Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes (2009)
Yanli Wang, Stefan Juranek, Haitao Li, Gang Sheng, Greg S. Wardle, Thomas Tuschl, ...
miRNA in situ hybridization in formaldehyde and EDC–fixed tissues (2009)
Cherin Sohn-Lee, Sara H Rouhanifard, Janos Ludwig, Markus Hafner, Aleksandra Mihailovic, ...
Huse, Jason T., Brennan, Cameron, Hambardzumyan, Dolores, Wee, Boyoung, Pena, John, Rouhanifard, Sara H., ...
Activated oncogenic signaling is central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. Research over the last two decades has...
Absolute quantification of microRNAs by using a universal reference (2009)
Bissels, Ute, Wild, Stefan, Tomiuk, Stefan, Holste, Angela, Hafner, Markus, Tuschl, Thomas, ...
MicroRNAs (miRNAs) are a species of small RNAs ∼21–23-nucleotides long that have been shown to play an important role in many different cellular, developmental, and physiological processes....
Absolute quantification of microRNAs by using a universal reference (2009)
Bissels, Ute, Wild, Stefan, Tomiuk, Stefan, Holste, Angela, Hafner, Markus, Tuschl, Thomas, ...
MicroRNAs (miRNAs) are a species of small RNAs ∼21–23-nucleotides long that have been shown to play an important role in many different cellular, developmental, and physiological processes....
Absolute quantification of microRNAs by using a universal reference (2009)
Bissels, Ute, Wild, Stefan, Tomiuk, Stefan, Holste, Angela, Hafner, Markus, Tuschl, Thomas, ...
MicroRNAs (miRNAs) are a species of small RNAs ∼21–23-nucleotides long that have been shown to play an important role in many different cellular, developmental, and physiological processes....
Chen, Po Yu, Weinmann, Lasse, Gaidatzis, Dimos, Pei, Yi, Zavolan, Mihaela, Tuschl, Thomas, ...
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) guide catalytic sequence-specific cleavage of fully or nearly fully complementary target mRNAs or control translation and/or stability of many...
Landthaler, Markus, Gaidatzis, Dimos, Rothballer, Andrea, Chen, Po Yu, Soll, Steven Joseph, Dinic, Lana, ...
microRNAs (miRNAs) regulate the expression of mRNAs in animals and plants through miRNA-containing ribonucleoprotein particles (RNPs). At the core of these miRNA silencing effector complexes are the...
Landthaler, Markus, Gaidatzis, Dimos, Rothballer, Andrea, Chen, Po Yu, Soll, Steven Joseph, Dinic, Lana, ...
microRNAs (miRNAs) regulate the expression of mRNAs in animals and plants through miRNA-containing ribonucleoprotein particles (RNPs). At the core of these miRNA silencing effector complexes are the...
Landthaler, Markus, Gaidatzis, Dimos, Rothballer, Andrea, Chen, Po Yu, Soll, Steven Joseph, Dinic, Lana, ...
microRNAs (miRNAs) regulate the expression of mRNAs in animals and plants through miRNA-containing ribonucleoprotein particles (RNPs). At the core of these miRNA silencing effector complexes are the...
Klenov, Mikhail S., Lavrov, Sergey A., Stolyarenko, Anastasia D., Ryazansky, Sergey S., Aravin, Alexei A., Tuschl, Thomas, ...
Silencing of genomic repeats, including transposable elements, in Drosophila melanogaster is mediated by repeat-associated short interfering RNAs (rasiRNAs) interacting with proteins of the Piwi...
Specificity, duplex degradation and subcellular localization of antagomirs (2007)
Krützfeldt, Jan, Kuwajima, Satoru, Braich, Ravi, Rajeev, Kallanthottathil G., Pena, John, Tuschl, Thomas, ...
MicroRNAs (miRNAs) are an abundant class of 20–23-nt long regulators of gene expression. The study of miRNA function in mice and potential therapeutic approaches largely depend on modified...
Zhang, Xiuren, Yuan, Yu-Ren, Pei, Yi, Lin, Shih-Shun, Tuschl, Thomas, Patel, Dinshaw J., ...
