Thomas Flatt

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes (2010)

Vogl, Claus, Flatt, Thomas, Fuhrmann, Bernd, Hofmann, Elisabeth, Wallner, Barbara, Stiefvater, Rita, ...

Abstract Background Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and...

Hormonal regulation of the humoral innate immune response in Drosophila melanogaster (2008)

Flatt, Thomas, Heyland, Andreas, Rus, Florentina, Porpiglia, Ermelinda, Sherlock, Chris, Yamamoto, Rochele, ...

Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for...

Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster (2007)

Flatt, Thomas, Kawecki, Tadeusz J.

Trade-offs between reproduction and life span are ubiquitous, but little is known about their underlying mechanisms. Here we combine treatment with the juvenile hormone analog (JHa) methoprene and...

Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster (2007)

Flatt, Thomas, Kawecki, Tadeusz J.

Trade-offs between reproduction and life span are ubiquitous, but little is known about their underlying mechanisms. Here we combine treatment with the juvenile hormone analog (JHa) methoprene and...

Comparing thyroid and insect hormone signaling (2006)

Flatt, Thomas, Moroz, Leonid L., Tatar, Marc, Heyland, Andreas

Synopsis Transitions between different states of development, physiology, and life history are typically mediated by hormones. In insects, metamorphosis and reproductive maturation are regulated by...

Comparing thyroid and insect hormone signaling (2006)

Flatt, Thomas, Moroz, Leonid L., Tatar, Marc, Heyland, Andreas

Transitions between different states of development, physiology, and life history are typically mediated by hormones. In insects, metamorphosis and reproductive maturation are regulated by an...

Comparing thyroid and insect hormone signaling (2006)

Flatt, Thomas, Moroz, Leonid L., Tatar, Marc, Heyland, Andreas

Synopsis Transitions between different states of development, physiology, and life history are typically mediated by hormones. In insects, metamorphosis and reproductive maturation are regulated by...

Stabilizing factors interact in promoting host–parasite coexistence (2005)

Flatt, Thomas, Scheuring, István

Understanding the mechanisms that promote coexistence among species is a fundamental problem in evolutionary ecology. Such mechanisms include environmental noise, spatial population structure,...

Winter weather affects asp viper Vipera aspis population dynamics through susceptible juveniles (2005)

Altwegg, Res, Dummermuth, Stefan, Anholt, Bradley R., Flatt, Thomas

Detailed studies on mammals and birds have shown that the effects of climate variation on population dynamics often depend on population composition, because weather affects different subsets of a...

Stabilizing factors interact in promoting host–parasite coexistence (2005)

Flatt, Thomas, Scheuring, István

Understanding the mechanisms that promote coexistence among species is a fundamental problem in evolutionary ecology. Such mechanisms include environmental noise, spatial population structure,...

Winter weather affects asp viper Vipera aspis population dynamics through susceptible juveniles (2005)

Altwegg, Res, Dummermuth, Stefan, Anholt, Bradley R., Flatt, Thomas

Detailed studies on mammals and birds have shown that the effects of climate variation on population dynamics often depend on population composition, because weather affects different subsets of a...

Evolution in group-structured populations can resolve the tragedy of the commons

Killingback, Timothy, Bieri, Jonas, Flatt, Thomas

Public goods are the key features of all human societies and are also important in many animal societies. Collaborative hunting and collective defence are but two examples of public goods that have...

Drosophila germ-line modulation of insulin signaling and lifespan

Flatt, Thomas, Min, Kyung-Jin, D'Alterio, Cecilia, Villa-Cuesta, Eugenia, Cumbers, John, Lehmann, Ruth, ...

Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF)...