Scientific Commons: Thomas Kuner

Clinical usage of cannabinoids in chronic pain states is limited by their central side effects and the pharmacodynamic tolerance that sets in after repeated dosage. Analgesic tolerance to...

Donut−like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: a novel structure−function module of the adult Calyx of Held (2006)

Wimmer, Verena C., Horstmann, Heinz, Groh, Alexander, Kuner, Thomas

Structural and functional properties of synapses are intricately and reciprocally coupled. To cope with the functional requirements in auditory processing, the calyx of Held developed distinct...

Two−Photon Imaging Reveals Somatodendritic Chloride Gradient in Retinal ON−Type Bipolar Cells Expressing the Biosensor Clomeleon (2006)

Dübel, Jens, Haverkamp, Silke, Schleich, Wolfram, Feng, Guoping, Augustine, George J., Kuner, Thomas, ...

A somatodendritic gradient of Cl− concentration ([Cl−]i) has been postulated to generate GABA−evoked responses of different polarity in retinal bipolar cells, hyperpolarizing in OFF cells with...

Two−Photon Imaging Reveals Somatodendritic Chloride Gradient in Retinal ON−Type Bipolar Cells Expressing the Biosensor Clomeleon (2006)

Dübel, Jens, Haverkamp, Silke, Schleich, Wolfram, Feng, Guoping, Augustine, George J., Kuner, Thomas, ...

A somatodendritic gradient of Cl− concentration ([Cl−]i) has been postulated to generate GABA−evoked responses of different polarity in retinal bipolar cells, hyperpolarizing in OFF cells with...

The primordial, blue−cone color system of the mouse retina (2005)

Haverkamp, Silke, Waessle, Heinz, Dübel, Jens, Kuner, Thomas, Augustine, George J., Feng, Guoping, ...

Humans and old world primates have trichromatic color vision based on three spectral types of cone [long−wavelength (L−), middle−wavelength (M−), and short−wavelength (S−) cones]. All...

The primordial, blue−cone color system of the mouse retina (2005)

Haverkamp, Silke, Waessle, Heinz, Dübel, Jens, Kuner, Thomas, Augustine, George J., Feng, Guoping, ...

Humans and old world primates have trichromatic color vision based on three spectral types of cone [long−wavelength (L−), middle−wavelength (M−), and short−wavelength (S−) cones]. All...

Maintaining Accuracy at the Expense of Speed: Stimulus Similarity Defines Odor Discrimination Time in Mice (2004)

Abraham,Nixon M., Spors,Hartwig, Carleton,Alan, Margrie,Troy W., Kuner,Thomas, Schaefer,Andreas T.

Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/no−go operant conditioning paradigm,...

Targeted in vivo expression of proteins in the calyx of Held (2004)

Wimmer,Verena C., Nevian,Thomas, Kuner,Thomas

Nitric Oxide Synthase (NOS)−Interacting Protein Interacts with Neuronal NOS and Regulates Its Distribution and Activity (2004)

Dreyer,Jacqueline, Schleicher,Michael, Tappe,Anke, Schilling,Kirstin, Kuner,Thomas, Kusumawidijaja,Grace, ...

Mechanisms governing the activity of neuronal nitric oxide synthase (nNOS), the major source of nitric oxide (NO) in the nervous system, are not completely understood. We report here a...

Cloning of a novel neuronally expressed orphan G−protein−coupled receptor which is up−regulated by erythropoietin, interacts with microtubule−associated protein 1b and colocalizes with the 5−hydroxytryptamine 2a receptor (2004)

Maurer,Martin H., Grunewald,Sylvia, Gassler,Nikolaus, Rossner,Moritz, Propst,Friedrich, Würz,Rebecca, ...

G−protein−coupled receptors (GPCRs) are the largest group of cell surface molecules involved in signal transduction and are receptors for a wide variety of stimuli ranging from light, calcium and...

Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor (2004)

Maurer,Martin H., Grünewald,Sylvia, Gassler,Nikolaus, Rossner,Moritz, Propst,Friedrich, Würz,Rebecca, ...

Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor (2004)

Maurer, Martin H., Grünewald, Sylvia, Gassler, Nikolaus, Rossner, Moritz, Propst, Friedrich, Würz, Rebecca, ...

Maintaining Accuracy at the Expense of Speed: Stimulus Similarity Defines Odor Discrimination Time in Mice (2004)

Abraham, Nixon M., Spors, Hartwig, Carleton, Alan, Margrie, Troy W., Kuner, Thomas, Schaefer, Andreas T.

