Thomas Mitchell-Olds

Genetics of Brassica rapa (syn. campestris). 2. Multiple disease resistance to three fungal pathogens: Peronospora parasitica, Albugo Candida and Leptosphaeria maculans (9999)

Thomas Mitchell-Olds, R Vaughn James, Mary J Palmer, Paul H Williams

Evolutionary and ecological functional genomics (9999)

Martin E. Feder, Thomas Mitchell-Olds

Gene Duplication in the Diversification of Secondary Metabolism: Tandem 2-Oxoglutarate–Dependent Dioxygenases Control Glucosinolate Biosynthesis (2008)

In Arabidopsis, Thomas Mitchell-olds

Secondary metabolites are a diverse set of plant compounds believed to have numerous functions in plant–environment interactions. The large chemical diversity of secondary metabolites undoubtedly...

Genetics of Drought Adaptation in Arabidopsis thaliana II. Qtl Analysis of a New Mapping Population, Kas-1 × Tsu-1 (2008)

John K. McKay, James H. Richards, Krishna S. Nemali, Saunak Sen, Thomas Mitchell-Olds, Sandra Boles, ...

Despite compelling evidence that adaptation to local climate is common in plant populations, little is known about the evolutionary genetics of traits that contribute to climatic adaptation. A screen...

The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) (2008)

Ray Ming, Shaobin Hou, Yun Feng, Qingyi Yu, Alexandre Dionne-Laporte, Jimmy H. Saw, ...

Comparative genetic mapping in Boechera stricta, a close relative of Arabidopsis (2007)

Schranz, Michael Eric, Windsor, Aaron Jared, Song, B. H., Lawton-Rauh, Amy, Mitchell-Olds, Thomas

Population genetic inference using a fixed number of segregating sites: a reassessment (2007)

Ramos Onsins, Sebastian, Mousset, S., Mitchell-Olds, Thomas, Stephan, W.

Mapping of QTL for Resistance against the Crucifer Specialist Herbivore Pieris brassicae in a New Arabidopsis Inbred Line Population, Da(1)-12×Ei-2 (2007)

Pfalz, M., Vogel, Heiko, Mitchell-Olds, Thomas, Kroymann, Juergen

The genetic basis of a coevolutionary key innovation and its effect on diversification rate (2007)

Wheat, Christopher, Vogel, Heiko, Wittstock, Ute, Braby, M., Underwood, D., Mitchell-Olds, Thomas

Different Transcript Patterns in Response to Specialist and Generalist Herbivores in the Wild Arabidopsis Relative Boechera divaricarpa (2007)

Vogel, Heiko, Kroymann, Juergen, Mitchell-Olds, Thomas

Mlcoalsim: Multilocus Coalescent Simulations (2007)

Sebastian E. Ramos-Onsins, Thomas Mitchell-Olds

Coalescent theory is a powerful tool for population geneticists as well as molecular biologists interested in understanding the patterns and levels of DNA variation. Using coalescent Monte Carlo...

Genetic mechanisms and evolutionary significance of natural variation in Arabidopsis (2006)

Thomas Mitchell-Olds, Johanna Schmitt

Expression profiling and local adaptation of Boechera holboellii populations for water use efficiency across a naturally occurring water stress gradient (2006)

Knight, Charles A., Vogel, Heiko, Kroymann, Juergen, Shumate, Alice, Witsenboer, Hanneke, Mitchell-Olds, Thomas

We studied the physiological basis of local adaptation to drought in Boechera holboellii, a perennial relative of Arabidopsis thaliana, and used cDNA-AFLPs to identify candidate genes showing...

Partial shotgun sequencing of the Boechera stricta genome reveals extensive microsynteny and promoter conservation with Arabidopsis (2006)

Windsor, Aaron Jared, Schranz, Michael Eric, Formanova, Natasa, Gebauer-Jung, Steffi, Bishop, John G., Schnabelrauch, Domenica, ...

Comparative genomics as a tool for gene discovery (2006)

Windsor, Aaron Jared, Mitchell-Olds, Thomas

Geographic patterns of microsatellite variation in Boechera stricta, a close relative of Arabidopsis (2006)

Song, B. H., Clauss, Maria J., Pepper, A., Mitchell-Olds, Thomas

Independent ancient polyploidy events in the sister families Brassicaceae and Cleomaceae (2006)

Schranz, Michael Eric, Mitchell-Olds, Thomas

Asexual reproduction in a close relative of Arabidopsis: a genetic investigation of apomixis in Boechera (Brassicaceae) (2006)

Schranz, Michael Eric, Kantama, L., De Jong, H., Mitchell-Olds, Thomas

Expression profiling and local adaptation of Boechera holboellii populations for water use efficiency across a naturally occurring water stress gradient (2006)

