David J. Mitola, Hannah Aaronson, Lars Kjøller, Jørgen K. Larsen, Kenneth M. Yamada, Dudley K. Strickl, ...
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
List, Karin, Szabo, Roman, Molinolo, Alfredo, Sriuranpong, Virote, Redeye, Vivien, Murdock, Tricia, ...
Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potential...
Prothrombin deficiency results in embryonic and neonatal lethality in mice
Sun, William Y., Witte, David P., Degen, Jay L., Colbert, Melissa C., Burkart, Melissa C., Holmbäck, Kenn, ...
The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and...
Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin
Tsirka, Stella E., Bugge, Thomas H., Degen, Jay L., Strickland, Sidney
Mice deficient for plasminogen exhibit a variety of pathologies, all of which examined to date are reversed when the animals are also made fibrin(ogen) deficient. These results suggested that the...
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis
Xiao, Qing, Danton, Mary Jo S., Witte, David P., Kowala, Mark C., Valentine, Maria T., Bugge, Thomas H., ...
A critical link between hemostatic factors and atherosclerosis has been inferred from a variety of indirect observations, including the expression of procoagulant and fibrinolytic factors within...
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
Bezerra, Jorge A., Bugge, Thomas H., Melin-Aldana, Hector, Sabla, Gregg, Kombrinck, Keith W., Witte, David P., ...
Cellular proliferation and tissue remodeling are central to the regenerative response after a toxic injury to the liver. To explore the role of plasminogen in hepatic tissue remodeling and...
Potent antitumor activity of a urokinase-activated engineered anthrax toxin
Liu, Shihui, Aaronson, Hannah, Mitola, David J., Leppla, Stephen H., Bugge, Thomas H.
The acquisition of cell-surface urokinase plasminogen activator activity is a hallmark of malignancy. We generated an engineered anthrax toxin that is activated by cell-surface urokinase in vivo and...
Yepes, Manuel, Sandkvist, Maria, Coleman, Timothy A., Moore, Elizabeth, Wu, Jiang-Young, Mitola, David, ...
Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal plasticity. In this study we demonstrate that endogenous tPA...
Yepes, Manuel, Sandkvist, Maria, Moore, Elizabeth G., Bugge, Thomas H., Strickland, Dudley K., Lawrence, Daniel A.
The regulation of cerebrovascular permeability is critical for normal brain homeostasis, and the “breakdown” of the blood-brain barrier (BBB) is associated with the development of vasogenic edema...
Gebbia, Joseph A., Monco, Juan Carlos Garcia, Degen, Jay L., Bugge, Thomas H., Benach, Jorge L.
The role of the plasminogen activation system (PAS) was investigated during the course of infection of a relapsing fever Borrelia species in plasminogen-deficient (plg –/–) and control (plg +/+...
List, Karin, Szabo, Roman, Molinolo, Alfredo, Sriuranpong, Virote, Redeye, Vivien, Murdock, Tricia, ...
Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potential...
Matriptase: Potent Proteolysis on the Cell Surface
List, Karin, Bugge, Thomas H, Szabo, Roman
Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor...
Prothrombin deficiency results in embryonic and neonatal lethality in mice
Sun, William Y., Witte, David P., Degen, Jay L., Colbert, Melissa C., Burkart, Melissa C., Holmbäck, Kenn, ...
The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and...
Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin
Tsirka, Stella E., Bugge, Thomas H., Degen, Jay L., Strickland, Sidney
Mice deficient for plasminogen exhibit a variety of pathologies, all of which examined to date are reversed when the animals are also made fibrin(ogen) deficient. These results suggested that the...
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis
Xiao, Qing, Danton, Mary Jo S., Witte, David P., Kowala, Mark C., Valentine, Maria T., Bugge, Thomas H., ...
A critical link between hemostatic factors and atherosclerosis has been inferred from a variety of indirect observations, including the expression of procoagulant and fibrinolytic factors within...
Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
Bezerra, Jorge A., Bugge, Thomas H., Melin-Aldana, Hector, Sabla, Gregg, Kombrinck, Keith W., Witte, David P., ...
Cellular proliferation and tissue remodeling are central to the regenerative response after a toxic injury to the liver. To explore the role of plasminogen in hepatic tissue remodeling and...
Potent antitumor activity of a urokinase-activated engineered anthrax toxin
Liu, Shihui, Aaronson, Hannah, Mitola, David J., Leppla, Stephen H., Bugge, Thomas H.
The acquisition of cell-surface urokinase plasminogen activator activity is a hallmark of malignancy. We generated an engineered anthrax toxin that is activated by cell-surface urokinase in vivo and...
Yepes, Manuel, Sandkvist, Maria, Coleman, Timothy A., Moore, Elizabeth, Wu, Jiang-Young, Mitola, David, ...
