Lomelí, Hilda, Starling, Christa, Gridley, Thomas
Abstract Background Members of the Snail gene family, which encode zinc finger proteins that function as transcriptional repressors, play essential roles during embryonic development in vertebrates....
The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo (2007)
Monet, Marie, Domenga, Valérie, Lemaire, Barbara, Souilhol, Céline, Langa, Francina, Babinet, Charles, ...
Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL) is the most prominent known cause of inherited stroke and vascular dementia in human adult. The...
Amy E. Kiernan, Jingxia Xu, Thomas Gridley
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their...
Amy E. Kiernan, Jingxia Xu, Thomas Gridley
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, the sensory cells, and their associated...
Savagner, Pierre, Kusewitt, Donna, Carver, Ethan, Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, ...
During re-epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial-mesenchymal transition (EMT), including migratory activity and...
Savagner, Pierre, Kusewitt, Donna, Carver, Ethan, Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, ...
During re-epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial-mesenchymal transition (EMT), including migratory activity and...
Savagner, Pierre, Kusewitt, Donna, Carver, Ethan, Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, ...
During re-epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial-mesenchymal transition (EMT), including migratory activity and...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells (2004)
Domenga, Valérie, Fardoux, Peggy, Lacombe, Pierre, Monet, Marie, Maciazek, Jacqueline, Krebs, Luke T., ...
Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and...
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression (2003)
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Notch signaling and inherited disease syndromes (2003)
The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in organisms as diverse as insects, nematodes, echinoderms and...
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression (2003)
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Notch signaling is essential for vascular morphogenesis in mice (2000)
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice (1998)
Jiang, Rulang, Lan, Yu, Chapman, Harry D., Shawber, Carrie, Norton, Christine R., Serreze, David V., ...
The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition
Carver, Ethan A., Jiang, Rulang, Lan, Yu, Oram, Kathleen F., Gridley, Thomas
Snail family genes encode DNA binding zinc finger proteins that act as transcriptional repressors. Mouse embryos deficient for the Snail (Sna) gene exhibit defects in the formation of the mesoderm...
Notch signaling regulates left–right asymmetry determination by inducing Nodal expression
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Generation of left–right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of...
Roles for Nkx3.1 in prostate development and cancer
Bhatia-Gaur, Rajula, Donjacour, Annemarie A., Sciavolino, Peter J., Kim, Minjung, Desai, Nishita, Young, Peter, ...
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcinoma. Although this hyperproliferative process has been proposed to represent an inappropriate...
Notch signaling is essential for vascular morphogenesis in mice
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
Jiang, Rulang, Lan, Yu, Chapman, Harry D., Shawber, Carrie, Norton, Christine R., Serreze, David V., ...
The Notch signaling pathway is a conserved intercellular signaling mechanism that is essential for proper embryonic development in numerous metazoan organisms. We have examined the in vivo role of...
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
Domenga, Valérie, Fardoux, Peggy, Lacombe, Pierre, Monet, Marie, Maciazek, Jacqueline, Krebs, Luke T., ...
Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and...
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
Anthony, Todd E., Mason, Heather A., Gridley, Thomas, Fishell, Gord, Heintz, Nathaniel
Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the...
The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, Amy E, Xu, Jingxia, Gridley, Thomas
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their...
Oram, Kathleen F., Gridley, Thomas
In Drosophila, mutations in the Twist gene interact with mutations in the Snail gene. We show that the mouse Twist1 mutation interacts with Snai1 and Snai2 mutations to enhance aberrant cranial...
The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition
Carver, Ethan A., Jiang, Rulang, Lan, Yu, Oram, Kathleen F., Gridley, Thomas
Snail family genes encode DNA binding zinc finger proteins that act as transcriptional repressors. Mouse embryos deficient for the Snail (Sna) gene exhibit defects in the formation of the mesoderm...
Notch signaling regulates left–right asymmetry determination by inducing Nodal expression
Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Lan, Yu, Jiang, Rulang, ...
Generation of left–right asymmetry is an integral part of the establishment of the vertebrate body plan. Here we show that the Notch signaling pathway plays a primary role in the establishment of...