Knight, Charles A., Vogel, Heiko, Kroymann, Juergen, Shumate, Alice, Witsenboer, H., Mitchell-Olds, Thomas

Natural variation in MAM within and between populations of Arabidopsis lyrata determines glucosinolate phenotype (2006)

Heidel, Andrew, Clauss, Maria J., Kroymann, Juergen, Savolainen, Outi, Mitchell-Olds, Thomas

Cis-regulatory evolution of chalcone-synthase expression in the genus Arabidopsis (2006)

De Meaux, Juliette, Pop, Ana, Mitchell-Olds, Thomas

Population genetic structure of Arabidopsis lyrata in Europe (2006)

Clauss, Maria J., Mitchell-Olds, Thomas

Glucosinolate and trichome defenses in a natural Arabidopsis lyrata population (2006)

Clauss, Maria J., Dietel, Sylke, Schubert, G., Mitchell-Olds, Thomas

Positive selection driving diversification in plant secondary metabolism (2006)

Benderoth, Markus, Textor, Susanne, Windsor, Aaron Jared, Mitchell-Olds, Thomas, Gershenzon, Jonathan, Kroymann, Juergen

Nucleotide variation at the myrosinase-encoding locus, TGG1, and quantitative myrosinase enzyme activity variation in Arabidopsis thaliana (2005)

Stranger, Barbara, Mitchell-Olds, Thomas

Biogeographic distribution of polyploidy and B chromosomes in the apomictic Boechera holboellii complex (2005)

Sharbel, Timothy F., Mitchell-Olds, Thomas, Dobes, Christopher, Kantama, L., De Jong, H.

Sexual reproduction, hybridization, apomixis, and polyploidization in the genus Boechera (Brassicaceae) (2005)

Schranz, Michael Eric, Dobes, Christopher, Koch, Marcus, Mitchell-Olds, Thomas

Geographic and evolutionary diversification of glucosinolates among near relatives of Arabidopsis thaliana (Brassicaceae) (2005)

Windsor, Aaron Jared, Reichelt, Michael, Figuth, Antje, Svatos, Ales, Kroymann, Juergen, Kliebenstein, Daniel J., ...

A multilocus sequence survey in Arabidopsis thaliana reveals a genome-wide departure from a neutral model of DNA sequence polymorphism (2005)

Schmid, Karl J., Ramos Onsins, Sebastian, Ringys-Beckstein, Henriette, Weisshaar, Bernd, Mitchell-Olds, Thomas

Allele-specific assay reveals functional variation in the chalcone synthase promoter of Arabidopsis thaliana that is compatible with neutral evolution (2005)

De Meaux, Juliette, Goebel, U., Pop, Ana, Mitchell-Olds, Thomas

Epistasis and balanced polymorphism influencing complex trait variation (2005)

Kroymann, Juergen, Mitchell-Olds, Thomas

Evolution of the trnF(GAA) gene in Arabidopsis relatives and the Brassicaceae family: Monophyletic origin and subsequent diversification of a plastidic pseudogene (2005)

Koch, Marcus, Dobes, Christopher, Matschinger, M., Bleeker, W., Vogel, J., Kiefer, M., ...

The glucosinolate-myrosinase system in an ecological and evolutionary context (2005)

Kliebenstein, Daniel J., Mitchell-Olds, Thomas, Kroymann, Juergen

Evolution of the trnF(GAA) Gene in Arabidopsis Relatives and the Brassicaceae Family: Monophyletic Origin and subsequent Diversification of a Plastidic Pseudogene (2005)

Koch, Marcus A., Dobe, Christoph, Matschinger, Michaela, Bleeker, Walter, Vogel, Johannes, Kiefer, Markus, ...

Recently we used the 5'-trnL(UAA)-trnF(GAA) region of the chloroplast DNA for phylogeographic reconstructions and phylogenetic analysis among the genera Arabidopsis, Boechera, Rorippa, Nasturtium and...

Evolution of the trnF(GAA) Gene in Arabidopsis Relatives and the Brassicaceae Family: Monophyletic Origin and Subsequent Diversification of a Plastidic Pseudogene (2005)

Koch, Marcus A., Dobes, Christoph, Matschinger, Michaela, Bleeker, Walter, Vogel, Johannes, Kiefer, Markus, ...

Recently, we used the 5′-trnL(UAA)–trnF(GAA) region of the chloroplast DNA for phylogeographic reconstructions and phylogenetic analysis among the genera Arabidopsis, Boechera, Rorippa,...

Evolution of the trnF(GAA) Gene in Arabidopsis Relatives and the Brassicaceae Family: Monophyletic Origin and subsequent Diversification of a Plastidic Pseudogene (2005)

Koch, Marcus A., Dobe, Christoph, Matschinger, Michaela, Bleeker, Walter, Vogel, Johannes, Kiefer, Markus, ...

