoid-specific proteins,...
Kirchner, Marieluise, Heuer, Dagmar, Meyer, Thomas F.
Neisseria gonorrhoeae is a gram-negative bacterial pathogen which infects the human mucosal epithelium. An early critical event in neisserial infection is the type IV pilus-mediated adherence to the...
Bauer, Bianca, Moese, Stefan, Bartfeld, Sina, Meyer, Thomas F., Selbach, Matthias
Helicobacter pylori persistently infects the human stomach and can cause gastritis, gastric ulceration, and gastric cancer. The type IV secretion system (TFSS) of virulent H. pylori strains...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Characterization of the ArsRS Regulon of Helicobacter pylori, Involved in Acid Adaptation†
Pflock, Michael, Finsterer, Nadja, Joseph, Biju, Mollenkopf, Hans, Meyer, Thomas F., Beier, Dagmar
The human gastric pathogen Helicobacter pylori is extremely well adapted to the highly acidic conditions encountered in the stomach. The pronounced acid resistance of H. pylori relies mainly on the...
Kühlewein, Christiane, Rechner, Cindy, Meyer, Thomas F., Rudel, Thomas
Obligate human-pathogenic Neisseria gonorrhoeae expresses numerous variant surface proteins mediating adherence to and invasion of target cells. The invariant major outer membrane porin PorB of...
Maurer, Jochen, Jose, Joachim, Meyer, Thomas F.
The current model for autodisplay suggests a mechanism that allows a passenger protein to be translocated across the outer membrane by coordinate action of a C-terminal β-barrel and its preceding...
Lattemann, Claus T., Maurer, Jochen, Gerland, Elke, Meyer, Thomas F.
Members of the protein family of immunoglobulin A1 protease-like autotransporters comprise multidomain precursors consisting of a C-terminal autotransporter domain that promotes the translocation of...
Scheuerpflug, Ina, Rudel, Thomas, Ryll, Roland, Pandit, Jasmine, Meyer, Thomas F.
Unlike other type 4 pili, the neisserial pili consist of at least two distinct proteins, the highly variable major subunit PilE forming the pilus fiber and the tip-associated adhesin PilC. PilC...
Hauck, Christof R., Gulbins, Erich, Lang, Florian, Meyer, Thomas F.
Opa proteins of Neisseria gonorrhoeae bind to CD66 receptors on human phagocytes, thereby inducing efficient uptake of the bacteria in the absence of opsonins. The interaction of Opa proteins and...
Muenzner, Petra, Dehio, Christoph, Fujiwara, Taku, Achtman, Mark, Meyer, Thomas F., Gray-Owen, Scott D.
The carcinoembryonic antigen (CEA) family member CEACAM1 (previously called biliary glycoprotein or CD66a) was previously shown to function as a receptor that can mediate the binding of Opa...
Neisseria gonorrhoeae Porin Modifies the Oxidative Burst of Human Professional Phagocytes
Lorenzen, Dirk R., Günther, Dirk, Pandit, Jasmine, Rudel, Thomas, Brandt, Ernst, Meyer, Thomas F.
A hallmark of infection with the gram-negative bacterium Neisseria gonorrhoeae is the local infiltration and subsequent activation of polymorphonuclear neutrophils. Several gonococcal outer membrane...
Aebischer, Toni, Laforsch, Stephanie, Hurwitz, Robert, Brombacher, Frank, Meyer, Thomas F.
Vaccination of interleukin-4 (IL-4) receptor α (IL-4Rα) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica...
Lucas, Bernadette, Bumann, Dirk, Walduck, Anna, Koesling, Jan, Develioglu, Leyla, Meyer, Thomas F., ...
Protection in the murine model of Helicobacter pylori infection may be mediated by CD4+ T cells, but the mechanism remains unclear. To better understand how protection occurs in this model, we...
Ramarao, Nalini, Meyer, Thomas F.
Helicobacter pylori infection of the stomach epithelium is characterized by an infiltration of polymorphonuclear and mononuclear cells. These immune cells contribute to mucosal damage which may...
Rajalingam, Krishnaraj, Al-Younes, Hesham, Müller, Anne, Meyer, Thomas F., Szczepek, Agnes J., Rudel, Thomas
The obligate intracellular pathogen Chlamydophila pneumoniae (Chlamydia pneumoniae) initiates infections in humans via the mucosal epithelia of the respiratory tract. Here, we report that epithelial...
Billker, Oliver, Popp, Andreas, Brinkmann, Volker, Wenig, Gerald, Schneider, Jutta, Caron, Emmanuelle, ...
Opa adhesins of pathogenic Neisseria species target four members of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family. CEACAM receptors mediate...
VDAC and the bacterial porin PorB of Neisseria gonorrhoeae share mitochondrial import pathways
Müller, Anne, Rassow, Joachim, Grimm, Jan, Machuy, Nikolaus, Meyer, Thomas F., Rudel, Thomas
The human pathogen Neisseria gonorrhoeae induces host cell apoptosis during infection by delivering the outer membrane protein PorB to the host cell’s mitochondria. PorB is a pore-forming β-barrel...