Odor discrimination times and their dependence on stimulus similarity were evaluated to test temporal and spatial models of odor representation in mice. In a go/no−go operant conditioning paradigm,...

Targeted in vivo expression of proteins in the calyx of Held (2004)

Wimmer, Verena C., Nevian, Thomas, Kuner, Thomas

Nitric Oxide Synthase (NOS)−Interacting Protein Interacts with Neuronal NOS and Regulates Its Distribution and Activity (2004)

Dreyer, Jacqueline, Schleicher, Michael, Tappe, Anke, Schilling, Kirstin, Kuner, Thomas, Kusumawidijaja, Grace, ...

Mechanisms governing the activity of neuronal nitric oxide synthase (nNOS), the major source of nitric oxide (NO) in the nervous system, are not completely understood. We report here a...

Cloning of a novel neuronally expressed orphan G−protein−coupled receptor which is up−regulated by erythropoietin, interacts with microtubule−associated protein 1b and colocalizes with the 5−hydroxytryptamine 2a receptor (2004)

Maurer, Martin H., Grunewald, Sylvia, Gassler, Nikolaus, Rossner, Moritz, Propst, Friedrich, Würz, Rebecca, ...

G−protein−coupled receptors (GPCRs) are the largest group of cell surface molecules involved in signal transduction and are receptors for a wide variety of stimuli ranging from light, calcium and...

A common architecture for K+ channels and ionotropic glutamate receptors? (2003)

Kuner,Thomas, Seeburg,Peter H., Guy,H. Robert

K+ channels and ionotropic glutamate receptors are thought to share a common architecture in their transmembrane pores. This oft-cited hypothesis has been derived from sequence comparisons, topology...

A common architecture for K+ channels and ionotropic glutamate receptors? (2003)

Kuner, Thomas, Seeburg, Peter H., Guy, H. Robert

K+ channels and ionotropic glutamate receptors are thought to share a common architecture in their transmembrane pores. This oft-cited hypothesis has been derived from sequence comparisons, topology...

Ionotrope Glutamatrezeptoren: Strukturelle Grundlagen und biophysikalische Mechanismen der Ionenpermeation (2003)

Kuner, Thomas

DRPEER: A Motif in the Extracellular Vestibule Conferring High Ca2+ Flux Rates in NMDA Receptor Channels (2002)

Watanabe,Junryo, Beck,Christine, Kuner,Thomas, Premkumar,Louis S., Wollmuth,Lonnie P.

The high flux rate of Ca2+ through NMDA receptor (NMDAR) channels is critical for their biological function and may depend on a Ca2+ binding site in the extracellular vestibule. We screened...

Peptides as probes of protein-protein interactions involved in neurotransmitter release (2002)

Kuner,Thomas, Tokumaru,Hiroshi, Augustine,George J.

DRPEER: A Motif in the Extracellular Vestibule Conferring High Ca2+ Flux Rates in NMDA Receptor Channels (2002)

Watanabe, Junryo, Beck, Christine, Kuner, Thomas, Premkumar, Louis S., Wollmuth, Lonnie P.

The high flux rate of Ca2+ through NMDA receptor (NMDAR) channels is critical for their biological function and may depend on a Ca2+ binding site in the extracellular vestibule. We screened...

Peptides as probes of protein-protein interactions involved in neurotransmitter release (2002)

Kuner, Thomas, Tokumaru, Hiroshi, Augustine, George J.

Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse (2001)

Seeburg,Peter H., Single,Frank N., Kuner,Thomas, Higuchi,Miyoko, Sprengel,Rolf

Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...

Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse (2001)

Seeburg,Peter H., Single,Frank N., Kuner,Thomas, Higuchi,Miyoko, Sprengel,Rolf

Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...

Channel-lining residues of the AMPA receptor M2 segment: Structural environment of the Q/R site and identification of the selectivity filter (2001)

Kuner,Thomas, Beck,Christine, Sakmann,Bert, Seeburg,Peter H.

In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...

Channel-lining residues of the AMPA receptor M2 segment: Structural environment of the Q/R site and identification of the selectivity filter (2001)

Kuner,Thomas, Beck,Christine, Sakmann,Bert, Seeburg,Peter H.

In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...

Glutamate receptor channel signatures (2001)

Sprengel,Rolf, Aronoff,Rachel, Völkner,Michaela, Schmitt,Bertram, Mosbach,Raphael, Kuner,Thomas

Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...