Recently we used the 5'-trnL(UAA)-trnF(GAA) region of the chloroplast DNA for phylogeographic reconstructions and phylogenetic analysis among the genera Arabidopsis, Boechera, Rorippa, Nasturtium and...

Rapid evolution of a pollen-specific oleosin-like gene family from Arabidopsis thaliana and closely related species (2004)

Schein, M., Yang, Z., Mitchell-Olds, Thomas, Schmid, Karl J.

Functional divergence in tandemly duplicated Arabidopsis thaliana trypsin inhibitor genes (2004)

Clauss, Maria J., Mitchell-Olds, Thomas

Intraspecific diversification in North American Boechera stricta (=Arabis drummondii), Boechera x divaricarpa, and Boechera holboellii (Brassicaceae) inferred from nuclear and chloroplast molecular markers - An integrative approach (2004)

Dobeš, C., Mitchell-Olds, Thomas, Koch, Marcus A.

Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A-lyrata (2004)

Ramos-Onsins, Sebastian, Stranger, Barbara, Mitchell-Olds, Thomas, Aguade, M.

Is the aneuploid chromosome in an apomictic Boechera holboellii a genuine B chromosome? (2004)

Sharbel, Timothy F., Voigt, Marie-Luise, Mitchell-Olds, Thomas, Kantama, L., De Jong, H.

Function and evolution of an Arabidopsis insect resistance QTL (2004)

Kroymann, Jürgen, Mitchell-Olds, Thomas

Comparing the linkage maps of the close relatives Arabidopsis lyrata and A-thaliana (2004)

Kuittinen, H., De Haan, A., Vogl, C., Oikarinen, S., Leppälä, J., Koch, Marcus A., ...

Extensive chloroplast haplotype variation indicates Pleistocene hybridization and radiation of North American Arabis drummondii, A. x divaricarpa, and A-holboellii (Brassicaceae) (2004)

Dobeš, C., Mitchell-Olds, Thomas, Koch, Marcus A.

Successful herbivore attack due to metabolic diversion of a plant chemical defense (2004)

Wittstock, Ute, Agerbirk, N., Stauber, Einar J., Olsen, C. E., Hippler, M., Mitchell-Olds, Thomas, ...

Intraspecific diversification in North American Boechera stricta (=Arabis drummondii), Boechera x divaricarpa, and Boechera holboellii (Brassicaceae) inferred from nuclear and chloroplast molecular markers - An integrative approach (2004)

Dobes, C., Mitchell-Olds, Thomas, Koch, M. A.

Rapid Evolution of a Pollen-Specific Oleosin-Like Gene Family from Arabidopsis Thaliana and Closely Related Species (2004)

Schein, Manja, Yang, Ziheng, Mitchell-Olds, Thomas, Schmid, Karl J.

It has been shown in a variety of species that genes expressed in reproductive tissues evolve rapidly, which often appears to be the result of positive Darwinian selection. We investigated the...

Rapid Evolution of a Pollen-Specific Oleosin-Like Gene Family from Arabidopsis thaliana and Closely Related Species (2004)

Schein, Manja, Yang, Ziheng, Mitchell-Olds, Thomas, Schmid, Karl J.

It has been shown in a variety of species that genes expressed in reproductive tissues evolve rapidly, which often appears to be the result of positive Darwinian selection. We investigated the...

Rapid Evolution of a Pollen-Specific Oleosin-Like Gene Family from Arabidopsis Thaliana and Closely Related Species (2004)

Schein, Manja, Yang, Ziheng, Mitchell-Olds, Thomas, Schmid, Karl J.

It has been shown in a variety of species that genes expressed in reproductive tissues evolve rapidly, which often appears to be the result of positive Darwinian selection. We investigated the...

Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus (2003)

Kroymann, Jürgen, Donnerhacke, S., Schnabelrauch, Domenica, Mitchell-Olds, Thomas

Establishment of a high-efficiency SNP-based framework marker set for Arabidopsis (2003)

Torjek, O., Berger, D., Meyer, R., Mussig, C., Schmid, Karl J., Sorensen, T. R., ...

Population genetics of tandem trypsin inhibitor genes in Arabidopsis species with contrasting ecology and life history (2003)

Clauss, Maria J., Mitchell-Olds, Thomas

Multiple hybrid formation in natural populations: Concerted evolution of the internal transcribed spacer of nuclear ribosomal DNA (ITS) in north American Arabis divaricarpa (Brassicaceae) (2003)

Koch, Marcus A., Dobeš, C., Mitchell-Olds, Thomas

Evolutionary and ecological functional genomics (2003)

Feder, M. E., Mitchell-Olds, Thomas

Genetics of drought adaptation in Arabidopsis thaliana: I. Pleiotropy contributes to genetic correlations among ecological traits (2003)

McKay, Jon K., Richards, J. H., Mitchell-Olds, Thomas

Large-scale identification and analysis of genome-wide single- nucleotide polymorphisms for mapping in Arabidopsis thaliana (2003)

Schmid, Karl J., Sorensen, T. R., Stracke, R., Torjek, O., Altmann, T., Mitchell-Olds, Thomas, ...

