Pauler, Florian M., Sloane, Mathew A., Huang, Ru, Regha, Kakkad, Koerner, Martha V., Tamir, Ido, ...
In mammals, genome-wide chromatin maps and immunofluorescence studies show that broad domains of repressive histone modifications are present on pericentromeric and telomeric repeats and on the...
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression (2009)
Savarese, Fabio, Dávila, Amparo, Nechanitzky, Robert, Pereira, Carlos F., Engelke, Rudolf, ...
Satb1 and the closely related Satb2 proteins regulate gene expression and higher-order chromatin structure of multigene clusters in vivo. In examining the role of Satb proteins in murine embryonic...
Schotta, Gunnar, Sengupta, Roopsha, Kubicek, Stefan, Malin, Stephen, Kauer, Monika, Callén, Elsa, ...
H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and...
Bradley, Sean P., Kaminski, Denise A., Jenuwein, Thomas, Stavnezer, Janet
Ab class (isotype) switching allows the humoral immune system to adaptively respond to different infectious organisms. Isotype switching occurs by intrachromosomal DNA recombination between switch...
The polycomb group protein EZH2 is required for mammalian circadian clock function (2006)
Etchegaray, Jean-Pierre, Yang, Xiaoming, DeBruyne, Jason P., Weaver, David R., Jenuwein, Thomas, ...
We examined the importance of histone methylation by the polycomb group proteins in the mouse circadian clock mechanism. Endogenous EZH2, a polycomb group enzyme that methylates lysine 27 on histone...
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells (2006)
Fodor, Barna D., Kubicek, Stefan, Yonezawa, Masato, OSullivan, Roderick J., Sengupta, Roopsha, Perez-Burgos, Laura, ...
Histone lysine trimethyl states represent some of the most robust epigenetic modifications in eukaryotic chromatin. Using a candidate approach, we identified the subgroup of murine Jmjd2 proteins to...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation (2004)
Alexander Kohlmaier, Fabio Savarese, Monika Lachner, Joost Martens, Thomas Jenuwein, Anton Wutz
In female mammals, one X chromosome is inactivated. Anton Wutz and colleagues find evidence for a very early event that 'marks' the chromosome for future stable inactivation.
A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation (2004)
Alexander Kohlmaier, Fabio Savarese, Monika Lachner, Joost Martens, Thomas Jenuwein, Anton Wutz
We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of...
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila (2004)
Ebert, Anja, Schotta, Gunnar, Lein, Sandro, Kubicek, Stefan, Krauss, Veiko, Jenuwein, Thomas, ...
Histone lysine methylation is an epigenetic mark to index chromosomal subdomains. In Drosophila, H3-K9 di- and trimethylation is mainly controlled by the heterochromatic SU(VAR)3-9 HMTase, a major...
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin (2004)
Schotta, Gunnar, Lachner, Monika, Sarma, Kavitha, Ebert, Anja, Sengupta, Roopsha, Reuter, Gunter, ...
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in...
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin (2004)
Schotta, Gunnar, Lachner, Monika, Sarma, Kavitha, Ebert, Anja, Sengupta, Roopsha, Reuter, Gunter, ...
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in...
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin (2004)
Schotta, Gunnar, Lachner, Monika, Sarma, Kavitha, Ebert, Anja, Sengupta, Roopsha, Reuter, Gunter, ...
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in...
Harry Scherthan, Susanne Opravil, Andrew R. Haynes, Götz Laible, Stephen Rea, ...
Higher-order chromatin has been implicated in epigenetic gene control and in the functional organization of chromosomes. We have recently discovered mouse (Suv39h1) and human (SUV39H1) histone H3...
Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation (1995)
Yuan, Dorothy, Dang, Tam, Hawley, Judy, Jenuwein, Thomas, Grosschedl, Rudolf, Tucker, P. W.
We have evaluated the importance of the OCTA site in both the promoter and enhancer regions for the induction of enhancement of IgH chain gene transcription after B cell activation. These studies...
Struktur-Funktions-Analyse viraler fos Onkogene. (1987)
Heidelberg, Univ., Diss., 1987 (Nicht f.d. Austausch).
Melcher, Martin, Schmid, Manfred, Aagaard, Louise, Selenko, Philipp, Laible, Götz, Jenuwein, Thomas
SUV39H1, a human homologue of the Drosophila position effect variegation modifier Su(var)3-9 and of the Schizosaccharomyces pombe silencing factor clr4, encodes a novel heterochromatic protein that...
The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development
O'Carroll, Dónal, Erhardt, Sylvia, Pagani, Michaela, Barton, Sheila C., Surani, M. Azim, Jenuwein, Thomas
Polycomb-group (Pc-G) genes are required for the stable repression of the homeotic selector genes and other developmentally regulated genes, presumably through the modulation of chromatin domains....