Glutamate receptor channel signatures (2001)

Sprengel,Rolf, Aronoff,Rachel, Völkner,Michaela, Schmitt,Bertram, Mosbach,Raphael, Kuner,Thomas

Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...

Channel-lining residues of the AMPA receptor M2 segment: Structural environment of the Q/R site and identification of the selectivity filter (2001)

Kuner, Thomas, Beck, Christine, Sakmann, Bert, Seeburg, Peter H.

In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...

Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse (2001)

Seeburg, Peter H., Single, Frank N., Kuner, Thomas, Higuchi, Miyoko, Sprengel, Rolf

Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...

Glutamate receptor channel signatures (2001)

Sprengel, Rolf, Aronoff, Rachel, Völkner, Michaela, Schmitt, Bertram, Mosbach, Raphael, Kuner, Thomas

Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...

Channel-lining residues of the AMPA receptor M2 segment: Structural environment of the Q/R site and identification of the selectivity filter (2001)

Kuner, Thomas, Beck, Christine, Sakmann, Bert, Seeburg, Peter H.

In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...

Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse (2001)

Seeburg, Peter H., Single, Frank N., Kuner, Thomas, Higuchi, Miyoko, Sprengel, Rolf

Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...

Glutamate receptor channel signatures (2001)

Sprengel, Rolf, Aronoff, Rachel, Völkner, Michaela, Schmitt, Bertram, Mosbach, Raphael, Kuner, Thomas

Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in...

A Genetically Encoded Ratiometric Indicator for Chloride: Capturing Chloride Transients in Cultured Hippocampal Neurons (2000)

Kuner,Thomas, Augustine,George J.

We constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow fluorescent protein with the chloride-insensitive cyan fluorescent protein. The ratio of...

The lurcher mutation identifies delta2 as an AMPA/kainate receptor-like channel that is potentiated by Ca2+ (2000)

Wollmuth,Lonnie P., Kuner,Thomas, Jatzke,Claudia, Seeburg,Peter H., Heintz,Nathaniel, Zuo,Jian

Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....

The lurcher mutation identifies delta2 as an AMPA/kainate receptor-like channel that is potentiated by Ca2+ (2000)

Wollmuth,Lonnie P., Kuner,Thomas, Jatzke,Claudia, Seeburg,Peter H., Heintz,Nathaniel, Zuo,Jian

Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....

A Genetically Encoded Ratiometric Indicator for Chloride: Capturing Chloride Transients in Cultured Hippocampal Neurons (2000)

Kuner, Thomas, Augustine, George J.

We constructed a novel optical indicator for chloride ions by fusing the chloride-sensitive yellow fluorescent protein with the chloride-insensitive cyan fluorescent protein. The ratio of...

The lurcher mutation identifies delta2 as an AMPA/kainate receptor-like channel that is potentiated by Ca2+ (2000)

Wollmuth, Lonnie P., Kuner, Thomas, Jatzke, Claudia, Seeburg, Peter H., Heintz, Nathaniel, Zuo, Jian

Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....

The lurcher mutation identifies delta2 as an AMPA/kainate receptor-like channel that is potentiated by Ca2+ (2000)

Wollmuth, Lonnie P., Kuner, Thomas, Jatzke, Claudia, Seeburg, Peter H., Heintz, Nathaniel, Zuo, Jian

Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....

Isoform-spezifische Wirkungen von Ethanol, Argiotoxin 636 und Magnesium (II)Ionen auf N-Methyl-D-Aspartat Rezeptorkanä le: Funktionelle Charakterisierung und Bestimmung struktureller Determinanten (1999)

Kuner, Thomas

...

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines (1999)

Beck,Christine, Wollmuth,Lonnie P., Seeburg,Peter H., Sakmann,Bert, Kuner,Thomas

In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines (1999)

Beck,Christine, Wollmuth,Lonnie P., Seeburg,Peter H., Sakmann,Bert, Kuner,Thomas

In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....

Novel GLRA1 Missense Mutation (P250T) in Dominant Hyperekplexia Defines an Intracellular Determinant of Glycine Receptor Channel Gating (1999)

Saul,Brigitta, Kuner,Thomas, Sobetzko,Diana, Brune,Wolfram, Hanefeld,Folker, Meinck,Hans-Michael, ...

Missense mutations as well as a null allele of the human glycine receptor alpha 1 subunit gene GLRA1 result in the neurological disorder hyperekplexia [startle disease, stiff baby syndrome, Mendelian...