Evolution of plant resistance at the molecular level: Ecological context of species interactions (2003)

De Meaux, Juliette, Mitchell-Olds, Thomas

Multiple Hybrid Formation in Natural Populations: Concerted Evolution of the Internal Transcribed Spacer of Nuclear Ribosomal DNA (ITS) in North American Arabis divaricarpa (Brassicaceae) (2003)

Koch, Marcus A., Dobe, Christoph, Mitchell-Olds, Thomas

DNA sequence variation of the internal transcribed spacer region of nuclear ribosomal DNA (ITS) from Arabis holboellii, A. drummondii and its putative hybrid A. divaricarpa was analyzed to study...

Multiple Hybrid Formation in Natural Populations: Concerted Evolution of the Internal Transcribed Spacer of Nuclear Ribosomal DNA (ITS) in North American Arabis divaricarpa (Brassicaceae) (2003)

Koch, Marcus A., Dobes, Christoph, Mitchell-Olds, Thomas

DNA sequence variation of the internal transcribed spacer (ITS) region of nuclear ribosomal DNA from Arabis holboellii, A. drummondii, and its putative hybrid A. divaricarpa was analyzed to study...

Multiple Hybrid Formation in Natural Populations: Concerted Evolution of the Internal Transcribed Spacer of Nuclear Ribosomal DNA (ITS) in North American Arabis divaricarpa (Brassicaceae) (2003)

Koch, Marcus A., Dobe, Christoph, Mitchell-Olds, Thomas

DNA sequence variation of the internal transcribed spacer region of nuclear ribosomal DNA (ITS) from Arabis holboellii, A. drummondii and its putative hybrid A. divaricarpa was analyzed to study...

Chaperones as Buffering Agents? (2002)

Mitchell-Olds, Thomas, Knight, Charles A.

Genetic architecture of plastic methyl jasmonate responses in Arabidopsis thaliana (2002)

Kliebenstein, Daniel J., Figuth, Antje, Mitchell-Olds, Thomas

Disarming the mustard oil bomb (2002)

Ratzka, Andreas, Vogel, Heiko, Kliebenstein, Daniel J., Mitchell-Olds, Thomas, Kroymann, Jürgen

Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana (2002)

Haubold, Bernhard, Kroymann, Jürgen, Ratzka, Andreas, Mitchell-Olds, Thomas, Wiehe, Thomas

Local and differential control of vegetative storage protein expression in response to herbivore damage in Arabidopsis thaliana (2002)

Berger, S., Mitchell-Olds, Thomas, Stotz, Henrik U.

Primers for 22 candidate genes for ecological adaptations in Brassicaceae (2002)

Kuittinen, H., Aquadé, M., Charlesworth, A., De Haan, A., Lauga, B., Mitchell-Olds, Thomas, ...

Cross-species microsatellite markers for elucidating population genetic structure in Arabidopsis and Arabis (Brassicaeae) (2002)

Clauss, Maria J., Cobban, Heather, Mitchell-Olds, Thomas

Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana (2002)

Kliebenstein, Daniel J., Pedersen, Deana, Barker, B., Mitchell-Olds, Thomas

Plant evolutionary genomics (2002)

Mitchell-Olds, Thomas, Clauss, Maria J.

Evolution: Chaperones as buffering agents? (2002)

Mitchell-Olds, Thomas, Knight, Charles

Cost of defense in the context of plant competition: Brassica rapa may grow and defend (2002)

Siemens, David H., Garner, S. H., Mitchell-Olds, Thomas, Callaway, R. M.

Evidence for regulation of resistance in Arabidopsis to Egyptian cotton worm by salicylic and jasmonic acid signaling pathways (2002)

Stotz, Henrik U., Koch, Thomas, Biedermann, Anja, Weniger, Kerstin, Boland, Wilhelm, Mitchell-Olds, Thomas

Benzoic acid glucosinolate esters and other glucosinolates from Arabidopsis thaliana (2002)

Reichelt, Michael, Brown, Paul D., Schneider, Bernd, Oldham, Neil J., Stauber, Einar J., Tokuhisa, Jim, ...