O'Carroll, Dónal, Scherthan, Harry, Opravil, Susanne, Haynes, Andrew R., Laible, Götz, ...
Higher-order chromatin has been implicated in epigenetic gene control and in the functional organization of chromosomes. We have recently discovered mouse (Suv39h1) and human (SUV39H1) histone H3...
Schotta, Gunnar, Ebert, Anja, Krauss, Veiko, Fischer, Andreas, Hoffmann, Jan, Rea, Stephen, ...
Su(var)3–9 is a dominant modifier of heterochromatin-induced gene silencing. Like its mammalian and Schizosaccharomyces pombe homologues, Su(var) 3–9 encodes a histone methyltransferase (HMTase),...
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
Lagger, Gerda, O’Carroll, Dónal, Rembold, Martina, Khier, Harald, Tischler, Julia, Weitzer, Georg, ...
Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously in the repression of...
Lachner, Monika, Vargas, Mark, Hamer, Karien M., Den Blaauwen, Jan L., Hendrix, Thijs, ...
Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of gene activity. Two distinct human PcG complexes have been...
Formation of facultative heterochromatin in the absence of HP1
Gilbert, Nick, Boyle, Shelagh, Sutherland, Heidi, De Las Heras, Jose, Allan, James, Jenuwein, Thomas, ...
Facultative heterochromatin is a cytological manifestation of epigenetic mechanisms that regulate gene expression. Constitutive heterochromatin is marked by distinctive histone H3 methylation and the...
Activation of the β globin locus by transcription factors and chromatin modifiers
McMorrow, Tara, Van Den Wijngaard, Arthur, Wollenschlaeger, Alex, Van De Corput, Mariëtte, Monkhorst, Kim, Trimborn, Tolleiv, ...
Locus control regions (LCRs) alleviate chromatin-mediated transcriptional repression. Incomplete LCRs partially lose this property when integrated in transcriptionally restrictive genomic regions...
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
Schotta, Gunnar, Lachner, Monika, Sarma, Kavitha, Ebert, Anja, Sengupta, Roopsha, Reuter, Gunter, ...
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in...
A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation
Kohlmaier, Alexander, Savarese, Fabio, Lachner, Monika, Martens, Joost, Jenuwein, Thomas, Wutz, Anton
We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of...
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3
Lindroth, Anders M, Shultis, David, Jasencakova, Zuzana, Fuchs, Jörg, Johnson, Lianna, Schubert, Daniel, ...
Both DNA methylation and post-translational histone modifications contribute to gene silencing, but the mechanistic relationship between these epigenetic marks is unclear. Mutations in two...
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes
Baxter, Jonathan, Sauer, Stephan, Peters, Antoine, John, Rosalind, Williams, Ruth, Caparros, Marie-Laure, ...
Post-translational modifications of histone amino termini are thought to convey epigenetic information that extends the coding potential of DNA. In particular, histone lysine methylation has been...
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
Ebert, Anja, Schotta, Gunnar, Lein, Sandro, Kubicek, Stefan, Krauss, Veiko, Jenuwein, Thomas, ...
Histone lysine methylation is an epigenetic mark to index chromosomal subdomains. In Drosophila, H3-K9 di- and trimethylation is mainly controlled by the heterochromatic SU(VAR)3-9 HMTase, a major...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
The profile of repeat-associated histone lysine methylation states in the mouse epigenome
Martens, Joost H A, O'Sullivan, Roderick J, Braunschweig, Ulrich, Opravil, Susanne, Radolf, Martin, Steinlein, Peter, ...
Histone lysine methylation has been shown to index silenced chromatin regions at, for example, pericentric heterochromatin or of the inactive X chromosome. Here, we examined the distribution of...
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis
Naumann, Kathrin, Fischer, Andreas, Hofmann, Ingo, Krauss, Veiko, Phalke, Sameer, Irmler, Kristina, ...
SU(VAR)3–9 like histone methyltransferases control heterochromatic domains in eukaryotes. In Arabidopsis, 10 SUVH genes encode SU(VAR)3–9 homologues where SUVH1, SUVH2 and SUVH4 (KRYPTONITE)...
Bao, Siqin, Miyoshi, Naoki, Okamoto, Ikuhiro, Jenuwein, Thomas, Heard, Edith, Azim Surani, M
The active and inactive X chromosomes have distinct epigenetic marks in somatic nuclei, which undergo reprogramming after transplantation into oocytes. We show that, despite the disappearance of Xist...
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, Dale K., Dechat, Thomas, Kohlmaier, Alexander, Adam, Stephen A., Bozovsky, Matthew R., Erdos, Michael R., ...