RNA silencing refers to small regulatory RNA-mediated processes that repress endogenous gene expression and defend hosts from offending viruses. As an anti-host defense mechanism, viruses encode...
Identification of clustered microRNAs using an ab initioprediction method (2005)
Sewer, Alain, Paul, Nicodème, Landgraf, Pablo, Aravin, Alexei, Pfeffer, Sébastien, Brownstein, Michael J, ...
Abstract Background MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway. Hundreds...
Silencing of microRNAs in vivo with ‘antagomirs’ (2005)
Jan Krützfeldt, Nikolaus Rajewsky, Ravi Braich, Kallanthottathil G. Rajeev, Thomas Tuschl, Muthiah Manoharan, ...
Correction: Human MicroRNA Targets (2005)
Bino John, Anton J. Enright, Alexei Aravin, Thomas Tuschl, Chris Sander, Debora S. Marks
Correction: Human MicroRNA Targets (2005)
Bino John, Anton J. Enright, Alexei Aravin, Thomas Tuschl, Chris Sander, Debora S. Marks
Identification of microRNAs of the herpesvirus family (2005)
Sébastien Pfeffer, Alain Sewer, Mariana Lagos-Quintana, Robert Sheridan, Chris Sander, Friedrich A Grässer, ...
Clustering and conservation patterns of human microRNAs (2005)
Altuvia, Yael, Landgraf, Pablo, Lithwick, Gila, Elefant, Naama, Pfeffer, Sébastien, Aravin, Alexei, ...
MicroRNAs (miRNAs) are ∼22 nt-long non-coding RNA molecules, believed to play important roles in gene regulation. We present a comprehensive analysis of the conservation and clustering patterns of...
The developmental miRNA profiles of zebrafish as determined by small RNA cloning (2005)
Chen, Po Yu, Manninga, Heiko, Slanchev, Krasimir, Chien, Minchen, Russo, James J., Ju, Jingyue, ...
MicroRNAs (miRNAs) represent a family of small, regulatory, noncoding RNAs that are found in plants and animals. Here, we describe the miRNA profile of the zebrafish Danio rerio resolved in a...
A pancreatic islet-specific microRNA regulates insulin secretion (2004)
Matthew N. Poy, Lena Eliasson, Jan Krutzfeldt, Satoru Kuwajima, Xiaosong Ma, Patrick E. MacDonald, ...
Bino John, Anton J. Enright, Alexei Aravin, Thomas Tuschl, Chris Sander, Debora S. Marks
This computational analysis provides evidence that as many as 10% of human genes are targets for regulation by small RNA molecules called microRNAs.
Bino John, Anton J. Enright, Alexei Aravin, Thomas Tuschl, Chris Sander, Debora S. Marks
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted...
WILL, CINDY L., SCHNEIDER, CLAUDIA, HOSSBACH, MARKUS, URLAUB, HENNING, RAUHUT, REINHARD, ELBASHIR, SAYDA, ...
U11 and U12 snRNPs bind U12-type pre-mRNAs as a preformed di-snRNP complex, simultaneously recognizing the 5′ splice site and branchpoint sequence. Thus, within the U12-type prespliceosome, U11/U12...
RISC is a 5' phosphomonoester-producing RNA endonuclease (2004)
Martinez, Javier, Tuschl, Thomas
Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). Here we describe the molecular mechanism of target...
siRNA Selection Server: an automated siRNA oligonucleotide prediction server (2004)
Yuan, Bingbing, Latek, Robert, Hossbach, Markus, Tuschl, Thomas, Lewitter, Fran
The Whitehead siRNA (short interfering RNA) Selection Web Server (http://jura.wi.mit.edu/bioc/siRNA) automates the design of short oligonucleotides that can specifically ‘knock down’ expression...
RISC is a 5' phosphomonoester-producing RNA endonuclease (2004)
Martinez, Javier, Tuschl, Thomas
Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). Here we describe the molecular mechanism of target...
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing (2004)
MEISTER, GUNTER, LANDTHALER, MARKUS, DORSETT, YAIR, TUSCHL, THOMAS
A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act to inhibit microRNA function would facilitate the study of this new...
