Normal RNAi response in human fragile × fibroblasts (2009)
Madsen, Charlotte, Grønskov, Karen, Brøndum-Nielsen, Karen, Jensen, Thomas G
Abstract Background Fragile × syndrome is caused by loss of expression of the FMRP protein involved in the control of a large number of mRNA targets. The Drosophila ortholog dFXR interacts with a...
Liu, Jian, Skjørringe, Tina, Gjetting, Torben, Jensen, Thomas G
Abstract Background PhiC31 integrase facilitates efficient integration of transgenes into human and mouse genomes and is considered for clinical gene therapy. However recent studies have shown that...
Regulated gene insertion by steroid-induced {Phi}C31 integrase (2008)
Sharma, Nynne, Moldt, Brian, Dalsgaard, Trine, Jensen, Thomas G., Mikkelsen, Jacob Giehm
Nonviral integration systems are widely used genetic tools in transgenesis and play increasingly important roles in strategies for therapeutic gene transfer. Methods to efficiently regulate the...
Nanomedicine: Techniques, potentials, and ethical implications (2006)
Ebbesen, Mette, Jensen, Thomas G.
Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on...
Nanomedicine: Techniques, Potentials, and Ethical Implications (2006)
Mette Ebbesen, Thomas G. Jensen
Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on...
Bross, Peter, Jespersen, Charlotte, Jensen, Thomas G., Andresen, Brage S., Kristensen, Morten Juhl, Winter, Vibeke, ...
We have used expression of human medium chain acyl-CoA dehydrogenase (MCAD) in Escherichia coli as a model system for dissecting the molecular effects of two mutations detected in patients with MCAD...
Bross, Peter, Jensen, Thomas G., Andresen, Brage S., Kjeldsen, Margrethe, Nandy, Andreas, Kølvraa, Steen, ...
Two-dimensional gel electrophoresis was used to study and compare wild type medium-chain acyl-CoA dehydrogenase (MCAD; EC 1.3.99.3) and missense mutant enzyme found in patients with MCAD deficiency....
Bross, Peter, Andresen, Brage S., Winter, Vibeke, Kräutle, Franz-Georg, Jensen, Thomas G., Nandy, Andreas, ...
The influence of co-overexpression of the bacterial chaperonins GroEL and GroES on solubility, tetramer formation and enzyme activity of three variants of heterologously-expressed human medium-chain...
Andresen, Brage Storstein, Bross, Peter, Jensen, Thomas G., Winter, Vibeke, Knudsen, Inga, Kølvraa, Steen, ...
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a serious and potentially fatal inherited defect in the β-oxidation of fatty acids. Approximately 80% of patients with MCAD deficiency are...
Andresen, Brage Storstein, Bross, Peter, Jensen, Thomas G., Winter, Vibeke, Knudsen, Inga, Kølvraa, Steen, ...
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is a serious and potentially fatal inherited defect in the β-oxidation of fatty acids. Approximately 80% of patients with MCAD deficiency are...
Nanomedicine: Techniques, Potentials, and Ethical Implications
Ebbesen, Mette, Jensen, Thomas G.
Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on...
Disease-causing Mutations in Exon 11 of the Medium-Chain Acyl-CoA Dehydrogenase Gene
Andresen, Brage Storstein, Jensen, Thomas G., Bross, Peter, Knudsen, Inga, Winter, Vibeke, Kølvraa, Steen, ...
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most commonly recognized defect of the mitochondrial β-oxidation in humans. It is a potentially fatal, autosomal recessive inherited...
Regulated gene insertion by steroid-induced ΦC31 integrase
Sharma, Nynne, Moldt, Brian, Dalsgaard, Trine, Jensen, Thomas G., Mikkelsen, Jacob Giehm
Nonviral integration systems are widely used genetic tools in transgenesis and play increasingly important roles in strategies for therapeutic gene transfer. Methods to efficiently regulate the...
Ethical Perspectives on RNA Interference Therapeutics
Ebbesen, Mette, Jensen, Thomas G., Andersen, Svend, Pedersen, Finn Skou
RNA interference is a mechanism for controlling normal gene expression which has recently begun to be employed as a potential therapeutic agent for a wide range of disorders, including cancer,...