Tian Jin

Admire- A Prototype of Large Scale E-collaboration Platform 1 (2008)

Tian Jin, Jian Lu, Xiangzhi Sheng

Abstract. In this paper, we will discuss the techniques of building up a large scale prototype platform for collaboration on IP-based network, and summarize the structure of that platform. To solve...

Negotiating contexts: a case study of a Tibetan boarding class in inland China from a Tibetan learner's perspective (2007)

Jin, Tian

This thesis presents a case study, exploring a Tibetan boarding class in inland China from a Tibetan learner’s perspective. As one of a number of forms of Chinese minority education, Tibetan...

Negotiating contexts: a case study of a Tibetan boarding class in inland China from a Tibetan learner's perspective (2007)

Jin, Tian

This thesis presents a case study, exploring a Tibetan boarding class in inland China from a Tibetan learner’s perspective. As one of a number of forms of Chinese minority education, Tibetan...

Negotiating contexts: a case study of a Tibetan boarding class in inland China from a Tibetan learner's perspective (2007)

Jin, Tian

This thesis presents a case study, exploring a Tibetan boarding class in inland China from a Tibetan learner’s perspective. As one of a number of forms of Chinese minority education, Tibetan...

Negotiating contexts: a case study of a Tibetan boarding class in inland China from a Tibetan learner's perspective (2007)

Jin, Tian

This thesis presents a case study, exploring a Tibetan boarding class in inland China from a Tibetan learner’s perspective. As one of a number of forms of Chinese minority education, Tibetan...

Negotiating contexts: a case study of a Tibetan boarding class in inland China from a Tibetan learner's perspective (2007)

Jin, Tian

This thesis presents a case study, exploring a Tibetan boarding class in inland China from a Tibetan learner’s perspective. As one of a number of forms of Chinese minority education, Tibetan...

Negotiating contexts: a case study of a Tibetan boarding class in inland China from a Tibetan learner's perspective (2007)

Jin, Tian

This thesis presents a case study, exploring a Tibetan boarding class in inland China from a Tibetan learner’s perspective. As one of a number of forms of Chinese minority education, Tibetan...

Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method (2006)

Martin Meier-Schellersheim, Xuehua Xu, Bastian Angermann, Eric J. Kunkel, Tian Jin, Ronald N. Germain

The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential...

Key role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method (2006)

Martin Meier-Schellersheim, Xuehua Xu, Bastian R Angermann, Erik J Kunkel, Tian Jin, Ronald N Germain

The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential...

Selection of Gβ Subunits with Point Mutations That Fail to Activate Specific Signaling Pathways In Vivo: Dissecting Cellular Responses Mediated by a Heterotrimeric G Protein in Dictyostelium discoideum

Jin, Tian, Amzel, Mario, Devreotes, Peter N., Wu, Lijun

In Dictyostelium discoideum, a unique Gβ subunit is required for a G protein–coupled receptor system that mediates a variety of cellular responses. Binding of cAMP to cAR1, the receptor linked to...

Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death

Shen, Han-Ming, Lin, Yong, Choksi, Swati, Tran, Jamie, Jin, Tian, Chang, Lufen, ...

Oxidative stress and reactive oxygen species (ROS) can elicit and modulate various physiological and pathological processes, including cell death. However, the mechanisms controlling ROS-induced cell...

Quantitative Imaging of Single Live Cells Reveals Spatiotemporal Dynamics of Multistep Signaling Events of Chemoattractant Gradient Sensing in DictyosteliumD⃞V⃞

Xu, Xuehua, Meier-Schellersheim, Martin, Jiao, Xuanmao, Nelson, Lauren E., Jin, Tian

Activation of G-protein-coupled chemoattractant receptors triggers dissociation of Gα and Gβγ subunits. These subunits induce intracellular responses that can be highly polarized when a cell...

Ligand-Induced Partitioning of Human CXCR1 Chemokine Receptors with Lipid Raft Microenvironments Facilitates G-Protein-Dependent Signaling

Jiao, Xuanmao, Zhang, Ning, Xu, Xuehua, Oppenheim, Joost J., Jin, Tian

Ligand binding to a chemokine receptor triggers signaling events through heterotrimeric G-proteins. The mechanisms underlying receptor-mediated G-protein activation in the heterogeneous...

Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method

Meier-Schellersheim, Martin, Xu, Xuehua, Angermann, Bastian, Kunkel, Eric J, Jin, Tian, Germain, Ronald N

The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential...

Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling

Sohn, Hae Won, Tolar, Pavel, Jin, Tian, Pierce, Susan K.

B cell responses are initiated by the clustering of the B cell receptor (BCR) by the binding of multivalent antigens. Clustering leads to phosphorylation of tyrosines in the cytoplasmic domains of...

