Thomas R. Jones

A case of purpura hemorrhagica in a horse / (1966)

Jones, Thomas R.

Senior seminar (D.V.M.)--Cornell University, 1966.

Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene

Van Zeijl, Marja, Fairhurst, Jeanette, Jones, Thomas R., Vernon, Steven K., Morin, John, LaRocque, James, ...

In our search for novel inhibitors of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was discovered. N-{4-[3-(5-Chloro-2,4-dimethoxyphenyl)-thioureido]-phenyl}-acetamide and...

RFI-641, a Potent Respiratory Syncytial Virus Inhibitor

Huntley, Clayton C., Weiss, William J., Gazumyan, Anna, Buklan, Aron, Feld, Boris, Hu, William, ...

Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV...

Identification of Small Molecule Compounds That Selectively Inhibit Varicella-Zoster Virus Replication

Visalli, Robert J., Fairhurst, Jeanette, Srinivas, Shamala, Hu, William, Feld, Boris, DiGrandi, Martin, ...

A series of nonnucleoside, N-α-methylbenzyl-N′-arylthiourea analogs were identified which demonstrated selective activity against varicella-zoster virus (VZV) but were inactive against other human...

Heterologous immunity provides a potent barrier to transplantation tolerance

Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...

Intravital microscopy identifies selectins that regulate T cell traffic into allografts

Jones, Thomas R., Shirasugi, Nozomu, Adams, Andrew B., Pearson, Thomas C., Larsen, Christian P.

T cell homing to sites of injury and inflammation is a critical step for adaptive immune responses. While much has been learned regarding T cell homing to lymphoid tissues, few studies have directly...

Phosphorylation of Human Cytomegalovirus Glycoprotein B (gB) at the Acidic Cluster Casein Kinase 2 Site (Ser900) Is Required for Localization of gB to the trans-Golgi Network and Efficient Virus Replication

Jarvis, Michael A., Jones, Thomas R., Drummond, Derek D., Smith, Patsy P., Britt, William J., Nelson, Jay A., ...

Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified...

Specific Inhibition of Human Cytomegalovirus Glycoprotein B-Mediated Fusion by a Novel Thiourea Small Molecule

Jones, Thomas R., Lee, Shi-Wu, Johann, Stephen V., Razinkov, Vladimir, Visalli, Robert J., Feld, Boris, ...

A novel small molecule inhibitor of human cytomegalovirus (HCMV) was identified as the result of screening a chemical library by using a whole-virus infected-cell assay. Synthetic chemistry efforts...

An Acidic Cluster of Human Cytomegalovirus UL99 Tegument Protein Is Required for Trafficking and Function

Jones, Thomas R., Lee, Shi-Wu

The human cytomegalovirus (HCMV) virion is comprised of a linear double-stranded DNA genome, proteinaceous capsid and tegument, and a lipid envelope containing virus-encoded glycoproteins. Of these...

Postattachment Events Associated with Viral Entry Are Necessary for Induction of Interferon-Stimulated Genes by Human Cytomegalovirus

Netterwald, James R., Jones, Thomas R., Britt, William J., Yang, Shao-Jun, McCrone, Ian P., Zhu, Hua

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results...

Assignment of Weight-Based Immunoglobulin G1 (IgG1) and IgG2 Units in Antipneumococcal Reference Serum Lot 89-S(F) for Pneumococcal Polysaccharide Serotypes 1, 4, 5, 7F, 9V, and 18C

Sikkema, Daniel J., Ziembiec, Nancy A., Jones, Thomas R., Hildreth, Stephen W., Madore, Dace V., Quataert, Sally A.

Weight-based assignments for immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to Streptococcus pneumoniae capsular polysaccharides (PnPs) in antipneumococcal standard reference serum lot 89-S...

Identification of Cytomegalovirus-Specific Cytotoxic T Lymphocytes In Vitro Is Greatly Enhanced by the Use of Recombinant Virus Lacking the US2 to US11 Region or Modified Vaccinia Virus Ankara Expressing Individual Viral Genes

Khan, Naeem, Bruton, Rachel, Taylor, Graham S., Cobbold, Mark, Jones, Thomas R., Rickinson, Alan B., ...

Cytomegalovirus (CMV) elicits a potent T-cell response in humans that appears to protect the host from virus-associated disease. Despite facing strong host defense mechanisms, CMV remains as a...

Approach to Validating an Opsonophagocytic Assay for Streptococcus pneumoniae

Hu, Branda T., Yu, Xinhong, Jones, Thomas R., Kirch, Carol, Harris, Sarah, Hildreth, Stephen W., ...

Streptococcus pneumoniae (pneumococcus) polysaccharide serotype-specific antibodies that have opsonophagocytic activity are considered a primary mechanism of host defense against pneumococcal...

Novel Class of Thiourea Compounds That Inhibit Herpes Simplex Virus Type 1 DNA Cleavage and Encapsidation: Resistance Maps to the UL6 Gene

Van Zeijl, Marja, Fairhurst, Jeanette, Jones, Thomas R., Vernon, Steven K., Morin, John, LaRocque, James, ...

In our search for novel inhibitors of herpes simplex virus type 1 (HSV-1), a new class of thiourea inhibitors was discovered. N-{4-[3-(5-Chloro-2,4-dimethoxyphenyl)-thioureido]-phenyl}-acetamide and...

RFI-641, a Potent Respiratory Syncytial Virus Inhibitor

Huntley, Clayton C., Weiss, William J., Gazumyan, Anna, Buklan, Aron, Feld, Boris, Hu, William, ...