Chaperones as buffering agents? (2002)

Mitchell-Olds, Thomas, Knight, Charles

Recurrent polyploid origins and chloroplast phylogeography in the Arabis holboellii complex (Brassicaceae) (2001)

Timothy F Sharbel, Thomas Mitchell-Olds

Comparative Genomics and Regulatory Evolution: Conservation and Function of the Chs and Apetala3 Promoters (2001)

Koch, Marcus A., Weisshaar, Bernd, Kroymann, Juergen, Haubold, Bernhard, Mitchell-Olds, Thomas

DNA sequence variations of chalcone synthase (Chs) and Apetala3 gene promoters from 22 cruciferous plant species were analyzed to identify putative conserved regulatory elements. Our comparative...

SGP-1: Prediction and Validation of Homologous Genes Based on Sequence Alignments (2001)

Wiehe, Thomas, Gebauer-Jung, Steffi, Mitchell-Olds, Thomas, Guigó, Roderic

Comparative Evolutionary Analysis of Chalcone Synthase and Alcohol Dehydrogenase Loci in Arabidopsis, Arabis, and Related Genera (Brassicaceae) (2000)

Koch, Marcus A., Haubold, Bernhard, Mitchell-Olds, Thomas

We analyzed sequence variation for chalcone synthase (Chs) and alcohol dehydrogenase (Adh) loci in 28 species in the genera Arabidopsis and Arabis and related taxa from tribe Arabideae. Chs was...

Induced Plant Defense Responses against Chewing Insects. Ethylene Signaling Reduces Resistance of Arabidopsis against Egyptian Cotton Worm But Not Diamondback Moth1

Stotz, Henrik U., Pittendrigh, Barry R., Kroymann, Jürgen, Weniger, Kerstin, Fritsche, Jacqueline, Bauke, Antje, ...

The induction of plant defenses by insect feeding is regulated via multiple signaling cascades. One of them, ethylene signaling, increases susceptibility of Arabidopsis to the generalist herbivore...

Genetic Control of Natural Variation in Arabidopsis Glucosinolate Accumulation

Kliebenstein, Daniel J., Kroymann, Juergen, Brown, Paul, Figuth, Antje, Pedersen, Deana, Gershenzon, Jonathan, ...

Glucosinolates are biologically active secondary metabolites of the Brassicaceae and related plant families that influence plant/insect interactions. Specific glucosinolates can act as feeding...

Disarming the mustard oil bomb

Ratzka, Andreas, Vogel, Heiko, Kliebenstein, Daniel J., Mitchell-Olds, Thomas, Kroymann, Juergen

Plants are attacked by a broad array of herbivores and pathogens. In response, plants deploy an arsenal of defensive traits. In Brassicaceae, the glucosinolate–myrosinase complex is a sophisticated...

A Gene Controlling Variation in Arabidopsis Glucosinolate Composition Is Part of the Methionine Chain Elongation Pathway1

Kroymann, Juergen, Textor, Susanne, Tokuhisa, Jim G., Falk, Kimberly L., Bartram, Stefan, Gershenzon, Jonathan, ...

Arabidopsis and other Brassicaceae produce an enormous diversity of aliphatic glucosinolates, a group of methionine (Met)-derived plant secondary compounds containing a β-thio-glucose moiety, a...

Gene Duplication in the Diversification of Secondary Metabolism: Tandem 2-Oxoglutarate–Dependent Dioxygenases Control Glucosinolate Biosynthesis in Arabidopsis

Kliebenstein, Daniel J., Lambrix, Virginia M., Reichelt, Michael, Gershenzon, Jonathan, Mitchell-Olds, Thomas

Secondary metabolites are a diverse set of plant compounds believed to have numerous functions in plant–environment interactions. The large chemical diversity of secondary metabolites undoubtedly...

The Arabidopsis Epithiospecifier Protein Promotes the Hydrolysis of Glucosinolates to Nitriles and Influences Trichoplusia ni Herbivory

Lambrix, Virginia, Reichelt, Michael, Mitchell-Olds, Thomas, Kliebenstein, Daniel J., Gershenzon, Jonathan

Glucosinolates are anionic thioglucosides that have become one of the most frequently studied groups of defensive metabolites in plants. When tissue damage occurs, the thioglucoside linkage is...

Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus

Kroymann, Juergen, Donnerhacke, Susanne, Schnabelrauch, Domenica, Mitchell-Olds, Thomas

Glucosinolate profiles differ among Arabidopsis thaliana ecotypes, caused by the composition of alleles at several glucosinolate biosynthetic loci. One of these, GS-Elong, harbors a family of...

SGP-1: Prediction and Validation of Homologous Genes Based on Sequence Alignments

Wiehe, Thomas, Gebauer-Jung, Steffi, Mitchell-Olds, Thomas, Guigó, Roderic

Conventional methods of gene prediction rely on the recognition of DNA-sequence signals, the coding potential or the comparison of a genomic sequence with a cDNA, EST, or protein database. Reasons...

Successful herbivore attack due to metabolic diversion of a plant chemical defense

Wittstock, Ute, Agerbirk, Niels, Stauber, Einar J., Olsen, Carl Erik, Hippler, Michael, Mitchell-Olds, Thomas, ...

