Timothy J. McDonnell

Selenium and Vitamin E: Cell Type- and Intervention-Specific Tissue Effects in Prostate Cancer (2009)

Tsavachidou, Dimitra, McDonnell, Timothy J., Wen, Sijin, Wang, Xuemei, Vakar-Lopez, Funda, Pisters, Louis L., ...

Background Secondary analyses of two randomized, controlled phase III trials demonstrated that selenium and vitamin E could reduce prostate cancer incidence. To characterize pharmacodynamic and gene...

Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer (2008)

McDonnell, Timothy J, Chari, Nikhil S, Cho-Vega, Jeong, Troncoso, Patricia, Wang, Xuemei, Bueso-Ramos, Carlos E, ...

Abstract Background: The early detection of prostate cancer has resulted in an increase in the number of patients with localized prostate cancer and has paralleled the reported reduction in prostate...

Merging microarray data, robust feature selection, and predicting prognosis in prostate cancer (2006)

Jing Wang, Kim Anh Do, Sijin Wen, Spyros Tsavachidis, Timothy J. McDonnell, Christopher J. Logothetis, ...

Motivation: Individual microarray studies searching for prognostic biomarkers often have few samples and low statistical power; however, publicly accessible data sets make it possible to combine data...

Merging microarray data, robust feature selection, and predicting prognosis in prostate cancer (2006)

Jing Wang, Kim Anh Do, Sijin Wen, Spyros Tsavachidis, Timothy J. McDonnell, Christopher J. Logothetis, ...

Motivation: Individual microarray studies searching for prognostic biomarkers often have few samples and low statistical power; however, publicly accessible data sets make it possible to combine data...

Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer (2005)

Kim, Jeri, Sun, Peiyu, Lam, Ying-Wai, Troncoso, Patricia, Sabichi, Anita L., Babaian, Richard J., ...

BACKGROUND: Evidence of the chemopreventive effects of the dietary antioxidants alpha-tocopherol (vitamin E) and l-selenomethionine (selenium) comes from secondary analysis of two phase III clinical...

Angiogenic Potential of Prostate Carcinoma Cells Overexpressing bcl-2 (2001)

Fernandez, Antonio, Udagawa, Taturo, Schwesinger, Catherine, Beecken, Wolf-Dietrich, Achilles-Gerte, Eike, McDonnell, Timothy J., ...

Background: Tumors commonly outgrow their blood supply, thereby creating hypoxic conditions, which induce apoptosis and increase expression of angiogenic growth factors. The bcl-2 oncogene inhibits...

High metastatic potential in mice inheriting a targeted p53 missense mutation

Liu, Geng, McDonnell, Timothy J., Kapoor, Mini, Mims, Betsy, El-Naggar, Adel K., ...

To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in...

High metastatic potential in mice inheriting a targeted p53 missense mutation

Liu, Geng, McDonnell, Timothy J., Kapoor, Mini, Mims, Betsy, El-Naggar, Adel K., ...

To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in...

Differential Expression of BCL-2 Family Proteins in ALK-Positive and ALK-Negative Anaplastic Large Cell Lymphoma of T/Null-Cell Lineage

Rassidakis, George Z., Sarris, Andreas H., Herling, Marco, Ford, Richard J., Cabanillas, Fernando, McDonnell, Timothy J., ...

Anaplastic large-cell lymphoma (ALCL) of T- or null-cell lineage, as defined in the revised European-American lymphoma classification, includes a subset of tumors that carry the t(2;5)(p23;q35)...