Chromosomal instability determines taxane sensitivity - supplementary materials (2009)
Swanton, Charles, Nicke, Barbara, Schuett, Marion, Eklund, Aron C., Ng, Charlotte, Li, Qiyuan, ...
Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in...
Madhvi B. Upender, Jens K. Habermann, Lisa M. Mcshane, Edward L. Korn, J. Carl Barrett, Thomas Ried
Chromosomal aneuploidies are observed in essentially all sporadic carcinomas. These aneuploidies result in tumor-specific patterns of genomic imbalances that are acquired early during tumorigenesis,...
A sequence-based survey of the complex structural organization of tumor genomes (2008)
Raphael, Benjamin J, Volik, Stanislav, Yu, Peng, Wu, Chunxiao, Huang, Guiqing, Linardopoulou, Elena V, ...
Abstract Background The genomes of many epithelial tumors exhibit extensive chromosomal rearrangements. All classes of genome rearrangements can be identified using end sequencing profiling, which...
Marta Chesi, P. Leif Bergsagel, Oluwatoyin O. Shonukan, Maria Luisa Martelli, Leslie A. Brents, Theresa Chen, ...
Dysregulation of oncogenes by translocation to an IgH (14q32) or IgL (�, 2p11 or �, 22q11) locus is a frequent event in the pathogenesis of B-cell tumors. Translocations involving an IgH locus...
Actin-dependent intranuclear repositioning of an active gene locus in vivo. (2007)
Dundr, Miroslav, Ospina, Jason K., Sung, Myong-Hee, John, Sam, Upender, Madhvi, Ried, Thomas, ...
Although bulk chromatin is thought to have limited mobility within the interphase eukaryotic nucleus, directed long-distance chromosome movements are not unknown. Cajal bodies (CBs) are nuclear...
Molecular and cytological features of the mouse B-cell lymphoma line iMycEμ-1 (2005)
Su Han, Seong, Shaffer, Arthur L, Peng, Liangping, Chung, Seung, Lim, Jae, Maeng, Sungho, ...
Abstract Background Myc -induced lymphoblastic B-cell lymphoma (LBL) in iMyc Eμ mice may provide a model system for the study of the mechanism by which human MYC facilitates the initiation and...
SMC1 involvement in fragile site expression (2005)
Musio, Antonio, Montagna, Cristina, Mariani, Tullio, Tilenni, Manuela, Focarelli, Maria Luisa, Brait, Lorenzo, ...
Common fragile sites have been involved in neoplastic transformation, although their molecular basis is still poorly understood. Here, we demonstrate that inhibition of the SMC1 by RNAi is sufficient...
Ataxia telangiectasia mutated is essential during adult neurogenesis (2001)
Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...
Darmstadt, Techn. Universiẗat, Diss., 1998.
Tocharoentanaphol, Chintana, Cremer, Marion, Schröck, Evelin, Blonden, Lau, Kilian, Karin, Cremer, Thomas, ...
We report on multicolor fluorescence in situ hybridization protocols for the simultaneous visualization of deletion-prone regions for carrier detection of Duchenne/ Becker (DMD/BMD) muscular...
Ried, Thomas, Petersen, Iver, Holtgreve-Grez, Heidi, Speicher, Michael R., Schröck, Evelin, Manoir, Stanislas Du, ...
Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens. The most abundant...
Schröck, Evelin, Thiel, G., Lozonova, T., Manoir, Stanislas Du, Meffert, M. C., Jauch, Anna, ...
Nine human malignant gliomas (2 astrocytomas grade III and 7 glioblastomas) were analyzed using comparative genomic hybridization (CGH). In addition to the amplification of the EGFR gene at 7p12 in 4...
Speicher, Michael R., Schoell, B., Manoir, Stanislas Du, Schröck, Evelin, Ried, Thomas, Cremer, Thomas, ...
We analyzed 19 chromophobe renal cell carcinomas by means of comparative genomic hybridization. Two tumors revealed no numerical abnormalities. In the remaining 17 cases we found loss of entire...
The role of chromosome territories in the funtional compartmentalization of the cell nucleus (1993)
Cremer, Thomas, Kurz, A., Zirbel, R. M., Dietzel, S., Rinke, B., Schröck, Evelin, ...
Speicher, Michael R., Manoir, Stanislas Du, Schröck, Evelin, Holtgreve-Grez, Heidi, Schoell, B., Lengauer, Christoph, ...
We present a technique which allows the detection and chromosomal localization of DNA sequence copy number changes in solid tumor genomes from frozen sections and paraffin embedded, formalin fixed...
Cremer, Thomas, Lichter, Peter, Popp, Susanne, Schröck, Evelin, Jauch, Anna, Manoir, Stanislas Du, ...
Spelcher, Michael R., Manoir, Stanislas Du, SchrÖck, Evelln, Holtgreve-Grez, Heidi, Schoell, Brlgltte, Lengauer, Christoph, ...
We present a technique which allows the detection and chromosomal localization of DNA sequence copy number changes in solid tumor genomes from frozen sections and paraffin embedded, formalin fixed...