Neisserial Immunoglobulin A1 Protease Induces Specific T-Cell Responses in Humans
Tsirpouchtsidis, Anastasios, Hurwitz, Robert, Brinkmann, Volker, Meyer, Thomas F., Haas, Gaby
We have previously shown that immunoglobulin A1 (IgA1) protease, an exoenzyme of pathogenic neisseriae, can trigger the release of proinflammatory cytokines from human monocytic subpopulations. Here,...
Selbach, Matthias, Moese, Stefan, Meyer, Thomas F., Backert, Steffen
The type IV secretion machinery encoded by the cag pathogenicity island (PAI) of Helicobacter pylori has been implicated in a series of host responses during infection. Here, we analyzed the function...
Kwok, Terry, Backert, Steffen, Schwarz, Heinz, Berger, Jürgen, Meyer, Thomas F.
Although Helicobacter pylori has generally been considered an extracellular pathogen, a number of in vitro infection experiments and biopsy examinations have shown that it is capable of occasionally...
Proteome Analysis of Secreted Proteins of the Gastric Pathogen Helicobacter pylori
Bumann, Dirk, Aksu, Sevil, Wendland, Meike, Janek, Katharina, Zimny-Arndt, Uschi, Sabarth, Nicolas, ...
Secreted proteins (the secretome) of the human pathogen Helicobacter pylori may mediate important pathogen-host interactions, but such proteins are technically difficult to analyze. Here, we report...
Moese, Stefan, Selbach, Matthias, Meyer, Thomas F., Backert, Steffen
Infection with cag+ but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule 1 is up-regulated and...
Bumann, Dirk, Holland, Petra, Siejak, Frank, Koesling, Jan, Sabarth, Nicolas, Lamer, Stefanie, ...
Preclinical mouse infection models are widely used for Helicobacter vaccine development, but how well such models mimic important aspects of human infections is unknown. A comparison of Helicobacter...
Selbach, Matthias, Moese, Stefan, Hurwitz, Robert, Hauck, Christof R., Meyer, Thomas F., Backert, Steffen
The gastric pathogen Helicobacter pylori translocates the CagA protein into epithelial cells by a type IV secretion process. Translocated CagA is tyrosine phosphorylated (CagAP-Tyr) on specific...
Rizos, Konstantin, Lattemann, Claus T., Bumann, Dirk, Meyer, Thomas F., Aebischer, Toni
Live attenuated Salmonella strains expressing antigens of pathogens are promising oral vaccine candidates. There is growing evidence that the topology of expression of the foreign antigens can have a...
Müller, Anne, Günther, Dirk, Brinkmann, Volker, Hurwitz, Robert, Meyer, Thomas F., Rudel, Thomas
Infection of cell cultures with Neisseria gonorrhoeae results in apoptosis that is mediated by the PorB porin. During the infection process porin translocates from the outer bacterial membrane into...
Backert, Steffen, Schwarz, Tobias, Miehlke, Stephan, Kirsch, Christian, Sommer, Christian, Kwok, Terry, ...
Helicobacter pylori is the causative agent of a variety of gastric diseases, but the clinical relevance of bacterial virulence factors is still controversial. Virulent strains carrying the cag...
Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins
Morand, Philippe C, Bille, Emmanuelle, Morelle, Sandrine, Eugène, Emmanuel, Beretti, Jean-Luc, Wolfgang, Matthew, ...
Pathogenic Neisseria express type IV pili (tfp), which have been shown to play a central role in the interactions of bacteria with their environment. The regulation of piliation thus constitutes a...
Helicobacter pylori Induces AGS Cell Motility and Elongation via Independent Signaling Pathways
Moese, Stefan, Selbach, Matthias, Kwok, Terry, Brinkmann, Volker, König, Wolfgang, Meyer, Thomas F., ...
Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in...
Interaction of Chlamydia trachomatis Serovar L2 with the Host Autophagic Pathway
Al-Younes, Hesham M., Brinkmann, Volker, Meyer, Thomas F.
Chlamydiae are obligate intracellular pathogens that replicate within a membrane-bound compartment (the inclusion) and are associated with important human diseases, such as trachoma, pneumonia, and...
Lack of Stage-Specific Proteins in Coccoid Helicobacter pylori Cells
Bumann, Dirk, Habibi, Hajar, Kan, Biao, Schmid, Monika, Goosmann, Christian, Brinkmann, Volker, ...
Helicobacter pylori exists in two distinct forms, rod shaped or coccoid, in stomachs of infected patients. Based on in vitro proteome comparisons, there are no detectable coccoid-specific proteins,...
Kirchner, Marieluise, Heuer, Dagmar, Meyer, Thomas F.
Neisseria gonorrhoeae is a gram-negative bacterial pathogen which infects the human mucosal epithelium. An early critical event in neisserial infection is the type IV pilus-mediated adherence to the...
