Thomas Sauter

Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach (2009)

Witt, Johannes, Barisic, Sandra, Schumann, Eva, Allgöwer, Frank, Sawodny, Oliver, Sauter, Thomas, ...

Abstract Background Biological effects of nuclear factor-κB (NFκB) can differ tremendously depending on the cellular context. For example, NFκB induced by interleukin-1 (IL-1) is converted from an...

A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks (2006)

Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Kholodenko, Boris N, Gilles, Ernst D

Abstract Background: Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial...

A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks (2006)

Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Kholodenko, Boris N., Gilles, Ernst D.

Background:Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinatorial explosion of...

A quantitative approach to catabolite repression in Escherichia coli (2006)

Katja Bettenbrock, Sophia Fischer, Andreas Kremling, Knut Jahreis, Thomas Sauter

A dynamic mathematical model was developed to describe the uptake of various carbohydrates (glucose, lactose, glycerol, sucrose, and galactose) in Escherichia coli. For validation a number of...

Die bakterielle Signalverarbeitung am Beispiel des Sucrose Phosphotransferasesystems in Escherichia coli : Modellierung und experimentelle Überprüfung (2004)

Sauter, Thomas

Die bakterielle Signalverarbeitung wurde am Beispiel des Sucrose Phosphotransferasesystems (Sucrose PTS) im Bakterium Escherichia coli untersucht. Die etwa 20 verschiedenen Phosphotransferasesysteme...

Die bakterielle Signalverarbeitung am Beispiel des Sucrose Phosphotransferasesystems in Escherichia coli : Modellierung und experimentelle Überprüfung (2004)

Sauter, Thomas

Die bakterielle Signalverarbeitung wurde am Beispiel des Sucrose Phosphotransferasesystems (Sucrose PTS) im Bakterium Escherichia coli untersucht. Die etwa 20 verschiedenen Phosphotransferasesysteme...

Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling (2004)

Conzelmann, Holger, Saez-Rodriguez, Julio, Sauter, Thomas, Bullinger, Eric, Allgöwer, Frank, Gilles, Ernst Dieter

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain...

A benchmark for methods in reverse engineering and model discrimination: Problem formulation and solutions (2004)

Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J, Sauter, Thomas, Bullinger, Eric, ...

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...

An approach for dividing models of biological reaction networks into functional units (2003)

Ederer, Michael, Sauter, Thomas, Bullinger, Eric, Gilles, E. D., Allgöwer, Frank

Biological reaction networks consist of many substances and reactions between them. Like many other biological systems, they have a modular structure. Therefore, a division of a biological reaction...

A Benchmark for Methods in Reverse Engineering and Model Discrimination: Problem Formulation and Solutions

Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J., Sauter, Thomas, Bullinger, Eric, ...

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...

A Benchmark for Methods in Reverse Engineering and Model Discrimination: Problem Formulation and Solutions

Kremling, Andreas, Fischer, Sophia, Gadkar, Kapil, Doyle, Francis J., Sauter, Thomas, Bullinger, Eric, ...

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one...

Modeling the VPAC2-Activated cAMP/PKA Signaling Pathway: From Receptor to Circadian Clock Gene Induction

Hao, Haiping, Zak, Daniel E., Sauter, Thomas, Schwaber, James, Ogunnaike, Babatunde A.

Increasing evidence suggests an important role for VPAC2-activated signal transduction pathways in maintaining a synchronized biological clock in the suprachiasmatic nucleus (SCN). Activation of the...

Correlation between Growth Rates, EIIACrr Phosphorylation, and Intracellular Cyclic AMP Levels in Escherichia coli K-12▿

Bettenbrock, Katja, Sauter, Thomas, Jahreis, Knut, Kremling, Andreas, Lengeler, Joseph W., Gilles, Ernst-Dieter

In Escherichia coli K-12, components of the phosphoenolpyruvate-dependent phosphotransferase systems (PTSs) represent a signal transduction system involved in the global control of carbon catabolism...