Selection of Gβ Subunits with Point Mutations That Fail to Activate Specific Signaling Pathways In Vivo: Dissecting Cellular Responses Mediated by a Heterotrimeric G Protein in Dictyostelium discoideum

Jin, Tian, Amzel, Mario, Devreotes, Peter N., Wu, Lijun

In Dictyostelium discoideum, a unique Gβ subunit is required for a G protein–coupled receptor system that mediates a variety of cellular responses. Binding of cAMP to cAR1, the receptor linked to...

Essential Roles of Receptor-Interacting Protein and TRAF2 in Oxidative Stress-Induced Cell Death

Shen, Han-Ming, Lin, Yong, Choksi, Swati, Tran, Jamie, Jin, Tian, Chang, Lufen, ...

Oxidative stress and reactive oxygen species (ROS) can elicit and modulate various physiological and pathological processes, including cell death. However, the mechanisms controlling ROS-induced cell...

Quantitative Imaging of Single Live Cells Reveals Spatiotemporal Dynamics of Multistep Signaling Events of Chemoattractant Gradient Sensing in DictyosteliumD⃞V⃞

Xu, Xuehua, Meier-Schellersheim, Martin, Jiao, Xuanmao, Nelson, Lauren E., Jin, Tian

Activation of G-protein-coupled chemoattractant receptors triggers dissociation of Gα and Gβγ subunits. These subunits induce intracellular responses that can be highly polarized when a cell...

Ligand-Induced Partitioning of Human CXCR1 Chemokine Receptors with Lipid Raft Microenvironments Facilitates G-Protein-Dependent Signaling

Jiao, Xuanmao, Zhang, Ning, Xu, Xuehua, Oppenheim, Joost J., Jin, Tian

Ligand binding to a chemokine receptor triggers signaling events through heterotrimeric G-proteins. The mechanisms underlying receptor-mediated G-protein activation in the heterogeneous...

Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling

Sohn, Hae Won, Tolar, Pavel, Jin, Tian, Pierce, Susan K.

B cell responses are initiated by the clustering of the B cell receptor (BCR) by the binding of multivalent antigens. Clustering leads to phosphorylation of tyrosines in the cytoplasmic domains of...

Key Role of Local Regulation in Chemosensing Revealed by a New Molecular Interaction-Based Modeling Method

Meier-Schellersheim, Martin, Xu, Xuehua, Angermann, Bastian, Kunkel, Eric J, Jin, Tian, Germain, Ronald N

The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential...

Attenuation of Phospholipid Signaling Provides a Novel Mechanism for the Action of Valproic Acid▿ †

Xu, Xuehua, Müller-Taubenberger, Annette, Adley, Kathryn E., Pawolleck, Nadine, Lee, Vivian W. Y., Wiedemann, Claudia, ...

Valproic acid (VPA) is used to treat epilepsy and bipolar disorder and to prevent migraine. It is also undergoing trials for cancer therapy. However, the biochemical and molecular biological actions...

Locally controlled inhibitory mechanisms are involved in eukaryotic GPCR-mediated chemosensing

Xu, Xuehua, Meier-Schellersheim, Martin, Yan, Jianshe, Jin, Tian

Gprotein–coupled receptor (GPCR) signaling mediates a balance of excitatory and inhibitory activities that regulate Dictyostelium chemosensing to cAMP. The molecular nature and kinetics of these...

A vesicle surface tyrosine kinase regulates phagosome maturation

Fang, Jun, Brzostowski, Joseph A., Ou, Stephen, Isik, Nilgun, Nair, Vinod, Jin, Tian

Phagocytosis is crucial for host defense against microbial pathogens and for obtaining nutrients in Dictyostelium discoideum. Phagocytosed particles are delivered via a complex route from phagosomes...

G Protein β Subunit–null Mutants Are Impaired in Phagocytosis and Chemotaxis Due to Inappropriate Regulation of the Actin Cytoskeleton

Peracino, Barbara, Borleis, Jane, Jin, Tian, Westphal, Monika, Schwartz, Jean-Marc, Wu, Lijun, ...

Chemotaxis and phagocytosis are basically similar in cells of the immune system and in Dictyostelium amebae. Deletion of the unique G protein β subunit in D. discoideum impaired phagocytosis but had...

Genetic analysis of the role of G protein–coupled receptor signaling in electrotaxis

Zhao, Min, Jin, Tian, McCaig, Colin D., Forrester, John V., Devreotes, Peter N.

Cells display chemotaxis and electrotaxis by migrating directionally in gradients of specific chemicals or electrical potential. Chemotaxis in Dictyostelium discoideum is mediated by G...

The Elmo family forms an ancient group of actin-regulating proteins

Brzostowski, Joseph A, Fey, Petra, Yan, Jianshe, Isik, Nilgun, Jin, Tian

The Elmo protein family members are important mediators of small G protein activity, regulating actin-mediated processes such as chemotaxis and engulfment. Until recently,1 Elmo function has not been...