Bellefroid, Eric J, Marine, Jean-Christophe, Ried, Thomas, Lecocq, Pierre J, Riviere, Michele, Amemiya, Chris, ...
KRAB zinc-finger proteins (KRAB-ZFPs) constitute a large subfamily of ZFPs of the Krüppel C2H2 type. KRAB (Krüppel-associated box) is an evolutionarily conserved protein domain found N-terminally...
Ried, Thomas, Lengauer, Christoph, Cremer, Thomas, Wiegant, Joop, Raap, Anton K., Van Der Ploeg, Mels, ...
Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma...
Localization of the human KRAB finger gene ZNF117 (HPF9) to chromosome 7q11.2 (1992)
Bellefroid, Eric J, Ried, Thomas, Riviere, Michele, Marine, Jean-Christophe, Levan, G, Szpirer, J, ...
A cluster of Kruppel type zinc finger genes of the KRAB subclass has recently been localized on human chromosome 19p12-p13.1. We now report that ZNF117 (HPF9), a closely related zinc finger gene of...
Ried, Thomas, Landes, Greg, Dackowski, William, Klinger, Katherine, Ward, David C.
The most frequent aneuploidies in newborns involve the autosomes 13, 18 and 21 as well as both sex chromosomes. Fluorescence in situ hybridization readily allows the detection of numerical...
In situ hybridisation with fluoresceinated DNA (1991)
Wiegant, Joop, Ried, Thomas, Nederlof, Petra M., Ploeg, Mels Van Der, Tanke, Hans J., Raap, Anton K.
We have used fluorescein-11-dUTP in a nick-translation format to produce fluoresceinated human nucleic acid probes. After In situ hybridization of fluoresceinated DNAs to human metaphase chromosomes,...
Ried, Thomas, Mahler, V., Vogt, Peter, Blonden, L., Cremer, Thomas
A basic problem in genetic counseling of families with Duchenne/Becker muscular dystrophy (DMD/BMD) concerns the carrier status of female relatives of an affected male. In about 60% of these...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Blaschke, Rüdiger J., Monaghan, A. Paula, Schiller, Simone, Schechinger, Birgit, Rao, Ercole, Padilla-Nash, Hesed, ...
Deletion of the SHOX region on the human sex chromosomes has been shown to result in idiopathic short stature and proposed to play a role in the short stature associated with Turner syndrome. We have...
Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Forgues, Marshonna, Difilippantonio, Michael J., Linke, Steven P., Ried, Thomas, Nagashima, Kunio, Feden, Jeffrey, ...
Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer...
Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout
Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, ...
Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1...
Srivastava, Meera, Montagna, Cristina, Leighton, Ximena, Glasman, Mirta, Naga, Shanmugam, Eidelman, Ofer, ...
Annexin 7 (ANX7) acts as a tumor suppressor gene in prostate cancer, where loss of heterozygosity and reduction of ANX7 protein expression is associated with aggressive metastatic tumors. To...
Knutsen, Turid, Gobu, Vasuki, Knaus, Rodger, Padilla-Nash, Hesed, Augustus, Meena, Strausberg, Robert L., ...
To catalogue data on chromosomal aberrations in cancer derived from emerging molecular cytogenetic techniques and to integrate these data with genome maps, we have established two resources, the NCI...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Molecular and cytological features of the mouse B-cell lymphoma line iMycEμ-1
Su Han, Seong, Shaffer, Arthur L, Peng, Liangping, Chung, Seung Tae, Lim, Jae Hwan, Maeng, Sungho, ...
Desper, Richard, Difilippantonio, Michael J., Ried, Thomas, Schäffer, Alejandro A.
Aneuploidy, the gain or loss of large regions of the genome, is a common feature in cancer cells. Irregularities in chromosomal copy number caused by missegregations of chromosomes during mitosis can...
Ataxia telangiectasia mutated is essential during adult neurogenesis
Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...
Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein...
Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...
The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...
Blaschke, Rüdiger J., Monaghan, A. Paula, Schiller, Simone, Schechinger, Birgit, Rao, Ercole, Padilla-Nash, Hesed, ...
Deletion of the SHOX region on the human sex chromosomes has been shown to result in idiopathic short stature and proposed to play a role in the short stature associated with Turner syndrome. We have...
Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...
RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice
Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...
Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...
Forgues, Marshonna, Difilippantonio, Michael J., Linke, Steven P., Ried, Thomas, Nagashima, Kunio, Feden, Jeffrey, ...
Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer...
Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout
Crabtree, Judy S., Scacheri, Peter C., Ward, Jerrold M., McNally, Sara R., Swain, Gary P., Montagna, Cristina, ...
Patients with multiple endocrine neoplasia type 1 (MEN1) develop multiple endocrine tumors, primarily affecting the parathyroid, pituitary, and endocrine pancreas, due to the inactivation of the MEN1...
Srivastava, Meera, Montagna, Cristina, Leighton, Ximena, Glasman, Mirta, Naga, Shanmugam, Eidelman, Ofer, ...
