Petersen, Steen V, Valnickova, Zuzana, Oury, Tim D, Crapo, James D, Chr Nielsen, Niels, Enghild, Jan J
Abstract Background Human extracellular superoxide dismutase (EC-SOD) is a tetrameric metalloenzyme responsible for the removal of superoxide anions from the extracellular space. We have previously...
Lizotte, Pierre-Paul, Hanford, Lana E, Enghild, Jan J, Nozik-Grayck, Eva, Giles, Brenda-Louise, Oury, Tim D
Abstract Background The receptor for advanced glycation end products (mRAGE) is associated with pathology in most tissues, while its soluble form (sRAGE) acts as a decoy receptor. The adult lung is...
Thiels,Edda, Urban,Nathaniel N., Gonzales-Burgos,Guillermo R., Kanterewicz,Beatriz I., Barrionuevo,German, Chu,Charleen T., ...
Reactive oxygen species, including superoxide, generally are considered neurotoxic molecules whose effects can be alleviated by antioxidants. Different from this view, we show that scavenging of...
Thiels, Edda, Urban, Nathaniel N., Gonzales-Burgos, Guillermo R., Kanterewicz, Beatriz I., Barrionuevo, German, Chu, Charleen T., ...
Reactive oxygen species, including superoxide, generally are considered neurotoxic molecules whose effects can be alleviated by antioxidants. Different from this view, we show that scavenging of...
The dual nature of human extracellular superoxide dismutase: One sequence and two structures
Petersen, Steen V., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Højrup, Peter, Crapo, James D., ...
Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart,...
The dual nature of human extracellular superoxide dismutase: One sequence and two structures
Petersen, Steen V., Oury, Tim D., Valnickova, Zuzana, Thøgersen, Ida B., Højrup, Peter, Crapo, James D., ...
Human extracellular superoxide dismutase (EC-SOD; EC 1.15.1.1) is a scavenger of superoxide anions in the extracellular space. The amino acid sequence is homologous to the intracellular counterpart,...
Lizotte, Pierre-Paul, Hanford, Lana E, Enghild, Jan J, Nozik-Grayck, Eva, Giles, Brenda-Louise, Oury, Tim D
Carbon Monoxide Suppresses Bleomycin-Induced Lung Fibrosis
Zhou, Zhihong, Song, Ruiping, Fattman, Cheryl L., Greenhill, Sara, Alber, Sean, Oury, Tim D., ...
Idiopathic pulmonary fibrosis is an incurable fibrosing disorder that progresses relentlessly to respiratory failure. We hypothesized that a product of heme oxygenase activity, carbon monoxide (CO),...
Yasuoka, Hidekata, Zhou, Zhihong, Pilewski, Joseph M., Oury, Tim D., Choi, Augustine M.K., Feghali-Bostwick, Carol A.
We have recently shown that insulin-like growth factor-binding protein (IGFBP)-5 is overexpressed in idiopathic pulmonary fibrosis lung tissues and increases collagen and fibronectin deposition....
Zhu, Jian-Hui, Kulich, Scott M., Oury, Tim D., Chu, Charleen T.
A better understanding of cellular mechanisms that occur in Parkinson’s disease and related Lewy body diseases is essential for development of new therapies. We previously found that...
Song, Ruiping, Kubo, Masatoshi, Morse, Danielle, Zhou, Zhihong, Zhang, Xuchen, Dauber, James H., ...
Successful lung transplantation has been limited by the high incidence of acute graft rejection. There is mounting evidence that the stress response gene heme oxygenase-1 (HO-1) and/or its catalytic...
Petersen, Steen V, Valnickova, Zuzana, Oury, Tim D, Crapo, James D, Chr Nielsen, Niels, Enghild, Jan J
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
Wang, Xiao Mei, Zhang, Yingze, Kim, Hong Pyo, Zhou, Zhihong, Feghali-Bostwick, Carol A., Liu, Fang, ...
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by activation of fibroblasts and overproduction of extracellular matrix (ECM). Caveolin-1 (cav-1), a principal...