Plants protect themselves against herbivory with a diverse array of repellent or toxic secondary metabolites. However, many herbivorous insects have developed counteradaptations that enable them to...

Allele-Specific Assay Reveals Functional Variation in the Chalcone Synthase Promoter of Arabidopsis thaliana That Is Compatible with Neutral EvolutionW⃞

De Meaux, Juliette, Goebel, Ulrike, Pop, Ana, Mitchell-Olds, Thomas

Promoters are thought to play a major role in adaptive evolution, yet little is known about the regulatory diversity within species, where microevolutionary processes take place. To investigate the...

A Multilocus Sequence Survey in Arabidopsis thaliana Reveals a Genome-Wide Departure From a Neutral Model of DNA Sequence Polymorphism

Schmid, Karl J., Ramos-Onsins, Sebastian, Ringys-Beckstein, Henriette, Weisshaar, Bernd, Mitchell-Olds, Thomas

The simultaneous analysis of multiple genomic loci is a powerful approach to studying the effects of population history and natural selection on patterns of genetic variation of a species. By...

Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana.

Kliebenstein, Daniel, Pedersen, Deana, Barker, Bridget, Mitchell-Olds, Thomas

Evolutionary interactions among insect herbivores and plant chemical defenses have generated systems where plant compounds have opposing fitness consequences for host plants, depending on attack by...

Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana.

Haubold, Bernhard, Kroymann, Jürgen, Ratzka, Andreas, Mitchell-Olds, Thomas, Wiehe, Thomas

Arabidopsis thaliana is a highly selfing plant that nevertheless appears to undergo substantial recombination. To reconcile its selfing habit with the observations of recombination, we have sampled...

Genetic architecture of plastic methyl jasmonate responses in Arabidopsis thaliana.

Kliebenstein, Daniel J, Figuth, Antje, Mitchell-Olds, Thomas

The ability of a single genotype to generate different phenotypes in disparate environments is termed phenotypic plasticity, which reflects the interaction of genotype and environment on...

Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata.

Ramos-Onsins, Sebastián E, Stranger, Barbara E, Mitchell-Olds, Thomas, Aguadé, Montserrat

Nucleotide variation in eight effectively unlinked genes was surveyed in species-wide samples of the closely related outbreeding species Arabidopsis halleri and A. lyrata ssp. petraea and in three of...

Natural Variation in MAM Within and Between Populations of Arabidopsis lyrata Determines Glucosinolate Phenotype

Heidel, Andrew J., Clauss, Maria J., Kroymann, Juergen, Savolainen, Outi, Mitchell-Olds, Thomas

The genetic variation that underlies the glucosinolate phenotype of Arabidopsis lyrata ssp. petraea was investigated between and within populations. A candidate glucosinolate biosynthetic locus (MAM,...

Positive selection driving diversification in plant secondary metabolism

Benderoth, Markus, Textor, Susanne, Windsor, Aaron J., Mitchell-Olds, Thomas, Gershenzon, Jonathan, Kroymann, Juergen

In Arabidopsis thaliana and related plants, glucosinolates are a major component in the blend of secondary metabolites and contribute to resistance against herbivorous insects. Methylthioalkylmalate...

Induced Plant Defense Responses against Chewing Insects. Ethylene Signaling Reduces Resistance of Arabidopsis against Egyptian Cotton Worm But Not Diamondback Moth1

Stotz, Henrik U., Pittendrigh, Barry R., Kroymann, Jürgen, Weniger, Kerstin, Fritsche, Jacqueline, Bauke, Antje, ...

The induction of plant defenses by insect feeding is regulated via multiple signaling cascades. One of them, ethylene signaling, increases susceptibility of Arabidopsis to the generalist herbivore...

Genetic Control of Natural Variation in Arabidopsis Glucosinolate Accumulation

Kliebenstein, Daniel J., Kroymann, Juergen, Brown, Paul, Figuth, Antje, Pedersen, Deana, Gershenzon, Jonathan, ...

Glucosinolates are biologically active secondary metabolites of the Brassicaceae and related plant families that influence plant/insect interactions. Specific glucosinolates can act as feeding...

Disarming the mustard oil bomb

Ratzka, Andreas, Vogel, Heiko, Kliebenstein, Daniel J., Mitchell-Olds, Thomas, Kroymann, Juergen

Plants are attacked by a broad array of herbivores and pathogens. In response, plants deploy an arsenal of defensive traits. In Brassicaceae, the glucosinolate–myrosinase complex is a sophisticated...

A Gene Controlling Variation in Arabidopsis Glucosinolate Composition Is Part of the Methionine Chain Elongation Pathway1

Kroymann, Juergen, Textor, Susanne, Tokuhisa, Jim G., Falk, Kimberly L., Bartram, Stefan, Gershenzon, Jonathan, ...

