Jin, Jinghua, Shie, Feng-Shiun, Liu, Jun, Wang, Yan, Davis, Jeanne, Schantz, Aimee M, ...
Abstract Background The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia...
Maezawa, Izumi, Zaja-Milatovic, Snjezana, Milatovic, Dejan, Stephen, Christina, Sokal, Izabela, Maeda, Nobuyo, ...
Abstract Background Innate immune activation, including a role for cluster of differentiation 14/toll-like receptor 4 co-receptors (CD14/TLR-4) co-receptors, has been implicated in paracrine damage...
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice (2006)
Maezawa, Izumi, Maeda, Nobuyo, Montine, Thomas J, Montine, Kathleen S
Abstract Background Inheritance of the three different alleles of the human apolipoprotein (apo) E gene ( APOE ) are associated with varying risk or clinical outcome from a variety of neurologic...
Milatovic, Dejan, Zaja-Milatovic, Snjezana, Montine, Kathleen S, Shie, Feng-Shiun, Montine, Thomas J
Abstract The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a...
Zhang, Jing, Perry, George, Smith, Mark A., Robertson, David, Olson, Sandra J., Graham, Doyle G., ...
Oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with Parkinson's disease (PD). To investigate the...
Includes vita and abstract.
Milatovic, Dejan, Zaja-Milatovic, Snjezana, Montine, Kathleen S, Shie, Feng-Shiun, Montine, Thomas J
The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of...
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
Maezawa, Izumi, Maeda, Nobuyo, Montine, Thomas J, Montine, Kathleen S
Maezawa, Izumi, Zaja-Milatovic, Snjezana, Milatovic, Dejan, Stephen, Christina, Sokal, Izabela, Maeda, Nobuyo, ...
Milatovic, Dejan, Zaja-Milatovic, Snjezana, Montine, Kathleen S, Shie, Feng-Shiun, Montine, Thomas J
The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of...
Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice
Maezawa, Izumi, Maeda, Nobuyo, Montine, Thomas J, Montine, Kathleen S
Maezawa, Izumi, Zaja-Milatovic, Snjezana, Milatovic, Dejan, Stephen, Christina, Sokal, Izabela, Maeda, Nobuyo, ...
Shie, Feng-Shiun, Breyer, Richard M., Montine, Thomas J.
Experimental therapies for Alzheimer’s disease (AD) are focused on enhanced clearance of neurotoxic Aβ peptides from brain. Microglia can be neuroprotective by phagocytosing Aβ; however, this...
Fatty Acid Oxidation in the Pathogenesis of Alzheimer’s Disease
Montine, Thomas J., Morrow, Jason D.
Alzheimer’s disease (AD) is the most common dementing illness of the elderly and is a mounting public health problem. Pharmacoepidemiological data, analytical data from human tissue and body...
Shie, Feng-Shiun, Neely, M. Diana, Maezawa, Izumi, Wu, Hope, Olson, Sandy J., Jürgens, Günther, ...
Ischemic injury to brain is associated with both disruption of the blood-brain barrier and increased oxidative stress. Given the neurotoxicity associated with exposure to oxidized low-density...
Zhang, Jing, Perry, George, Smith, Mark A., Robertson, David, Olson, Sandra J., Graham, Doyle G., ...
Oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with Parkinson’s disease (PD). To investigate...
Montine, Thomas J., Markesbery, William R., Zackert, William, Sanchez, Stephanie C., Roberts, L. Jackson, Morrow, Jason D.
Numerous post mortem studies have demonstrated increased accumulation of lipid peroxidation products in diseased regions of Alzheimer’s disease (AD) brain; however, few have used techniques that...
Reich, Erin E., Markesbery, William R., Roberts, L. Jackson, Swift, Larry L., Morrow, Jason D., Montine, Thomas J.
Isoprostanes (IsoP) are produced exclusively from free radical damage to arachidonic acid, a fatty acid that is evenly distributed throughout white matter and gray matter, whereas neuroprostanes...
Yang, Wan, Woltjer, Randall L., Sokal, Izabela, Pan, Catherine, Wang, Yan, Brodey, Mary, ...
Parkinsonism-dementia complex (PDC) remains a significant health burden to the Chamorro population. We tested the hypothesis that quantitative proteomics might provide fresh insight into this...
F2-Dihomo-isoprostanes arise from free radical attack on adrenic acid*
VanRollins, Mike, Woltjer, Randall L., Yin, Huiyong, Morrow, Jason D., Montine, Thomas J.
Unlike F4-neuroprostanes (F4-NeuroPs), which are relatively selective in vivo markers of oxidative damage to neuronal membranes, there currently is no method to assess the extent of free radical...
Musiek, Erik S., Brooks, Joshua D., Joo, Myungsoo, Brunoldi, Enrico, Porta, Alessio, Zanoni, Giuseppe, ...
The ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) possesses potent anti-inflammatory properties and has shown therapeutic benefit in numerous inflammatory diseases. However, the...