Human respiratory syncytial virus (RSV), a paramyxovirus, is a major cause of acute upper and lower respiratory tract infections in infants, young children, and adults. RFI-641 is a novel anti-RSV...

Identification of Small Molecule Compounds That Selectively Inhibit Varicella-Zoster Virus Replication

Visalli, Robert J., Fairhurst, Jeanette, Srinivas, Shamala, Hu, William, Feld, Boris, DiGrandi, Martin, ...

A series of nonnucleoside, N-α-methylbenzyl-N′-arylthiourea analogs were identified which demonstrated selective activity against varicella-zoster virus (VZV) but were inactive against other human...

Heterologous immunity provides a potent barrier to transplantation tolerance

Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...

Intravital microscopy identifies selectins that regulate T cell traffic into allografts

Jones, Thomas R., Shirasugi, Nozomu, Adams, Andrew B., Pearson, Thomas C., Larsen, Christian P.

T cell homing to sites of injury and inflammation is a critical step for adaptive immune responses. While much has been learned regarding T cell homing to lymphoid tissues, few studies have directly...

Phosphorylation of Human Cytomegalovirus Glycoprotein B (gB) at the Acidic Cluster Casein Kinase 2 Site (Ser900) Is Required for Localization of gB to the trans-Golgi Network and Efficient Virus Replication

Jarvis, Michael A., Jones, Thomas R., Drummond, Derek D., Smith, Patsy P., Britt, William J., Nelson, Jay A., ...

Human cytomegalovirus (HCMV) glycoprotein B (gB), encoded by the UL55 open reading frame, is an essential envelope glycoprotein involved in cell attachment and entry. Previously, we identified...

Specific Inhibition of Human Cytomegalovirus Glycoprotein B-Mediated Fusion by a Novel Thiourea Small Molecule

Jones, Thomas R., Lee, Shi-Wu, Johann, Stephen V., Razinkov, Vladimir, Visalli, Robert J., Feld, Boris, ...

A novel small molecule inhibitor of human cytomegalovirus (HCMV) was identified as the result of screening a chemical library by using a whole-virus infected-cell assay. Synthetic chemistry efforts...

An Acidic Cluster of Human Cytomegalovirus UL99 Tegument Protein Is Required for Trafficking and Function

Jones, Thomas R., Lee, Shi-Wu

The human cytomegalovirus (HCMV) virion is comprised of a linear double-stranded DNA genome, proteinaceous capsid and tegument, and a lipid envelope containing virus-encoded glycoproteins. Of these...

Postattachment Events Associated with Viral Entry Are Necessary for Induction of Interferon-Stimulated Genes by Human Cytomegalovirus

Netterwald, James R., Jones, Thomas R., Britt, William J., Yang, Shao-Jun, McCrone, Ian P., Zhu, Hua

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results...

Assignment of Weight-Based Immunoglobulin G1 (IgG1) and IgG2 Units in Antipneumococcal Reference Serum Lot 89-S(F) for Pneumococcal Polysaccharide Serotypes 1, 4, 5, 7F, 9V, and 18C

Sikkema, Daniel J., Ziembiec, Nancy A., Jones, Thomas R., Hildreth, Stephen W., Madore, Dace V., Quataert, Sally A.

Weight-based assignments for immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to Streptococcus pneumoniae capsular polysaccharides (PnPs) in antipneumococcal standard reference serum lot 89-S...

Identification of Cytomegalovirus-Specific Cytotoxic T Lymphocytes In Vitro Is Greatly Enhanced by the Use of Recombinant Virus Lacking the US2 to US11 Region or Modified Vaccinia Virus Ankara Expressing Individual Viral Genes

Khan, Naeem, Bruton, Rachel, Taylor, Graham S., Cobbold, Mark, Jones, Thomas R., Rickinson, Alan B., ...

Cytomegalovirus (CMV) elicits a potent T-cell response in humans that appears to protect the host from virus-associated disease. Despite facing strong host defense mechanisms, CMV remains as a...

Approach to Validating an Opsonophagocytic Assay for Streptococcus pneumoniae

Hu, Branda T., Yu, Xinhong, Jones, Thomas R., Kirch, Carol, Harris, Sarah, Hildreth, Stephen W., ...

Streptococcus pneumoniae (pneumococcus) polysaccharide serotype-specific antibodies that have opsonophagocytic activity are considered a primary mechanism of host defense against pneumococcal...

The HCMV Gene Products US11 and US2 Differ in Their Ability to Attack Allelic Forms of Murine Major Histocompatibility Complex (MHC) Class I Heavy Chains

Machold, Robert P., Jones, Thomas R., Ploegh, H.L.

Human cytomegalovirus downregulates the expression of human class I major histocompatibility complex (MHC) molecules by accelerating destruction of newly synthesized class I heavy chains. The HCMV...

Chemokine Sequestration by Viral Chemoreceptors as a Novel Viral Escape Strategy: Withdrawal of Chemokines from the Environment of Cytomegalovirus-infected Cells

Bodaghi, Bahram, Jones, Thomas R., Zipeto, Donato, Vita, Claudio, Sun, Lei, Laurent, Lysiane, ...

Human cytomegalovirus (HCMV), a betaherpesvirus, has developed several ways to evade the immune system, notably downregulation of cell surface expression of major histocompatibility complex class I...

Dislocation of Type I Membrane Proteins from the ER to the Cytosol Is Sensitive to Changes in Redox Potential

Tortorella, Domenico, Story, Craig M., Huppa, Johannes B., Jones, Thomas R., Ploegh, Hidde L.

The human cytomegalovirus (HCMV) gene products US2 and US11 dislocate major histocompatibility class I heavy chains from the ER and target them for proteasomal degradation in the cytosol. The...