Arabidopsis and other Brassicaceae produce an enormous diversity of aliphatic glucosinolates, a group of methionine (Met)-derived plant secondary compounds containing a β-thio-glucose moiety, a...

Gene Duplication in the Diversification of Secondary Metabolism: Tandem 2-Oxoglutarate–Dependent Dioxygenases Control Glucosinolate Biosynthesis in Arabidopsis

Kliebenstein, Daniel J., Lambrix, Virginia M., Reichelt, Michael, Gershenzon, Jonathan, Mitchell-Olds, Thomas

Secondary metabolites are a diverse set of plant compounds believed to have numerous functions in plant–environment interactions. The large chemical diversity of secondary metabolites undoubtedly...

The Arabidopsis Epithiospecifier Protein Promotes the Hydrolysis of Glucosinolates to Nitriles and Influences Trichoplusia ni Herbivory

Lambrix, Virginia, Reichelt, Michael, Mitchell-Olds, Thomas, Kliebenstein, Daniel J., Gershenzon, Jonathan

Glucosinolates are anionic thioglucosides that have become one of the most frequently studied groups of defensive metabolites in plants. When tissue damage occurs, the thioglucoside linkage is...

Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus

Kroymann, Juergen, Donnerhacke, Susanne, Schnabelrauch, Domenica, Mitchell-Olds, Thomas

Glucosinolate profiles differ among Arabidopsis thaliana ecotypes, caused by the composition of alleles at several glucosinolate biosynthetic loci. One of these, GS-Elong, harbors a family of...

SGP-1: Prediction and Validation of Homologous Genes Based on Sequence Alignments

Wiehe, Thomas, Gebauer-Jung, Steffi, Mitchell-Olds, Thomas, Guigó, Roderic

Conventional methods of gene prediction rely on the recognition of DNA-sequence signals, the coding potential or the comparison of a genomic sequence with a cDNA, EST, or protein database. Reasons...

Successful herbivore attack due to metabolic diversion of a plant chemical defense

Wittstock, Ute, Agerbirk, Niels, Stauber, Einar J., Olsen, Carl Erik, Hippler, Michael, Mitchell-Olds, Thomas, ...

Plants protect themselves against herbivory with a diverse array of repellent or toxic secondary metabolites. However, many herbivorous insects have developed counteradaptations that enable them to...

Allele-Specific Assay Reveals Functional Variation in the Chalcone Synthase Promoter of Arabidopsis thaliana That Is Compatible with Neutral EvolutionW⃞

De Meaux, Juliette, Goebel, Ulrike, Pop, Ana, Mitchell-Olds, Thomas

Promoters are thought to play a major role in adaptive evolution, yet little is known about the regulatory diversity within species, where microevolutionary processes take place. To investigate the...

A Multilocus Sequence Survey in Arabidopsis thaliana Reveals a Genome-Wide Departure From a Neutral Model of DNA Sequence Polymorphism

Schmid, Karl J., Ramos-Onsins, Sebastian, Ringys-Beckstein, Henriette, Weisshaar, Bernd, Mitchell-Olds, Thomas

The simultaneous analysis of multiple genomic loci is a powerful approach to studying the effects of population history and natural selection on patterns of genetic variation of a species. By...

Comparative analysis of quantitative trait loci controlling glucosinolates, myrosinase and insect resistance in Arabidopsis thaliana.

Kliebenstein, Daniel, Pedersen, Deana, Barker, Bridget, Mitchell-Olds, Thomas

Evolutionary interactions among insect herbivores and plant chemical defenses have generated systems where plant compounds have opposing fitness consequences for host plants, depending on attack by...

Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana.

Haubold, Bernhard, Kroymann, Jürgen, Ratzka, Andreas, Mitchell-Olds, Thomas, Wiehe, Thomas

Arabidopsis thaliana is a highly selfing plant that nevertheless appears to undergo substantial recombination. To reconcile its selfing habit with the observations of recombination, we have sampled...

Genetic architecture of plastic methyl jasmonate responses in Arabidopsis thaliana.

Kliebenstein, Daniel J, Figuth, Antje, Mitchell-Olds, Thomas

The ability of a single genotype to generate different phenotypes in disparate environments is termed phenotypic plasticity, which reflects the interaction of genotype and environment on...

Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata.

Ramos-Onsins, Sebastián E, Stranger, Barbara E, Mitchell-Olds, Thomas, Aguadé, Montserrat

Nucleotide variation in eight effectively unlinked genes was surveyed in species-wide samples of the closely related outbreeding species Arabidopsis halleri and A. lyrata ssp. petraea and in three of...