RISC is a 5' phosphomonoester-producing RNA endonuclease (2004)
Martinez, Javier, Tuschl, Thomas
Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). Here we describe the molecular mechanism of target...
MicroRNA targets in Drosophila (2003)
Enright, Anton J, John, Bino, Gaul, Ulrike, Tuschl, Thomas, Sander, Chris, Marks, Debora S
Abstract Background The recent discoveries of microRNA (miRNA) genes and characterization of the first few target genes regulated by miRNAs in Caenorhabditis elegans and Drosophila melanogaster have...
MicroRNA Targets in Drosophila (2003)
Enright, Anton, John, Bino, Gaul, Ulrike, Tuschl, Thomas, Sander, Chris, Marks, Debora
Abstract The recent discoveries of microRNAs (miRNAs) and characterization of the first few targets of their gene products in Caenorhabditis elegans and Drosophila melanogaster have set the stage for...
MicroRNA targets in Drosophila (2003)
Anton J Enright, Bino John, Ulrike Gaul, Thomas Tuschl, Chris S, Debora S Marks
The electronic version of this article is the complete one and can be found online at
Analysis of mammalian gene function using small interfering RNAs (2003)
Martinez, Javier, Patkaniowska, Agnieszka, Elbashir, Sayda M., Harborth, Jens, Hossbach, Markus, Urlaub, Henning, ...
A uniform system for microRNA annotation (2003)
AMBROS, VICTOR, BARTEL, BONNIE, BARTEL, DAVID P., BURGE, CHRISTOPHER B., CARRINGTON, JAMES C., CHEN, XUEMEI, ...
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for...
New microRNAs from mouse and human (2003)
LAGOS-QUINTANA, MARIANA, RAUHUT, REINHARD, MEYER, JUTTA, BORKHARDT, ARNDT, TUSCHL, THOMAS
MicroRNAs (miRNAs) represent a new class of noncoding RNAs encoded in the genomes of plants, invertebrates, and vertebrates. MicroRNAs regulate translation and stability of target mRNAs based on...
Analysis of mammalian gene function using small interfering RNAs (2003)
Martinez, Javier, Patkaniowska, Agnieszka, Elbashir, Sayda M., Harborth, Jens, Hossbach, Markus, Urlaub, Henning, ...
Anton J Enright, Bino John, Ulrike Gaul, Thomas Tuschl, Chris S, Debora S Marks
The electronic version of this article is the complete one and can be found online at
Hutvagner, Gyorgy, McLachlan, Juanita, Pasquinelli, Amy E., Balint, Eva, Tuschl, Thomas, Zamore, Phillip D.
The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in...
Targeted mRNA degradation by double-stranded RNA in vitro (1999)
Tuschl, Thomas, Zamore, Phillip D., Lehmann, Ruth, Bartel, David P., Sharp, Phillip A.
Aurup, Helle, Tuschl, Thomas, Benseler, Fritz, Ludwig, Janos, Eckstein, Fritz
Thermal stabilities of oligonucleotides containing 2′-amino-2′-deoxycytidines were determined and compared to those of the unmodified oligonucleotides. The presence of the 2′-aminonucleoside...
Activity of hammerhead ribozymes containing nonnucleotidic linkers (1993)
Thomson, James B., Tuschl, Thomas, Eckstein, Fritz
Hammerhead ribozymes were synthesized in which the tetranucleotide loop II was replaced by non-nucleotidic linkers of 7, 13, 17 and 19 atoms length. Ribozymes with 17 and 19 atom linkers, in...
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
Elbashir, Sayda M., Martinez, Javier, Patkaniowska, Agnieszka, Lendeckel, Winfried, Tuschl, Thomas
Duplexes of 21–23 nucleotide (nt) RNAs are the sequence-specific mediators of RNA interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short interfering RNAs (siRNAs) were...
Targeted mRNA degradation by double-stranded RNA in vitro
Tuschl, Thomas, Zamore, Phillip D., Lehmann, Ruth, Bartel, David P., Sharp, Phillip A.
Double-stranded RNA (dsRNA) directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function. The biochemical...