Bauer, Bianca, Moese, Stefan, Bartfeld, Sina, Meyer, Thomas F., Selbach, Matthias
Helicobacter pylori persistently infects the human stomach and can cause gastritis, gastric ulceration, and gastric cancer. The type IV secretion system (TFSS) of virulent H. pylori strains...
Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Gressmann, Helga, Linz, Bodo, Ghai, Rohit, Pleissner, Klaus-Peter, Schlapbach, Ralph, Yamaoka, Yoshio, ...
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, but...
Characterization of the ArsRS Regulon of Helicobacter pylori, Involved in Acid Adaptation†
Pflock, Michael, Finsterer, Nadja, Joseph, Biju, Mollenkopf, Hans, Meyer, Thomas F., Beier, Dagmar
The human gastric pathogen Helicobacter pylori is extremely well adapted to the highly acidic conditions encountered in the stomach. The pronounced acid resistance of H. pylori relies mainly on the...
Kühlewein, Christiane, Rechner, Cindy, Meyer, Thomas F., Rudel, Thomas
Obligate human-pathogenic Neisseria gonorrhoeae expresses numerous variant surface proteins mediating adherence to and invasion of target cells. The invariant major outer membrane porin PorB of...
Mäurer, André P, Mehlitz, Adrian, Mollenkopf, Hans J, Meyer, Thomas F
The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic...
Pflock, Michael, Bathon, Melanie, Schär, Jennifer, Müller, Stefanie, Mollenkopf, Hans, Meyer, Thomas F., ...
Helicobacter pylori is a gastric pathogen for which no nonhuman reservoir is known. In accordance with the tight adaptation to its unique habitat, the human stomach, H. pylori is endowed with a very...
Lorenzen, Dirk R., Düx, Frank, Wölk, Uwe, Tsirpouchtsidis, Anastasios, Haas, Gaby, Meyer, Thomas F.
A characteristic of human pathogenic Neisseriae is the production and secretion of an immunoglobulin (Ig)A1-specific serine protease (IgA1 protease) that cleaves preferentially human IgA1 and other...
Naumann, Michael, Weßler, Silja, Bartsch, Cornelia, Wieland, Björn, Meyer, Thomas F.
We have studied the effect of human bacterial pathogen Neisseria gonorrhoeae (Ngo) on the activation of nuclear factor (NF)-κB and the transcriptional activation of inflammatory cytokine genes upon...
Naumann, Michael, Rudel, Thomas, Wieland, Björn, Bartsch, Cornelia, Meyer, Thomas F.
Neisseria gonorrhoeae (Ngo), the etiologic agent of gonorrhea, induce a number of proinflammatory cytokines by contact to epithelial cells. Cytokine genes and a variety of other immune response genes...
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
Churin, Yuri, Al-Ghoul, Laila, Kepp, Oliver, Meyer, Thomas F., Birchmeier, Walter, Naumann, Michael
Infection with the human microbial pathogen Helicobacter pylori is assumed to lead to invasive gastric cancer. We find that H. pylori activates the hepatocyte growth factor/scatter factor receptor...
Braun, Peter R., Al-Younes, Hesham, Gussmann, Joscha, Klein, Jeannette, Schneider, Erwin, Meyer, Thomas F.
Chlamydiaceae are obligate intracellular bacterial pathogens that strictly depend on host metabolites, such as nucleotides, lipids, and amino acids. Depletion of amino acids in cell culture media...
The Autodisplay Story, from Discovery to Biotechnical and Biomedical Applications
Jose, Joachim, Meyer, Thomas F.
Summary: Among the pathways used by gram-negative bacteria for protein secretion, the autotransporter pathway represents a solution of impressive simplicity. Proteins are transported, independent of...
IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via Autophagy
Al-Zeer, Munir A., Al-Younes, Hesham M., Braun, Peter R., Zerrahn, Jens, Meyer, Thomas F.
Chlamydial infection of the host cell induces Gamma interferon (IFNγ), a central immunoprotector for humans and mice. The primary defense against Chlamydia infection in the mouse involves the...
Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo
Walduck, Anna K, Weber, Matthias, Wunder, Christian, Juettner, Stefan, Stolte, Manfred, Vieth, Michael, ...
Bramsen, Jesper B., Laursen, Maria B., Nielsen, Anne F., Hansen, Thomas B., Bus, Claus, Langkjær, Niels, ...
The use of chemically synthesized short interfering RNAs (siRNAs) is currently the method of choice to manipulate gene expression in mammalian cell culture, yet improvements of siRNA design is...
Morand, Philippe C., Drab, Marek, Rajalingam, Krishnaraj, Nassif, Xavier, Meyer, Thomas F.
Neisseria meningitidis is a strictly human pathogen that has two facets since asymptomatic carriage can unpredictably turn into fulminant forms of infection. Meningococcal pathogenesis relies on the...
Lipinski, Anette Rejman, Heymann, Julia, Meissner, Charlotte, Karlas, Alexander, Brinkmann, Volker, Meyer, Thomas F., ...
Many intracellular pathogens that replicate in special membrane bound compartments exploit cellular trafficking pathways by targeting small GTPases, including Rab proteins. Members of the...