The ion-conducting pore of glutamate receptor channels (1999)

Kuner,Thomas, Wollmuth,Lonnie P., Sakmann,Bert

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines (1999)

Beck, Christine, Wollmuth, Lonnie P., Seeburg, Peter H., Sakmann, Bert, Kuner, Thomas

In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....

Novel GLRA1 Missense Mutation (P250T) in Dominant Hyperekplexia Defines an Intracellular Determinant of Glycine Receptor Channel Gating (1999)

Saul, Brigitta, Kuner, Thomas, Sobetzko, Diana, Brune, Wolfram, Hanefeld, Folker, Meinck, Hans-Michael, ...

Missense mutations as well as a null allele of the human glycine receptor alpha 1 subunit gene GLRA1 result in the neurological disorder hyperekplexia [startle disease, stiff baby syndrome, Mendelian...

The ion-conducting pore of glutamate receptor channels (1999)

Kuner, Thomas, Wollmuth, Lonnie P., Sakmann, Bert

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines (1999)

Beck, Christine, Wollmuth, Lonnie P., Seeburg, Peter H., Sakmann, Bert, Kuner, Thomas

In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+ (1998)

Wollmuth,Lonnie P., Kuner,Thomas, Sakmann,Bert

The voltage-dependent block of N-methyl-D-aspartate (NMDA) receptor channels by extracellular Mg2+ is a critical determinant of its contribution to CNS synaptic physiology. The function of the narrow...

Intracellular Mg2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel (1998)

Wollmuth,Lonnie P., Kuner,Thomas, Sakmann,Bert

N-methyl-D-aspartate (NMDA) receptor channels are blocked by intracellular Mg2+ in a voltage-dependent manner. Amino acid residues positioned at or near the narrow constriction that interact with...

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+ (1998)

Wollmuth, Lonnie P., Kuner, Thomas, Sakmann, Bert

The voltage-dependent block of N-methyl-D-aspartate (NMDA) receptor channels by extracellular Mg2+ is a critical determinant of its contribution to CNS synaptic physiology. The function of the narrow...

Intracellular Mg2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel (1998)

Wollmuth, Lonnie P., Kuner, Thomas, Sakmann, Bert

N-methyl-D-aspartate (NMDA) receptor channels are blocked by intracellular Mg2+ in a voltage-dependent manner. Amino acid residues positioned at or near the narrow constriction that interact with...

Isoform-spezifische Wirkungen von Ethanol, Argiotoxin 636 und Magnesium (II)Ionen auf N-Methyl-D-Aspartat Rezeptorkanä le: Funktionelle Charakterisierung und Bestimmung struktureller Determinanten (1998)

Kuner, Thomas

...

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines (1996)

Kuner,Thomas, Wollmuth,Lonnie P., Karlin,Arthur, Seeburg,Peter H., Sakmann,Bert

The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines (1996)

Kuner,Thomas, Wollmuth,Lonnie P., Karlin,Arthur, Seeburg,Peter H., Sakmann,Bert

The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...

Multiple Structural Elements Determine Subunit Specificity of Mg2+ Block in NMDA Receptor Channels (1996)

Kuner,Thomas, Schoepfer,Ralf

In NMDA receptor channels, subtype-specific differences of Mg2+ block are determined by the NR2 subunits. Channels assembled from the NR1-NR2A or NR1-NR2B subunits are blocked more strongly than...

Multiple Structural Elements Determine Subunit Specificity of Mg2+ Block in NMDA Receptor Channels (1996)

Kuner,Thomas, Schoepfer,Ralf

In NMDA receptor channels, subtype-specific differences of Mg2+ block are determined by the NR2 subunits. Channels assembled from the NR1-NR2A or NR1-NR2B subunits are blocked more strongly than...

Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels (1996)

Wollmuth,Lonnie P., Kuner,Thomas, Seeburg,Peter H., Sakmann,Bert

1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...

Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels (1996)

Wollmuth,Lonnie P., Kuner,Thomas, Seeburg,Peter H., Sakmann,Bert

1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...

Multiple Structural Elements Determine Subunit Specificity of Mg2+ Block in NMDA Receptor Channels (1996)

Kuner, Thomas, Schoepfer, Ralf

In NMDA receptor channels, subtype-specific differences of Mg2+ block are determined by the NR2 subunits. Channels assembled from the NR1-NR2A or NR1-NR2B subunits are blocked more strongly than...

