Thornley, Thomas B., Phillips, Nancy E., Beaudette-Zlatanova, Britte C., Markees, Thomas G., Bahl, Kapil, Brehm, Michael A., ...
TLR activation of innate immunity prevents the induction of transplantation tolerance and shortens skin allograft survival in mice treated with costimulation blockade. The mechanism by which TLR...
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice (2007)
Yamazaki, Masahiro, Pearson, Todd, Brehm, Michael A., Miller, David M., Mangada, Julie A., Markees, Thomas G., ...
Regulatory T cells (Treg) are important in peripheral tolerance, but their role in establishing and maintaining hematopoietic mixed chimerism and generating central tolerance is unclear. We now show...
Brehm, Michael A., Mangada, Julie A., Markees, Thomas G., Pearson, Todd, Daniels, Keith A., Thornley, Thomas B., ...
Allograft transplantation requires chronic immunosuppression, but there is no effective strategy to evaluate the long-term maintenance of immunosuppression other than assessment of graft function....
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts (2006)
Thornley, Thomas B., Brehm, Michael A., Markees, Thomas G., Shultz, Leonard D., Mordes, John P., Welsh, Raymond M., ...
Costimulation blockade protocols are effective in prolonging allograft survival in animal models and are entering clinical trials, but how environmental perturbants affect graft survival remains...
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice (2004)
Gordon, Ethel J., Wicker, Linda S., Peterson, Laurence B., Serreze, David V., Markees, Thomas G., Shultz, Leonard D., ...
Costimulation blockade induces prolonged rat islet and skin xenograft survival in C57BL/6 mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune diabetes, are resistant to...
Markees, Thomas G., Pearson, Todd, Cuthbert, Amy, Pearson, Andrea L., Shultz, Leonard D., Leif, Jean H., ...
BACKGROUND: Treatment with anti-CD154 monoclonal antibody (mAb) plus a donor-specific transfusion (DST) of spleen cells prolongs skin allograft survival in mice through a mechanism involving deletion...
Pearson, Todd, Weiser, Peter, Markees, Thomas G., Serreze, David V., Wicker, Linda S., Peterson, Laurence B., ...
NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance to transplantation tolerance induction. These two phenotypes are genetically separable. Costimulation blockade...
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms (2003)
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...
Recent advances in islet transplantation have enabled physicians to cure type 1 autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side effects and long-term health...
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice (2003)
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Marron, Michele P., Wicker, Linda S., ...
Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction...
Brehm, Michael A., Markees, Thomas G., Daniels, Keith A., Greiner, Dale L., Rossini, Aldo A., Welsh, Raymond M.
CD8 T cell cross-reactivity between heterologous viruses has been shown to provide protective immunity, induce immunopathology, influence the immunodominance of epitope-specific T cell responses, and...
Phillips, Nancy E., Markees, Thomas G., Mordes, John P., Greiner, Dale L., Rossini, Aldo A.
Treatment of mice with a single donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb to block CD40-mediated signaling uniformly induces donor-specific transplantation tolerance....
Pearson, Todd, Markees, Thomas G., Wicker, Linda S., Serreze, David V., Peterson, Laurence B., Mordes, John P., ...
The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD mice resist...
Forman, Daron, Welsh, Raymond M., Markees, Thomas G., Woda, Bruce A., Mordes, John P., Rossini, Aldo A., ...
Tolerance-based stem cell transplantation using sublethal conditioning is being considered for the treatment of human disease, but safety and efficacy remain to be established. We have shown that...
Skin allograft maintenance in a new synchimeric model system of tolerance (2001)
Iwakoshi, Neal N., Markees, Thomas G., Turgeon, Nicole A., Thornley, Thomas B., Cuthbert, Amy, Leif, Jean, ...
Treatment of mice with a single donor-specific transfusion plus a brief course of anti-CD154 mAb uniformly induces donor-specific transplantation tolerance characterized by the deletion of...
Seung, Edward, Iwakoshi, Neal N., Woda, Bruce A., Markees, Thomas G., Mordes, John P., Rossini, Aldo A., ...
We describe a tolerance-based stem cell transplantation protocol that combines sublethal radiation with transient blockade of the CD40-CD154 costimulatory pathway using an anti-CD154 antibody. With...
Welsh, Raymond M., Markees, Thomas G., Woda, Bruce A., Daniels, Keith A., Brehm, Michael A., Mordes, John P., ...
Treatment with a 2-week course of anti-CD154 antibody and a single transfusion of donor leukocytes (a donor-specific transfusion or DST) permits skin allografts to survive for >100 days in...
Iwakoshi, Neal N., Mordes, John P., Markees, Thomas G., Phillips, Nancy E., Rossini, Aldo A., Greiner, Dale L.
A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. To study...
NOD mice have a generalized defect in their response to transplantation tolerance induction (1999)
Markees, Thomas G., Serreze, David V., Phillips, Nancy E., Sorli, Christopher H., Gordon, Ethel J., Shultz, Leonard D., ...
A protocol consisting of a single donor-specific transfusion (DST) plus a brief course of anti-CD154 monoclonal antibody (anti-CD40 ligand mAb) induces permanent islet allograft survival in...
Markees, Thomas G., Phillips, Nancy E., Gordon, Ethel J., Noelle, Randolph J., Shultz, Leonard D., Mordes, John P., ...
Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and anti-CD154 (anti-CD40-ligand) antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin grafts to survive...
Bouvé College of Pharmacy and Health Sciences.
Welsh, Raymond M., Markees, Thomas G., Woda, Bruce A., Daniels, Keith A., Brehm, Michael A., Mordes, John P., ...
Treatment with a 2-week course of anti-CD154 antibody and a single transfusion of donor leukocytes (a donor-specific transfusion or DST) permits skin allografts to survive for >100 days in...
Welsh, Raymond M., Markees, Thomas G., Woda, Bruce A., Daniels, Keith A., Brehm, Michael A., Mordes, John P., ...
Treatment with a 2-week course of anti-CD154 antibody and a single transfusion of donor leukocytes (a donor-specific transfusion or DST) permits skin allografts to survive for >100 days in...
Brehm, Michael A., Mangada, Julie, Markees, Thomas G., Pearson, Todd, Daniels, Keith A., Thornley, Thomas B., ...
Allograft transplantation requires chronic immunosuppression, but there is no effective strategy to evaluate the long-term maintenance of immunosuppression other than assessment of graft function....