Thomas Jacobs

ABSTRACT MULTIMEDIA ON GLOBAL GRIDS: A CASE STUDY IN DISTRIBUTED RAY TRACING (2008)

Bader Aljaber, Thomas Jacobs, Krishna Nadiminti, Rajkumar Buyya

Grid computing, a form of distributed computing, has become a hot topic recently. Currently, there are many ways in which Grids are being used in order to enhance existing IT infrastructure to better...

A Peer-to-Peer Browsable File Index using a Popularity Based Global Namespace (2007)

Jacobs, Thomas, Harwood, Aaron

The distribution of files using decentralized, peer-to-peer (P2P) systems, has significant advantages over centralized approaches. It is however more difficult to settle on the best approach for file...

An Exceptionally Short α-actinin-like Protein from the Protozoan Parasite Entamoeba histolytica (2005)

Heike Bruhn, Thomas Jacobs, Britta Urban, Matthias Leippe

For a primitive phagocytosing cell such as the protozoan Entamoeba histolytica, dynamic fluctuations of the cytoskeleton are crucial for morphological changes involved in cellular movement as well as...

An Exceptionally Short α-actinin-like Protein from the Protozoan Parasite Entamoeba histolytica (2005)

Heike Bruhn, Thomas Jacobs, Britta Urban, Matthias Leippe

For a primitive phagocytosing cell such as the protozoan Entamoeba histolytica, dynamic fluctuations of the cytoskeleton are crucial for morphological changes involved in cellular movement as well as...

Localhost: A browsable peer-to-peer file sharing system (2005)

Aaron Harwood, Thomas Jacobs

Peer-to-peer (P2P) file sharing is increasing in use on the Internet. This thesis proposes Localhost, a P2P file sharing system that allows users to find files in the system by browsing a...

Role of Listeria monocytogenes Exotoxins Listeriolysin and Phosphatidylinositol-Specific Phospholipase C in Activation of Human Neutrophils

Sibelius, Ulf, Schulz, Eva-Cathrin, Rose, Frank, Hattar, Katja, Jacobs, Thomas, Weiss, Siegfried, ...

Polymorphonuclear leukocytes (PMN) are essential for resolution of infections with Listeria monocytogenes. The present study investigated the role of the listerial exotoxins listeriolysin (LLO) and...

NK-Lysin and Its Shortened Analog NK-2 Exhibit Potent Activities against Trypanosoma cruzi

Jacobs, Thomas, Bruhn, Heike, Gaworski, Iris, Fleischer, Bernhard, Leippe, Matthias

Antimicrobial peptides are widespread in nature and have been evolutionarily conserved as essential tools for combating a variety of pathogens. Among the plethora of natural peptides and synthetic...

NK Cells Contribute to the Control of Trypanosoma cruzi Infection by Killing Free Parasites by Perforin-Independent Mechanisms

Lieke, Thorsten, Graefe, Sebastian E. B., Klauenberg, Ulricke, Fleischer, Bernhard, Jacobs, Thomas

The protozoan parasite Trypanosoma cruzi circulates in the blood as trypomastigotes and invades a variety of cells to multiply intracellularly as amastigotes. The acute phase leads to an immune...

Sexual Dimorphism in the Control of Amebic Liver Abscess in a Mouse Model of Disease

Lotter, Hannelore, Jacobs, Thomas, Gaworski, Iris, Tannich, Egbert

Amebic liver abscess (ALA) is the most common extraintestinal manifestation of human infection by the enteric protozoan parasite Entamoeba histolytica. In contrast to intestinal infection, ALA...

Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria

Tartz, Susanne, Kamanova, Jana, Simsova, Marcela, Sebo, Peter, Bolte, Stefanie, Heussler, Volker, ...

The adenylate cyclase toxoid (ACT) of Bordetella pertussis is capable of delivering its N-terminal catalytic domain into the cytosol of CD11b-expressing professional antigen-presenting cells such as...