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines (1996)

Kuner, Thomas, Wollmuth, Lonnie P., Karlin, Arthur, Seeburg, Peter H., Sakmann, Bert

The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...

Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels (1996)

Wollmuth, Lonnie P., Kuner, Thomas, Seeburg, Peter H., Sakmann, Bert

1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...

Multiple Structural Elements Determine Subunit Specificity of Mg2+ Block in NMDA Receptor Channels (1996)

Kuner, Thomas, Schoepfer, Ralf

In NMDA receptor channels, subtype-specific differences of Mg2+ block are determined by the NR2 subunits. Channels assembled from the NR1-NR2A or NR1-NR2B subunits are blocked more strongly than...

Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines (1996)

Kuner, Thomas, Wollmuth, Lonnie P., Karlin, Arthur, Seeburg, Peter H., Sakmann, Bert

The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...

Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels (1996)

Wollmuth, Lonnie P., Kuner, Thomas, Seeburg, Peter H., Sakmann, Bert

1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...

Selective antagonist for the cerebellar granule cell-specific g-aminobutyric acid type A receptor (1995)

Korpi,Esa R., Kuner,Thomas, Seeburg,Peter H., Lüddens,H.

Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...

Selective antagonist for the cerebellar granule cell-specific g-aminobutyric acid type A receptor (1995)

Korpi,Esa R., Kuner,Thomas, Seeburg,Peter H., Lüddens,H.

Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...

The NMDA receptor channel: molecular design of a coincidence detector (1995)

Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah

The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)

Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah

Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)

Seeburg,Peter H., Sprengel,Rolf, Monyer,Hannah, Higuchi,Miyoko, Kuner,Thomas, Köhr,Georg, ...

The NMDA receptor channel: molecular design of a coincidence detector (1995)

Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah

The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)

Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah

Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)

Seeburg,Peter H., Sprengel,Rolf, Monyer,Hannah, Higuchi,Miyoko, Kuner,Thomas, Köhr,Georg, ...

Selective antagonist for the cerebellar granule cell-specific g-aminobutyric acid type A receptor (1995)

Korpi, Esa R., Kuner, Thomas, Seeburg, Peter H., Lüddens, H.

Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...

The NMDA receptor channel: molecular design of a coincidence detector (1995)

Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah

The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)

Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah

Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)

Seeburg, Peter H., Sprengel, Rolf, Monyer, Hannah, Higuchi, Miyoko, Kuner, Thomas, Köhr, Georg, ...

Selective antagonist for the cerebellar granule cell-specific g-aminobutyric acid type A receptor (1995)

Korpi, Esa R., Kuner, Thomas, Seeburg, Peter H., Lüddens, H.

Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...

The NMDA receptor channel: molecular design of a coincidence detector (1995)

Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah

The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)

Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah

Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)

Seeburg, Peter H., Sprengel, Rolf, Monyer, Hannah, Higuchi, Miyoko, Kuner, Thomas, Köhr, Georg, ...

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)

Lomeli,H., Mosbacher,Johannes, Melcher,H., Höger,T., Geiger,Jörg R. P., Kuner,Thomas, ...

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)

Lomeli,H., Mosbacher,Johannes, Melcher,H., Höger,T., Geiger,Jörg R. P., Kuner,Thomas, ...

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...

Small N-terminal deletion by splicing in cerebellar a6 subunit abolishes GABAA receptor function (1994)

Korpi,Esa R., Kuner,Thomas, Kristo,P., Köhler,Martin, Herb,Anne, Lüddens,H., ...

Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...

Small N-terminal deletion by splicing in cerebellar a6 subunit abolishes GABAA receptor function (1994)

Korpi,Esa R., Kuner,Thomas, Kristo,P., Köhler,Martin, Herb,Anne, Lüddens,H., ...

Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...

Molecular biology of glutamate receptors (1994)

Schoepfer,Ralf, Monyer,Hannah, Sommer,B., Wisden,William, Sprengel,Rolf, Kuner,Thomas, ...

Molecular biology of glutamate receptors (1994)

Schoepfer,Ralf, Monyer,Hannah, Sommer,B., Wisden,William, Sprengel,Rolf, Kuner,Thomas, ...

Molecular biology of glutamate receptors (1994)

Schoepfer, Ralf, Monyer, Hannah, Sommer, B., Wisden, William, Sprengel, Rolf, Kuner, Thomas, ...

Molecular biology of glutamate receptors (1994)

Schoepfer, Ralf, Monyer, Hannah, Sommer, B., Wisden, William, Sprengel, Rolf, Kuner, Thomas, ...