MicroRNA targets in Drosophila
Enright, Anton J, John, Bino, Gaul, Ulrike, Tuschl, Thomas, Sander, Chris, Marks, Debora S
A computational method for whole-genome prediction of microRNA target genes is presented. Application of this method to the Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae...
siRNA Selection Server: an automated siRNA oligonucleotide prediction server
Yuan, Bingbing, Latek, Robert, Hossbach, Markus, Tuschl, Thomas, Lewitter, Fran
The Whitehead siRNA (short interfering RNA) Selection Web Server (http://jura.wi.mit.edu/bioc/siRNA) automates the design of short oligonucleotides that can specifically ‘knock down’ expression...
John, Bino, Enright, Anton J, Aravin, Alexei, Tuschl, Thomas, Sander, Chris, Marks, Debora S
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted...
Clustering and conservation patterns of human microRNAs
Altuvia, Yael, Landgraf, Pablo, Lithwick, Gila, Elefant, Naama, Pfeffer, Sébastien, Aravin, Alexei, ...
MicroRNAs (miRNAs) are ∼22 nt-long non-coding RNA molecules, believed to play important roles in gene regulation. We present a comprehensive analysis of the conservation and clustering patterns of...
The developmental miRNA profiles of zebrafish as determined by small RNA cloning
Chen, Po Yu, Manninga, Heiko, Slanchev, Krasimir, Chien, Minchen, Russo, James J., Ju, Jingyue, ...
MicroRNAs (miRNAs) represent a family of small, regulatory, noncoding RNAs that are found in plants and animals. Here, we describe the miRNA profile of the zebrafish Danio rerio resolved in a...
Correction: Human MicroRNA Targets
John, Bino, Enright, Anton J, Aravin, Alexei, Tuschl, Thomas, Sander, Chris, Marks, Debora S
Identification of clustered microRNAs using an ab initio prediction method
Sewer, Alain, Paul, Nicodème, Landgraf, Pablo, Aravin, Alexei, Pfeffer, Sébastien, Brownstein, Michael J, ...
New microRNAs from mouse and human
LAGOS-QUINTANA, MARIANA, RAUHUT, REINHARD, MEYER, JUTTA, BORKHARDT, ARNDT, TUSCHL, THOMAS
MicroRNAs (miRNAs) represent a new class of noncoding RNAs encoded in the genomes of plants, invertebrates, and vertebrates. MicroRNAs regulate translation and stability of target mRNAs based on...
A uniform system for microRNA annotation
AMBROS, VICTOR, BARTEL, BONNIE, BARTEL, DAVID P., BURGE, CHRISTOPHER B., CARRINGTON, JAMES C., CHEN, XUEMEI, ...
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for...
WILL, CINDY L., SCHNEIDER, CLAUDIA, HOSSBACH, MARKUS, URLAUB, HENNING, RAUHUT, REINHARD, ELBASHIR, SAYDA, ...
U11 and U12 snRNPs bind U12-type pre-mRNAs as a preformed di-snRNP complex, simultaneously recognizing the 5′ splice site and branchpoint sequence. Thus, within the U12-type prespliceosome, U11/U12...
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
MEISTER, GUNTER, LANDTHALER, MARKUS, DORSETT, YAIR, TUSCHL, THOMAS
A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act to inhibit microRNA function would facilitate the study of this new...
RNA interference is mediated by 21- and 22-nucleotide RNAs
Elbashir, Sayda M., Lendeckel, Winfried, Tuschl, Thomas
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
RISC is a 5′ phosphomonoester-producing RNA endonuclease
Martinez, Javier, Tuschl, Thomas
Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). Here we describe the molecular mechanism of target...
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
Elbashir, Sayda M., Martinez, Javier, Patkaniowska, Agnieszka, Lendeckel, Winfried, Tuschl, Thomas
Duplexes of 21–23 nucleotide (nt) RNAs are the sequence-specific mediators of RNA interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short interfering RNAs (siRNAs) were...
RNA interference is mediated by 21- and 22-nucleotide RNAs
Elbashir, Sayda M., Lendeckel, Winfried, Tuschl, Thomas
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
Targeted mRNA degradation by double-stranded RNA in vitro
Tuschl, Thomas, Zamore, Phillip D., Lehmann, Ruth, Bartel, David P., Sharp, Phillip A.
