Wüst, Stefan, Kumsta, Robert, Treutlein, Jens, Frank, Josef, Entringer, Sonja, Schulze, Thomas G., ...
Objective: A key regulator of serotonergic neurotransmission is the serotonin transporter (5-HTT) and a common 5HTT gene promoter polymorphism, termed 5HTTLPR, is associated with phenotypes related...
Schumacher, Johannes, Laje, Gonzalo, Jamra, Rami Abou, Becker, Tim, Mühleisen, Thomas W., Vasilescu, Catalina, ...
Association studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia. DISC1 encodes a multifunctional...
Identification of loci associated with schizophrenia by genome-wide association and follow-up (2008)
Donovan, Michael C., Craddock, Nicholas, Norton, Nadine, Williams, Hywel, Peirce, Timothy, Moskvina, Valentina, ...
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10-5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong...
Cichon, Sven, Winge, Ingeborg, Mattheisen, Manuel, Georgi, Alexander, Karpushova, Anna, Freudenberg, Jan, ...
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] controls a broad range of biological functions that are disturbed in affective disorder. In the brain, 5-HT production is controlled by...
Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome (2004)
Schulze, Thomas G., Zhang, Kui, Chen, Yu-Sheng, Akula, Nirmala, Sun, Fengzhu, McMahon, Francis J.
Recent studies suggest that the genome is organized into blocks of haplotypes, and efforts to create a genome-wide haplotype map of single-nucleotide polymorphisms (SNPs) are already underway....
Thomas G. Schulze, Kui Zhang, Yu-sheng Chen, Nirmala Akula, Fengzhu Sun, Francis J. Mcmahon
haplotype blocks and tag single-nucleotide
Schulze, Thomas G., Zhang, Kui, Chen, Yu-Sheng, Akula, Nirmala, Sun, Fengzhu, McMahon, Francis J.
Recent studies suggest that the genome is organized into blocks of haplotypes, and efforts to create a genome-wide haplotype map of SNPs are already underway. Haplotype blocks are defined...
Schulze, Thomas G., Zhang, Kui, Chen, Yu-Sheng, Akula, Nirmala, Sun, Fengzhu, McMahon, Francis J.
Recent studies suggest that the genome is organized into blocks of haplotypes, and efforts to create a genome-wide haplotype map of SNPs are already underway. Haplotype blocks are defined...
Can long-range microsatellite data be used to predict short-range linkage disequilibrium? (2002)
Schulze, Thomas G., Chen, Yu-Sheng, Akula, Nirmala, Hennessy, Kathleen, Badner, Judith A., McInnis, Melvin G., ...
The distribution of linkage disequilibrium (LD) across the genome is highly complex. Little is known about the relationship between long-range and short-range LD in a genomic region. We assessed...
Cichon, Sven, Schumacher, Johannes, Müller, Daniel J., Hürter, Martina, Windemuth, Christine, Strauch, Konstantin, ...
Cichon, Sven, Schumacher, Johannes, Müller, Daniel J., Hürter, Martina, Windemuth, Christine, Strauch, Konstantin, ...
Bipolar affective disorder (BPAD), also known as manic depressive illness, is a severe psychiatric disorder characterized by episodes of mania and depression. It has a lifetime prevalence of...
Schumacher, Johannes, Kaneva, Radka, Jamra, Rami Abou, Diaz, Guillermo Orozco, Ohlraun, Stephanie, Milanova, Vihra, ...
We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian...
The DTNBP1 (Dysbindin) Gene Contributes to Schizophrenia, Depending on Family History of the Disease
Van Den Bogaert, Ann, Schumacher, Johannes, Schulze, Thomas G., Otte, Andreas C., Ohlraun, Stephanie, Kovalenko, Svetlana, ...
We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of...
Hillmer, Axel M., Hanneken, Sandra, Ritzmann, Sibylle, Becker, Tim, Freudenberg, Jan, Brockschmidt, Felix F., ...
Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the...
Schumacher, Johannes, Kaneva, Radka, Jamra, Rami Abou, Diaz, Guillermo Orozco, Ohlraun, Stephanie, Milanova, Vihra, ...
We present the findings of a large linkage study of bipolar affective disorder (BPAD) that involved genomewide analysis of 52 families (448 genotyped individuals) of Spanish, Romany, and Bulgarian...