Role of Listeria monocytogenes Exotoxins Listeriolysin and Phosphatidylinositol-Specific Phospholipase C in Activation of Human Neutrophils

Sibelius, Ulf, Schulz, Eva-Cathrin, Rose, Frank, Hattar, Katja, Jacobs, Thomas, Weiss, Siegfried, ...

Polymorphonuclear leukocytes (PMN) are essential for resolution of infections with Listeria monocytogenes. The present study investigated the role of the listerial exotoxins listeriolysin (LLO) and...

NK-Lysin and Its Shortened Analog NK-2 Exhibit Potent Activities against Trypanosoma cruzi

Jacobs, Thomas, Bruhn, Heike, Gaworski, Iris, Fleischer, Bernhard, Leippe, Matthias

Antimicrobial peptides are widespread in nature and have been evolutionarily conserved as essential tools for combating a variety of pathogens. Among the plethora of natural peptides and synthetic...

NK Cells Contribute to the Control of Trypanosoma cruzi Infection by Killing Free Parasites by Perforin-Independent Mechanisms

Lieke, Thorsten, Graefe, Sebastian E. B., Klauenberg, Ulricke, Fleischer, Bernhard, Jacobs, Thomas

The protozoan parasite Trypanosoma cruzi circulates in the blood as trypomastigotes and invades a variety of cells to multiply intracellularly as amastigotes. The acute phase leads to an immune...

Sexual Dimorphism in the Control of Amebic Liver Abscess in a Mouse Model of Disease

Lotter, Hannelore, Jacobs, Thomas, Gaworski, Iris, Tannich, Egbert

Amebic liver abscess (ALA) is the most common extraintestinal manifestation of human infection by the enteric protozoan parasite Entamoeba histolytica. In contrast to intestinal infection, ALA...

Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage Malaria

Tartz, Susanne, Kamanova, Jana, Simsova, Marcela, Sebo, Peter, Bolte, Stefanie, Heussler, Volker, ...

The adenylate cyclase toxoid (ACT) of Bordetella pertussis is capable of delivering its N-terminal catalytic domain into the cytosol of CD11b-expressing professional antigen-presenting cells such as...

Spontaneous Recovery of Pathogenicity by Leishmania major hsp100−/− Alters the Immune Response in Mice

Reiling, Linda, Jacobs, Thomas, Kroemer, Manfred, Gaworski, Iris, Graefe, Sebastian, Clos, Joachim

By using repeated mouse infection cycles, we obtained an escape variant with restored infectivity and pathogenicity that originated from a single, noninfectious hsp100−/− gene (formerly known as...

The Antimicrobial Peptide NK-2, the Core Region of Mammalian NK-Lysin, Kills Intraerythrocytic Plasmodium falciparum▿

Gelhaus, Christoph, Jacobs, Thomas, Andrä, Jörg, Leippe, Matthias

In a time of dramatically increasing resistance of microbes to all kinds of antibiotics, natural antimicrobial peptides and synthetic analogs thereof have emerged as compounds with potentially...

Natural Killer T Cells Activated by a Lipopeptidophosphoglycan from Entamoeba histolytica Are Critically Important To Control Amebic Liver Abscess

Lotter, Hannelore, González-Roldán, Nestor, Lindner, Buko, Winau, Florian, Isibasi, Armando, Moreno-Lafont, Martha, ...

The innate immune response is supposed to play an essential role in the control of amebic liver abscess (ALA), a severe form of invasive amoebiasis due to infection with the protozoan parasite...

The Natural History of Primary Hyperparathyroidism with or without Parathyroid Surgery after 15 Years

Rubin, Mishaela R., Bilezikian, John P., McMahon, Donald J., Jacobs, Thomas, Shane, Elizabeth, Siris, Ethel, ...

Over 15 years of follow-up, mild primary hyperparathyroidism patients’ biochemical and densitometric features were generally stable for the first 8–10 years in those who did not undergo surgery....