Timothy P. Dalton

A space for absence (2008)

Dalton, Timothy P.

Thesis (M.F.A.)--Virginia Commonwealth University, 2008.

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes (2007)

Shertzer, Howard G., Genter, Mary B., Talaska, Glenn, Curran, Christine P., Nebert, Daniel W., Dalton, Timothy P.

Found in tobacco smoke, fossil fuel and other organic combustion products, 7H-dibenzo[c,g]carbazole (DBC) is a potent mouse lung carcinogen and potential human carcinogen. Although the first...

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis (2006)

Daniel W. Nebert, Timothy P. Dalton

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes (2006)

Shertzer, Howard G., Genter, Mary Beth, Talaska, Glenn, Curran, Christine P., Nebert, Daniel W., Dalton, Timothy P.

Found in tobacco smoke, fossil fuel and other organic combustion products, 7H-dibenzo[c,g]carbazole (DBC) is a potent mouse lung carcinogen and potential human carcinogen. Although the first...

Genetic Differences in Lethality of Newborn Mice Treated In Utero with Coplanar versus Non-Coplanar Hexabromobiphenyl (2006)

Curran, Christine P., Miller, Kevin A., Dalton, Timothy P., Vorhees, Charles V., Miller, Marian L., Shertzer, Howard G., ...

Polybrominated biphenyl (PBB) exposure in humans is known to cause immunotoxicity and disorders related to the central nervous system. Coplanar PBBs bind to the aryl hydrocarbon receptor (AHR) in...

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes (2006)

Shertzer, Howard G., Genter, Mary Beth, Talaska, Glenn, Curran, Christine P., Nebert, Daniel W., Dalton, Timothy P.

Found in tobacco smoke, fossil fuel and other organic combustion products, 7H-dibenzo[c,g]carbazole (DBC) is a potent mouse lung carcinogen and potential human carcinogen. Although the first...

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status (2005)

Kann, Simone, Estes, Cameron, Reichard, John F., Huang, Ming-ya, Sartor, Maureen A., Schwemberger, Sandy, ...

Arsenic, first among the top environmentally hazardous substances, is associated with skin, lung, liver, kidney, prostate and bladder cancer. Arsenic is also a cardiovascular and a central nervous...

Genetic Differences in Lethality of Newborn Mice Treated in utero with Coplanar versus Non-Coplanar Hexabromobiphenyl (2005)

Curran, Christine P., Miller, Kevin A., Dalton, Timothy P., Vorhees, Charles V., Miller, Marian L., Shertzer, Howard G., ...

Polybrominated biphenyl (PBB) exposure in humans is known to cause immunotoxicity and disorders related to the central nervous system. Coplanar PBBs bind to the aryl hydrocarbon receptor (AHR) in...

Butylhydroquinone Protects Cells Genetically Deficient in Glutathione Biosynthesis from Arsenite-Induced Apoptosis Without Significantly Changing Their Prooxidant Status (2005)

Kann, Simone, Estes, Cameron, Reichard, John F., Huang, Ming-ya, Sartor, Maureen A., Schwemberger, Sandy, ...

Arsenic, first among the top environmentally hazardous substances, is associated with skin, lung, liver, kidney, prostate, and bladder cancer. Arsenic is also a cardiovascular and a central nervous...

Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status (2005)

Kann, Simone, Estes, Cameron, Reichard, John F., Huang, Ming-ya, Sartor, Maureen A., Schwemberger, Sandy, ...

Arsenic, first among the top environmentally hazardous substances, is associated with skin, lung, liver, kidney, prostate and bladder cancer. Arsenic is also a cardiovascular and a central nervous...

Genetic Differences in Lethality of Newborn Mice Treated in utero with Coplanar versus Non-Coplanar Hexabromobiphenyl (2005)

Curran, Christine P., Miller, Kevin A., Dalton, Timothy P., Vorhees, Charles V., Miller, Marian L., Shertzer, Howard G., ...

Polybrominated biphenyl (PBB) exposure in humans is known to cause immunotoxicity and disorders related to the central nervous system. Coplanar PBBs bind to the aryl hydrocarbon receptor (AHR) in...

Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse (2003)

Smith, Andrew G., Davies, Reginald, Dalton, Timothy P., Miller, Marian L., Judah, David J., Riley, Joan, ...

Also published as EHP Toxicogenomics. 2003 Jan;111(1T):45-51.

4-Aminobiphenyl–Induced Liver and Urinary Bladder DNA Adduct Formation in Cyp1a2(–/–) and Cyp1a2(+/+) Mice (2003)

Tsuneoka, Yutaka, Dalton, Timothy P., Miller, Marian L., Clay, Corey D., Shertzer, Howard G., Talaska, Glenn, ...

Background: Metabolites of the potent human carcinogen 4-aminobiphenyl (ABP) induce oxidative stress and form DNA adducts that are associated with hepatic and urinary bladder toxicity and bladder...

Cellular aspects of phosphatidylinositol transfer protein /--by Timothy P. Dalton. (1992)

Dalton, Timothy P.

Thesis (Ph. D.)--University of Kansas, Biochemistry and Molecular Biology, 1992.

Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis

Dalton, Timothy P., He, Lei, Wang, Bin, Miller, Marian L., Jin, Li, Stringer, Keith F., ...

Testicular necrosis is a sensitive endpoint for cadmium (Cd2+, Cd) toxicity across all species tested. Resistance to Cd-induced testicular damage is a recessive trait assigned to the Cdm locus on...

Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis

Dalton, Timothy P., He, Lei, Wang, Bin, Miller, Marian L., Jin, Li, Stringer, Keith F., ...

Testicular necrosis is a sensitive endpoint for cadmium (Cd2+, Cd) toxicity across all species tested. Resistance to Cd-induced testicular damage is a recessive trait assigned to the Cdm locus on...

Induction of Oxidative Stress Responses by Dioxin and other Ligands of the Aryl Hydrocarbon Receptor

Reichard, John F., Dalton, Timothy P., Shertzer, Howard G., Puga, Alvaro

TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) have been classically considered as non-genotoxic compounds because they fail to be directly...

The Role of Metallothionein in the Pathogenesis of Acute Lung Injury

Wesselkamper, Scott C., McDowell, Susan A., Medvedovic, Mario, Dalton, Timothy P., Deshmukh, Hitesh S., Sartor, Maureen A., ...

Often fatal, acute lung injury has a complicated etiology. Previous studies from our laboratory in mice have demonstrated that survival during acute lung injury is a complex trait governed by...

Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

Dong, Hongbin, Dalton, Timothy P., Miller, Marian L., Chen, Ying, Uno, Shigeyuki, Shi, Zhanquan, ...

In the past, CYP1A1 protein was known to be located in the endoplasmic reticulum (ER; microsomes). More recently, CYP1A1 was shown also to be targeted to the inner mitochondrial membrane;...