Positive selection driving diversification in plant secondary metabolism

Benderoth, Markus, Textor, Susanne, Windsor, Aaron J., Mitchell-Olds, Thomas, Gershenzon, Jonathan, Kroymann, Juergen

In Arabidopsis thaliana and related plants, glucosinolates are a major component in the blend of secondary metabolites and contribute to resistance against herbivorous insects. Methylthioalkylmalate...

Natural Variation in MAM Within and Between Populations of Arabidopsis lyrata Determines Glucosinolate Phenotype

Heidel, Andrew J., Clauss, Maria J., Kroymann, Juergen, Savolainen, Outi, Mitchell-Olds, Thomas

The genetic variation that underlies the glucosinolate phenotype of Arabidopsis lyrata ssp. petraea was investigated between and within populations. A candidate glucosinolate biosynthetic locus (MAM,...

Partial Shotgun Sequencing of the Boechera stricta Genome Reveals Extensive Microsynteny and Promoter Conservation with Arabidopsis1[W]

Windsor, Aaron J., Schranz, M. Eric, Formanová, Nataša, Gebauer-Jung, Steffi, Bishop, John G., Schnabelrauch, Domenica, ...

Comparative genomics provides insight into the evolutionary dynamics that shape discrete sequences as well as whole genomes. To advance comparative genomics within the Brassicaceae, we have end...

Independent Ancient Polyploidy Events in the Sister Families Brassicaceae and Cleomaceae[W]

Schranz, M. Eric, Mitchell-Olds, Thomas

Recent studies have elucidated the ancient polyploid history of the Arabidopsis thaliana (Brassicaceae) genome. The studies concur that there was at least one polyploidy event occurring some 14.5 to...

Mapping of QTL for Resistance against the Crucifer Specialist Herbivore Pieris brassicae in a New Arabidopsis Inbred Line Population, Da(1)-12×Ei-2

Pfalz, Marina, Vogel, Heiko, Mitchell-Olds, Thomas, Kroymann, Juergen

Different Transcript Patterns in Response to Specialist and Generalist Herbivores in the Wild Arabidopsis Relative Boechera divaricarpa

Vogel, Heiko, Kroymann, Juergen, Mitchell-Olds, Thomas

Diploid apomicts of the Boechera holboellii complex display large-scale chromosome substitutions and aberrant chromosomes

Kantama, Laksana, Sharbel, Timothy F., Schranz, M. Eric, Mitchell-Olds, Thomas, De Vries, Sacco, De Jong, Hans

We conducted a cytogenetic study of sexual lines of Boechera stricta and Boechera holboellii (2n = 14) and seven diploid apomictic accessions of their interspecific hybrid Boechera divaricarpa and B....

Comparative Genetic Mapping in Boechera stricta, a Close Relative of Arabidopsis1[C][W][OA]

Schranz, M. Eric, Windsor, Aaron J., Song, Bao-hua, Lawton-Rauh, Amy, Mitchell-Olds, Thomas

The angiosperm family Brassicaceae contains both the research model Arabidopsis (Arabidopsis thaliana) and the agricultural genus Brassica. Comparative genomics in the Brassicaceae has largely...

The genetic basis of a plant–insect coevolutionary key innovation

Wheat, Christopher W., Vogel, Heiko, Wittstock, Ute, Braby, Michael F., Underwood, Dessie, Mitchell-Olds, Thomas

Ehrlich and Raven formally introduced the concept of stepwise coevolution using butterfly and angiosperm interactions in an attempt to account for the impressive biological diversity of these groups....

Mlcoalsim: Multilocus Coalescent Simulations

Ramos-Onsins, Sebastian E., Mitchell-Olds, Thomas

Coalescent theory is a powerful tool for population geneticists as well as molecular biologists interested in understanding the patterns and levels of DNA variation. Using coalescent Monte Carlo...

Multilocus Patterns of Nucleotide Diversity, Population Structure and Linkage Disequilibrium in Boechera stricta, a Wild Relative of Arabidopsis

Song, Bao-Hua, Windsor, Aaron J., Schmid, Karl J., Ramos-Onsins, Sebastian, Schranz, M. Eric, Heidel, Andrew J., ...

Information about polymorphism, population structure, and linkage disequilibrium (LD) is crucial for association studies of complex trait variation. However, most genomewide studies have focused on...

A Novel 2-Oxoacid-Dependent Dioxygenase Involved in the Formation of the Goiterogenic 2-Hydroxybut-3-enyl Glucosinolate and Generalist Insect Resistance in Arabidopsis[C][W][OA]

Hansen, Bjarne G., Kerwin, Rachel E., Ober, James A., Lambrix, Virginia M., Mitchell-Olds, Thomas, Gershenzon, Jonathan, ...

Glucosinolates are secondary metabolites found almost exclusively in the order Brassicales. They are synthesized from a variety of amino acids and can have numerous side chain modifications that...