Roles for Nkx3.1 in prostate development and cancer
Bhatia-Gaur, Rajula, Donjacour, Annemarie A., Sciavolino, Peter J., Kim, Minjung, Desai, Nishita, Young, Peter, ...
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcinoma. Although this hyperproliferative process has been proposed to represent an inappropriate...
Notch signaling is essential for vascular morphogenesis in mice
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
Jiang, Rulang, Lan, Yu, Chapman, Harry D., Shawber, Carrie, Norton, Christine R., Serreze, David V., ...
The Notch signaling pathway is a conserved intercellular signaling mechanism that is essential for proper embryonic development in numerous metazoan organisms. We have examined the in vivo role of...
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells
Domenga, Valérie, Fardoux, Peggy, Lacombe, Pierre, Monet, Marie, Maciazek, Jacqueline, Krebs, Luke T., ...
Formation of a fully functional artery proceeds through a multistep process. Here we show that Notch3 is required to generate functional arteries in mice by regulating arterial differentiation and...
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
Krebs, Luke T., Shutter, John R., Tanigaki, Kenji, Honjo, Tasuku, Stark, Kevin L., Gridley, Thomas
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand...
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells
Anthony, Todd E., Mason, Heather A., Gridley, Thomas, Fishell, Gord, Heintz, Nathaniel
Radial glia function during CNS development both as neural progenitors and as a scaffolding supporting neuronal migration. To elucidate pathways involved in these functions, we mapped in vivo the...
The Notch Ligand JAG1 Is Required for Sensory Progenitor Development in the Mammalian Inner Ear
Kiernan, Amy E, Xu, Jingxia, Gridley, Thomas
In mammals, six separate sensory regions in the inner ear are essential for hearing and balance function. Each sensory region is made up of hair cells, which are the sensory cells, and their...
Oram, Kathleen F., Gridley, Thomas
In Drosophila, mutations in the Twist gene interact with mutations in the Snail gene. We show that the mouse Twist1 mutation interacts with Snai1 and Snai2 mutations to enhance aberrant cranial...
Murray, Stephen A., Gridley, Thomas
Snail family genes encode zinc finger transcriptional repressors that are key regulators of epithelial–mesenchymal transitions in vertebrates, including the transitions that generate the mesoderm...
Howell, Gareth R., Shindo, Mami, Murray, Stephen, Gridley, Thomas, Wilson, Lawriston A., Schimenti, John C.
L5Jcs1 is a perinatal lethal mutation uncovered in a screen for ENU-induced mutations on mouse chromosome 5. L5Jcs1 homozygotes exhibit posterior-to-anterior transformations of the vertebral column...
Genetic Background Modifies Inner Ear and Eye Phenotypes of Jag1 Heterozygous Mice
Kiernan, Amy E., Li, Renhua, Hawes, Norman L., Churchill, Gary A., Gridley, Thomas
Mice heterozygous for missense mutations of the Notch ligand Jagged1 (Jag1) exhibit head-shaking behavior indicative of an inner ear vestibular defect. In contrast, mice heterozygous for a targeted...
Escrivà, Maria, Peiró, Sandra, Herranz, Nicolás, Villagrasa, Patricia, Dave, Natàlia, Montserrat-Sentís, Bàrbara, ...
The product of the Snail1 gene is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition. Furthermore, ectopic expression of Snail1 in epithelial cells promotes...
Robert-Moreno, Àlex, Guiu, Jordi, Ruiz-Herguido, Cristina, López, M Eugenia, Inglés-Esteve, Julia, Riera, Lluis, ...
Specific deletion of Notch1 and RBPjκ in the mouse results in abrogation of definitive haematopoiesis concomitant with the loss of arterial identity at embryonic stage. As prior arterial...
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
Rodilla, Verónica, Villanueva, Alberto, Obrador-Hevia, Antonia, Robert-Moreno, Àlex, Fernández-Majada, Vanessa, Grilli, Andrea, ...
Notch has been linked to β-catenin-dependent tumorigenesis; however, the mechanisms leading to Notch activation and the contribution of the Notch pathway to colorectal cancer is not yet understood....