Double-stranded RNA (dsRNA) directs gene-specific, post-transcriptional silencing in many organisms, including vertebrates, and has provided a new tool for studying gene function. The biochemical...
MicroRNA targets in Drosophila
Enright, Anton J, John, Bino, Gaul, Ulrike, Tuschl, Thomas, Sander, Chris, Marks, Debora S
A computational method for whole-genome prediction of microRNA target genes is presented. Application of this method to the Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae...
RISC is a 5′ phosphomonoester-producing RNA endonuclease
Martinez, Javier, Tuschl, Thomas
Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). Here we describe the molecular mechanism of target...
siRNA Selection Server: an automated siRNA oligonucleotide prediction server
Yuan, Bingbing, Latek, Robert, Hossbach, Markus, Tuschl, Thomas, Lewitter, Fran
The Whitehead siRNA (short interfering RNA) Selection Web Server (http://jura.wi.mit.edu/bioc/siRNA) automates the design of short oligonucleotides that can specifically ‘knock down’ expression...
John, Bino, Enright, Anton J, Aravin, Alexei, Tuschl, Thomas, Sander, Chris, Marks, Debora S
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted...
Clustering and conservation patterns of human microRNAs
Altuvia, Yael, Landgraf, Pablo, Lithwick, Gila, Elefant, Naama, Pfeffer, Sébastien, Aravin, Alexei, ...
MicroRNAs (miRNAs) are ∼22 nt-long non-coding RNA molecules, believed to play important roles in gene regulation. We present a comprehensive analysis of the conservation and clustering patterns of...
The developmental miRNA profiles of zebrafish as determined by small RNA cloning
Chen, Po Yu, Manninga, Heiko, Slanchev, Krasimir, Chien, Minchen, Russo, James J., Ju, Jingyue, ...
MicroRNAs (miRNAs) represent a family of small, regulatory, noncoding RNAs that are found in plants and animals. Here, we describe the miRNA profile of the zebrafish Danio rerio resolved in a...
Correction: Human MicroRNA Targets
John, Bino, Enright, Anton J, Aravin, Alexei, Tuschl, Thomas, Sander, Chris, Marks, Debora S
Identification of clustered microRNAs using an ab initio prediction method
Sewer, Alain, Paul, Nicodème, Landgraf, Pablo, Aravin, Alexei, Pfeffer, Sébastien, Brownstein, Michael J, ...
New microRNAs from mouse and human
LAGOS-QUINTANA, MARIANA, RAUHUT, REINHARD, MEYER, JUTTA, BORKHARDT, ARNDT, TUSCHL, THOMAS
MicroRNAs (miRNAs) represent a new class of noncoding RNAs encoded in the genomes of plants, invertebrates, and vertebrates. MicroRNAs regulate translation and stability of target mRNAs based on...
A uniform system for microRNA annotation
AMBROS, VICTOR, BARTEL, BONNIE, BARTEL, DAVID P., BURGE, CHRISTOPHER B., CARRINGTON, JAMES C., CHEN, XUEMEI, ...
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for...
WILL, CINDY L., SCHNEIDER, CLAUDIA, HOSSBACH, MARKUS, URLAUB, HENNING, RAUHUT, REINHARD, ELBASHIR, SAYDA, ...
U11 and U12 snRNPs bind U12-type pre-mRNAs as a preformed di-snRNP complex, simultaneously recognizing the 5′ splice site and branchpoint sequence. Thus, within the U12-type prespliceosome, U11/U12...
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
MEISTER, GUNTER, LANDTHALER, MARKUS, DORSETT, YAIR, TUSCHL, THOMAS
A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act to inhibit microRNA function would facilitate the study of this new...
Zhang, Xiuren, Yuan, Yu-Ren, Pei, Yi, Lin, Shih-Shun, Tuschl, Thomas, Patel, Dinshaw J., ...
RNA silencing refers to small regulatory RNA-mediated processes that repress endogenous gene expression and defend hosts from offending viruses. As an anti-host defense mechanism, viruses encode...