The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and display a loss of...
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
Fodor, Barna D., Kubicek, Stefan, Yonezawa, Masato, O’Sullivan, Roderick J., Sengupta, Roopsha, Perez-Burgos, Laura, ...
Histone lysine trimethyl states represent some of the most robust epigenetic modifications in eukaryotic chromatin. Using a candidate approach, we identified the subgroup of murine Jmjd2 proteins to...
Melcher, Martin, Schmid, Manfred, Aagaard, Louise, Selenko, Philipp, Laible, Götz, Jenuwein, Thomas
SUV39H1, a human homologue of the Drosophila position effect variegation modifier Su(var)3-9 and of the Schizosaccharomyces pombe silencing factor clr4, encodes a novel heterochromatic protein that...
The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development
O'Carroll, Dónal, Erhardt, Sylvia, Pagani, Michaela, Barton, Sheila C., Surani, M. Azim, Jenuwein, Thomas
Polycomb-group (Pc-G) genes are required for the stable repression of the homeotic selector genes and other developmentally regulated genes, presumably through the modulation of chromatin domains....
O'Carroll, Dónal, Scherthan, Harry, Opravil, Susanne, Haynes, Andrew R., Laible, Götz, ...
Higher-order chromatin has been implicated in epigenetic gene control and in the functional organization of chromosomes. We have recently discovered mouse (Suv39h1) and human (SUV39H1) histone H3...
Schotta, Gunnar, Ebert, Anja, Krauss, Veiko, Fischer, Andreas, Hoffmann, Jan, Rea, Stephen, ...
Su(var)3–9 is a dominant modifier of heterochromatin-induced gene silencing. Like its mammalian and Schizosaccharomyces pombe homologues, Su(var) 3–9 encodes a histone methyltransferase (HMTase),...
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
Lagger, Gerda, O’Carroll, Dónal, Rembold, Martina, Khier, Harald, Tischler, Julia, Weitzer, Georg, ...
Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously in the repression of...
Lachner, Monika, Vargas, Mark, Hamer, Karien M., Den Blaauwen, Jan L., Hendrix, Thijs, ...
Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of gene activity. Two distinct human PcG complexes have been...
Formation of facultative heterochromatin in the absence of HP1
Gilbert, Nick, Boyle, Shelagh, Sutherland, Heidi, De Las Heras, Jose, Allan, James, Jenuwein, Thomas, ...
Facultative heterochromatin is a cytological manifestation of epigenetic mechanisms that regulate gene expression. Constitutive heterochromatin is marked by distinctive histone H3 methylation and the...
Activation of the β globin locus by transcription factors and chromatin modifiers
McMorrow, Tara, Van Den Wijngaard, Arthur, Wollenschlaeger, Alex, Van De Corput, Mariëtte, Monkhorst, Kim, Trimborn, Tolleiv, ...
Locus control regions (LCRs) alleviate chromatin-mediated transcriptional repression. Incomplete LCRs partially lose this property when integrated in transcriptionally restrictive genomic regions...
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin
Schotta, Gunnar, Lachner, Monika, Sarma, Kavitha, Ebert, Anja, Sengupta, Roopsha, Reuter, Gunter, ...
Histone lysine methylation is a central modification to mark functionally distinct chromatin regions. In particular, H3-K9 trimethylation has emerged as a hallmark of pericentric heterochromatin in...
A Chromosomal Memory Triggered by Xist Regulates Histone Methylation in X Inactivation
Kohlmaier, Alexander, Savarese, Fabio, Lachner, Monika, Martens, Joost, Jenuwein, Thomas, Wutz, Anton
We have elucidated the kinetics of histone methylation during X inactivation using an inducible Xist expression system in mouse embryonic stem (ES) cells. Previous reports showed that the ability of...
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3
Lindroth, Anders M, Shultis, David, Jasencakova, Zuzana, Fuchs, Jörg, Johnson, Lianna, Schubert, Daniel, ...
Both DNA methylation and post-translational histone modifications contribute to gene silencing, but the mechanistic relationship between these epigenetic marks is unclear. Mutations in two...
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes
Baxter, Jonathan, Sauer, Stephan, Peters, Antoine, John, Rosalind, Williams, Ruth, Caparros, Marie-Laure, ...
Post-translational modifications of histone amino termini are thought to convey epigenetic information that extends the coding potential of DNA. In particular, histone lysine methylation has been...
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
Ebert, Anja, Schotta, Gunnar, Lein, Sandro, Kubicek, Stefan, Krauss, Veiko, Jenuwein, Thomas, ...