Tissue-type plasminogen activator (tPA) is a highly specific serine proteinase expressed in the CNS during events that require neuronal plasticity. In this study we demonstrate that endogenous tPA...
Yepes, Manuel, Sandkvist, Maria, Moore, Elizabeth G., Bugge, Thomas H., Strickland, Dudley K., Lawrence, Daniel A.
The regulation of cerebrovascular permeability is critical for normal brain homeostasis, and the “breakdown” of the blood-brain barrier (BBB) is associated with the development of vasogenic edema...
Gebbia, Joseph A., Monco, Juan Carlos Garcia, Degen, Jay L., Bugge, Thomas H., Benach, Jorge L.
The role of the plasminogen activation system (PAS) was investigated during the course of infection of a relapsing fever Borrelia species in plasminogen-deficient (plg –/–) and control (plg +/+...
List, Karin, Szabo, Roman, Molinolo, Alfredo, Sriuranpong, Virote, Redeye, Vivien, Murdock, Tricia, ...
Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potential...
Matriptase: Potent Proteolysis on the Cell Surface
List, Karin, Bugge, Thomas H, Szabo, Roman
Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor...
List, Karin, Szabo, Roman, Molinolo, Alfredo, Nielsen, Boye Schnack, Bugge, Thomas H.
The membrane serine protease matriptase is required for epidermal barrier function, hair formation, and thymocyte development in mice, and dysregulated matriptase expression causes epidermal squamous...
Plasminogen Activators Direct Reorganization of the Liver Lobule after Acute Injury
Bezerra, Jorge A., Currier, Angela R., Melin-Aldana, Hector, Sabla, Gregg, Bugge, Thomas H., Kombrinck, Keith W., ...
Tissue repair requires an adequate cellular proliferation coordinated with the timely proteolysis of matrix elements. Based on the properties of plasminogen activators in liver cell proliferation and...
Complementary Roles of Intracellular and Pericellular Collagen Degradation Pathways In Vivo▿ †
Wagenaar-Miller, Rebecca A., Engelholm, Lars H., Gavard, Julie, Yamada, Susan S., Gutkind, J. Silvio, Behrendt, Niels, ...
Collagen degradation is essential for cell migration, proliferation, and differentiation. Two key turnover pathways have been described for collagen: intracellular cathepsin-mediated degradation and...
Curino, Alejandro C., Engelholm, Lars H., Yamada, Susan S., Holmbeck, Kenn, Lund, Leif R., Molinolo, Alfredo A., ...
We recently reported that uPARAP/Endo180 can mediate the cellular uptake and lysosomal degradation of collagen by cultured fibroblasts. Here, we show that uPARAP/Endo180 has a key role in the...
Filippov, Sergey, Koenig, Gerald C., Chun, Tae-Hwa, Hotary, Kevin B., Ota, Ichiro, Bugge, Thomas H., ...
During pathologic vessel remodeling, vascular smooth muscle cells (VSMCs) embedded within the collagen-rich matrix of the artery wall mobilize uncharacterized proteolytic systems to infiltrate the...
Engelholm, Lars H., List, Karin, Netzel-Arnett, Sarah, Cukierman, Edna, Mitola, David J., Aaronson, Hannah, ...
The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue. However, the molecular mechanisms governing this pathway are poorly...
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1
List, Karin, Szabo, Roman, Wertz, Philip W., Segre, Julie, Haudenschild, Christian C., Kim, Soo-Youl, ...
Profilaggrin is a large epidermal polyprotein that is proteolytically processed during keratinocyte differentiation to release multiple filaggrin monomer units as well as a calcium-binding regulatory...
Wu, Yan Ping, Siao, Chia-Jen, Lu, Weiquan, Sung, Tsung-Chang, Frohman, Michael A., Milev, Peter, ...
Short seizure episodes are associated with remodeling of neuronal connections. One region where such reorganization occurs is the hippocampus, and in particular, the mossy fiber pathway. Using...
Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin▿
Chaipan, Chawaree, Kobasa, Darwyn, Bertram, Stephanie, Glowacka, Ilona, Steffen, Imke, Solomon Tsegaye, Theodros, ...
Proteolytic activation of the hemagglutinin (HA) protein is indispensable for influenza virus infectivity, and the tissue expression of the responsible cellular proteases impacts viral tropism and...
Szabo, Roman, Hobson, John P., List, Karin, Molinolo, Alfredo, Lin, Chen-Yong, Bugge, Thomas H.
Hepatocyte growth factor activator inhibitors (HAI)-1 and -2 are recently identified and closely related Kunitz-type transmembrane serine protease inhibitors. Whereas HAI-1 is well established as an...