Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction (2005)
Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A., Maren, Stephen
In recent studies, inactivation of the dorsal hippocampus before the retrieval of extinguished fear memories disrupted the context-dependent expression of these memories. In the present experiments,...
Moffat, Bradford A., Hall, Daniel E., Young, John M., Desmond, Timothy J., Carter, Julie, Pietronigro, Dennis, ...
Solvent facilitated perfusion (SFP) has been proposed as a technique to increase the delivery of chemotherapeutic agents to tumors. SFP entails direct injection of the agent into the tumor in a...
Maren, Stephen, Ferrario, Carrie R., Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A.
The amygdala is an essential neural substrate for Pavlovian fear conditioning. Nevertheless, long-term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to...
Striatal monoaminergic terminals in Lewy body and Alzheimer's dementias (2002)
Suzuki, Masahiko, Desmond, Timothy J., Albin, Roger L., Frey, Kirk A.
Vesicular monoamine transporter type 2 and benzodiazepine binding site expressions were examined with quantitative autoradiography in postmortem striata from 19 patients with dementia with Lewy...
Suzuki, Masahiko, Desmond, Timothy J., Albin, Roger L., Frey, Kirk A.
Markers of identified neuronal populations have previously suggested selective degeneration of projection neurons in Huntington's disease (HD) striatum. Interpretations are, however, limited by...
Snyder, Scott E., Sherman, Phillip S., Desmond, Timothy J., Frey, Kirk A., Kilbourn, Michael R.
Deficits in Complex I (NADH-ubiquinone oxidoreductase) of the electron transport chain may play an important role in the inception and progression of neurodegenerative diseases such as Parkinson's...
50 Ampere Turn-Off Switch. (1998)
New, Thorndike C., Desmond, Timothy J.
The subject of the report is the developmental work performed on a 50 ampere, gate controlled switch. Effort was continued on refinement of the basic process and structural design. Several basic...
50 Ampere Turn-Off Switch. (1998)
New, Thorndike C., Desmond, Timothy J.
The improvement of the fabrication process for the gate controlled switch has been performed as planned. The control of silicon wafer flatness, the attainment of the blocking voltage above 1000V at...
50 Ampere Turn-Off Switch. (1998)
New, Thorndike C., Desmond, Timothy J.
Gold doping of the GCS by diffusion is discussed. The typical gold doped device without additional gate inductance can now turn off 40A in less than the 5 microsec required in the contract. Using the...
50 Ampere Turn-Off Switch. (1998)
New, Thorndike C., Desmond, Timothy J.
The development of a manufacturing process for a 50A/300V gate controlled switch is described. The unit is a 0.91 in. diameter wafer, alloyed to a molybdenum disc and enclosed in a compression bonded...
Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain (1994)
Levey, A. I., Edmunds, S. M., Heilman, C. J., Desmond, Timothy J., Frey, Kirk A
A family of receptor subtypes, defined either by molecular (ml-m5) or pharmacological (M1-M4) analysis, mediates muscarinic cholinergic neurotransmission in brain. The distribution and functions of...
Hieber, V., Siegel, George J., Desmond, Timothy J., Liu, J., Ernst, Stephen A.
A clone encoding mouse brain Na, K-ATPase Α-subunit was isolated from a mouse brain lambda gt11 cDNA library by using antisera to mouse and bovine brain Α-subunit A comparison of the nucleotide...
(Na + +K + )-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice (1987)
Sheedlo, Harold J., Siegel, George J., Desmond, Timothy J., Ernst, Stephen A.
The myelin-deficient Shiverer (Shi/Shi) mutant mouse may be a useful model in assessing the dependence of brain (Na + +K + )-ATPase concentration and composition on myelin membrane formation. Brain...
(Na+ + K+)-ATPase in C6 glioma and rat cerebrum (1987)
Sheedlo, Harold J., Starosta-Rubinstein, Simon, Desmond, Timothy J., Siegel, George J.
The content and distribution of the membranee-bound enzyme (Na+ + K+)-ATPase in a rat cerebral C6 glioma was determined by immunocytochemistry, immunoblots and enzyme assay. In the C6 glioma cell...