A Role for the Receptor for Advanced Glycation End Products in Idiopathic Pulmonary Fibrosis
Englert, Judson M., Hanford, Lana E., Kaminski, Naftali, Tobolewski, Jacob M., Tan, Roderick J., Fattman, Cheryl L., ...
Idiopathic pulmonary fibrosis (IPF) is a severely debilitating disease associated with a dismal prognosis. There are currently no effective therapies for IPF, thus the identification of novel...
Kliment, Corrine R., Clemens, Kristen, Oury, Tim D.
Erionite, a fibrous zeolite mineral, has been categorized as a class I carcinogenic agent for its causative role in mesothelioma. In select villages in Turkey, erionite is the cause of more than 50%...
Gremlin-mediated Decrease in Bone Morphogenetic Protein Signaling Promotes Pulmonary Fibrosis
Myllärniemi, Marjukka, Lindholm, Pamela, Ryynänen, Merja J., Kliment, Corrine R., Salmenkivi, Kaisa, Keski-Oja, Jorma, ...
Rationale: Members of the transforming growth factor (TGF)-β superfamily, including TGF-βs and bone morphogenetic proteins (BMPs), are essential for the maintenance of tissue homeostasis and...
Inflammatory Cells as a Source of Airspace Extracellular Superoxide Dismutase after Pulmonary Injury
Tan, Roderick J., Lee, Janet S., Manni, Michelle L., Fattman, Cheryl L., Tobolewski, Jacob M., Zheng, Mingquan, ...
Extracellular superoxide dismutase (EC-SOD) is an antioxidant abundant in the lung. Previous studies demonstrated depletion of lung parenchymal EC-SOD in mouse models of interstitial lung disease...
Matrix Metalloproteinases Promote Inflammation and Fibrosis in Asbestos-Induced Lung Injury in Mice
Tan, Roderick J., Fattman, Cheryl L., Niehouse, Laura M., Tobolewski, Jacob M., Hanford, Lana E., Li, Qinglang, ...
Inhalation of asbestos fibers causes pulmonary inflammation and eventual pulmonary fibrosis (asbestosis). Although the underlying molecular events are poorly understood, protease/antiprotease and...
Potential Clinical Importance of the Activation Peptide of Prostate-specific Antigen
Voeghtly, Laura M., Thøgersen, Ida B., Valnickova, Zuzana, Sanggaard, Kristian W., Chu, Charleen T., Oury, Tim D., ...
Prostate cancer is the second leading cause of cancer death in men. Prostate specific antigen (PSA) is currently the best marker available for screening and monitoring disease recurrence, but its use...
Oxidative Stress in Pulmonary Fibrosis: A Possible Role for Redox Modulatory Therapy
Kinnula, Vuokko L., Fattman, Cheryl L., Tan, Roderick J., Oury, Tim D.
Idiopathic ulmonary fibrosis (histopathology of usual interstitial pneumonia) is a progressive lung disease of unknown etiology. No treatment has been shown to improve the prognosis of the patients...
Oxidative Stress Alters Syndecan-1 Distribution in Lungs with Pulmonary Fibrosis*S⃞
Kliment, Corrine R., Englert, Judson M., Gochuico, Bernadette R., Yu, Guoying, Kaminski, Naftali, Rosas, Ivan, ...
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by severe, progressive fibrosis. Roles for inflammation and oxidative stress have recently been demonstrated, but...
The Role of the Receptor for Advanced Glycation End-Products in a Murine Model of Silicosis
Ramsgaard, Lasse, Englert, Judson M., Tobolewski, Jacob, Tomai, Lauren, Fattman, Cheryl L., Leme, Adriana S., ...
Superoxide dismutase 3, extracellular (SOD3) variants and lung function
Ganguly, Koustav, Depner, Martin, Fattman, Cheryl, Bein, Kiflai, Oury, Tim D., Wesselkamper, Scott C., ...
Polymorphisms in Superoxide dismutase 3, extracellular (SOD3) have been associated with reduced lung function and susceptibility to chronic obstructive pulmonary disease (COPD) in adults. Previously,...