Thomas R. O’Brien

A simple relationship between viral load and survival time in HIV-1 infection

Arnaout, Ramy A., Lloyd, Alun L., O’Brien, Thomas R., Goedert, James J., Leonard, John M., Nowak, Martin A.

Despite important recent insights into the short-term dynamics of HIV-1 infection, our understanding of the long-term pathogenesis of AIDS remains unclear. Using an approach that places rapid...

CCR2-64I Polymorphism Is Not Associated with Altered CCR5 Expression or Coreceptor Function

Mariani, Roberto, Wong, Sally, Mulder, Lubbertus C. F., Wilkinson, David A., Reinhart, Amy L., LaRosa, Gregory, ...

A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of...

Exclusive and Persistent Use of the Entry Coreceptor CXCR4 by Human Immunodeficiency Virus Type 1 from a Subject Homozygous for CCR5 Δ32

Michael, Nelson L., Nelson, Julie A. E., KewalRamani, Vineet N., Chang, George, O’Brien, Stephen J., Mascola, John R., ...

Individuals who are homozygous for the 32-bp deletion in the gene coding for the chemokine receptor and major human immunodeficiency virus type 1 (HIV-1) coreceptor CCR5 (CCR5 −/−) lack...

A simple relationship between viral load and survival time in HIV-1 infection

Arnaout, Ramy A., Lloyd, Alun L., O’Brien, Thomas R., Goedert, James J., Leonard, John M., Nowak, Martin A.

Despite important recent insights into the short-term dynamics of HIV-1 infection, our understanding of the long-term pathogenesis of AIDS remains unclear. Using an approach that places rapid...

CCR2-64I Polymorphism Is Not Associated with Altered CCR5 Expression or Coreceptor Function

Mariani, Roberto, Wong, Sally, Mulder, Lubbertus C. F., Wilkinson, David A., Reinhart, Amy L., LaRosa, Gregory, ...

A polymorphism in the gene encoding CCR2 is associated with a delay in progression to AIDS in human immunodeficiency virus (HIV)-infected individuals. The polymorphism, CCR2-64I, changes valine 64 of...

Exclusive and Persistent Use of the Entry Coreceptor CXCR4 by Human Immunodeficiency Virus Type 1 from a Subject Homozygous for CCR5 Δ32

Michael, Nelson L., Nelson, Julie A. E., KewalRamani, Vineet N., Chang, George, O’Brien, Stephen J., Mascola, John R., ...

Individuals who are homozygous for the 32-bp deletion in the gene coding for the chemokine receptor and major human immunodeficiency virus type 1 (HIV-1) coreceptor CCR5 (CCR5 −/−) lack...