Small N-terminal deletion by splicing in cerebellar a6 subunit abolishes GABAA receptor function (1994)

Korpi, Esa R., Kuner, Thomas, Kristo, P., Köhler, Martin, Herb, Anne, Lüddens, H., ...

Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)

Lomeli, H., Mosbacher, Johannes, Melcher, H., Höger, T., Geiger, Jörg R. P., Kuner, Thomas, ...

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...

Small N-terminal deletion by splicing in cerebellar a6 subunit abolishes GABAA receptor function (1994)

Korpi, Esa R., Kuner, Thomas, Kristo, P., Köhler, Martin, Herb, Anne, Lüddens, H., ...

Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...

Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)

Lomeli, H., Mosbacher, Johannes, Melcher, H., Höger, T., Geiger, Jörg R. P., Kuner, Thomas, ...

AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...

Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)

Raditsch,Martin, Ruppersberg,J. Peter, Kuner,Thomas, Günther,Willy, Schoepfer,Ralf, Seeburg,Peter H., ...

Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...

Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)

Raditsch,Martin, Ruppersberg,J. Peter, Kuner,Thomas, Günther,Willy, Schoepfer,Ralf, Seeburg,Peter H., ...

Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...

Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)

Raditsch,Martin, Ruppersberg,J. Peter, Kuner,Thomas, Günther,Willy, Schoepfer,Ralf, Seeburg,Peter H., ...

Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...

Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes (1993)

Kuner,Thomas, Schoepfer,Ralf, Korpi,Esa R.

Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C...

Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes (1993)

Kuner,Thomas, Schoepfer,Ralf, Korpi,Esa R.

Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C...

Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes (1993)

Kuner, Thomas, Schoepfer, Ralf, Korpi, Esa R.

Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C...

Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)

Raditsch, Martin, Ruppersberg, J. Peter, Kuner, Thomas, Günther, Willy, Schoepfer, Ralf, Seeburg, Peter H., ...

Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...

Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes (1993)

Kuner, Thomas, Schoepfer, Ralf, Korpi, Esa R.

Maximal L-glutamate/glycine-evoked currents were inhibited by ethanol in Xenopus laevis oocytes expressing recombinant heteromeric NMDA receptors consisting of NR1-NR2A, NR1-NR2B, and NR1-NR2C...

Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)

Raditsch, Martin, Ruppersberg, J. Peter, Kuner, Thomas, Günther, Willy, Schoepfer, Ralf, Seeburg, Peter H., ...

Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...

Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)

Raditsch, Martin, Ruppersberg, J. Peter, Kuner, Thomas, Günther, Willy, Schoepfer, Ralf, Seeburg, Peter H., ...

Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...

Chloride imaging in ON−type bipolar cells of a Clomeleon indicator mouse line, ARVO #1324 (0001)

Dübel, Jens, Haverkamp, S., Kuner, Thomas, Euler, Thomas

Chloride imaging in ON−type bipolar cells of a Clomeleon indicator mouse line, ARVO #1324 (0001)

Dübel, Jens, Haverkamp, S., Kuner, Thomas, Euler, Thomas

Chloride imaging in ON−type bipolar cells of a Clomeleon indicator mouse line, ARVO #1324

Dübel,Jens, Haverkamp,S., Kuner,Thomas, Euler,Thomas

Chloride imaging in ON−type bipolar cells of a Clomeleon indicator mouse line, ARVO #1324

Dübel,Jens, Haverkamp,S., Kuner,Thomas, Euler,Thomas

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+

Wollmuth, Lonnie P, Kuner, Thomas, Sakmann, Bert

The voltage-dependent block of N-methyl-D-aspartate (NMDA) receptor channels by extracellular Mg2+ is a critical determinant of its contribution to CNS synaptic physiology. The function of the narrow...

Intracellular Mg2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel

Wollmuth, Lonnie P, Kuner, Thomas, Sakmann, Bert

N-methyl-D-aspartate (NMDA) receptor channels are blocked by intracellular Mg2+ in a voltage-dependent manner. Amino acid residues positioned at or near the narrow constriction that interact with...

Imaging synaptic inhibition throughout the brain via genetically targeted Clomeleon

Berglund, Ken, Schleich, Wolfram, Wang, Hong, Feng, Guoping, Hall, William C., Kuner, Thomas, ...

Here we survey a molecular genetic approach for imaging synaptic inhibition. This approach is based on measuring intracellular chloride concentration ([Cl−]i) with the fluorescent chloride...

Thomas Kuner

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