Histone lysine methylation is an epigenetic mark to index chromosomal subdomains. In Drosophila, H3-K9 di- and trimethylation is mainly controlled by the heterochromatic SU(VAR)3-9 HMTase, a major...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
The profile of repeat-associated histone lysine methylation states in the mouse epigenome
Martens, Joost H A, O'Sullivan, Roderick J, Braunschweig, Ulrich, Opravil, Susanne, Radolf, Martin, Steinlein, Peter, ...
Histone lysine methylation has been shown to index silenced chromatin regions at, for example, pericentric heterochromatin or of the inactive X chromosome. Here, we examined the distribution of...
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis
Naumann, Kathrin, Fischer, Andreas, Hofmann, Ingo, Krauss, Veiko, Phalke, Sameer, Irmler, Kristina, ...
SU(VAR)3–9 like histone methyltransferases control heterochromatic domains in eukaryotes. In Arabidopsis, 10 SUVH genes encode SU(VAR)3–9 homologues where SUVH1, SUVH2 and SUVH4 (KRYPTONITE)...
Bao, Siqin, Miyoshi, Naoki, Okamoto, Ikuhiro, Jenuwein, Thomas, Heard, Edith, Azim Surani, M
The active and inactive X chromosomes have distinct epigenetic marks in somatic nuclei, which undergo reprogramming after transplantation into oocytes. We show that, despite the disappearance of Xist...
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, Dale K., Dechat, Thomas, Kohlmaier, Alexander, Adam, Stephen A., Bozovsky, Matthew R., Erdos, Michael R., ...
The premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS) is caused by a mutant lamin A (LAΔ50). Nuclei in cells expressing LAΔ50 are abnormally shaped and display a loss of...
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
Fodor, Barna D., Kubicek, Stefan, Yonezawa, Masato, O’Sullivan, Roderick J., Sengupta, Roopsha, Perez-Burgos, Laura, ...
Histone lysine trimethyl states represent some of the most robust epigenetic modifications in eukaryotic chromatin. Using a candidate approach, we identified the subgroup of murine Jmjd2 proteins to...
Histone modification patterns associated with the human X chromosome
Brinkman, Arie B, Roelofsen, Thijs, Pennings, Sebastiaan W C, Martens, Joost H A, Jenuwein, Thomas, Stunnenberg, Hendrik G
X inactivation is associated with chromosome-wide establishment of inactive chromatin. Although this is classically regarded as facultative heterochromatin that is uniform in nature, the exact...
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing
Schoeftner, Stefan, Sengupta, Aditya K, Kubicek, Stefan, Mechtler, Karl, Spahn, Laura, Koseki, Haruhiko, ...
In mammals X inactivation is initiated by expression of Xist RNA and involves the recruitment of Polycomb repressive complex 1 (PRC1) and 2 (PRC2), which mediate chromosome-wide ubiquitination of...
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27
Schubert, Daniel, Primavesi, Lucia, Bishopp, Anthony, Roberts, Gethin, Doonan, John, Jenuwein, Thomas, ...
The plant Polycomb-group (Pc-G) protein CURLY LEAF (CLF) is required to repress targets such as AGAMOUS (AG) and SHOOTMERISTEMLESS (STM). Using chromatin immunoprecipitation, we identify AG and STM...
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination
Benetti, Roberta, Gonzalo, Susana, Jaco, Isabel, Schotta, Gunnar, Klatt, Peter, Jenuwein, Thomas, ...
Mammalian telomeres have heterochromatic features, including trimethylated histone H3 at lysine 9 (H3K9me3) and trimethylated histone H4 at lysine 20 (H4K20me3). In addition, subtelomeric DNA is...
Schotta, Gunnar, Sengupta, Roopsha, Kubicek, Stefan, Malin, Stephen, Kauer, Monika, Callén, Elsa, ...
H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and...
Trojer, Patrick, Zhang, Jin, Yonezawa, Masato, Schmidt, Andreas, Zheng, Haiyan, Jenuwein, Thomas, ...
The linker histone H1 generally participates in the establishment of chromatin structure. However, of the seven somatic H1 isotypes in humans some are also implicated in the regulation of local gene...
PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse
Pannetier, Maëlle, Julien, Eric, Schotta, Gunnar, Tardat, Mathieu, Sardet, Claude, Jenuwein, Thomas, ...
Imprinted genes are important in development and their allelic expression is mediated by imprinting control regions (ICRs). On their DNA-methylated allele, ICRs are marked by trimethylation at H3 Lys...
Pauler, Florian M., Sloane, Mathew A., Huang, Ru, Regha, Kakkad, Koerner, Martha V., Tamir, Ido, ...
In mammals, genome-wide chromatin maps and immunofluorescence studies show that broad domains of repressive histone modifications are present on pericentromeric and telomeric repeats and on the...