Annexin 7 (ANX7) acts as a tumor suppressor gene in prostate cancer, where loss of heterozygosity and reduction of ANX7 protein expression is associated with aggressive metastatic tumors. To...
Ataxia telangiectasia mutated is essential during adult neurogenesis
Allen, Duane M., Van Praag, Henriette, Ray, Jasodhara, Weaver, Zoë, Winrow, Christopher J., Carter, Todd A., ...
Ataxia telangiectasia (A-T) is an autosomal recessive disease characterized by normal brain development followed by progressive neurodegeneration. The gene mutated in A-T (ATM) is a serine protein...
53BP1 Cooperates with p53 and Functions as a Haploinsufficient Tumor Suppressor in Mice
Ward, Irene M., Difilippantonio, Simone, Minn, Kay, Mueller, Melissa D., Molina, Julian R., Yu, Xiaochun, ...
p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both...
Molecular and cytological features of the mouse B-cell lymphoma line iMycEμ-1
Su Han, Seong, Shaffer, Arthur L, Peng, Liangping, Chung, Seung Tae, Lim, Jae Hwan, Maeng, Sungho, ...
Artificially Introduced Aneuploid Chromosomes Assume a Conserved Position in Colon Cancer Cells
Sengupta, Kundan, Upender, Madhvi B., Barenboim-Stapleton, Linda, Nguyen, Quang Tri, Wincovitch, Stephen M., Garfield, Susan H., ...
Heselmeyer-Haddad, Kerstin, Sommerfeld, Kathrin, White, Nicole M., Chaudhri, Nadia, Morrison, Larry E., Palanisamy, Nallasivam, ...
Invasive cervical carcinomas almost invariably carry extra copies of chromosome arm 3q, resulting in a gain of the human telomerase gene (TERC). This provided the rationale for the development of a...
Ghadimi, B. Michael, Schröck, Evelin, Walker, Robert L., Wangsa, Danny, Jauho, Annukka, Meltzer, Paul S., ...
To screen pancreatic carcinomas for chromosomal aberrations we have applied molecular cytogenetic techniques, including fluorescent in situ hybridization, comparative genomic hybridization, and...
Heselmeyer-Haddad, Kerstin, Janz, Viktor, Castle, Philip E., Chaudhri, Nadia, White, Nicole, Wilber, Kim, ...
Invasive cervical carcinomas frequently reveal additional copies of the long arm of chromosome 3. The detection of this genetic aberration in diagnostic samples could therefore complement the...
Schròck, Evelin, Thiel, Gundula, Lozanova, Tanka, Du Manoir, Stanislas, Meffert, Marie-Christine, Jauch, Anna, ...
Nine human malignant gliomas (2 astrocytomas grade III and 7 glioblastomas) were analyzed using comparative genomic hybridization (CGH). In addition to the amplification of the EGFR gene at 7p12 in 4...
Difilippantonio, Michael J., Petersen, Simone, Chen, Hua Tang, Johnson, Roger, Jasin, Maria, Kanaar, Roland, ...
Nonreciprocal translocations and gene amplifications are commonly found in human tumors. Although little is known about the mechanisms leading to such aberrations, tissue culture models predict that...
Kovalchuk, Alexander L., DuBois, Wendy, Mushinski, Elizabeth, McNeil, Nicole E., Hirt, Carsten, Qi, Chen-Feng, ...
Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) class switch recombination and somatic hypermutation, and has also been implicated in translocations between Ig switch...
A sequence-based survey of the complex structural organization of tumor genomes
Raphael, Benjamin J, Volik, Stanislav, Yu, Peng, Wu, Chunxiao, Huang, Guiqing, Linardopoulou, Elena V, ...
Tumors and cancer cell lines were surveyed with end-sequencing profiling, yielding the largest available collection of sequence-ready tumor genome breakpoints and providing evidence that some...
Hsu, Cary, Jones, Stephanie A., Cohen, Cyrille J., Zheng, Zhili, Kerstann, Keith, Zhou, Juhua, ...
Malignancies arising from retrovirally transduced hematopoietic stem cells have been reported in animal models and human gene therapy trials. Whether mature lymphocytes are susceptible to insertional...
Actin-dependent intranuclear repositioning of an active gene locus in vivo
Dundr, Miroslav, Ospina, Jason K., Sung, Myong-Hee, John, Sam, Upender, Madhvi, Ried, Thomas, ...
Although bulk chromatin is thought to have limited mobility within the interphase eukaryotic nucleus, directed long-distance chromosome movements are not unknown. Cajal bodies (CBs) are nuclear...
Xu, Mai, Yu, Qing, Subrahmanyam, Ramesh, Difilippantonio, Michael J., Ried, Thomas, Sen, Jyoti Misra
The expression of β-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of oncogenic β-catenin in thymocytes resulted in...
Garman, Katherine S., Acharya, Chaitanya R., Edelman, Elena, Grade, Marian, Gaedcke, Jochen, Sud, Shivani, ...
Gene expression profiles provide an opportunity to dissect the heterogeneity of solid tumors, including colon cancer, to improve prognosis and predict response to therapies. Bayesian binary...