The synthesis and in vivo evaluation of 2',2' - Difluoro KRN7000 (2009)
Leung, Leo, Tomassi, Cyrille, Van Beneden, Katrien, Decruy, Tine, Trappeniers, Matthias, Elewaut, Dirk, ...
Bouman, Claudia, Elliott, Tim, Vroon, Pieter Z
We have studied the sedimentary and basaltic inputs of lithium to subduction zones. Various sediments from DSDP and ODP drill cores in front of the Mariana, South Sandwich, Banda, East Sunda and...
Taraban, Vadim Y., Martin, Sonya, Attfield, Kathrine E., Glennie, Martin J., Elliott, Tim, Elewaut, Dirk, ...
Activation of invariant NK T (iNKT) cells with the glycolipid alpha-galactosylceramide promotes CD8(+) cytotoxic T cell responses, a property that has been used to enhance the efficacy of antitumor...
Thirdborough, Stephen M., Roddick, Joanne S., Radcliffe, Joanna N., Howarth, Mark, Stevenson, Freda K., Elliott, Tim
Peptide loading of MHC class I molecules involves multiple cofactors including tapasin. We showed previously in vitro that tapasin edits the peptide repertoire by favoring the binding of peptides...
Constraints on the Genesis of Potassium-rich Italian Volcanic Rocks from U/Th Disequilibrium (2008)
Avanzinelli, Riccardo, Elliott, Tim, Tommasini, Simone, Conticelli, Sandro
We present new U-series isotope, 87Sr/ 86Sr, 143Nd/ 144Nd and trace element data for a set of mafic, K-rich rocks from volcanoes in Central–Southern Italy. These shoshonitic to ultrapotassic lavas...
Awen Gallimore, Ann Glithero, Andreas Plückthun, Tim Elliott, Andrew Godkin, Hans Hengartner, ...
this paper: b 2 M, b2 microglobulin; CD, cluster of differentiation; DTT, dithiothreitol; GP, glycoprotein; LCMV, lymphocytic choriomeningitis virus; NP, nucleoprotein; VV, vaccinia virus.
Consequences of Melt Transport for Uranium Series Disequilibrium in Young Lavas (2007)
Radioactive disequilibrium of 238 U nuclides is commonly observed in young lavas and has often been used to infer the rates of melting and melt migration. However, previous calculations do not...
Taylor, Mark, Bolton, Louise M, Johnson, Peter, Elliott, Tim, Murray, Nick
Abstract Introduction Cancer-testis antigens (CTAGs) are expressed solely in germ cells and in malignant tissues. They are targets of immune responses mediated by cytotoxic T cells in some cancers,...
Taylor, Mark, Bolton, Louise M., Johnson, Peter, Elliott, Tim, Murray, Nick
Introduction Cancer-testis antigens ( CTAGs) are expressed solely in germ cells and in malignant tissues. They are targets of immune responses mediated by cytotoxic T cells in some cancers, and there...
Mimura, Yusuke, Mimura-Kimura, Yuka, Doores, Katie, Golgher, Denise, Davis, Benjamin G., Dwek, Raymond A., ...
CD4+ and CD8+ T cell responses to endogenous retroviral envelope glycoprotein gp90 generate protective immunity to murine colon carcinoma CT26. A panel of I-Ad-restricted T cell hybridomas recognize...
Glithero, Ann, Tormo, Jose, Doering, Klaus, Kojima, Mayumi, Jones, E. Yvonne, Elliott, Tim
In the absence of bound peptide ligands, major histocompatibility complex (MHC) class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I...
Glithero, Ann, Tormo, Jose, Doering, Klaus, Kojima, Mayumi, Jones, E. Yvonne, Elliott, Tim
In the absence of bound peptide ligands, MHC class I molecules are unstable. In an attempt to determine the minimum requirement for peptide-dependent MHC class I stabilisation we have used short...
The 'chop-and-change' of MHC class I assembly (2006)
CD8+ T cell recognition of peptides presented by major histocompatibility complex class I molecules is essential for effective antiviral and antitumor immune responses. How the repertoire of peptides...
Brooks, Collin R., Elliott, Tim, Parham, Peter, Khakoo, Salim I.
Signals transduced by inhibitory receptors that recognize self-MHC class I molecules prevent NK cells from being activated by autologous healthy target cells. In order for NK cells to be activated...
Brooks, Colin R., Elliott, Tim, Parham, Peter, Khakoo, Salim I.
Signals transduced by inhibitory receptors that recognize self-MHC class I molecules prevent NK cells from being activated by autologous healthy target cells. In order for NK cells to be activated...
Direct deprotected glycosyl-asparagine ligation (2006)
Doores, Katie J., Mimura, Yusuke, Dwek, Raymond A., Rudd, Pauline M., Elliott, Tim, Davis, Benjamin G.