Specificity, duplex degradation and subcellular localization of antagomirs
Krützfeldt, Jan, Kuwajima, Satoru, Braich, Ravi, Rajeev, Kallanthottathil G., Pena, John, Tuschl, Thomas, ...
MicroRNAs (miRNAs) are an abundant class of 20–23-nt long regulators of gene expression. The study of miRNA function in mice and potential therapeutic approaches largely depend on modified...
Klenov, Mikhail S., Lavrov, Sergey A., Stolyarenko, Anastasia D., Ryazansky, Sergey S., Aravin, Alexei A., Tuschl, Thomas, ...
Silencing of genomic repeats, including transposable elements, in Drosophila melanogaster is mediated by repeat-associated short interfering RNAs (rasiRNAs) interacting with proteins of the Piwi...
Cellular cofactors affecting hepatitis C virus infection and replication
Randall, Glenn, Panis, Maryline, Cooper, Jacob D., Tellinghuisen, Timothy L., Sukhodolets, Karen E., Pfeffer, Sebastien, ...
Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide a genetic system to evaluate the significance of virus–host interactions for HCV replication. We...
Chen, Po Yu, Weinmann, Lasse, Gaidatzis, Dimos, Pei, Yi, Zavolan, Mihaela, Tuschl, Thomas, ...
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) guide catalytic sequence-specific cleavage of fully or nearly fully complementary target mRNAs or control translation and/or stability of many...
Nie, Kui, Gomez, Mario, Landgraf, Pablo, Garcia, Jose-Francisco, Liu, Yifang, Tan, Leonard H.C., ...
PRDM1/Blimp-1, a master regulator in terminal B-cell differentiation, has been recently identified as a tumor suppressor target for mutational inactivation in diffuse large B-cell lymphomas of the...
Connolly, Erin, Melegari, Margherita, Landgraf, Pablo, Tchaikovskaya, Tatyana, Tennant, Bud C., Slagle, Betty L., ...
Alterations in microRNA (miRNA) expression in both human and animal models have been linked to many forms of cancer. Such miRNAs, which act directly as repressors of gene expression, have been found...
Landthaler, Markus, Gaidatzis, Dimos, Rothballer, Andrea, Chen, Po Yu, Soll, Steven Joseph, Dinic, Lana, ...
microRNAs (miRNAs) regulate the expression of mRNAs in animals and plants through miRNA-containing ribonucleoprotein particles (RNPs). At the core of these miRNA silencing effector complexes are the...
DGCR8-dependent microRNA biogenesis is essential for skin development
Yi, Rui, Pasolli, H. Amalia, Landthaler, Markus, Hafner, Markus, Ojo, Tolulope, Sheridan, Robert, ...
MicroRNAs play important roles in animal development. Numerous conditional knockout (cKO) studies of Dicer have been performed to interrogate the functions of microRNA during mammalian development....
A Drosophila pasha Mutant Distinguishes the Canonical MicroRNA and Mirtron Pathways▿ ‡
Martin, Raquel, Smibert, Peter, Yalcin, Abdullah, Tyler, David M., Schäfer, Ulrich, Tuschl, Thomas, ...
Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route to generating mature ∼22 nucleotide regulatory RNAs. We generated a null...
Taulli, Riccardo, Bersani, Francesca, Foglizzo, Valentina, Linari, Alessandra, Vigna, Elisa, Ladanyi, Marc, ...
Many microRNAs (miRNAs), posttranscriptional regulators of numerous cellular processes and developmental events, are downregulated in tumors. However, their role in tumorigenesis remains largely...
Huse, Jason T., Brennan, Cameron, Hambardzumyan, Dolores, Wee, Boyoung, Pena, John, Rouhanifard, Sara H., ...
Activated oncogenic signaling is central to the development of nearly all forms of cancer, including the most common class of primary brain tumor, glioma. Research over the last two decades has...
Absolute quantification of microRNAs by using a universal reference
Bissels, Ute, Wild, Stefan, Tomiuk, Stefan, Holste, Angela, Hafner, Markus, Tuschl, Thomas, ...
MicroRNAs (miRNAs) are a species of small RNAs ∼21–23-nucleotides long that have been shown to play an important role in many different cellular, developmental, and physiological processes....