A simple and efficient synthesis of N-linked glycoamino acids and glycopeptides from deprotected sugars using the Staudinger reaction
Immunogenicity of calreticulin-bound murine leukemia virus glycoprotein gp90 (2005)
Mimura, Yusuke, Golgher, Denise, Mimura-Kimura, Yuka, Dwek, Raymond A., Rudd, Pauline M., Elliott, Tim
Yingyongnarongkul, Boon-ek, Howarth, Mark, Elliott, Tim, Bradley, Mark
The ability of non-viral gene delivery systems to overcome extracellular and intracellular barriers is a critical issue for future clinical applications of gene therapy. In recent years much effort...
Tapasin enhances MHC class I peptide presentation according to peptide half-life (2004)
Howarth, Mark, Williams, Anthony, Tolstrup, Anne B., Elliott, Tim
Understanding how peptides are selected for presentation by MHC class I is crucial to vaccination strategies based on cytotoxic T lymphocyte priming. We have studied this selection of the MHC class I...
The influence of CD25+ cells on the generation of immunity to tumour cell lines in mice (2004)
Jones, Emma, Golgher, Denise, Simon, Anna Katharina, Dahm-Vicker, Michaela, Screaton, Gavin, Elliott, Tim, ...
CD25+ regulatory T cells comprise 5–10% of CD4+ T cells in naïve mice and have been shown in several in vivo murine models to prevent the induction of autoimmune disease and inflammatory disease....
Assembly and export of MHC class I peptide ligands (2003)
Antoniou, Antony N., Powis, Simon J., Elliott, Tim
During the assembly of MHC class I molecules with peptide, a series of transient interactions are made with endoplasmic reticulum-resident chaperones and MHC class I-specific accessory molecules....
Bird, Lucy A., Peh, Chen Au, Kollnberger, Simon, Elliott, Tim, McMichael, Andrew J., Bowness, Paul
The MHC class I allele HLA-B27 is very strongly associated with development of autoimmune spondyloarthritis, although the disease mechanism remains unknown. Class I molecules classically associate in...
Construction of block-coil high-field model dipoles for future hadron colliders (2002)
Blackburn, Raymond, Elliott, Tim, Henchel, William, McInturff, Al, McIntyre, Peter, Sattarov, Akhdior
Optimization of the MHC class I peptide cargo is dependent on tapasin (2002)
Williams, Anthony P., Peh, Chen Au, Purcell, Anthony W., McCluskey, James, Elliott, Tim
The loading of MHC class I molecules with their peptide cargo is undertaken by a multimolecular peptide loading complex within the endoplasmic reticulum. We show that MHC class I molecules can...
Gao, Bin, Adhikari, Raju, Howarth, Mark, Nakamura, Kimitoshi, Gold, Marielle C., Hill, Ann B., ...
MHC class I molecules expressed in a calreticulin-deficient cell line (K42) assembled with β 2-microglobulin (β2-m) normally, but their subsequent loading with optimal peptides was defective....
Antoniou, Antony N., Ford, Stuart, Alphey, Magnus, Osborne, Andrew, Elliott, Tim, Powis, Simon J.
The oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the...
Golgher, Denise, Jones, Emma, Powrie, Fiona, Elliott, Tim, Gallimore, Awen
Although it is known that the immune system can mount responses to a variety of tumors it is clear that most tumors exhibit weak or even undetectable immunogenicity. Recent findings suggest that the...
Rice, Jason, Elliott, Tim, Buchan, Sarah, Stevenson, Freda K.
DNA vaccination offers a strategy to induce immune attack on cancer cells, but tumor Ags are often weak. Inclusion of a "foreign" protein increases immunogenicity, and we found previously that fusion...
Glycosylation and the immune system (2001)
Rudd, Pauline M., Elliott, Tim, Cresswell, Peter, Wilson, Ian A., Dwek, Raymond A.
Almost all of the key molecules involved in the innate and adaptive immune response are glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding, quality control,...
MHC-restricted T cell responses against posttranslationally modified peptide antigens (2001)
Kastrup, Ingelise Bjerring, Andersen, Mads Hald, Elliott, Tim, Haurum, John S.
Paper Alert: Immunology (2001)
Elliott, Tim, Bonneville, Marc, Kruisbeek, Ada, Walker, Paul R., Glaichenhaus, Nicolas, Rowland-Jones, Sarah, ...
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in immunology.
Godkin, Andrew J., Smith, Katherine J., Willis, Anthony, Tejada-Simon, Maria V., Zhang, Jingwu, Elliott, Tim, ...
MHC class II heterodimers bind peptides 12–20 aa in length. The peptide flanking residues (PFRs) of these ligands extend from a central binding core consisting of nine amino acids. Increasing...
Multiple antigen-specific processing pathways for activating naive CD8+ T cells in vivo (2001)
Norbury, Christopher C., Princiotta, Michael F., Bacik, Igor, Brutkiewicz, Randy R., Wood, Phillip, Elliott, Tim, ...
Current knowledge of the processing of viral Ags into MHC class I-associated ligands is based almost completely on in vitro studies using nonprofessional APCs (pAPCs). This is two steps removed from...
Golgher, Denise, Korangy, Firouzeh, Gao, Bin, Gorski, Kevin, Jaffee, Elizabeth, Edidin, Michael, ...
There is accumulating evidence that CD4+ T cell responses are important in antitumor immunity. Accordingly, we generated CD4+ T cells against the murine CT26 colon cancer. Three of three independent...
Oxygen isotope geochemistry of oceanic-arc lava (2000)
Eiler, J. M., Crawford, Anthony, Elliott, Tim, Farley, Kenneth A., Valley, John W., Stolper, Edward M.
Variations of oxygen isotope ratios in arc-related lavas can constrain the contributions of subducted crustal igneous rocks, sediments, and fluids to the sub-arc mantle. We have measured oxygen...
Oxygen Isotope Geochemistry of Oceanic-Arc Lavas (2000)
EILER, JOHN M., CRAWFORD, ANTHONY, ELLIOTT, TIM, FARLEY, KENNETH A., VALLEY, JOHN W., STOLPER, EDWARD M.
Variations of oxygen isotope ratios in arc-related lavas can constrain the contributions of subducted crustal igneous rocks, sediments, and fluids to the sub-arc mantle. We have measured oxygen...
Sexuality and Genetic Identity in the Agaricus Section Arvenses
Calvo-Bado, Leo, Noble, Ralph, Challen, Mike, Dobrovin-Pennington, Andreja, Elliott, Tim
Twelve wild collections and one commercial strain were used to characterize breeding systems and to develop molecular identities in the Arvenses section of the genus Agaricus, which includes the...
Antoniou, Antony N., Ford, Stuart, Alphey, Magnus, Osborne, Andrew, Elliott, Tim, Powis, Simon J.
The oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the...
Tapasin enhances MHC class I peptide presentation according to peptide half-life
Howarth, Mark, Williams, Anthony, Tolstrup, Anne B., Elliott, Tim
Understanding how peptides are selected for presentation by MHC class I is crucial to vaccination strategies based on cytotoxic T lymphocyte priming. We have studied this selection of the MHC class I...
Sexuality and Genetic Identity in the Agaricus Section Arvenses
Calvo-Bado, Leo, Noble, Ralph, Challen, Mike, Dobrovin-Pennington, Andreja, Elliott, Tim
Twelve wild collections and one commercial strain were used to characterize breeding systems and to develop molecular identities in the Arvenses section of the genus Agaricus, which includes the...
Antoniou, Antony N., Ford, Stuart, Alphey, Magnus, Osborne, Andrew, Elliott, Tim, Powis, Simon J.
The oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the...
Tapasin enhances MHC class I peptide presentation according to peptide half-life
Howarth, Mark, Williams, Anthony, Tolstrup, Anne B., Elliott, Tim
Understanding how peptides are selected for presentation by MHC class I is crucial to vaccination strategies based on cytotoxic T lymphocyte priming. We have studied this selection of the MHC class I...
Mimura, Yusuke, Mimura-Kimura, Yuka, Doores, Katie, Golgher, Denise, Davis, Benjamin G., Dwek, Raymond A., ...
CD4+ and CD8+ T cell responses to endogenous retroviral envelope glycoprotein gp90 generate protective immunity to murine colon carcinoma CT26. A panel of I-Ad-restricted T cell hybridomas recognize...
Gallimore, Awen, Glithero, Ann, Godkin, Andrew, Tissot, Alain C., Plückthun, Andreas, Elliott, Tim, ...
This study describes the construction of soluble major histocompatibility complexes consisting of the mouse class I molecule, H-2Db, chemically biotinylated β2 microglobulin and a peptide epitope...
We and others have shown that influenza A nucleoprotein (NP) targeted to the secretory pathway cannot be processed to yield several cytotoxic T lymphocyte (CTL) epitopes in cell lines that lack the...
Haurum, John S., Høier, Ingelise Bjerring, Arsequell, Gemma, Neisig, Anne, Valencia, Gregorio, Zeuthen, Jesper, ...
Antigens presented by class I major histocompatibility complex (MHC) molecules for recognition by cytotoxic T lymphocytes consist of 8–10-amino-acid-long cytosolic peptides. It is not known whether...
Ireland, Breanna S., Brockmeier, Ulf, Howe, Christopher M., Elliott, Tim, Williams, David B.
Calreticulin is a molecular chaperone of the endoplasmic reticulum that uses both a lectin site specific for Glc1Man5-9GlcNAc2 oligosaccharides and a polypeptide binding site to interact with nascent...